This is a Validated Antibody Database (VAD) review about human PAXX, based on 4 published articles (read how Labome selects the articles), using PAXX antibody in all methods. It is aimed to help Labome visitors find the most suited PAXX antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
PAXX synonym: C9orf142; XLS; protein PAXX; XRCC4-like small protein; paralog of XRCC4 and XLF

Knockout validation
Abcam
rabbit polyclonal
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 1d
In order to study the contribution of PAXX to non-homologous end-joining, Abcam PAXX antibody (Abcam, ab126353) was used in western blot knockout validation on mouse samples at 1:1000 (fig 1d). Nat Commun (2017) ncbi
Abcam
rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig 1a
Abcam PAXX antibody (Abcam, ab126353) was used in western blot knockout validation on mouse samples (fig 1a). Genes Dev (2016) ncbi
Abcam
rabbit polyclonal
  • western blot knockout validation; mouse; 1:1000; fig 1
In order to examine the contribution of paralog of XRCC4 and XLF to V(D)J recombination, Abcam PAXX antibody (Abcam, ab126353) was used in western blot knockout validation on mouse samples at 1:1000 (fig 1). Cell Rep (2016) ncbi
Abcam
rabbit polyclonal
  • western blot knockout validation; human; 1:500; fig s6
  • immunoprecipitation; human; fig 2
In order to determine how PAXX interacts with Ku to promote DNA double-strand break repair, Abcam PAXX antibody (Abcam, ab126353) was used in western blot knockout validation on human samples at 1:500 (fig s6) and in immunoprecipitation on human samples (fig 2). Science (2015) ncbi
Abcam
rabbit polyclonal
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 1d
In order to study the contribution of PAXX to non-homologous end-joining, Abcam PAXX antibody (Abcam, ab126353) was used in western blot knockout validation on mouse samples at 1:1000 (fig 1d). Nat Commun (2017) ncbi
rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig 1a
Abcam PAXX antibody (Abcam, ab126353) was used in western blot knockout validation on mouse samples (fig 1a). Genes Dev (2016) ncbi
rabbit polyclonal
  • western blot knockout validation; mouse; 1:1000; fig 1
In order to examine the contribution of paralog of XRCC4 and XLF to V(D)J recombination, Abcam PAXX antibody (Abcam, ab126353) was used in western blot knockout validation on mouse samples at 1:1000 (fig 1). Cell Rep (2016) ncbi
rabbit polyclonal
  • western blot knockout validation; human; 1:500; fig s6
  • immunoprecipitation; human; fig 2
In order to determine how PAXX interacts with Ku to promote DNA double-strand break repair, Abcam PAXX antibody (Abcam, ab126353) was used in western blot knockout validation on human samples at 1:500 (fig s6) and in immunoprecipitation on human samples (fig 2). Science (2015) ncbi
Articles Reviewed
  1. Liu X, Shao Z, Jiang W, Lee B, Zha S. PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice. Nat Commun. 2017;8:13816 pubmed publisher
  2. Balmus G, Barros A, Wijnhoven P, Lescale C, Hasse H, Boroviak K, et al. Synthetic lethality between PAXX and XLF in mammalian development. Genes Dev. 2016;30:2152-2157 pubmed
  3. Lescale C, Lenden Hasse H, Blackford A, Balmus G, Bianchi J, Yu W, et al. Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination. Cell Rep. 2016;16:2967-2979 pubmed publisher
  4. Ochi T, Blackford A, Coates J, Jhujh S, Mehmood S, Tamura N, et al. DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair. Science. 2015;347:185-188 pubmed publisher