This is a Validated Antibody Database (VAD) review about human NR1I2, based on 7 published articles (read how Labome selects the articles), using NR1I2 antibody in all methods. It is aimed to help Labome visitors find the most suited NR1I2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
NR1I2 synonym: BXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR; nuclear receptor subfamily 1 group I member 2; orphan nuclear receptor PAR1; orphan nuclear receptor PXR; pregnane X nuclear receptor variant 2; pregnane X receptor; steroid and xenobiotic receptor

Santa Cruz Biotechnology
mouse monoclonal (H-11)
  • western blot; human; loading ...; fig 4d
Santa Cruz Biotechnology NR1I2 antibody (Santa Cruz Biotechnology, H11) was used in western blot on human samples (fig 4d). Sci Rep (2017) ncbi
mouse monoclonal (G-11)
  • western blot; human; 1:1000; loading ...; fig 4
Santa Cruz Biotechnology NR1I2 antibody (Santa Cruz, SC-48403) was used in western blot on human samples at 1:1000 (fig 4). Front Pharmacol (2017) ncbi
mouse monoclonal (G-11)
  • western blot; human; 1:500; fig 2
Santa Cruz Biotechnology NR1I2 antibody (Santa Cruz, sc-48403) was used in western blot on human samples at 1:500 (fig 2). J Immunol Res (2015) ncbi
mouse monoclonal (H-11)
  • western blot; mouse; fig 1
Santa Cruz Biotechnology NR1I2 antibody (Santa Cruz, H-11) was used in western blot on mouse samples (fig 1). Drug Metab Dispos (2015) ncbi
mouse monoclonal (H-11)
  • western blot; human; 1:500
Santa Cruz Biotechnology NR1I2 antibody (Santa Cruz Biotechnology, sc-48340) was used in western blot on human samples at 1:500. Arch Toxicol (2014) ncbi
Abcam
rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:100; fig 1
Abcam NR1I2 antibody (Abcam, ab85451) was used in immunohistochemistry - paraffin section on human samples at 1:100 (fig 1). Oncol Lett (2016) ncbi
rabbit polyclonal
  • western blot; human; 1:5000; fig 1
In order to study down-regulation of organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator by the pregane X receptor, Abcam NR1I2 antibody (Abcam, ab85451) was used in western blot on human samples at 1:5000 (fig 1). Br J Pharmacol (2016) ncbi
Articles Reviewed
  1. Oladimeji P, Lin W, Brewer C, Chen T. Glucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase. Sci Rep. 2017;7:46751 pubmed publisher
  2. Okada N, Murakami A, Urushizaki S, Matsuda M, Kawazoe K, Ishizawa K. Extracts of Immature Orange (Aurantii fructus immaturus) and Citrus Unshiu Peel (Citri unshiu pericarpium) Induce P-Glycoprotein and Cytochrome P450 3A4 Expression via Upregulation of Pregnane X Receptor. Front Pharmacol. 2017;8:84 pubmed publisher
  3. Kong Q, Han Z, Zuo X, Wei H, Huang W. Co-expression of pregnane X receptor and ATP-binding cassette sub-family B member 1 in peripheral blood: A prospective indicator for drug resistance prediction in non-small cell lung cancer. Oncol Lett. 2016;11:3033-3039 pubmed
  4. Hyrsová L, Smutny T, Carazo A, Moravcik S, Mandíková J, Trejtnar F, et al. The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator. Br J Pharmacol. 2016;173:1703-15 pubmed publisher
  5. Wunsch E, Klak M, Wasik U, Milkiewicz M, Blatkiewicz M, Urasinska E, et al. Liver Expression of Sulphotransferase 2A1 Enzyme Is Impaired in Patients with Primary Sclerosing Cholangitis: Lack of the Response to Enhanced Expression of PXR. J Immunol Res. 2015;2015:571353 pubmed publisher
  6. Cui W, Sun M, Galeva N, Williams T, Azuma Y, Staudinger J. SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes. Drug Metab Dispos. 2015;43:1316-25 pubmed publisher
  7. Smutny T, Bitman M, Urban M, Dubecka M, Vrzal R, Dvorak Z, et al. U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells. Arch Toxicol. 2014;88:2243-59 pubmed publisher