This is a Validated Antibody Database (VAD) review about human PIK3CB, based on 16 published articles (read how Labome selects the articles), using PIK3CB antibody in all methods. It is aimed to help Labome visitors find the most suited PIK3CB antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
PIK3CB synonym: P110BETA; PI3K; PI3KBETA; PIK3C1; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; PI3-kinase p110 subunit beta; PI3-kinase subunit beta; PI3K-beta; PtdIns-3-kinase p110; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphoinositide-3-kinase, catalytic, beta polypeptide; ptdIns-3-kinase subunit beta; ptdIns-3-kinase subunit p110-beta

Knockout validation
Cell Signaling Technology
rabbit monoclonal (C33D4)
  • western blot knockout validation; mouse; fig 1
In order to elucidate the compartmentalization of p110alpha and p110beta, Cell Signaling Technology PIK3CB antibody (Cell Signaling, 3011) was used in western blot knockout validation on mouse samples (fig 1). elife (2016) ncbi
Abcam
rabbit monoclonal (EPR5515(2))
  • western blot; mouse; 1:1000; loading ...; fig 5b
Abcam PIK3CB antibody (Abcam, ab151549) was used in western blot on mouse samples at 1:1000 (fig 5b). Biosci Rep (2019) ncbi
rabbit monoclonal (EPR5515(2))
  • western blot; rat; loading ...; fig 5d
Abcam PIK3CB antibody (Abcam, ab151549) was used in western blot on rat samples (fig 5d). Oxid Med Cell Longev (2017) ncbi
rabbit monoclonal (EPR5515(2))
  • immunocytochemistry; human; 1:50; fig 4
In order to study key functions in nucleolar localisation and polyphosphoinositide interaction by a polybasic motif in ErbB3-binding-protein 1 (EBP1), Abcam PIK3CB antibody (Abcam, ab151549) was used in immunocytochemistry on human samples at 1:50 (fig 4). Biochem J (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (B-5)
  • other; human; loading ...; fig 4c
Santa Cruz Biotechnology PIK3CB antibody (SantaCruz, sc-376412) was used in other on human samples (fig 4c). Cancer Cell (2018) ncbi
mouse monoclonal (D-2)
  • western blot; mouse; loading ...; fig 2a
In order to examine the role of topoisomerase II in mitotic clonal expansion and adipogenesis, Santa Cruz Biotechnology PIK3CB antibody (Santa Cruz, sc-376492) was used in western blot on mouse samples (fig 2a). Cell Signal (2016) ncbi
mouse monoclonal (D-4)
  • western blot; human; 1:200
Santa Cruz Biotechnology PIK3CB antibody (Santa Cruz Biotechnology Inc, sc-8010) was used in western blot on human samples at 1:200. PLoS ONE (2014) ncbi
GeneTex
rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 4a
In order to elucidate the upstream mechanisms of apoptosis triggered by an anti-microtubule drug, ABT-751, GeneTex PIK3CB antibody (GeneTex, GTX111173) was used in western blot on human samples at 1:1000 (fig 4a). Toxicol Appl Pharmacol (2016) ncbi
Cell Signaling Technology
rabbit monoclonal (C33D4)
  • western blot; mouse; 1:1000; loading ...; fig 1a
Cell Signaling Technology PIK3CB antibody (Cell Signaling, 3011) was used in western blot on mouse samples at 1:1000 (fig 1a). Nat Commun (2019) ncbi
rabbit monoclonal (C33D4)
  • western blot; human; fig 6a
Cell Signaling Technology PIK3CB antibody (Cell signaling, 3011s) was used in western blot on human samples (fig 6a). Cancer Med (2017) ncbi
rabbit monoclonal (C33D4)
  • western blot; human; 1:1000; loading ...; fig 6c
Cell Signaling Technology PIK3CB antibody (Cell Signaling, C33D4) was used in western blot on human samples at 1:1000 (fig 6c). Nat Commun (2016) ncbi
rabbit monoclonal (C33D4)
  • western blot knockout validation; mouse; fig 1
In order to elucidate the compartmentalization of p110alpha and p110beta, Cell Signaling Technology PIK3CB antibody (Cell Signaling, 3011) was used in western blot knockout validation on mouse samples (fig 1). elife (2016) ncbi
rabbit monoclonal (C33D4)
  • western blot; human; fig s1
Cell Signaling Technology PIK3CB antibody (Cell Signaling, 3011) was used in western blot on human samples (fig s1). Cell Discov (2016) ncbi
rabbit monoclonal (C33D4)
  • western blot; human; loading ...; fig 4c
Cell Signaling Technology PIK3CB antibody (Cell Signaling, C33D4) was used in western blot on human samples (fig 4c). Oncotarget (2016) ncbi
rabbit monoclonal (C33D4)
  • western blot; human; loading ...; fig 4
In order to find tumor types sensitive to phosphoinositide 3-kinase pathway inhibitors, Cell Signaling Technology PIK3CB antibody (Cell Signaling, 3011) was used in western blot on human samples (fig 4). Oncotarget (2016) ncbi
rabbit monoclonal (C33D4)
  • western blot; human
Cell Signaling Technology PIK3CB antibody (Cell Signaling, C33D4) was used in western blot on human samples . Mol Cell Biol (2014) ncbi
EMD Millipore
rabbit monoclonal (Y384)
  • western blot; human; 1:1000; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, EMD Millipore PIK3CB antibody (Millipore, 04-400) was used in western blot on human samples at 1:1000 (fig st1). Nat Commun (2016) ncbi
Articles Reviewed
  1. You Y, Qin Z, Zhang H, Yuan Z, Yu X. MicroRNA-153 promotes brain-derived neurotrophic factor and hippocampal neuron proliferation to alleviate autism symptoms through inhibition of JAK-STAT pathway by LEPR. Biosci Rep. 2019;: pubmed publisher
  2. Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan A, et al. Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue. Nat Commun. 2019;10:1546 pubmed publisher
  3. Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  4. Gomes J, Fernandes T, Soci U, Silveira A, Barretti D, Negrao C, et al. Obesity Downregulates MicroRNA-126 Inducing Capillary Rarefaction in Skeletal Muscle: Effects of Aerobic Exercise Training. Oxid Med Cell Longev. 2017;2017:2415246 pubmed publisher
  5. Liu S, Gao G, Yan D, Chen X, Yao X, Guo S, et al. Effects of miR-145-5p through NRAS on the cell proliferation, apoptosis, migration, and invasion in melanoma by inhibiting MAPK and PI3K/AKT pathways. Cancer Med. 2017;6:819-833 pubmed publisher
  6. Yang J, Savvatis K, Kang J, Fan P, Zhong H, Schwartz K, et al. Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment. Nat Commun. 2016;7:13710 pubmed publisher
  7. Cizmecioglu O, Ni J, Xie S, Zhao J, Roberts T. Rac1-mediated membrane raft localization of PI3K/p110? is required for its activation by GPCRs or PTEN loss. elife. 2016;5: pubmed publisher
  8. Wei R, Lin S, Wu W, Chen L, Li C, Chen H, et al. A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells. Toxicol Appl Pharmacol. 2016;311:88-98 pubmed publisher
  9. Yuzugullu H, Von T, Thorpe L, Walker S, Roberts T, Frank D, et al. NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K-AKT and JAK-STAT3 pathways. Cell Discov. 2016;2:16030 pubmed publisher
  10. Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  11. Jacobsen R, Mazloumi Gavgani F, Mellgren G, Lewis A. DNA Topoisomerase II? contributes to the early steps of adipogenesis in 3T3-L1 cells. Cell Signal. 2016;28:1593-603 pubmed publisher
  12. Monica V, Lo Iacono M, Bracco E, Busso S, di Blasio L, Primo L, et al. Dasatinib modulates sensitivity to pemetrexed in malignant pleural mesothelioma cell lines. Oncotarget. 2016;7:76577-76589 pubmed publisher
  13. Karlsson T, Altankhuyag A, Dobrovolska O, Turcu D, Lewis A. A polybasic motif in ErbB3-binding protein 1 (EBP1) has key functions in nucleolar localization and polyphosphoinositide interaction. Biochem J. 2016;473:2033-47 pubmed publisher
  14. Lynch J, McEwen R, Crafter C, McDermott U, Garnett M, Barry S, et al. Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen. Oncotarget. 2016;7:22128-39 pubmed publisher
  15. Parenti R, Cardile V, Graziano A, Parenti C, Venuti A, Bertuccio M, et al. Wilms' tumor gene 1 (WT1) silencing inhibits proliferation of malignant peripheral nerve sheath tumor sNF96.2 cell line. PLoS ONE. 2014;9:e114333 pubmed publisher
  16. Perez García V, Redondo Muñoz J, Kumar A, Carrera A. Cell activation-induced phosphoinositide 3-kinase alpha/beta dimerization regulates PTEN activity. Mol Cell Biol. 2014;34:3359-73 pubmed publisher