This is a Validated Antibody Database (VAD) review about human PPAR, based on 29 published articles (read how Labome selects the articles), using PPAR antibody in all methods. It is aimed to help Labome visitors find the most suited PPAR antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
PPAR synonym: NR1C1; PPAR; PPARalpha; hPPAR; peroxisome proliferator-activated receptor alpha; PPAR-alpha; nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor, alpha; peroxisome proliferator-activated nuclear receptor alpha variant 3

Knockout validation
Abcam
mouse monoclonal (H0723)
  • western blot knockout validation; mouse; loading ...; fig 1d
Abcam PPAR antibody (Abcam, ab97609) was used in western blot knockout validation on mouse samples (fig 1d). Oncotarget (2014) ncbi
Cayman Chemical
rabbit polyclonal
  • western blot knockout validation; mouse; fig 5
Cayman Chemical PPAR antibody (Cayman Chemical, 101710) was used in western blot knockout validation on mouse samples (fig 5). elife (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal
  • western blot; human; loading ...; fig 3f
Santa Cruz Biotechnology PPAR antibody (Santa Cruz, sc398394) was used in western blot on human samples (fig 3f). Br J Pharmacol (2018) ncbi
mouse monoclonal
  • immunohistochemistry - frozen section; mouse; loading ...; fig 4c
Santa Cruz Biotechnology PPAR antibody (Santa Cruz Biotechnology Inc, sc-398394) was used in immunohistochemistry - frozen section on mouse samples (fig 4c). J Biol Chem (2018) ncbi
mouse monoclonal
  • western blot; human; fig 12c
Santa Cruz Biotechnology PPAR antibody (Santa Cruz, sc-398394) was used in western blot on human samples (fig 12c). Mol Cell Endocrinol (2018) ncbi
mouse monoclonal (467D1a)
  • western blot; rat; 1:200; fig 4
Santa Cruz Biotechnology PPAR antibody (Santa Cruz, sc-130640) was used in western blot on rat samples at 1:200 (fig 4). Mol Med Rep (2015) ncbi
mouse monoclonal (467D1a)
  • western blot; human; fig 6b
Santa Cruz Biotechnology PPAR antibody (santa cruz, sc-130640) was used in western blot on human samples (fig 6b). Int J Mol Med (2015) ncbi
Invitrogen
mouse monoclonal (3B6/PPAR)
  • western blot; mouse; loading ...; fig 2c
In order to determine the protective effects of pepsin-digested chicken liver hydrolysates against chronic alcohol consumption, Invitrogen PPAR antibody (Thermo Fisher Scientific, MA1-822) was used in western blot on mouse samples (fig 2c). Food Funct (2017) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig 6i
In order to clarify the contributions of SCP2/SCPx gene ablation on dietary phytol-induced whole body and hepatic lipid phenotypes, Invitrogen PPAR antibody (Pierce, PA1-822A) was used in western blot on mouse samples (fig 6i). Biochim Biophys Acta Mol Cell Biol Lipids (2017) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:250; fig 1
  • western blot; human; 1:400; fig 4
In order to determine the relationship with aryl hydrocarbon receptor interacting protein (AIP) and in vitor effects of fenofibrate in GH3 cells to study expression of peroxisome proliferator-activated receptor alpha (PPAR-alpha) in somatotropinomas, Invitrogen PPAR antibody (Thermo Scientific, PA1-822A) was used in immunohistochemistry - paraffin section on human samples at 1:250 (fig 1) and in western blot on human samples at 1:400 (fig 4). Mol Cell Endocrinol (2016) ncbi
rabbit polyclonal
  • immunohistochemistry; mouse; 1:200; fig 2
  • western blot; human; 1:1000; fig 1
In order to determine the role of decreased PPAR-delta in Huntington's disease and therapeutic targets, Invitrogen PPAR antibody (Pierce, PA1-822A) was used in immunohistochemistry on mouse samples at 1:200 (fig 2) and in western blot on human samples at 1:1000 (fig 1). Nat Med (2016) ncbi
rabbit polyclonal
  • western blot; mouse
In order to investigate the role of L-FABP and SCP-2/SCP-x in hepatic lipid metabolism, Invitrogen PPAR antibody (Pierce, PA1-822A) was used in western blot on mouse samples . Arch Biochem Biophys (2015) ncbi
rabbit polyclonal
  • western blot; mouse
In order to investigate the role of SCP-2/SCP-x and dietary cholesterol in hepatic lipid metabolism, Invitrogen PPAR antibody (ThermoFisher Scientific, PA1-822A) was used in western blot on mouse samples . Am J Physiol Gastrointest Liver Physiol (2015) ncbi
rabbit polyclonal
  • western blot; mouse; fig 7
In order to characterize ablation of L-FABP in SCP-2/SCP-x null mice and the impairment of bile acid metabolism and biliary HDL-cholesterol secretion, Invitrogen PPAR antibody (Pierce, PA1-822A) was used in western blot on mouse samples (fig 7). Am J Physiol Gastrointest Liver Physiol (2014) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000
In order to study the mechanisms underlying the beneficial effects of a dietary pine bark extract on glucose tolerance in a murine model of type 2 diabetes, Invitrogen PPAR antibody (Thermo Scientific, PA1-822A) was used in western blot on mouse samples at 1:1000. J Pharm Pharmacol (2014) ncbi
Abcam
rabbit polyclonal
  • western blot; rat; loading ...; fig 3a
In order to elucidate the effects of baicalin in an infant rodent model of pulmonary hypertension, Abcam PPAR antibody (Abcam, Ab3484) was used in western blot on rat samples (fig 3a). FEBS Open Bio (2017) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig 1b
In order to delineate the role of microRNA-21 in non-alcoholic steatohepatitis, Abcam PPAR antibody (Abcam, Ab24509) was used in western blot on mouse samples (fig 1b). Gut (2016) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000
Abcam PPAR antibody (Abcam, 24509) was used in western blot on mouse samples at 1:1000. Cardiovasc Diabetol (2015) ncbi
rabbit polyclonal
  • western blot; mouse
Abcam PPAR antibody (Abcam, Ab24509) was used in western blot on mouse samples . BMC Endocr Disord (2015) ncbi
mouse monoclonal (H0723)
  • western blot knockout validation; mouse; loading ...; fig 1d
Abcam PPAR antibody (Abcam, ab97609) was used in western blot knockout validation on mouse samples (fig 1d). Oncotarget (2014) ncbi
rabbit polyclonal
  • western blot; rat
Abcam PPAR antibody (Abcam, ab24509) was used in western blot on rat samples . PLoS ONE (2014) ncbi
rabbit polyclonal
  • western blot; rat; 1:500
Abcam PPAR antibody (Abcam, Ab24509) was used in western blot on rat samples at 1:500. Endocrinology (2014) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; rat; 1:500
Abcam PPAR antibody (Abcam, ab24509) was used in immunohistochemistry - paraffin section on rat samples at 1:500. Toxicol Sci (2013) ncbi
Abnova
rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig st3
In order to find the E3 ubiquitin ligase Mule is essential for cardiac homeostasis by regulating mitochondrial function via maintenance of Pgc-1alpha and Pink1 expression and persistent negative regulation of c-Myc, Abnova PPAR antibody (Abnova, PAB11321) was used in western blot on mouse samples at 1:1000 (fig st3). Sci Rep (2017) ncbi
Proteintech Group
rabbit polyclonal
  • western blot; mouse; loading ...; fig 5a
In order to report that Zfp407 overexpression improved glucose homeostasis, Proteintech Group PPAR antibody (Proteintech, 15540-1) was used in western blot on mouse samples (fig 5a). Am J Physiol Endocrinol Metab (2016) ncbi
Enzo Life Sciences
mouse monoclonal (3B6/PPAR)
  • western blot; human; fig 4b
Enzo Life Sciences PPAR antibody (Enzo, 3B6/PPAR) was used in western blot on human samples (fig 4b). PLoS Genet (2015) ncbi
MilliporeSigma
mouse monoclonal (3B6/PPAR)
  • western blot; rat; 1:1000; loading ...; fig 4a
In order to measure brain insulin signaling in response to dexamethasone treatment in female Charles Foster rats, MilliporeSigma PPAR antibody (Sigma, P 0869) was used in western blot on rat samples at 1:1000 (fig 4a). Mol Neurobiol (2017) ncbi
rabbit polyclonal
  • western blot; mouse; fig 4
In order to study the protective effects against cardiac steatosis and dilated cardiomyopathy of specifically overexpressing triglyceride lipase in cardiomyocytes in a murine model of diet-induced obesity, MilliporeSigma PPAR antibody (Sigma, P0369) was used in western blot on mouse samples (fig 4). Int J Obes (Lond) (2014) ncbi
Cayman Chemical
rabbit polyclonal
  • western blot knockout validation; mouse; fig 5
Cayman Chemical PPAR antibody (Cayman Chemical, 101710) was used in western blot knockout validation on mouse samples (fig 5). elife (2016) ncbi
EMD Millipore
rabbit polyclonal
  • western blot; rat; 1:1000; fig 11
EMD Millipore PPAR antibody (Millipore, 07-466) was used in western blot on rat samples at 1:1000 (fig 11). Mol Med Rep (2016) ncbi
rabbit polyclonal
  • EMSA; human
In order to study the regulation of brown adipocyte UCP3 transcription by a novel intronic enhancer that binds SP1 and SP3, EMD Millipore PPAR antibody (Millipore, 07-466) was used in EMSA on human samples . PLoS ONE (2013) ncbi
Articles Reviewed
  1. Zhang C, Deng J, Liu D, Tuo X, Xiao L, Lai B, et al. Nuciferine ameliorates hepatic steatosis in high-fat diet/streptozocin-induced diabetic mice through a PPARα/PPARγ coactivator-1α pathway. Br J Pharmacol. 2018;175:4218-4228 pubmed publisher
  2. Huang L, Liu J, Zhang X, Sibley K, Najjar S, Lee M, et al. Inhibition of protein arginine methyltransferase 5 enhances hepatic mitochondrial biogenesis. J Biol Chem. 2018;293:10884-10894 pubmed publisher
  3. Valanejad L, Ghareeb M, Shiffka S, Nadolny C, Chen Y, Guo L, et al. Dysregulation of Δ4-3-oxosteroid 5β-reductase in diabetic patients: Implications and mechanisms. Mol Cell Endocrinol. 2018;470:127-141 pubmed publisher
  4. Lin Y, Tai S, Chen J, Chou C, Fu S, Chen Y. Ameliorative effects of pepsin-digested chicken liver hydrolysates on development of alcoholic fatty livers in mice. Food Funct. 2017;8:1763-1774 pubmed publisher
  5. Chen Z, Wang Q. Activation of PPAR? by baicalin attenuates pulmonary hypertension in an infant rat model by suppressing HMGB1/RAGE signaling. FEBS Open Bio. 2017;7:477-484 pubmed publisher
  6. Dadson K, Hauck L, Hao Z, Grothe D, Rao V, Mak T, et al. The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1. Sci Rep. 2017;7:41490 pubmed publisher
  7. Milligan S, Martin G, Landrock D, McIntosh A, Mackie J, Schroeder F, et al. Impact of dietary phytol on lipid metabolism in SCP2/SCPX/L-FABP null mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:291-304 pubmed publisher
  8. Chruvattil R, Banerjee S, Nath S, Machhi J, Kharkwal G, Yadav M, et al. Dexamethasone Alters the Appetite Regulation via Induction of Hypothalamic Insulin Resistance in Rat Brain. Mol Neurobiol. 2017;54:7483-7496 pubmed publisher
  9. Charrier A, Wang L, Stephenson E, Ghanta S, Ko C, Croniger C, et al. Zinc finger protein 407 overexpression upregulates PPAR target gene expression and improves glucose homeostasis in mice. Am J Physiol Endocrinol Metab. 2016;311:E869-E880 pubmed publisher
  10. Rando G, Tan C, Khaled N, Montagner A, Leuenberger N, Bertrand Michel J, et al. Glucocorticoid receptor-PPAR? axis in fetal mouse liver prepares neonates for milk lipid catabolism. elife. 2016;5: pubmed publisher
  11. Rotondi S, Modarelli A, Oliva M, Rostomyan L, Sanità P, Ventura L, et al. Expression of Peroxisome Proliferator-Activated Receptor alpha (PPARα) in somatotropinomas: Relationship with Aryl hydrocarbon receptor Interacting Protein (AIP) and in vitro effects of fenofibrate in GH3 cells. Mol Cell Endocrinol. 2016;426:61-72 pubmed publisher
  12. Dickey A, Pineda V, Tsunemi T, Liu P, Miranda H, Gilmore Hall S, et al. PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically. Nat Med. 2016;22:37-45 pubmed publisher
  13. Wang Y, Zhu G, Wang J, Chen J. Irradiation alters the differentiation potential of bone marrow mesenchymal stem cells. Mol Med Rep. 2016;13:213-23 pubmed publisher
  14. Li P, Luo S, Pan C, Cheng X. Modulation of fatty acid metabolism is involved in the alleviation of isoproterenol-induced rat heart failure by fenofibrate. Mol Med Rep. 2015;12:7899-906 pubmed publisher
  15. Cheng Y, Seibert O, Klöting N, Dietrich A, Straßburger K, Fernández Veledo S, et al. PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis. PLoS Genet. 2015;11:e1005561 pubmed publisher
  16. Loyer X, Paradis V, Hénique C, Vion A, Colnot N, Guerin C, et al. Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression. Gut. 2016;65:1882-1894 pubmed publisher
  17. He J, Quintana M, Sullivan J, L Parry T, J Grevengoed T, Schisler J, et al. MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet. Cardiovasc Diabetol. 2015;14:97 pubmed publisher
  18. Quintana M, He J, Sullivan J, Grevengoed T, Schisler J, Han Y, et al. Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet. BMC Endocr Disord. 2015;15:36 pubmed publisher
  19. Martin G, Atshaves B, Landrock K, Landrock D, Schroeder F, Kier A. Loss of L-FABP, SCP-2/SCP-x, or both induces hepatic lipid accumulation in female mice. Arch Biochem Biophys. 2015;580:41-9 pubmed publisher
  20. Klipsic D, Landrock D, Martin G, McIntosh A, Landrock K, Mackie J, et al. Impact of SCP-2/SCP-x gene ablation and dietary cholesterol on hepatic lipid accumulation. Am J Physiol Gastrointest Liver Physiol. 2015;309:G387-99 pubmed publisher
  21. Kang O, Kim S, Mun S, Seo Y, Hwang H, Lee Y, et al. Puerarin ameliorates hepatic steatosis by activating the PPARα and AMPK signaling pathways in hepatocytes. Int J Mol Med. 2015;35:803-9 pubmed publisher
  22. Zhang N, Chu E, Zhang J, Li X, Liang Q, Chen J, et al. Peroxisome proliferator activated receptor alpha inhibits hepatocarcinogenesis through mediating NF-κB signaling pathway. Oncotarget. 2014;5:8330-40 pubmed
  23. Martin G, Atshaves B, Landrock K, Landrock D, Storey S, Howles P, et al. Ablating L-FABP in SCP-2/SCP-x null mice impairs bile acid metabolism and biliary HDL-cholesterol secretion. Am J Physiol Gastrointest Liver Physiol. 2014;307:G1130-43 pubmed publisher
  24. Bang C, Choung S. Enzogenol improves diabetes-related metabolic change in C57BL/KsJ-db/db mice, a model of type 2 diabetes mellitus. J Pharm Pharmacol. 2014;66:875-85 pubmed publisher
  25. Carrier B, Wen S, Zigouras S, Browne R, Li Z, Patel M, et al. Alpha-lipoic acid reduces LDL-particle number and PCSK9 concentrations in high-fat fed obese Zucker rats. PLoS ONE. 2014;9:e90863 pubmed publisher
  26. Hoffmann C, Zimmermann A, Hinney A, Volckmar A, Jarrett H, Fromme T, et al. A novel SP1/SP3 dependent intronic enhancer governing transcription of the UCP3 gene in brown adipocytes. PLoS ONE. 2013;8:e83426 pubmed publisher
  27. Nikolaenko L, Jia Y, Wang C, Diaz Arjonilla M, Yee J, French S, et al. Testosterone replacement ameliorates nonalcoholic fatty liver disease in castrated male rats. Endocrinology. 2014;155:417-28 pubmed publisher
  28. Pulinilkunnil T, Kienesberger P, Nagendran J, Sharma N, Young M, Dyck J. Cardiac-specific adipose triglyceride lipase overexpression protects from cardiac steatosis and dilated cardiomyopathy following diet-induced obesity. Int J Obes (Lond). 2014;38:205-15 pubmed publisher
  29. Plummer S, Dan D, Quinney J, Hallmark N, Phillips R, Millar M, et al. Identification of transcription factors and coactivators affected by dibutylphthalate interactions in fetal rat testes. Toxicol Sci. 2013;132:443-57 pubmed publisher