This is a Validated Antibody Database (VAD) review about human PAK3, based on 19 published articles (read how Labome selects the articles), using PAK3 antibody in all methods. It is aimed to help Labome visitors find the most suited PAK3 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
PAK3 synonym: ARA; MRX30; MRX47; OPHN3; PAK-3; PAK3beta; bPAK; beta-PAK; serine/threonine-protein kinase PAK 3; adriamycin resistance-associated; oligophrenin-3; p21 (CDKN1A)-activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 3

Invitrogen
rabbit polyclonal
  • western blot; human; 1:1000; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Invitrogen PAK3 antibody (Biosource, 44-940G) was used in western blot on human samples at 1:1000 (fig st1). Nat Commun (2016) ncbi
rabbit polyclonal
  • immunocytochemistry; African green monkey; 1:150; fig s8
In order to determine regulation of spine structural plasticity and memory and learning by the calcium sensor Copine-6, Invitrogen PAK3 antibody (Life Technologies, 44940G) was used in immunocytochemistry on African green monkey samples at 1:150 (fig s8). Nat Commun (2016) ncbi
rabbit polyclonal
  • western blot; human
In order to assess the contribution of tissue damage and extracellular matrix fragmentation during inflammation, Invitrogen PAK3 antibody (Invitrogen, 44940G) was used in western blot on human samples . Sci Adv (2015) ncbi
rabbit polyclonal
  • western blot; rat; 1:1000
In order to study the temporal and spatial relationship between dendritic protein synthesis and actin cytoskeleton reorganization, Invitrogen PAK3 antibody (Invitrogen, 44940) was used in western blot on rat samples at 1:1000. J Neurosci (2015) ncbi
rabbit polyclonal
  • western blot; human; fig 4
In order to study the molecular mechanisms underlying malignant changes of meningioma cells, Invitrogen PAK3 antibody (Invitrogen, 44940G) was used in western blot on human samples (fig 4). Oncotarget (2015) ncbi
rabbit polyclonal
  • western blot; mouse; 1:500
In order to study 5-HT7R in a mouse model of Rett syndrome, Invitrogen PAK3 antibody (Invitrogen, 44940G) was used in western blot on mouse samples at 1:500. Neuropsychopharmacology (2014) ncbi
rabbit polyclonal
  • immunocytochemistry; human; 1:100; fig 1
In order to elucidate how Rho GTPases orchestrate cytoskeletal dynamics in migrating neutrophils, Invitrogen PAK3 antibody (Invitrogen, 44?C942G) was used in immunocytochemistry on human samples at 1:100 (fig 1). PLoS ONE (2013) ncbi
rabbit polyclonal
  • western blot; mouse; fig 4
In order to elucidate the hair cell-intrinsic polarity machinery, Invitrogen PAK3 antibody (Invitrogen, #44940G, lot #980627A) was used in western blot on mouse samples (fig 4). Development (2013) ncbi
rabbit polyclonal
  • western blot; mouse; fig 3
In order to study glucocorticoid signaling in the spine, Invitrogen PAK3 antibody (Invitrogen, 44-940G) was used in western blot on mouse samples (fig 3). Mol Neurobiol (2012) ncbi
rabbit polyclonal
  • immunohistochemistry; mouse; 1:100; fig 3
In order to investigate the Rac>PAK signaling pathway in a Fmr1-knockout mouse model, Invitrogen PAK3 antibody (Invitrogen, 44-940G) was used in immunohistochemistry on mouse samples at 1:100 (fig 3). J Neurosci (2010) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; 1:50; fig 1
  • immunohistochemistry - paraffin section; human; 1:50; fig 6
In order to identify PAK as a kinase protein whose activity is modified in platelet-derived growth factor B-chain promoter-driven APP transgenic mice, Invitrogen PAK3 antibody (Biosource, 44-940G) was used in immunohistochemistry - paraffin section on mouse samples at 1:50 (fig 1) and in immunohistochemistry - paraffin section on human samples at 1:50 (fig 6). J Neurochem (2008) ncbi
rabbit polyclonal
In order to test if induction of long-term potentiation by theta-burst stimulation activates an actin regulatory pathway and alters synapse morphology within the same dendritic spines, Invitrogen PAK3 antibody (Biosource, 44-940G) was used . J Neurosci (2007) ncbi
Santa Cruz Biotechnology
mouse monoclonal (A-6)
  • western blot; mouse; loading ...; fig 5D
Santa Cruz Biotechnology PAK3 antibody (Santa Cruz, sc-166887) was used in western blot on mouse samples (fig 5D). elife (2017) ncbi
mouse monoclonal (D-8)
  • immunohistochemistry; human; loading ...; fig 2a
  • western blot; human; loading ...; fig 3b
Santa Cruz Biotechnology PAK3 antibody (Santa Cruz Biotechnology, sc-166174) was used in immunohistochemistry on human samples (fig 2a) and in western blot on human samples (fig 3b). Oncotarget (2016) ncbi
mouse monoclonal (A-6)
  • western blot; human; 1:400
Santa Cruz Biotechnology PAK3 antibody (Santa Cruz, sc-166887) was used in western blot on human samples at 1:400. PLoS ONE (2016) ncbi
mouse monoclonal (A-6)
  • immunoprecipitation; human; fig 6
  • western blot; human; fig 5
Santa Cruz Biotechnology PAK3 antibody (Santa Cruz Biotechnologies, sc-166887) was used in immunoprecipitation on human samples (fig 6) and in western blot on human samples (fig 5). Blood (2015) ncbi
R&D Systems
sheep polyclonal
  • immunohistochemistry - paraffin section; hamsters; 1:80
  • immunocytochemistry; hamsters; 1:50
  • western blot; hamsters
R&D Systems PAK3 antibody (R&D Systems, AF6897) was used in immunohistochemistry - paraffin section on hamsters samples at 1:80, in immunocytochemistry on hamsters samples at 1:50 and in western blot on hamsters samples . Med Microbiol Immunol (2014) ncbi
Cell Signaling Technology
rabbit polyclonal
  • western blot; mouse; 1:1000; fig s8
Cell Signaling Technology PAK3 antibody (Cell Signalling, 2609) was used in western blot on mouse samples at 1:1000 (fig s8). Nat Commun (2016) ncbi
rabbit polyclonal
  • immunoprecipitation; mouse; loading ...; fig 1
  • western blot; mouse; 1:1000; loading ...; fig 1
Cell Signaling Technology PAK3 antibody (Cell Signaling, 2609) was used in immunoprecipitation on mouse samples (fig 1) and in western blot on mouse samples at 1:1000 (fig 1). Nat Commun (2015) ncbi
rabbit polyclonal
  • western blot; mouse
In order to study the molecular mechanisms underlying malignant changes of meningioma cells, Cell Signaling Technology PAK3 antibody (Cell Signaling Technology, 2609) was used in western blot on mouse samples . Oncotarget (2015) ncbi
Articles Reviewed
  1. Jeannot P, Nowosad A, Perchey R, Callot C, Bennana E, Katsube T, et al. p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway. elife. 2017;6: pubmed publisher
  2. Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  3. Martin K, Pritchett J, Llewellyn J, Mullan A, Athwal V, Dobie R, et al. PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis. Nat Commun. 2016;7:12502 pubmed publisher
  4. Yuan W, Guo Y, Li X, Deng M, Shen Z, Bo C, et al. MicroRNA-126 inhibits colon cancer cell proliferation and invasion by targeting the chemokine (C-X-C motif) receptor 4 and Ras homolog gene family, member A, signaling pathway. Oncotarget. 2016;7:60230-60244 pubmed publisher
  5. Reinhard J, Kriz A, Galic M, Angliker N, Rajalu M, Vogt K, et al. The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nat Commun. 2016;7:11613 pubmed publisher
  6. Wang Y, Gratzke C, Tamalunas A, Wiemer N, Ciotkowska A, Rutz B, et al. P21-Activated Kinase Inhibitors FRAX486 and IPA3: Inhibition of Prostate Stromal Cell Growth and Effects on Smooth Muscle Contraction in the Human Prostate. PLoS ONE. 2016;11:e0153312 pubmed publisher
  7. Hahn C, Scott D, Xu X, Roda M, Payne G, Wells J, et al. The matrikine N-α-PGP couples extracellular matrix fragmentation to endothelial permeability. Sci Adv. 2015;1: pubmed
  8. Singh N, Kotla S, Dyukova E, Traylor J, Orr A, Chernoff J, et al. Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice. Nat Commun. 2015;6:7450 pubmed publisher
  9. Briz V, Zhu G, Wang Y, Liu Y, Avetisyan M, Bi X, et al. Activity-dependent rapid local RhoA synthesis is required for hippocampal synaptic plasticity. J Neurosci. 2015;35:2269-82 pubmed publisher
  10. Chow H, Dong B, Duron S, Campbell D, Ong C, Hoeflich K, et al. Group I Paks as therapeutic targets in NF2-deficient meningioma. Oncotarget. 2015;6:1981-94 pubmed
  11. Badolia R, Manne B, Dangelmaier C, Chernoff J, Kunapuli S. Gq-mediated Akt translocation to the membrane: a novel PIP3-independent mechanism in platelets. Blood. 2015;125:175-84 pubmed publisher
  12. Meng G, Tian C, Wang H, Xu Y, Zhang B, Shi Q, et al. Remarkable reductions of PAKs in the brain tissues of scrapie-infected rodent possibly linked closely with neuron loss. Med Microbiol Immunol. 2014;203:291-302 pubmed publisher
  13. De Filippis B, Nativio P, Fabbri A, Ricceri L, Adriani W, Lacivita E, et al. Pharmacological stimulation of the brain serotonin receptor 7 as a novel therapeutic approach for Rett syndrome. Neuropsychopharmacology. 2014;39:2506-18 pubmed publisher
  14. Itakura A, Aslan J, Kusanto B, Phillips K, Porter J, Newton P, et al. p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils. PLoS ONE. 2013;8:e73063 pubmed publisher
  15. Sipe C, Liu L, Lee J, Grimsley Myers C, Lu X. Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization. Development. 2013;140:1785-95 pubmed publisher
  16. Jafari M, Seese R, Babayan A, Gall C, Lauterborn J. Glucocorticoid receptors are localized to dendritic spines and influence local actin signaling. Mol Neurobiol. 2012;46:304-15 pubmed publisher
  17. Chen L, Rex C, Babayan A, Kramar E, Lynch G, Gall C, et al. Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome. J Neurosci. 2010;30:10977-84 pubmed publisher
  18. Nguyen T, Galvan V, Huang W, Banwait S, Tang H, Zhang J, et al. Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664. J Neurochem. 2008;104:1065-80 pubmed
  19. Chen L, Rex C, Casale M, Gall C, Lynch G. Changes in synaptic morphology accompany actin signaling during LTP. J Neurosci. 2007;27:5363-72 pubmed