This is a Validated Antibody Database (VAD) review about human NOX4, based on 37 published articles (read how Labome selects the articles), using NOX4 antibody in all methods. It is aimed to help Labome visitors find the most suited NOX4 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
NOX4 synonym: KOX; KOX-1; RENOX

Knockout validation
Abcam
domestic rabbit monoclonal (UOTR1B493)
  • western blot knockout validation; human; 1:1000; loading ...; fig 2c
Abcam NOX4 antibody (Abcam, ab133303) was used in western blot knockout validation on human samples at 1:1000 (fig 2c). Nat Chem Biol (2020) ncbi
Abcam
domestic rabbit monoclonal (UOTR1B493)
  • immunohistochemistry - paraffin section; human; 1:2000; loading ...; fig 1i
  • western blot; human; loading ...; fig 2
Abcam NOX4 antibody (Abcam, ab133303) was used in immunohistochemistry - paraffin section on human samples at 1:2000 (fig 1i) and in western blot on human samples (fig 2). Medicine (Baltimore) (2022) ncbi
domestic rabbit monoclonal (UOTR1B493)
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 8i
  • western blot; mouse; 1:1000; loading ...; fig 8g
Abcam NOX4 antibody (Abcam, ab133303) was used in immunohistochemistry - frozen section on mouse samples at 1:200 (fig 8i) and in western blot on mouse samples at 1:1000 (fig 8g). Int J Biol Sci (2022) ncbi
domestic rabbit monoclonal (UOTR1B493)
  • western blot; rat; 1:500; fig 2g
Abcam NOX4 antibody (Abcam, ab133303) was used in western blot on rat samples at 1:500 (fig 2g). Antioxidants (Basel) (2021) ncbi
domestic rabbit monoclonal (UOTR1B492)
  • western blot; rat; 1:1000; loading ...; fig 3b
Abcam NOX4 antibody (Abcam, ab109225) was used in western blot on rat samples at 1:1000 (fig 3b). Mol Med Rep (2021) ncbi
domestic rabbit monoclonal (UOTR1B493)
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 1e
Abcam NOX4 antibody (Abcam, ab133303) was used in immunohistochemistry - paraffin section on mouse samples (fig 1e). Clin Transl Med (2021) ncbi
domestic rabbit monoclonal (UOTR1B493)
  • western blot; mouse; 1:1000; loading ...; fig 6f
Abcam NOX4 antibody (Abcam, ab133303) was used in western blot on mouse samples at 1:1000 (fig 6f). Aging (Albany NY) (2021) ncbi
domestic rabbit monoclonal (UOTR1B493)
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 7b
Abcam NOX4 antibody (Abcam, ab133303) was used in immunohistochemistry on mouse samples at 1:1000 (fig 7b). Aging (Albany NY) (2020) ncbi
domestic rabbit monoclonal (UOTR1B493)
  • western blot knockout validation; human; 1:1000; loading ...; fig 2c
Abcam NOX4 antibody (Abcam, ab133303) was used in western blot knockout validation on human samples at 1:1000 (fig 2c). Nat Chem Biol (2020) ncbi
domestic rabbit monoclonal (UOTR1B493)
  • western blot; human; loading ...; fig 2d
Abcam NOX4 antibody (Abcam, ab133303) was used in western blot on human samples (fig 2d). Mol Cell (2019) ncbi
domestic rabbit monoclonal (UOTR1B493)
  • immunocytochemistry; human; loading ...; fig s6b
Abcam NOX4 antibody (Abcam, ab133303) was used in immunocytochemistry on human samples (fig s6b). J Clin Invest (2019) ncbi
domestic rabbit monoclonal (UOTR1B493)
  • immunohistochemistry; human; loading ...; fig 1b
  • western blot; human; loading ...; fig 3a
Abcam NOX4 antibody (Abcam, ab133303) was used in immunohistochemistry on human samples (fig 1b) and in western blot on human samples (fig 3a). Redox Biol (2019) ncbi
domestic rabbit monoclonal (UOTR1B493)
  • western blot; rat; loading ...; fig 5b
Abcam NOX4 antibody (Abcam, ab133303) was used in western blot on rat samples (fig 5b). Cancer Lett (2018) ncbi
domestic rabbit monoclonal (UOTR1B493)
  • western blot; mouse; loading ...; fig EV4a
Abcam NOX4 antibody (Abcam, ab133303) was used in western blot on mouse samples (fig EV4a). EMBO Mol Med (2017) ncbi
domestic rabbit monoclonal (UOTR1B493)
  • immunohistochemistry - paraffin section; mouse; fig 2f
  • western blot; mouse; loading ...; fig S4c
  • western blot; human; 1:2000; loading ...; fig S3b; 3c
In order to determine the contribution of NOX4 to the development of pancreatic ductal adenocarcinoma, Abcam NOX4 antibody (Abcam, ab133303) was used in immunohistochemistry - paraffin section on mouse samples (fig 2f), in western blot on mouse samples (fig S4c) and in western blot on human samples at 1:2000 (fig S3b; 3c). Nat Commun (2017) ncbi
domestic rabbit monoclonal (UOTR1B493)
  • western blot; human; loading ...; fig 1b
Abcam NOX4 antibody (Abcam, ab133303) was used in western blot on human samples (fig 1b). Free Radic Biol Med (2016) ncbi
domestic rabbit monoclonal (UOTR1B493)
  • western blot; mouse; 1:2500; fig st2
Abcam NOX4 antibody (Abcam, ab133303) was used in western blot on mouse samples at 1:2500 (fig st2). PLoS ONE (2016) ncbi
domestic rabbit monoclonal (UOTR1B492)
  • immunohistochemistry; rat; fig 1
Abcam NOX4 antibody (abcam, ab109225) was used in immunohistochemistry on rat samples (fig 1). Physiol Rep (2016) ncbi
domestic rabbit monoclonal (UOTR1B493)
  • western blot; mouse; fig 5
Abcam NOX4 antibody (Abcam, ab133303) was used in western blot on mouse samples (fig 5). Oncotarget (2016) ncbi
domestic rabbit monoclonal (UOTR1B492)
  • western blot; rat; 1:1000; fig 2
Abcam NOX4 antibody (Abcam, ab109225) was used in western blot on rat samples at 1:1000 (fig 2). Nat Commun (2016) ncbi
domestic rabbit monoclonal (UOTR1B492)
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 8
Abcam NOX4 antibody (Abcam, ab109225) was used in immunohistochemistry - paraffin section on mouse samples at 1:100 (fig 8). Nat Commun (2015) ncbi
domestic rabbit monoclonal (UOTR1B492)
  • western blot; mouse; 1:1000; fig 4
In order to research bone metastases in mice by excess TGF-beta mediating muscle weakness, Abcam NOX4 antibody (Abcam, 109225) was used in western blot on mouse samples at 1:1000 (fig 4). Nat Med (2015) ncbi
domestic rabbit monoclonal (UOTR1B492)
  • western blot; rat; 1:500; fig 3
Abcam NOX4 antibody (Abcam, ab109225) was used in western blot on rat samples at 1:500 (fig 3). J Am Heart Assoc (2015) ncbi
domestic rabbit monoclonal (UOTR1B492)
  • western blot; rat; fig 3
In order to study NADPH oxidase and its dynamic regulation of cytosolic accumulation of small nucleolar RNAS (snoRNAs), Abcam NOX4 antibody (Abcam, ab109225) was used in western blot on rat samples (fig 3). J Biol Chem (2015) ncbi
domestic rabbit monoclonal (UOTR1B492)
  • western blot; human; fig 3
Abcam NOX4 antibody (Abcam, ab109225) was used in western blot on human samples (fig 3). PLoS ONE (2014) ncbi
domestic rabbit monoclonal (UOTR1B492)
  • western blot; mouse
In order to evaluate the effect of iron chelator deferoxamine on renal fibrosis, Abcam NOX4 antibody (Abcam, ab109225) was used in western blot on mouse samples . PLoS ONE (2014) ncbi
Novus Biologicals
domestic rabbit polyclonal (6C5cc)
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 1c
  • western blot; mouse; 1:1000; loading ...; fig 1b
Novus Biologicals NOX4 antibody (Novus, NB110-58851) was used in immunohistochemistry - frozen section on mouse samples at 1:100 (fig 1c) and in western blot on mouse samples at 1:1000 (fig 1b). Redox Biol (2021) ncbi
domestic rabbit polyclonal (5B12)
  • western blot; mouse; loading ...; fig 1b
Novus Biologicals NOX4 antibody (Novus, NB110-58849) was used in western blot on mouse samples (fig 1b). Endocr Relat Cancer (2021) ncbi
domestic rabbit polyclonal (5B12)
  • western blot; human; fig 4m
Novus Biologicals NOX4 antibody (Novus Biologicals, NB110?\58849) was used in western blot on human samples (fig 4m). Mol Oncol (2021) ncbi
domestic rabbit polyclonal (5B12)
  • western blot; mouse; loading ...; fig s1
  • western blot; human; loading ...; fig s7
Novus Biologicals NOX4 antibody (Novus, NB110-58849) was used in western blot on mouse samples (fig s1) and in western blot on human samples (fig s7). Sci Rep (2020) ncbi
domestic rabbit polyclonal (5B12)
  • western blot; mouse; 1:500; loading ...; fig 3
Novus Biologicals NOX4 antibody (Novus Biologicals, NB110-58849) was used in western blot on mouse samples at 1:500 (fig 3). Tissue Eng Part C Methods (2019) ncbi
domestic rabbit polyclonal (5B12)
  • western blot; rat; loading ...; fig 3f
Novus Biologicals NOX4 antibody (Novus Biologicals, NB110-58849) was used in western blot on rat samples (fig 3f). Oxid Med Cell Longev (2018) ncbi
domestic rabbit polyclonal (5B12)
  • immunohistochemistry - paraffin section; mouse; fig 5
  • western blot; human; fig 2
Novus Biologicals NOX4 antibody (novus Biologicals, NB110-58849) was used in immunohistochemistry - paraffin section on mouse samples (fig 5) and in western blot on human samples (fig 2). Respir Res (2016) ncbi
domestic rabbit polyclonal (5B12)
In order to identify the role of angiopoietin like-2 in angiotensin II-induced cerebral endothelial dysfunction in mice, Novus Biologicals NOX4 antibody (Novus Biologicals, NB110-58849) was used . Am J Physiol Heart Circ Physiol (2015) ncbi
domestic rabbit polyclonal (5B12)
In order to discuss drugs that prevent the epithelial-mesenchymal transition, Novus Biologicals NOX4 antibody (Novus Biologicals, NB110-58849) was used . COPD (2015) ncbi
Invitrogen
domestic rabbit recombinant (SY0214)
  • western blot; human; 1:1000; fig 1c
Invitrogen NOX4 antibody (Thermo Fisher, MA5-32090) was used in western blot on human samples at 1:1000 (fig 1c). elife (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 3h
Invitrogen NOX4 antibody (Thermo Fisher Scientific, PA5-72816) was used in western blot on mouse samples at 1:1000 (fig 3h). Biochem Biophys Res Commun (2018) ncbi
ProSci
  • western blot; human; loading ...; fig 6a
ProSci NOX4 antibody (ProSci, 7927) was used in western blot on human samples (fig 6a). J Clin Invest (2019) ncbi
  • western blot; human; loading ...; fig 1d
ProSci NOX4 antibody (ProSci, 7927) was used in western blot on human samples (fig 1d). PLoS ONE (2017) ncbi
Articles Reviewed
  1. Wei X, Xue M, Kang C, Gao L, Zhang M, Ma C, et al. Increased NOX1 and DUOX2 expression in the colonic mucosa of patients with chronic functional constipation. Medicine (Baltimore). 2022;101:e30028 pubmed publisher
  2. Wan L, Bai X, Zhou Q, Chen C, Wang H, Liu T, et al. The advanced glycation end-products (AGEs)/ROS/NLRP3 inflammasome axis contributes to delayed diabetic corneal wound healing and nerve regeneration. Int J Biol Sci. 2022;18:809-825 pubmed publisher
  3. Sayour A, Ruppert M, Olah A, Benke K, Barta B, Zsáry E, et al. Left Ventricular SGLT1 Protein Expression Correlates with the Extent of Myocardial Nitro-Oxidative Stress in Rats with Pressure and Volume Overload-Induced Heart Failure. Antioxidants (Basel). 2021;10: pubmed publisher
  4. Dong J, Viswanathan S, Adami E, Schafer S, Kuthubudeen F, Widjaja A, et al. The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling. elife. 2021;10: pubmed publisher
  5. Shi Y, Hou S. Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4. Mol Med Rep. 2021;24: pubmed publisher
  6. Chen C, Wang S, Yu L, Mueller J, Fortunato F, Rausch V, et al. H2O2-mediated autophagy during ethanol metabolism. Redox Biol. 2021;46:102081 pubmed publisher
  7. Luckett K, Cracchiolo J, Krishnamoorthy G, Leandro García L, Nagarajah J, Saqcena M, et al. Co-inhibition of SMAD and MAPK signaling enhances 124I uptake in BRAF-mutant thyroid cancers. Endocr Relat Cancer. 2021;28:391-402 pubmed publisher
  8. Casagrande V, Iuliani G, Menini S, Pugliese G, Federici M, Menghini R. Restoration of renal TIMP3 levels via genetics and pharmacological approach prevents experimental diabetic nephropathy. Clin Transl Med. 2021;11:e305 pubmed publisher
  9. Huang S, You S, Qian J, Dai C, Shen S, Wang J, et al. Myeloid differentiation 2 deficiency attenuates AngII-induced arterial vascular oxidative stress, inflammation, and remodeling. Aging (Albany NY). 2021;13:4409-4427 pubmed publisher
  10. Mota M, Metge B, Hinshaw D, Alsheikh H, Chen D, Samant R, et al. Merlin deficiency alters the redox management program in breast cancer. Mol Oncol. 2021;15:942-956 pubmed publisher
  11. Xiao L, Zhong M, Huang Y, Zhu J, Tang W, Li D, et al. Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6/ROS-dependent MAPK/NF-κB signaling pathways. Aging (Albany NY). 2020;12:21706-21729 pubmed publisher
  12. Kim Y, Kim J, Gu S, Jo S, Kim S, Young Kim S, et al. Identification of highly potent and selective inhibitor, TIPTP, of the p22phox-Rubicon axis as a therapeutic agent for rheumatoid arthritis. Sci Rep. 2020;10:4570 pubmed publisher
  13. Zou Y, Li H, Graham E, Deik A, Eaton J, Wang W, et al. Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis. Nat Chem Biol. 2020;16:302-309 pubmed publisher
  14. Gao X, Zhao L, Liu S, Li Y, Xia S, Chen D, et al. γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A. Mol Cell. 2019;76:857-871.e9 pubmed publisher
  15. Pan C, Jin L, Wang X, Li Y, Chun J, Boese A, et al. Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance. J Clin Invest. 2019;129:2431-2445 pubmed publisher
  16. Zhang J, Li H, Wu Q, Chen Y, Deng Y, Yang Z, et al. Tumoral NOX4 recruits M2 tumor-associated macrophages via ROS/PI3K signaling-dependent various cytokine production to promote NSCLC growth. Redox Biol. 2019;22:101116 pubmed publisher
  17. Dyikanov D, Vasiluev P, Rysenkova K, Aleksandrushkina N, Tyurin Kuzmin P, Kulebyakin K, et al. Optimization of CRISPR/Cas9 technology to knock-out genes of interest in aneuploid cell lines. Tissue Eng Part C Methods. 2019;: pubmed publisher
  18. Bitar M, Nader J, Al Ali W, Al Madhoun A, Arefanian H, Al Mulla F. Hydrogen Sulfide Donor NaHS Improves Metabolism and Reduces Muscle Atrophy in Type 2 Diabetes: Implication for Understanding Sarcopenic Pathophysiology. Oxid Med Cell Longev. 2018;2018:6825452 pubmed publisher
  19. Gong F, Gu J, Wang H. Up regulated Tmbim1 activation promotes high fat diet (HFD)-induced cardiomyopathy by enhancement of inflammation and oxidative stress. Biochem Biophys Res Commun. 2018;504:797-804 pubmed publisher
  20. Wang Z, Ding Y, Wang X, Lu S, Wang C, He C, et al. Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT. Cancer Lett. 2018;428:21-33 pubmed publisher
  21. Hammers D, Merscham Banda M, Hsiao J, ENGST S, Hartman J, Sweeney H. Supraphysiological levels of GDF11 induce striated muscle atrophy. EMBO Mol Med. 2017;9:531-544 pubmed publisher
  22. Ju H, Ying H, Tian T, Ling J, Fu J, Lu Y, et al. Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma. Nat Commun. 2017;8:14437 pubmed publisher
  23. Jafari N, Kim H, Park R, Li L, Jang M, Morris A, et al. CRISPR-Cas9 Mediated NOX4 Knockout Inhibits Cell Proliferation and Invasion in HeLa Cells. PLoS ONE. 2017;12:e0170327 pubmed publisher
  24. Zeng C, Wu Q, Wang J, Yao B, Ma L, Yang Z, et al. NOX4 supports glycolysis and promotes glutamine metabolism in non-small cell lung cancer cells. Free Radic Biol Med. 2016;101:236-248 pubmed publisher
  25. Sato N, Takasaka N, Yoshida M, Tsubouchi K, Minagawa S, Araya J, et al. Metformin attenuates lung fibrosis development via NOX4 suppression. Respir Res. 2016;17:107 pubmed publisher
  26. Gharib M, Tao H, Fungwe T, Hajri T. Cluster Differentiating 36 (CD36) Deficiency Attenuates Obesity-Associated Oxidative Stress in the Heart. PLoS ONE. 2016;11:e0155611 pubmed publisher
  27. Saez F, Hong N, Garvin J. Luminal flow induces NADPH oxidase 4 translocation to the nuclei of thick ascending limbs. Physiol Rep. 2016;4: pubmed publisher
  28. Liu S, Wu C, Huang K, Wang C, Guan S, Chen L, et al. C/EBP homologous protein (CHOP) deficiency ameliorates renal fibrosis in unilateral ureteral obstructive kidney disease. Oncotarget. 2016;7:21900-12 pubmed publisher
  29. Cannavo A, Liccardo D, Eguchi A, Elliott K, Traynham C, Ibetti J, et al. Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases. Nat Commun. 2016;7:10877 pubmed publisher
  30. Dvash E, Har Tal M, Barak S, Meir O, Rubinstein M. Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage. Nat Commun. 2015;6:10112 pubmed publisher
  31. Waning D, Mohammad K, Reiken S, Xie W, Andersson D, John S, et al. Excess TGF-β mediates muscle weakness associated with bone metastases in mice. Nat Med. 2015;21:1262-1271 pubmed publisher
  32. Aoki K, Teshima Y, Kondo H, Saito S, Fukui A, Fukunaga N, et al. Role of Indoxyl Sulfate as a Predisposing Factor for Atrial Fibrillation in Renal Dysfunction. J Am Heart Assoc. 2015;4:e002023 pubmed publisher
  33. Holley C, Li M, Scruggs B, Matkovich S, Ory D, Schaffer J. Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase. J Biol Chem. 2015;290:11741-8 pubmed publisher
  34. Yu C, Luo X, Duquette N, Thorin Trescases N, Thorin E. Knockdown of angiopoietin like-2 protects against angiotensin II-induced cerebral endothelial dysfunction in mice. Am J Physiol Heart Circ Physiol. 2015;308:H386-97 pubmed publisher
  35. Chatterjee A, Sharma A, Chen M, Toy R, Mottola G, Conte M. The pro-resolving lipid mediator maresin 1 (MaR1) attenuates inflammatory signaling pathways in vascular smooth muscle and endothelial cells. PLoS ONE. 2014;9:e113480 pubmed publisher
  36. Milara J, Peiró T, Serrano A, Artigues E, Aparicio J, Tenor H, et al. Simvastatin Increases the Ability of Roflumilast N-oxide to Inhibit Cigarette Smoke-Induced Epithelial to Mesenchymal Transition in Well-differentiated Human Bronchial Epithelial Cells in vitro. COPD. 2015;12:320-31 pubmed publisher
  37. Ikeda Y, Ozono I, Tajima S, Imao M, Horinouchi Y, Izawa Ishizawa Y, et al. Iron chelation by deferoxamine prevents renal interstitial fibrosis in mice with unilateral ureteral obstruction. PLoS ONE. 2014;9:e89355 pubmed publisher