This is a Validated Antibody Database (VAD) review about human PP2AC, based on 32 published articles (read how Labome selects the articles), using PP2AC antibody in all methods. It is aimed to help Labome visitors find the most suited PP2AC antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
PP2AC synonym: NEDLBA; PP2Ac; PP2CA; PP2Calpha; RP-C

Santa Cruz Biotechnology
mouse monoclonal (F-8)
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 3d
  • western blot; mouse; 1:100; loading ...; fig 7a
Santa Cruz Biotechnology PP2AC antibody (Santa Cruz, sc-271903) was used in immunohistochemistry - paraffin section on mouse samples at 1:50 (fig 3d) and in western blot on mouse samples at 1:100 (fig 7a). Commun Biol (2021) ncbi
mouse monoclonal (2A10)
  • western blot; human; loading ...; fig 7e
  • western blot; rat; loading ...; fig 4g
Santa Cruz Biotechnology PP2AC antibody (Santa Cruz, sc-81603) was used in western blot on human samples (fig 7e) and in western blot on rat samples (fig 4g). Aging (Albany NY) (2020) ncbi
mouse monoclonal (F-8)
  • western blot; human; loading ...; fig 1i
Santa Cruz Biotechnology PP2AC antibody (Santa Cruz Biotechnology, sc-271903) was used in western blot on human samples (fig 1i). Mol Cell (2019) ncbi
mouse monoclonal (F-8)
  • immunoprecipitation; human; loading ...; fig 6a
  • immunocytochemistry; human; loading ...; fig 4c
  • western blot; human; loading ...; fig 6a
Santa Cruz Biotechnology PP2AC antibody (Santa Cruz Biotechnology, sc-271903) was used in immunoprecipitation on human samples (fig 6a), in immunocytochemistry on human samples (fig 4c) and in western blot on human samples (fig 6a). Oncotarget (2017) ncbi
mouse monoclonal (4B7)
  • immunoprecipitation; rat; 1:300
  • western blot; rat
In order to report the signaling mechanisms by which PKC-zeta activation affects EMAP-II-induced BTB hyperpermeability, Santa Cruz Biotechnology PP2AC antibody (Santa Cruz, sc-13601) was used in immunoprecipitation on rat samples at 1:300 and in western blot on rat samples . Exp Cell Res (2015) ncbi
mouse monoclonal (4B7)
  • western blot; rat
Santa Cruz Biotechnology PP2AC antibody (Santa Cruz Biotechnology, sc-13601) was used in western blot on rat samples . Brain Res (2015) ncbi
mouse monoclonal (C-1)
  • western blot; human; loading ...; fig 2a
Santa Cruz Biotechnology PP2AC antibody (SantaCruz, sc-376673) was used in western blot on human samples (fig 2a). PLoS ONE (2014) ncbi
mouse monoclonal (G-4)
  • western blot; human; 1:1000; fig 7
Santa Cruz Biotechnology PP2AC antibody (Santa Cruz Biotechnology, sc-166034) was used in western blot on human samples at 1:1000 (fig 7). FEBS Lett (2014) ncbi
mouse monoclonal (2A10)
  • western blot; rat
Santa Cruz Biotechnology PP2AC antibody (Santa Cruz Biotechnology, sc-81603) was used in western blot on rat samples . J Appl Physiol (1985) (2012) ncbi
Invitrogen
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 4e
Invitrogen PP2AC antibody (Thermo, PA5-17510) was used in western blot on mouse samples (fig 4e). Mol Neurodegener (2020) ncbi
mouse monoclonal (7A6)
  • western blot; human; 1:1000; loading ...; fig 2b
Invitrogen PP2AC antibody (Thermo Fisher, MA5-18060) was used in western blot on human samples at 1:1000 (fig 2b). J Biol Chem (2019) ncbi
domestic rabbit polyclonal
In order to study an increase in tau phosphorylation via P38 mitogen-activated protein kinase dye to glucose deprivation, Invitrogen PP2AC antibody (Thermo Scientific, PA5-17510) was used . Aging Cell (2015) ncbi
domestic rabbit polyclonal
In order to characterize the behavioral, biochemical, and neuropathologic effects of 8ISO in the triple transgenic mouse model of Alzheimer's disease, Invitrogen PP2AC antibody (Thermo Scientific, PA5-17510) was used . Neurobiol Aging (2015) ncbi
BioLegend
mouse monoclonal (1D7)
  • western blot; human; loading ...; fig 4a
BioLegend PP2AC antibody (BioLegend, 1D7) was used in western blot on human samples (fig 4a). Am J Hum Genet (2019) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (52F8)
  • western blot; human; 1:1000; loading ...; fig 5c
Cell Signaling Technology PP2AC antibody (CST, 2259) was used in western blot on human samples at 1:1000 (fig 5c). iScience (2022) ncbi
domestic rabbit monoclonal (52F8)
  • western blot; human; fig 4d
Cell Signaling Technology PP2AC antibody (Cell signaling, 2259) was used in western blot on human samples (fig 4d). iScience (2021) ncbi
domestic rabbit monoclonal (52F8)
  • western blot; human; loading ...; fig 4c
Cell Signaling Technology PP2AC antibody (Cell Signaling, 2259) was used in western blot on human samples (fig 4c). elife (2020) ncbi
domestic rabbit monoclonal (52F8)
  • western blot; rat; loading ...; fig 4g
  • western blot; human; loading ...; fig 7e
Cell Signaling Technology PP2AC antibody (Cell Signaling, 2259) was used in western blot on rat samples (fig 4g) and in western blot on human samples (fig 7e). Aging (Albany NY) (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 3c
Cell Signaling Technology PP2AC antibody (Cell Signaling Technology, 2038) was used in western blot on human samples (fig 3c). elife (2020) ncbi
domestic rabbit monoclonal (52F8)
  • western blot; mouse; 1:1000; loading ...; fig 3a
Cell Signaling Technology PP2AC antibody (Cell Signaling, 2259T) was used in western blot on mouse samples at 1:1000 (fig 3a). Nature (2019) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 1a
Cell Signaling Technology PP2AC antibody (Cell Signaling Technology, 2038S) was used in western blot on human samples (fig 1a). Mol Cell (2019) ncbi
domestic rabbit monoclonal (52F8)
  • western blot; mouse; loading ...; fig 5b
Cell Signaling Technology PP2AC antibody (Cell Signaling, 2259) was used in western blot on mouse samples (fig 5b). J Clin Invest (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig s1f
Cell Signaling Technology PP2AC antibody (Cell Signaling Technology, 2038) was used in western blot on mouse samples at 1:1000 (fig s1f). J Clin Invest (2019) ncbi
domestic rabbit monoclonal (52F8)
  • western blot; mouse; fig 6e
  • western blot; human; fig 7a
Cell Signaling Technology PP2AC antibody (Cell Signaling, 2259) was used in western blot on mouse samples (fig 6e) and in western blot on human samples (fig 7a). Cell (2018) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...
Cell Signaling Technology PP2AC antibody (Cell Signaling, 2038) was used in western blot on human samples . J Clin Invest (2017) ncbi
domestic rabbit monoclonal (52F8)
  • western blot; human; 1:200; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology PP2AC antibody (Cell Signaling, 2259) was used in western blot on human samples at 1:200 (fig st1). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • immunoprecipitation; human; fig 6
Cell Signaling Technology PP2AC antibody (Cell Signaling, 2038) was used in immunoprecipitation on human samples (fig 6). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 4
In order to study triple-negative breast cancer and BET bromodomain inhibitor response and resistance, Cell Signaling Technology PP2AC antibody (Cell Signaling, 2038) was used in western blot on human samples (fig 4). Nature (2016) ncbi
domestic rabbit monoclonal (52F8)
  • western blot; mouse; 1:1000; fig 3
  • western blot; human; 1:1000; fig s7
Cell Signaling Technology PP2AC antibody (Cell Signaling, 2259) was used in western blot on mouse samples at 1:1000 (fig 3) and in western blot on human samples at 1:1000 (fig s7). Nat Commun (2015) ncbi
domestic rabbit monoclonal (52F8)
  • western blot; mouse; fig 3
In order to show that MID1 regulates cytotoxic lymphocytes responses, Cell Signaling Technology PP2AC antibody (Cell Signaling, 52F8) was used in western blot on mouse samples (fig 3). Eur J Immunol (2014) ncbi
domestic rabbit polyclonal
  • western blot; rat; fig 7
In order to develop a bioreactor system that allows for the control of the mechanical stimulation of engineered cardiac tissue on a cycle-by-cycle basis, Cell Signaling Technology PP2AC antibody (Cell Signalin g Technology, 2038S) was used in western blot on rat samples (fig 7). J Tissue Eng Regen Med (2017) ncbi
domestic rabbit monoclonal (52F8)
  • immunoprecipitation; human; 1:500
  • western blot; human; fig 5
In order to present a mechanism for the N-myc downstream-regulated gene 2-dependent regulation of PTEN phosphatase activity via the dephosphorylation of PTEN, Cell Signaling Technology PP2AC antibody (Cell Signaling Technology, 52F8) was used in immunoprecipitation on human samples at 1:500 and in western blot on human samples (fig 5). Nat Commun (2014) ncbi
MilliporeSigma
mouse monoclonal (7A6)
  • western blot; rat; 1:1000; fig s2
MilliporeSigma PP2AC antibody (Sigma, SAB4200266) was used in western blot on rat samples at 1:1000 (fig s2). Nat Commun (2021) ncbi
mouse monoclonal (7A6)
  • immunohistochemistry; rat
MilliporeSigma PP2AC antibody (Sigma-Aldrich, SAB4200266) was used in immunohistochemistry on rat samples . Biochim Biophys Acta (2014) ncbi
Articles Reviewed
  1. Narayan S, Raza A, Mahmud I, Koo N, Garrett T, LAW M, et al. Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A. iScience. 2022;25:104518 pubmed publisher
  2. Yoshida J, Ohishi T, Abe H, Ohba S, Inoue H, Usami I, et al. Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment. iScience. 2021;24:103497 pubmed publisher
  3. Yen Y, Chien M, Wu P, Hung S. PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation. Commun Biol. 2021;4:658 pubmed publisher
  4. Liu D, Song A, Qi X, van Vliet P, Xiao J, Xiong F, et al. Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel. Nat Commun. 2021;12:2551 pubmed publisher
  5. Bae S, Ni L, Luo X. STK25 suppresses Hippo signaling by regulating SAV1-STRIPAK antagonism. elife. 2020;9: pubmed publisher
  6. Kitada M, Ogura Y, Monno I, Xu J, Koya D. Methionine abrogates the renoprotective effect of a low-protein diet against diabetic kidney disease in obese rats with type 2 diabetes. Aging (Albany NY). 2020;12:4489-4505 pubmed publisher
  7. Li J, Chiu J, Ramanjulu M, Blass B, Pratico D. A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles. Mol Neurodegener. 2020;15:1 pubmed publisher
  8. Kim J, Berrios C, Kim M, SCHADE A, Adelmant G, Yeerna H, et al. STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells. elife. 2020;9: pubmed publisher
  9. Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt S, Vieira Saecker A, et al. NLRP3 inflammasome activation drives tau pathology. Nature. 2019;: pubmed publisher
  10. Gao X, Zhao L, Liu S, Li Y, Xia S, Chen D, et al. γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A. Mol Cell. 2019;76:857-871.e9 pubmed publisher
  11. Loh J, Xu S, Huo J, Kim S, Wang Y, Lam K. Dok3-protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil-dependent antifungal immunity. J Clin Invest. 2019;129:2717-2729 pubmed publisher
  12. Lin D, Chung B, Huang J, Wang X, Huang L, Kaiser P. Microhomology based CRISPR tagging tools for protein tracking, purification, and depletion. J Biol Chem. 2019;: pubmed publisher
  13. Beckelman B, Yang W, Kasica N, Zimmermann H, Zhou X, Keene C, et al. Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice. J Clin Invest. 2019;129:820-833 pubmed publisher
  14. Reynhout S, Jansen S, Haesen D, Van Belle S, de Munnik S, Bongers E, et al. De Novo Mutations Affecting the Catalytic Cα Subunit of PP2A, PPP2CA, Cause Syndromic Intellectual Disability Resembling Other PP2A-Related Neurodevelopmental Disorders. Am J Hum Genet. 2019;104:139-156 pubmed publisher
  15. Xiao G, Chan L, Klemm L, Braas D, Chen Z, Geng H, et al. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell. 2018;173:470-484.e18 pubmed publisher
  16. Sangodkar J, Perl A, Tohme R, Kiselar J, Kastrinsky D, Zaware N, et al. Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth. J Clin Invest. 2017;127:2081-2090 pubmed publisher
  17. Wang X, Wang R, Luo M, Li C, Wang H, Huan C, et al. (DEAD)-box RNA helicase 3 modulates NF-κB signal pathway by controlling the phosphorylation of PP2A-C subunit. Oncotarget. 2017;8:33197-33213 pubmed publisher
  18. Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  19. Liu C, Lin S, Hsu H, Yang S, Lin C, Yang M, et al. Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells. Nat Commun. 2016;7:11798 pubmed publisher
  20. Shu S, Lin C, He H, Witwicki R, Tabassum D, Roberts J, et al. Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer. Nature. 2016;529:413-417 pubmed publisher
  21. Yu C, Ji S, Sha Q, Sun Q, Fan H. CRL4-DCAF1 ubiquitin E3 ligase directs protein phosphatase 2A degradation to control oocyte meiotic maturation. Nat Commun. 2015;6:8017 pubmed publisher
  22. Lauretti E, Praticò D. Glucose deprivation increases tau phosphorylation via P38 mitogen-activated protein kinase. Aging Cell. 2015;14:1067-74 pubmed publisher
  23. Li Z, Liu Y, Liu X, Xue Y, Wang P, Liu L. Low-dose endothelial monocyte-activating polypeptide-II increases permeability of blood-tumor barrier via a PKC-ζ/PP2A-dependent signaling mechanism. Exp Cell Res. 2015;331:257-66 pubmed publisher
  24. Darna M, Beckmann J, Gipson C, Bardo M, Dwoskin L. Effect of environmental enrichment on dopamine and serotonin transporters and glutamate neurotransmission in medial prefrontal and orbitofrontal cortex. Brain Res. 2015;1599:115-25 pubmed publisher
  25. Lauretti E, di Meco A, Chu J, Praticò D. Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor. Neurobiol Aging. 2015;36:812-20 pubmed publisher
  26. Silva P, Muzi Filho H, Pereira Acácio A, Dias J, Martins J, Landim Vieira M, et al. Altered signaling pathways linked to angiotensin II underpin the upregulation of renal Na(+)-ATPase in chronically undernourished rats. Biochim Biophys Acta. 2014;1842:2357-66 pubmed publisher
  27. Du H, Wu K, Didoronkute A, Levy M, Todi N, Shchelokova A, et al. MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac. PLoS ONE. 2014;9:e107428 pubmed publisher
  28. Boding L, Hansen A, Meroni G, Johansen B, Braunstein T, Bonefeld C, et al. Midline 1 directs lytic granule exocytosis and cytotoxicity of mouse killer T cells. Eur J Immunol. 2014;44:3109-18 pubmed publisher
  29. Morgan K, Black L. Investigation into the effects of varying frequency of mechanical stimulation in a cycle-by-cycle manner on engineered cardiac construct function. J Tissue Eng Regen Med. 2017;11:342-353 pubmed publisher
  30. Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, et al. Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. Nat Commun. 2014;5:3393 pubmed publisher
  31. Amsailale R, Beyaert M, Smal C, Janssens V, Van Den Neste E, Bontemps F. Protein phosphatase 2A regulates deoxycytidine kinase activity via Ser-74 dephosphorylation. FEBS Lett. 2014;588:727-32 pubmed publisher
  32. Schweitzer G, Arias E, Cartee G. Sustained postexercise increases in AS160 Thr642 and Ser588 phosphorylation in skeletal muscle without sustained increases in kinase phosphorylation. J Appl Physiol (1985). 2012;113:1852-61 pubmed publisher