This is a Validated Antibody Database (VAD) review about human PNKP, based on 2 published articles (read how Labome selects the articles), using PNKP antibody in all methods. It is aimed to help Labome visitors find the most suited PNKP antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
PNKP synonym: AOA4; EIEE10; MCSZ; PNK; bifunctional polynucleotide phosphatase/kinase; DNA 5'-kinase/3'-phosphatase; Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP)

Abcam
rabbit monoclonal (EPR11934(B))
  • immunocytochemistry; human; 1:100; loading ...; fig s8a
  • western blot; human; 1:1000; loading ...; fig s8a
In order to study the DNA damage response in senescent epithelial cells, Abcam PNKP antibody (Abcam, ab170954) was used in immunocytochemistry on human samples at 1:100 (fig s8a) and in western blot on human samples at 1:1000 (fig s8a). Nat Commun (2016) ncbi
Novus Biologicals
rabbit polyclonal
  • western blot; mouse; 1:1000
In order to investigate how PNKP inactivation impacts neurogenesis, Novus Biologicals PNKP antibody (Novus, cat# NBP1-87257) was used in western blot on mouse samples at 1:1000. EMBO J (2015) ncbi
Articles Reviewed
  1. Nassour J, Martien S, Martin N, Deruy E, Tomellini E, Malaquin N, et al. Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells. Nat Commun. 2016;7:10399 pubmed publisher
  2. Shimada M, Dumitrache L, Russell H, McKinnon P. Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability. EMBO J. 2015;34:2465-80 pubmed publisher