This is a Validated Antibody Database (VAD) review about human ORAI1, based on 12 published articles (read how Labome selects the articles), using ORAI1 antibody in all methods. It is aimed to help Labome visitors find the most suited ORAI1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
ORAI1 synonym: CRACM1; IMD9; ORAT1; TAM2; TMEM142A

Knockout validation
Abcam
mouse monoclonal (266.1)
  • immunohistochemistry knockout validation; mouse; loading ...; fig s1i
  • immunohistochemistry - free floating section; mouse; loading ...; fig s1h
Abcam ORAI1 antibody (Abcam, ab175040) was used in immunohistochemistry knockout validation on mouse samples (fig s1i) and in immunohistochemistry - free floating section on mouse samples (fig s1h). Cell Rep (2020) ncbi
Abcam
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 4b
Abcam ORAI1 antibody (Abcam, ab244352) was used in western blot on human samples (fig 4b). Theranostics (2021) ncbi
mouse monoclonal (266.1)
  • immunohistochemistry knockout validation; mouse; loading ...; fig s1i
  • immunohistochemistry - free floating section; mouse; loading ...; fig s1h
Abcam ORAI1 antibody (Abcam, ab175040) was used in immunohistochemistry knockout validation on mouse samples (fig s1i) and in immunohistochemistry - free floating section on mouse samples (fig s1h). Cell Rep (2020) ncbi
Alomone Labs
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; fig 1a
  • western blot; human; 1:500; fig 1e
Alomone Labs ORAI1 antibody (Alomone Labs, ACC-060) was used in immunohistochemistry - paraffin section on human samples (fig 1a) and in western blot on human samples at 1:500 (fig 1e). Nat Commun (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:500; fig 8a
In order to report that PABPN1 regulates crucial processes during myotube formation, Alomone Labs ORAI1 antibody (Alomone Labs, ACC-062) was used in western blot on mouse samples at 1:500 (fig 8a). J Physiol (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 3c
Alomone Labs ORAI1 antibody (Alomone Labs, ACC-062) was used in western blot on mouse samples (fig 3c). Cell Death Differ (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (G-2)
  • immunohistochemistry - paraffin section; human; loading ...; fig 4b
In order to examine calcium-regulating protein expression in the plaques of patients with psoriasis vulgaris with or without joint inflammation, Santa Cruz Biotechnology ORAI1 antibody (Santa Cruz, sc-377281) was used in immunohistochemistry - paraffin section on human samples (fig 4b). Int J Mol Med (2016) ncbi
mouse monoclonal (G-2)
  • immunoprecipitation; human; 1:1000; loading ...; fig 3e
Santa Cruz Biotechnology ORAI1 antibody (Santa Cruz Biotechnology, SC-377281) was used in immunoprecipitation on human samples at 1:1000 (fig 3e). Sci Rep (2015) ncbi
Invitrogen
mouse monoclonal (3F6H5)
  • western blot; mouse; 1:500; loading ...; fig 1b
In order to examine the effects of marijuana on CB1R activation in skeletal muscle, Invitrogen ORAI1 antibody (Thermo Fisher, MA5-1577) was used in western blot on mouse samples at 1:500 (fig 1b). J Physiol (2016) ncbi
ProSci
domestic rabbit polyclonal
  • western blot; human; fig s2
ProSci ORAI1 antibody (ProSci, 4041) was used in western blot on human samples (fig s2). Sci Rep (2016) ncbi
mouse monoclonal (6D11A11)
  • immunocytochemistry; mouse; 1:500; tbl 1
  • western blot; mouse; 1:1000; tbl 1
In order to examine the interaction between store-operated calcium entry and store content and its role in cardiac pacemaking, ProSci ORAI1 antibody (ProSci, PM-5207) was used in immunocytochemistry on mouse samples at 1:500 (tbl 1) and in western blot on mouse samples at 1:1000 (tbl 1). Front Physiol (2015) ncbi
mouse monoclonal (3F6H5)
  • western blot; human; loading ...; fig 1b
ProSci ORAI1 antibody (ProSci Inc., PM-5205) was used in western blot on human samples (fig 1b). Biochim Biophys Acta (2014) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 2a
MilliporeSigma ORAI1 antibody (Sigma, O8264) was used in western blot on human samples (fig 2a). Biochim Biophys Acta Mol Cell Res (2017) ncbi
domestic rabbit polyclonal
  • immunoprecipitation; human; fig s2
  • western blot; human; fig s1
MilliporeSigma ORAI1 antibody (Sigma, O8264) was used in immunoprecipitation on human samples (fig s2) and in western blot on human samples (fig s1). Sci Rep (2016) ncbi
Articles Reviewed
  1. Wang J, Zhao H, Zheng L, Zhou Y, Wu L, Xu Y, et al. FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells. Theranostics. 2021;11:5045-5060 pubmed publisher
  2. Maneshi M, Toth A, Ishii T, Hori K, Tsujikawa S, Shum A, et al. Orai1 Channels Are Essential for Amplification of Glutamate-Evoked Ca2+ Signals in Dendritic Spines to Regulate Working and Associative Memory. Cell Rep. 2020;33:108464 pubmed publisher
  3. Zeng B, Chen G, Garcia Vaz E, Bhandari S, Daskoulidou N, Berglund L, et al. ORAI channels are critical for receptor-mediated endocytosis of albumin. Nat Commun. 2017;8:1920 pubmed publisher
  4. García Castañeda M, Vega A, Rodríguez R, Montiel Jaen M, Cisneros B, Zarain Herzberg A, et al. Functional impact of an oculopharyngeal muscular dystrophy mutation in PABPN1. J Physiol. 2017;595:4167-4187 pubmed publisher
  5. Diez Bello R, Jardin I, Salido G, Rosado J. Orai1 and Orai2 mediate store-operated calcium entry that regulates HL60 cell migration and FAK phosphorylation. Biochim Biophys Acta Mol Cell Res. 2017;1864:1064-1070 pubmed publisher
  6. Oláh T, Bodnár D, Tóth A, Vincze J, Fodor J, Reischl B, et al. Cannabinoid signalling inhibits sarcoplasmic Ca2+ release and regulates excitation-contraction coupling in mammalian skeletal muscle. J Physiol. 2016;594:7381-7398 pubmed publisher
  7. Cubillos S, Norgauer J. Low vitamin D-modulated calcium-regulating proteins in psoriasis vulgaris plaques: S100A7 overexpression depends on joint involvement. Int J Mol Med. 2016;38:1083-92 pubmed publisher
  8. Albarrán L, Lopez J, Amor N, Martin Cano F, Berna Erro A, Smani T, et al. Dynamic interaction of SARAF with STIM1 and Orai1 to modulate store-operated calcium entry. Sci Rep. 2016;6:24452 pubmed publisher
  9. Lisak D, Schacht T, Gawlitza A, Albrecht P, Aktas O, Koop B, et al. BAX inhibitor-1 is a Ca(2+) channel critically important for immune cell function and survival. Cell Death Differ. 2016;23:358-68 pubmed publisher
  10. Wang L, Zhang L, Li S, Zheng Y, Yan X, Chen M, et al. Retrograde regulation of STIM1-Orai1 interaction and store-operated Ca2+ entry by calsequestrin. Sci Rep. 2015;5:11349 pubmed publisher
  11. Liu J, Xin L, Benson V, Allen D, Ju Y. Store-operated calcium entry and the localization of STIM1 and Orai1 proteins in isolated mouse sinoatrial node cells. Front Physiol. 2015;6:69 pubmed publisher
  12. Kondratska K, Kondratskyi A, Yassine M, Lemonnier L, Lepage G, Morabito A, et al. Orai1 and STIM1 mediate SOCE and contribute to apoptotic resistance of pancreatic adenocarcinoma. Biochim Biophys Acta. 2014;1843:2263-9 pubmed publisher