OTULIN antibody | antibody review based on formal publications

This is a Validated Antibody Database (VAD) review about human OTULIN, based on 9 published articles (read how Labome selects the articles), using OTULIN antibody in all methods. It is aimed to help Labome visitors find the most suited OTULIN antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.

OTULIN synonym: AIPDS; FAM105B; GUM

Knockout validation

Abcam domestic rabbit polyclonal ab151117	western blot knockout validation; human; 1:2000; loading ...; fig e2b	Abcam OTULIN antibody (Abcam, ab151117) was used in western blot knockout validation on human samples at 1:2000 (fig e2b). EMBO Mol Med (2022) ncbi
Abcam domestic rabbit polyclonal ab151117	western blot knockout validation; human; loading ...; fig 2f	Abcam OTULIN antibody (Abcam, ab151117) was used in western blot knockout validation on human samples (fig 2f). Nat Microbiol (2017) ncbi
Cell Signaling Technology domestic rabbit polyclonal 14127	western blot knockout validation; human; 1:2000; loading ...; fig e2b	Cell Signaling Technology OTULIN antibody (CST, 14127) was used in western blot knockout validation on human samples at 1:2000 (fig e2b). EMBO Mol Med (2022) ncbi
Cell Signaling Technology domestic rabbit polyclonal 14127	western blot knockout validation; mouse; 1:1000; loading ...; fig 3c	Cell Signaling Technology OTULIN antibody (Cell Signaling, 14127) was used in western blot knockout validation on mouse samples at 1:1000 (fig 3c). Nat Commun (2021) ncbi
Cell Signaling Technology domestic rabbit polyclonal 14127	western blot knockout validation; mouse; 1:1000; loading ...; fig 7d	Cell Signaling Technology OTULIN antibody (Cell Signalling Technology, 14127) was used in western blot knockout validation on mouse samples at 1:1000 (fig 7d). Nat Commun (2021) ncbi
Cell Signaling Technology domestic rabbit polyclonal 14127	western blot; human; fig 1 western blot knockout validation; mouse; fig 7	In order to demonstrate that OTULIN is essential for preventing TNF-associated systemic inflammation in humans and mice, Cell Signaling Technology OTULIN antibody (Cell Signaling Technology, 14127) was used in western blot on human samples (fig 1) and in western blot knockout validation on mouse samples (fig 7). Cell (2016) ncbi

Abcam

domestic rabbit polyclonal ab151117	western blot knockout validation; human; 1:2000; loading ...; fig e2b	Abcam OTULIN antibody (Abcam, ab151117) was used in western blot knockout validation on human samples at 1:2000 (fig e2b). EMBO Mol Med (2022) ncbi
domestic rabbit polyclonal ab151117	western blot knockout validation; human; loading ...; fig 2f	Abcam OTULIN antibody (Abcam, ab151117) was used in western blot knockout validation on human samples (fig 2f). Nat Microbiol (2017) ncbi
domestic rabbit polyclonal ab151117	western blot; human; loading ...; fig EV2b western blot; mouse; loading ...; fig EV2c	Abcam OTULIN antibody (Abcam, ab151117) was used in western blot on human samples (fig EV2b) and in western blot on mouse samples (fig EV2c). EMBO J (2017) ncbi
domestic rabbit polyclonal ab151117	western blot; human; fig 1	Abcam OTULIN antibody (Abcam, ab151117) was used in western blot on human samples (fig 1). Cell Rep (2016) ncbi
domestic rabbit polyclonal ab151117		Abcam OTULIN antibody (Abcam, ab151117) was used . Nat Commun (2015) ncbi

Cell Signaling Technology

domestic rabbit polyclonal 14127	western blot knockout validation; human; 1:2000; loading ...; fig e2b	Cell Signaling Technology OTULIN antibody (CST, 14127) was used in western blot knockout validation on human samples at 1:2000 (fig e2b). EMBO Mol Med (2022) ncbi
domestic rabbit polyclonal 14127	western blot knockout validation; mouse; 1:1000; loading ...; fig 3c	Cell Signaling Technology OTULIN antibody (Cell Signaling, 14127) was used in western blot knockout validation on mouse samples at 1:1000 (fig 3c). Nat Commun (2021) ncbi
domestic rabbit polyclonal 14127	western blot knockout validation; mouse; 1:1000; loading ...; fig 7d	Cell Signaling Technology OTULIN antibody (Cell Signalling Technology, 14127) was used in western blot knockout validation on mouse samples at 1:1000 (fig 7d). Nat Commun (2021) ncbi
domestic rabbit polyclonal 14127	western blot; human; fig 1	Cell Signaling Technology OTULIN antibody (Cell Signaling, 14127) was used in western blot on human samples (fig 1). Proc Natl Acad Sci U S A (2016) ncbi
domestic rabbit polyclonal 14127	western blot; human; fig 1 western blot knockout validation; mouse; fig 7	In order to demonstrate that OTULIN is essential for preventing TNF-associated systemic inflammation in humans and mice, Cell Signaling Technology OTULIN antibody (Cell Signaling Technology, 14127) was used in western blot on human samples (fig 1) and in western blot knockout validation on mouse samples (fig 7). Cell (2016) ncbi

Articles Reviewed

Zinngrebe J, Moepps B, Monecke T, Gierschik P, Schlichtig F, Barth T, et al. Compound heterozygous variants in OTULIN are associated with fulminant atypical late-onset ORAS. EMBO Mol Med. 2022;14:e14901 pubmed publisher
Schünke H, Göbel U, Dikic I, Pasparakis M. OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice. Nat Commun. 2021;12:5912 pubmed publisher
Hoste E, Lecomte K, Annusver K, Vandamme N, Roels J, Maschalidi S, et al. OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity. Nat Commun. 2021;12:5913 pubmed publisher
van Wijk S, Fricke F, Herhaus L, Gupta J, Hötte K, Pampaloni F, et al. Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-?B and restricts bacterial proliferation. Nat Microbiol. 2017;2:17066 pubmed publisher
Lafont E, Kantari Mimoun C, Dráber P, De Miguel D, Hartwig T, Reichert M, et al. The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. EMBO J. 2017;36:1147-1166 pubmed publisher
Zhou Q, Yu X, Demirkaya E, Deuitch N, Stone D, Tsai W, et al. Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease. Proc Natl Acad Sci U S A. 2016;113:10127-32 pubmed publisher
Kupka S, De Miguel D, Dráber P, Martino L, Surinova S, Rittinger K, et al. SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes. Cell Rep. 2016;16:2271-80 pubmed publisher
Damgaard R, Walker J, Marco Casanova P, Morgan N, Titheradge H, Elliott P, et al. The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Cell. 2016;166:1215-1230.e20 pubmed publisher
Klein T, Fung S, Renner F, Blank M, Dufour A, Kang S, et al. The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-ÎºB signalling. Nat Commun. 2015;6:8777 pubmed publisher

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