This is a Validated Antibody Database (VAD) review about human NLRC4, based on 7 published articles (read how Labome selects the articles), using NLRC4 antibody in all methods. It is aimed to help Labome visitors find the most suited NLRC4 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
NLRC4 synonym: AIFEC; CARD12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; FCAS4; IPAF

Abcam
domestic rabbit monoclonal (EPR19733)
  • immunoprecipitation; mouse; 1:50; loading ...; fig 6a
Abcam NLRC4 antibody (Abcam, ab201792) was used in immunoprecipitation on mouse samples at 1:50 (fig 6a). Nat Commun (2022) ncbi
domestic rabbit monoclonal (EPR19733)
  • immunocytochemistry; mouse; loading ...; fig 5e
  • western blot; mouse; 1:1000; loading ...; fig 3c
Abcam NLRC4 antibody (Abcam, ab201792) was used in immunocytochemistry on mouse samples (fig 5e) and in western blot on mouse samples at 1:1000 (fig 3c). Aging (Albany NY) (2021) ncbi
BioLegend
mouse monoclonal (6H9B13)
  • western blot; human; loading ...; fig 2c
BioLegend NLRC4 antibody (BioLegend, 659702) was used in western blot on human samples (fig 2c). J Allergy Clin Immunol (2019) ncbi
Invitrogen
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 4f, s7b
Invitrogen NLRC4 antibody (Invitrogen, PA5-79739) was used in western blot on mouse samples at 1:1000 (fig 4f, s7b). Nat Commun (2019) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D5Y8E)
  • western blot; mouse; 1:2500; loading ...; fig 6b
Cell Signaling Technology NLRC4 antibody (Cell Signaling Technology, D5Y8E) was used in western blot on mouse samples at 1:2500 (fig 6b). Front Physiol (2021) ncbi
domestic rabbit monoclonal (D5Y8E)
  • western blot; human; loading ...; fig s2b
Cell Signaling Technology NLRC4 antibody (Cell Signaling, 12421) was used in western blot on human samples (fig s2b). PLoS Pathog (2017) ncbi
ProSci
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; loading ...; fig 2b
ProSci NLRC4 antibody (ProSci, 3107) was used in immunohistochemistry - paraffin section on human samples (fig 2b). J Clin Invest (2016) ncbi
Articles Reviewed
  1. Mohamed M, Gupta K, Goldufsky J, Roy R, Callaghan L, Wetzel D, et al. CrkII/Abl phosphorylation cascade is critical for NLRC4 inflammasome activity and is blocked by Pseudomonas aeruginosa ExoT. Nat Commun. 2022;13:1295 pubmed publisher
  2. Kucsera D, T xf3 th V, Gerg x151 D, V xf6 r xf6 s I, On xf3 di Z, G xf6 rbe A, et al. Characterization of the CDAA Diet-Induced Non-alcoholic Steatohepatitis Model: Sex-Specific Differences in Inflammation, Fibrosis, and Cholesterol Metabolism in Middle-Aged Mice. Front Physiol. 2021;12:609465 pubmed publisher
  3. Wang S, Yan C, Luo J. NLRC4 gene silencing-dependent blockade of NOD-like receptor pathway inhibits inflammation, reduces proliferation and increases apoptosis of dendritic cells in mice with septic shock. Aging (Albany NY). 2021;13:1440-1457 pubmed publisher
  4. Quach C, Song Y, Guo H, Li S, Maazi H, Fung M, et al. A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. Nat Commun. 2019;10:5681 pubmed publisher
  5. Gordon E, Yao X, Xu H, Karkowsky W, Kaler M, Kalchiem Dekel O, et al. Apolipoprotein E is a concentration-dependent pulmonary danger signal that activates the NLRP3 inflammasome and IL-1β secretion by bronchoalveolar fluid macrophages from asthmatic subjects. J Allergy Clin Immunol. 2019;: pubmed publisher
  6. Koh H, Kim Y, Kim J, Yun J, Jang K, Yang C. Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKCα. PLoS Pathog. 2017;13:e1006126 pubmed publisher
  7. Janowski A, Colegio O, Hornick E, McNiff J, Martin M, Badovinac V, et al. NLRC4 suppresses melanoma tumor progression independently of inflammasome activation. J Clin Invest. 2016;126:3917-3928 pubmed publisher