This is a Validated Antibody Database (VAD) review about human Noxa, based on 18 published articles (read how Labome selects the articles), using Noxa antibody in all methods. It is aimed to help Labome visitors find the most suited Noxa antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Noxa synonym: APR; NOXA

Knockout validation
MilliporeSigma
mouse monoclonal (114C307)
  • western blot knockout validation; human; 1:1000; loading ...; fig 5a
MilliporeSigma Noxa antibody (Sigma-Aldrich, OP180) was used in western blot knockout validation on human samples at 1:1000 (fig 5a). Nat Commun (2020) ncbi
Enzo Life Sciences
mouse monoclonal (114C307.1)
  • western blot; human; 1:500; fig 4a
Enzo Life Sciences Noxa antibody (Alexis Biochemicals, ALX-804-408) was used in western blot on human samples at 1:500 (fig 4a). elife (2019) ncbi
mouse monoclonal (114C307.1)
  • western blot; human; fig 1
Enzo Life Sciences Noxa antibody (Enzo Life Sciences, ALX-804-408) was used in western blot on human samples (fig 1). Oncotarget (2016) ncbi
mouse monoclonal (114C307.1)
  • western blot; human; fig 2
Enzo Life Sciences Noxa antibody (Enzo, ALX-804-408) was used in western blot on human samples (fig 2). Cell Death Dis (2016) ncbi
mouse monoclonal (114C307.1)
  • western blot; human; 1:1000; fig 8
Enzo Life Sciences Noxa antibody (Enzo, ALX-804-408-C100) was used in western blot on human samples at 1:1000 (fig 8). Oncotarget (2015) ncbi
mouse monoclonal (114C307.1)
  • western blot; human
In order to examine the effects of miR-23a in cell death, Enzo Life Sciences Noxa antibody (Enzo, 114C307.1) was used in western blot on human samples . Cell Death Dis (2014) ncbi
mouse monoclonal (114C307.1)
  • western blot; human; 1:1000
Enzo Life Sciences Noxa antibody (Alexis Biochemicals, 114C307.1) was used in western blot on human samples at 1:1000. Hepatol Res (2010) ncbi
Invitrogen
mouse monoclonal (114C307.1)
  • western blot; human; loading ...; fig 2c
In order to explore the role of chaperone-mediated autophagy in non-small-cell lung cancer, Invitrogen Noxa antibody (Thermo Fisher, 114C307.1) was used in western blot on human samples (fig 2c). Biochem Biophys Res Commun (2017) ncbi
mouse monoclonal (114C307.1)
  • western blot; human; loading ...; fig 1b
In order to report that Noxa-mediated MCL-1 phosphorylation and subsequent MCL-1 degradation is critical for DNA damaging agent-induced apoptosis, Invitrogen Noxa antibody (Thermo Fisher, 114C307.1) was used in western blot on human samples (fig 1b). Oncotarget (2016) ncbi
mouse monoclonal (114C307.1)
  • western blot; human; loading ...; fig 1a
In order to elucidate the mechanism of cisplatin-induced non-small-cell lung cancer cell apoptosis, Invitrogen Noxa antibody (Thermo Fisher, 114C307.1) was used in western blot on human samples (fig 1a). Biochem Biophys Res Commun (2016) ncbi
mouse monoclonal (114C307.1)
  • western blot; human; loading ...; fig 1
In order to study the effects of HDAC inhibitors and BCL-2 inhibitors on small cell lung cancer lines, Invitrogen Noxa antibody (Thermo Fisher, 114C307.1) was used in western blot on human samples (fig 1). Cancer Biol Ther (2016) ncbi
mouse monoclonal (114C307.1)
  • western blot; human
In order to evaluate the effect of Noxa on the localization and stability of MCL-1 in small cell lung cancer, Invitrogen Noxa antibody (Thermo Fisher Scientific, 114C307.1) was used in western blot on human samples . Cell Death Dis (2014) ncbi
MilliporeSigma
mouse monoclonal (114C307)
  • western blot knockout validation; human; 1:1000; loading ...; fig 5a
MilliporeSigma Noxa antibody (Sigma-Aldrich, OP180) was used in western blot knockout validation on human samples at 1:1000 (fig 5a). Nat Commun (2020) ncbi
Santa Cruz Biotechnology
mouse monoclonal (114C307)
  • western blot; human; fig 4
Santa Cruz Biotechnology Noxa antibody (Santa Cruz, sc-56169) was used in western blot on human samples (fig 4). PLoS ONE (2016) ncbi
mouse monoclonal (114C307)
  • western blot; human; fig 3
Santa Cruz Biotechnology Noxa antibody (Santa Cruz, sc-56169) was used in western blot on human samples (fig 3). Genes Dev (2016) ncbi
mouse monoclonal (114C307)
  • western blot; human; 1:500; tbl 1
Santa Cruz Biotechnology Noxa antibody (Santa Cruz, sc-56169) was used in western blot on human samples at 1:500 (tbl 1). Methods Mol Biol (2015) ncbi
Novus Biologicals
mouse monoclonal (114C307.1)
  • western blot; human; loading ...; fig st2
Novus Biologicals Noxa antibody (Imgenex, 114C307.1) was used in western blot on human samples (fig st2). Oncotarget (2015) ncbi
mouse monoclonal (114C307.1)
  • western blot; human; fig 4
Novus Biologicals Noxa antibody (Imgenex, 114C307.1) was used in western blot on human samples (fig 4). Oncotarget (2015) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D8L7U)
  • western blot; human; loading ...; fig 6
Cell Signaling Technology Noxa antibody (Cell Signaling, 14766) was used in western blot on human samples (fig 6). Oncotarget (2017) ncbi
Articles Reviewed
  1. Bajpai R, Sharma A, Achreja A, Edgar C, Wei C, Siddiqa A, et al. Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma. Nat Commun. 2020;11:1228 pubmed publisher
  2. Hagenbuchner J, Obsilova V, Kaserer T, Kaiser N, Rass B, Psenakova K, et al. Modulating FOXO3 transcriptional activity by small, DBD-binding molecules. elife. 2019;8: pubmed publisher
  3. Lee T, Pelletier J. Dependence of p53-deficient cells on the DHX9 DExH-box helicase. Oncotarget. 2017;8:30908-30921 pubmed publisher
  4. Suzuki J, Nakajima W, Suzuki H, Asano Y, Tanaka N. Chaperone-mediated autophagy promotes lung cancer cell survival through selective stabilization of the pro-survival protein, MCL1. Biochem Biophys Res Commun. 2017;482:1334-1340 pubmed publisher
  5. Twardziok M, Kleinsimon S, Rolff J, Jäger S, Eggert A, Seifert G, et al. Multiple Active Compounds from Viscum album L. Synergistically Converge to Promote Apoptosis in Ewing Sarcoma. PLoS ONE. 2016;11:e0159749 pubmed publisher
  6. Nakajima W, Sharma K, Lee J, Maxim N, Hicks M, Vu T, et al. DNA damaging agent-induced apoptosis is regulated by MCL-1 phosphorylation and degradation mediated by the Noxa/MCL-1/CDK2 complex. Oncotarget. 2016;7:36353-36365 pubmed publisher
  7. O Neill K, Huang K, Zhang J, Chen Y, Luo X. Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane. Genes Dev. 2016;30:973-88 pubmed publisher
  8. Matsumoto M, Nakajima W, Seike M, Gemma A, Tanaka N. Cisplatin-induced apoptosis in non-small-cell lung cancer cells is dependent on Bax- and Bak-induction pathway and synergistically activated by BH3-mimetic ABT-263 in p53 wild-type and mutant cells. Biochem Biophys Res Commun. 2016;473:490-6 pubmed publisher
  9. Gilormini M, Malesys C, Armandy E, Manas P, Guy J, Magne N, et al. Preferential targeting of cancer stem cells in the radiosensitizing effect of ABT-737 on HNSCC. Oncotarget. 2016;7:16731-44 pubmed publisher
  10. Le Pen J, Maillet L, Sarosiek K, Vuillier C, Gautier F, Montessuit S, et al. Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL. Cell Death Dis. 2016;7:e2083 pubmed publisher
  11. Nakajima W, Sharma K, Hicks M, Le N, Brown R, Krystal G, et al. Combination with vorinostat overcomes ABT-263 (navitoclax) resistance of small cell lung cancer. Cancer Biol Ther. 2016;17:27-35 pubmed publisher
  12. Vétillard A, Jonchère B, Moreau M, Toutain B, Henry C, Fontanel S, et al. Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis. Oncotarget. 2015;6:43342-62 pubmed publisher
  13. Tiffen J, Gunatilake D, Gallagher S, Gowrishankar K, Heinemann A, Cullinane C, et al. Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes. Oncotarget. 2015;6:27023-36 pubmed publisher
  14. Heinemann A, Cullinane C, De Paoli Iseppi R, Wilmott J, Gunatilake D, Madore J, et al. Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling. Oncotarget. 2015;6:21507-21 pubmed
  15. Roufayel R, Johnston D, Mosser D. The elimination of miR-23a in heat-stressed cells promotes NOXA-induced cell death and is prevented by HSP70. Cell Death Dis. 2014;5:e1546 pubmed publisher
  16. Vega Naredo I, Cunha Oliveira T, Serafim T, Sardao V, Oliveira P. Analysis of pro-apoptotic protein trafficking to and from mitochondria. Methods Mol Biol. 2015;1241:163-80 pubmed publisher
  17. Nakajima W, Hicks M, Tanaka N, Krystal G, Harada H. Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer. Cell Death Dis. 2014;5:e1052 pubmed publisher
  18. Sosa Seda I, Mott J, Akazawa Y, Barreyro F, Bronk S, Kaufmann S, et al. Noxa mediates hepatic stellate cell apoptosis by proteasome inhibition. Hepatol Res. 2010;40:701-10 pubmed publisher