This is a Validated Antibody Database (VAD) review about human NR1, based on 51 published articles (read how Labome selects the articles), using NR1 antibody in all methods. It is aimed to help Labome visitors find the most suited NR1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
NR1 synonym: GluN1; MRD8; NDHMSD; NDHMSR; NMD-R1; NMDA1; NMDAR1; NR1

Invitrogen
mouse monoclonal (54.1)
  • western blot; mouse; loading ...; fig 2g
In order to characterize PSD95 postsynaptic supercomplexes, Invitrogen NR1 antibody (Thermo, 32-0500) was used in western blot on mouse samples (fig 2g). J Neurochem (2017) ncbi
mouse monoclonal (54.1)
  • western blot; rat; loading ...; fig 3a
In order to determine the in vivo effects of pentobarbital on brain plasma membranes and lipid rafts, Invitrogen NR1 antibody (Zymed, 320500) was used in western blot on rat samples (fig 3a). Biochim Biophys Acta (2016) ncbi
mouse monoclonal (54.1)
  • immunohistochemistry - paraffin section; human; 1:50; fig 1
  • western blot; human; fig 1
  • immunohistochemistry; mouse; 1:50; fig 3
  • western blot; mouse; fig 3
In order to analyze the participation in the progression of diabetic kidney disease by decreasing Cdc42-GTP activation in podocytes by NMDA receptors, Invitrogen NR1 antibody (Life Technologies, 32-0500) was used in immunohistochemistry - paraffin section on human samples at 1:50 (fig 1), in western blot on human samples (fig 1), in immunohistochemistry on mouse samples at 1:50 (fig 3) and in western blot on mouse samples (fig 3). J Pathol (2016) ncbi
mouse monoclonal (54.1)
  • western blot; mouse; 1:1000; fig 1
In order to analyze selective partitioning into complexes and supercomplexes during synapse maturation by NMDA receptors, Invitrogen NR1 antibody (Invitrogen, 32-0500) was used in western blot on mouse samples at 1:1000 (fig 1). Nat Commun (2016) ncbi
domestic rabbit recombinant (1H13L3)
  • blocking or activating experiments; rat; fig s2
In order to determine impairment of NMDA receptor function by sterotactic injection of cerebrospinal fluid from anti-NMDA receptor encephalitis into rat dentate gyrus, Invitrogen NR1 antibody (ThermoFisher, 700685) was used in blocking or activating experiments on rat samples (fig s2). Brain Res (2016) ncbi
mouse monoclonal (54.1)
  • western blot; rat; 1:5000
In order to study how activation of mGluR2/3 affects NMDAR function, Invitrogen NR1 antibody (Invitrogen, 32-0500) was used in western blot on rat samples at 1:5000. Exp Neurol (2015) ncbi
mouse monoclonal (54.1)
  • immunocytochemistry; mouse; 1:1500
In order to assess the role of the GluN2B subunit during development and in synaptic plasticity, Invitrogen NR1 antibody (Invitrogen, MAb 54.1) was used in immunocytochemistry on mouse samples at 1:1500. J Neurosci (2015) ncbi
domestic rabbit polyclonal
In order to study the effects of methyl beta-cyclodextrin on GluA1-dependent synaptic potentiation, Invitrogen NR1 antibody (Thermo Fisher Scientific, PA3-102) was used . J Neurochem (2015) ncbi
mouse monoclonal (54.1)
  • western blot; mouse; 1:1000
In order to characterize the mutant disrupted-in-schizophrenia 1 protein in astrocytes, Invitrogen NR1 antibody (Life Technolog., 32-0500) was used in western blot on mouse samples at 1:1000. J Neurosci Res (2014) ncbi
mouse monoclonal (54.1)
  • western blot; rat
In order to study the effect of LTP induction on the distribution of ionotropic glutamate receptors in vivo, Invitrogen NR1 antibody (Zymed, 32-0500) was used in western blot on rat samples . PLoS ONE (2014) ncbi
mouse monoclonal (54.1)
  • immunocytochemistry; rat; fig 2
In order to study the control of NMDA receptor surface trafficking by the binding of glutamate to GluN2B subunits, Invitrogen NR1 antibody (Invitrogen, 32-0500) was used in immunocytochemistry on rat samples (fig 2). J Biol Chem (2012) ncbi
mouse monoclonal (54.1)
  • immunocytochemistry; mouse; 1:1000; fig 3
In order to investigate the role of NMDA receptor in synaptic competition in primary neuron culture, Invitrogen NR1 antibody (Invitrogen, 32-0500) was used in immunocytochemistry on mouse samples at 1:1000 (fig 3). PLoS ONE (2011) ncbi
mouse monoclonal (54.1)
  • western blot; rat; fig 5
In order to identify the long term electrophysiological, anatomical and molecular changes in a rat model of temporal lobe epilepsy, Invitrogen NR1 antibody (Zymed, 32-0500) was used in western blot on rat samples (fig 5). Neurobiol Dis (2011) ncbi
mouse monoclonal (54.1)
  • western blot; rat; fig 5
In order to measure the developmental expression of stargazin and AMPA receptor trafficking in the Genetic Absence Epilepsy Rats from Strasbourg model, Invitrogen NR1 antibody (Invitrogen, 32-0500) was used in western blot on rat samples (fig 5). Neurobiol Dis (2011) ncbi
mouse monoclonal (54.1)
  • immunohistochemistry - free floating section; little skate; 1:1000; fig 3
In order to study the NMDA receptor using the South American electric fish, Invitrogen NR1 antibody (Invitrogen, 32-0500) was used in immunohistochemistry - free floating section on little skate samples at 1:1000 (fig 3). J Exp Biol (2010) ncbi
mouse monoclonal (54.1)
  • western blot; rat; 1:400; fig 4
In order to use a rat model to study epileptogenesis, Invitrogen NR1 antibody (Zymed, 32-0500) was used in western blot on rat samples at 1:400 (fig 4). Eur J Neurosci (2010) ncbi
mouse monoclonal (54.1)
  • western blot; human
In order to study synaptosomal associated protein 25 kDa immunoreactivity in the hippocampus of patients with schizophrenia, Invitrogen NR1 antibody (Zymed, 54.1) was used in western blot on human samples . Prog Neuropsychopharmacol Biol Psychiatry (2003) ncbi
Synaptic Systems
mouse monoclonal (M68)
  • immunohistochemistry; zebrafish ; 1:400; loading ...; fig 6c
Synaptic Systems NR1 antibody (Synaptic Systems, 114 011) was used in immunohistochemistry on zebrafish samples at 1:400 (fig 6c). Invest Ophthalmol Vis Sci (2021) ncbi
mouse monoclonal (M68)
  • immunohistochemistry; zebrafish ; 1:200; loading ...; fig 4d
Synaptic Systems NR1 antibody (Synaptic Systems, 114011) was used in immunohistochemistry on zebrafish samples at 1:200 (fig 4d). Sci Adv (2021) ncbi
mouse monoclonal (M68)
  • western blot; mouse; loading ...; fig 3g
Synaptic Systems NR1 antibody (Synaptic Systems, 114011) was used in western blot on mouse samples (fig 3g). Neuron (2021) ncbi
mouse monoclonal (M68)
  • immunohistochemistry - free floating section; mouse; 1:200; loading ...; fig 6e
Synaptic Systems NR1 antibody (Synaptic Systems, 114-011) was used in immunohistochemistry - free floating section on mouse samples at 1:200 (fig 6e). Front Neurosci (2019) ncbi
mouse monoclonal (M68)
  • western blot; mouse; 1:1000; loading ...; fig 5d
Synaptic Systems NR1 antibody (Synaptic systems, 114 011) was used in western blot on mouse samples at 1:1000 (fig 5d). elife (2020) ncbi
mouse monoclonal (M68)
  • western blot; mouse; 1:1000; loading ...; fig s6c
Synaptic Systems NR1 antibody (Synaptic Systems, 114011) was used in western blot on mouse samples at 1:1000 (fig s6c). Proc Natl Acad Sci U S A (2018) ncbi
mouse monoclonal (M68)
  • western blot; mouse; 1:1000; fig s2
In order to determine modulation of glutamatergic transmission by Lrp4 in astrocytes, Synaptic Systems NR1 antibody (Synaptic Systems, 114011) was used in western blot on mouse samples at 1:1000 (fig s2). Nat Neurosci (2016) ncbi
mouse monoclonal (M68)
  • western blot; mouse; 1:3000; loading ...; fig 1c
Synaptic Systems NR1 antibody (Synaptic Systems, 114011) was used in western blot on mouse samples at 1:3000 (fig 1c). Science (2016) ncbi
mouse monoclonal (M68)
  • western blot; rat; 1:1000; fig s3
Synaptic Systems NR1 antibody (Synaptic Systems, 114 011) was used in western blot on rat samples at 1:1000 (fig s3). Mol Biol Cell (2015) ncbi
mouse monoclonal (M68)
  • western blot; mouse; fig 6
In order to test if presenilin and nicastrin regulate synaptic function in a gamma-secretase-dependent or -independent manner, Synaptic Systems NR1 antibody (SYSY, M68) was used in western blot on mouse samples (fig 6). Proc Natl Acad Sci U S A (2014) ncbi
Abcam
domestic rabbit monoclonal (EPR2481(2))
  • western blot; mouse; loading ...; fig 4p
Abcam NR1 antibody (Abcam, ab109182) was used in western blot on mouse samples (fig 4p). EBioMedicine (2022) ncbi
domestic rabbit monoclonal (EPR2480Y)
  • western blot; rat; 1:1000; loading ...; fig 2f
Abcam NR1 antibody (Abcam, ab68144) was used in western blot on rat samples at 1:1000 (fig 2f). Aging Cell (2020) ncbi
domestic rabbit monoclonal (EPR2481(2))
  • western blot; mouse; loading ...; fig 4a
Abcam NR1 antibody (Abcam, ab109182) was used in western blot on mouse samples (fig 4a). J Clin Invest (2019) ncbi
domestic rabbit monoclonal (EPR2481(2))
  • western blot; rat; 1:2000; fig 5
Abcam NR1 antibody (Abcam, ab109182) was used in western blot on rat samples at 1:2000 (fig 5). Sci Rep (2016) ncbi
domestic rabbit monoclonal (EPR2481(2))
  • western blot; mouse; 1:1000; fig 1
Abcam NR1 antibody (Epitomics, 2824-1) was used in western blot on mouse samples at 1:1000 (fig 1). Nat Commun (2016) ncbi
mouse monoclonal (S308-48)
  • immunohistochemistry - frozen section; human; 1:250; fig 5
  • immunocytochemistry; human; 1:250; fig 5
  • western blot; human; 1:500; fig 5
Abcam NR1 antibody (abcam, ab134308) was used in immunohistochemistry - frozen section on human samples at 1:250 (fig 5), in immunocytochemistry on human samples at 1:250 (fig 5) and in western blot on human samples at 1:500 (fig 5). PLoS ONE (2015) ncbi
domestic rabbit monoclonal (EPR2481(2))
  • western blot; mouse; fig 7
Abcam NR1 antibody (Abcam, ab109182) was used in western blot on mouse samples (fig 7). J Neurosci (2015) ncbi
Novus Biologicals
mouse monoclonal (R1JHL)
  • western blot; mouse; 1:2000; loading ...; fig 7a
Novus Biologicals NR1 antibody (Novus, NB300-118) was used in western blot on mouse samples at 1:2000 (fig 7a). Mol Neurodegener (2022) ncbi
Alomone Labs
domestic rabbit polyclonal
  • immunohistochemistry - free floating section; human; 1:400; loading ...; fig 3a
Alomone Labs NR1 antibody (Alomone, AGC-001) was used in immunohistochemistry - free floating section on human samples at 1:400 (fig 3a). Front Neuroanat (2022) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; mouse; 1:300; loading ...; fig 1e
Alomone Labs NR1 antibody (Alomone labs, AGC-001) was used in immunohistochemistry on mouse samples at 1:300 (fig 1e). Sci Rep (2021) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; mouse; 1:100; loading ...; fig s2
Alomone Labs NR1 antibody (Alomone Labs, AGC-001) was used in immunocytochemistry on mouse samples at 1:100 (fig s2). Diabetes (2016) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D65B7)
  • western blot; mouse; 1:2000; loading ...; fig 5f
Cell Signaling Technology NR1 antibody (CST, 5704) was used in western blot on mouse samples at 1:2000 (fig 5f). elife (2022) ncbi
domestic rabbit monoclonal (D65B7)
  • western blot; mouse; 1:1000; loading ...; fig 4g
Cell Signaling Technology NR1 antibody (Cell Signaling, 5704S) was used in western blot on mouse samples at 1:1000 (fig 4g). Nat Commun (2019) ncbi
domestic rabbit monoclonal (D65B7)
  • western blot; mouse; 1:1000; loading ...; fig 3b
Cell Signaling Technology NR1 antibody (Cell Signaling, 5704) was used in western blot on mouse samples at 1:1000 (fig 3b). Brain (2019) ncbi
domestic rabbit monoclonal (D65B7)
  • western blot; mouse; 1:1000; fig 3a
Cell Signaling Technology NR1 antibody (Cell Signaling Technology, D65B7) was used in western blot on mouse samples at 1:1000 (fig 3a). J Neurosci (2018) ncbi
domestic rabbit monoclonal (D65B7)
  • western blot; mouse; loading ...; fig 4I
In order to find that CNS-specific snx6-knockout mice exhibit deficits in spatial learning and memory, accompanied with loss of spines from distal dendrites of hippocampal CA1 pyramidal cells, Cell Signaling Technology NR1 antibody (Cell Signaling, D65B7) was used in western blot on mouse samples (fig 4I). elife (2017) ncbi
domestic rabbit monoclonal (D65B7)
  • immunocytochemistry; mouse; loading ...; fig 1g
  • western blot; mouse; loading ...; fig 1h
Cell Signaling Technology NR1 antibody (Cell Signaling, 5704) was used in immunocytochemistry on mouse samples (fig 1g) and in western blot on mouse samples (fig 1h). Exp Neurol (2017) ncbi
domestic rabbit monoclonal (D65B7)
  • western blot; mouse; 1:2000; loading ...; fig 7b
In order to report the abnormal behavioral phenotypes of mice deficient in Ninjurin 1, Cell Signaling Technology NR1 antibody (Cell signaling, 5704S) was used in western blot on mouse samples at 1:2000 (fig 7b). Mol Neurobiol (2017) ncbi
domestic rabbit monoclonal (D65B7)
  • western blot; rat; 1:1000; loading ...; fig 7a
In order to use rats to study sex differences in spatial memory, Cell Signaling Technology NR1 antibody (Cell Signaling, 5704) was used in western blot on rat samples at 1:1000 (fig 7a). PLoS ONE (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; fig 6
Cell Signaling Technology NR1 antibody (Cell signaling, 3381) was used in western blot on mouse samples at 1:1000 (fig 6). Int J Neuropsychopharmacol (2016) ncbi
domestic rabbit monoclonal (D65B7)
  • western blot; mouse; 1:500; fig 5
In order to determine the correlation between neuronal caMKII-CREB and astroglial JAK2-STAT3 cascades in mice and how spinal IL-33/ST2 signaling contributes to neuropathic pain, Cell Signaling Technology NR1 antibody (Cell Signaling Technology, D65B7) was used in western blot on mouse samples at 1:500 (fig 5). Anesthesiology (2015) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • immunoprecipitation; mouse; 1:1000; loading ...; fig 1d
In order to show that ephrin-B2 antagonizes the pathogenic effects of patients' N-methyl-D-aspartate receptor antibodies on memory and synaptic plasticity, MilliporeSigma NR1 antibody (Sigma, G8913) was used in immunoprecipitation on mouse samples at 1:1000 (fig 1d). Ann Neurol (2016) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - frozen section; mouse; 1:200; fig s1
MilliporeSigma NR1 antibody (Sigma, G8913) was used in immunohistochemistry - frozen section on mouse samples at 1:200 (fig s1). Front Cell Neurosci (2016) ncbi
domestic rabbit polyclonal
In order to study the role of excitotoxicity in neuronal death, MilliporeSigma NR1 antibody (Sigma, G8913) was used . J Neurosci (2015) ncbi
Articles Reviewed
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  23. Pan B, Huang X, Deng C. Chronic administration of aripiprazole activates GSK3β-dependent signalling pathways, and up-regulates GABAA receptor expression and CREB1 activity in rats. Sci Rep. 2016;6:30040 pubmed publisher
  24. Planaguma J, Haselmann H, Mannara F, Petit Pedrol M, Grünewald B, Aguilar E, et al. Ephrin-B2 prevents N-methyl-D-aspartate receptor antibody effects on memory and neuroplasticity. Ann Neurol. 2016;80:388-400 pubmed publisher
  25. Roshanravan H, Kim E, Dryer S. NMDA Receptors as Potential Therapeutic Targets in Diabetic Nephropathy: Increased Renal NMDA Receptor Subunit Expression in Akita Mice and Reduced Nephropathy Following Sustained Treatment With Memantine or MK-801. Diabetes. 2016;65:3139-50 pubmed publisher
  26. Shen J, Wang R, He Z, Huang H, He X, Zhou J, et al. NMDA receptors participate in the progression of diabetic kidney disease by decreasing Cdc42-GTP activation in podocytes. J Pathol. 2016;240:149-60 pubmed publisher
  27. Sun X, Li L, Liu F, Huang Z, Bean J, Jiao H, et al. Lrp4 in astrocytes modulates glutamatergic transmission. Nat Neurosci. 2016;19:1010-8 pubmed publisher
  28. Zhang H, Kang E, Wang Y, Yang C, Yu H, Wang Q, et al. Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice. Nat Commun. 2016;7: pubmed publisher
  29. Heise C, Schroeder J, Schoen M, Halbedl S, Reim D, Woelfle S, et al. Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus. Front Cell Neurosci. 2016;10:106 pubmed publisher
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  32. Würdemann T, Kersten M, Tokay T, Guli X, Kober M, Rohde M, et al. Stereotactic injection of cerebrospinal fluid from anti-NMDA receptor encephalitis into rat dentate gyrus impairs NMDA receptor function. Brain Res. 2016;1633:10-18 pubmed publisher
  33. Posa L, Accarie A, Noble F, Marie N. Methadone Reverses Analgesic Tolerance Induced by Morphine Pretreatment. Int J Neuropsychopharmacol. 2016;19: pubmed publisher
  34. Liu S, Mi W, Li Q, Zhang M, Han P, Hu S, et al. Spinal IL-33/ST2 Signaling Contributes to Neuropathic Pain via Neuronal CaMKII-CREB and Astroglial JAK2-STAT3 Cascades in Mice. Anesthesiology. 2015;123:1154-69 pubmed publisher
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  37. Gingras S, Earls L, Howell S, Smeyne R, Zakharenko S, Pelletier S. SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus. J Neurosci. 2015;35:10510-22 pubmed publisher
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  39. Lo S, Wang Y, Weber M, Larson J, Scearce Levie K, Sheng M. Caspase-3 deficiency results in disrupted synaptic homeostasis and impaired attention control. J Neurosci. 2015;35:2118-32 pubmed publisher
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  41. Choi T, Jung S, Nah J, Ko H, Jo S, Chung G, et al. Low levels of methyl β-cyclodextrin disrupt GluA1-dependent synaptic potentiation but not synaptic depression. J Neurochem. 2015;132:276-85 pubmed publisher
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  46. She K, Craig A. NMDA receptors mediate synaptic competition in culture. PLoS ONE. 2011;6:e24423 pubmed publisher
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  48. Kennard J, Barmanray R, Sampurno S, Ozturk E, Reid C, Paradiso L, et al. Stargazin and AMPA receptor membrane expression is increased in the somatosensory cortex of Genetic Absence Epilepsy Rats from Strasbourg. Neurobiol Dis. 2011;42:48-54 pubmed publisher
  49. Zhang Z, Bodznick D. The importance of N-methyl-D-aspartate (NMDA) receptors in subtraction of electrosensory reafference in the dorsal nucleus of skates. J Exp Biol. 2010;213:2700-9 pubmed publisher
  50. Ouardouz M, Lema P, Awad P, Di Cristo G, Carmant L. N-methyl-D-aspartate, hyperpolarization-activated cation current (Ih) and gamma-aminobutyric acid conductances govern the risk of epileptogenesis following febrile seizures in rat hippocampus. Eur J Neurosci. 2010;31:1252-60 pubmed publisher
  51. Thompson P, Egbufoama S, Vawter M. SNAP-25 reduction in the hippocampus of patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2003;27:411-7 pubmed