This is a Validated Antibody Database (VAD) review about human MUS81, based on 13 published articles (read how Labome selects the articles), using MUS81 antibody in all methods. It is aimed to help Labome visitors find the most suited MUS81 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
MUS81 synonym: SLX3

Knockout validation
Abcam
mouse monoclonal (MTA30 2G10/3)
  • western blot knockout validation; human; 1:500; loading ...; fig 8a
Abcam MUS81 antibody (Abcam, ab14387) was used in western blot knockout validation on human samples at 1:500 (fig 8a). Nat Commun (2021) ncbi
Abcam
mouse monoclonal (MTA30 2G10/3)
  • western blot knockout validation; human; 1:2000; fig 3
In order to study the role of Mus81 in DNA replication, Abcam MUS81 antibody (Abcam, ab14387) was used in western blot knockout validation on human samples at 1:2000 (fig 3). Nat Commun (2015) ncbi
Abcam
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 1e
  • western blot; human; 1:1000; loading ...; fig 2c, 2d
Abcam MUS81 antibody (Abcam, ab247136) was used in immunohistochemistry - paraffin section on human samples at 1:200 (fig 1e) and in western blot on human samples at 1:1000 (fig 2c, 2d). J Exp Clin Cancer Res (2021) ncbi
mouse monoclonal (MTA30 2G10/3)
  • western blot knockout validation; human; 1:500; loading ...; fig 8a
Abcam MUS81 antibody (Abcam, ab14387) was used in western blot knockout validation on human samples at 1:500 (fig 8a). Nat Commun (2021) ncbi
mouse monoclonal (MTA30 2G10/3)
  • western blot; human; loading ...; fig 5g
Abcam MUS81 antibody (Abcam, ab14387) was used in western blot on human samples (fig 5g). Sci Adv (2019) ncbi
mouse monoclonal (MTA30 2G10/3)
  • western blot; human; loading ...; fig 5f
Abcam MUS81 antibody (Abcam, ab14387) was used in western blot on human samples (fig 5f). Nucleic Acids Res (2017) ncbi
mouse monoclonal (MTA30 2G10/3)
  • western blot; human; loading ...; fig 5c
In order to discover that SDE2 is a genome surveillance factor regulated by proliferating cell nuclear antigen, Abcam MUS81 antibody (Abcam, MTA30 2G10/3) was used in western blot on human samples (fig 5c). PLoS Genet (2016) ncbi
mouse monoclonal (MTA30 2G10/3)
  • western blot; human; 1:1000; fig 2
Abcam MUS81 antibody (Abcam, ab14387) was used in western blot on human samples at 1:1000 (fig 2). Oncotarget (2015) ncbi
mouse monoclonal (MTA30 2G10/3)
  • western blot knockout validation; human; 1:2000; fig 3
In order to study the role of Mus81 in DNA replication, Abcam MUS81 antibody (Abcam, ab14387) was used in western blot knockout validation on human samples at 1:2000 (fig 3). Nat Commun (2015) ncbi
mouse monoclonal (MTA30 2G10/3)
  • chromatin immunoprecipitation; human; 1:1000; fig 4
In order to identify a novel DNA2- and WRN-dependent mechanism of reversed replication fork processing and restart after prolonged genotoxic stress, Abcam MUS81 antibody (Abcam, ab14387) was used in chromatin immunoprecipitation on human samples at 1:1000 (fig 4). J Cell Biol (2015) ncbi
mouse monoclonal (MTA30 2G10/3)
  • western blot; human; 1:200; fig 4a
In order to show that TRF2 stimulates initial homologous recombination events and inhibits their resolution via its N-terminal domain, Abcam MUS81 antibody (ABCAM, ab14387) was used in western blot on human samples at 1:200 (fig 4a). Cell Cycle (2014) ncbi
mouse monoclonal (MTA30 2G10/3)
  • western blot; human; fig 2
Abcam MUS81 antibody (Abcam, ab14387) was used in western blot on human samples (fig 2). Cell (2014) ncbi
mouse monoclonal (MTA30 2G10/3)
  • immunoprecipitation; human
  • western blot; human
In order to study a novel Fanconi anemia subtype in which SLX4 is mutated, Abcam MUS81 antibody (Abcam, ab14387) was used in immunoprecipitation on human samples and in western blot on human samples . Nat Genet (2011) ncbi
Santa Cruz Biotechnology
mouse monoclonal (2G10/3)
  • western blot; human; 1:1000; fig s4
Santa Cruz Biotechnology MUS81 antibody (Santa Cruz, sc-47692) was used in western blot on human samples at 1:1000 (fig s4). Nat Commun (2014) ncbi
mouse monoclonal (MTA30 2G10/3)
  • western blot; human
Santa Cruz Biotechnology MUS81 antibody (Santa, sc-53382) was used in western blot on human samples . Genes Dev (2014) ncbi
Articles Reviewed
  1. Li C, Shen Q, Zhang P, Wang T, Liu W, Li R, et al. Targeting MUS81 promotes the anticancer effect of WEE1 inhibitor and immune checkpoint blocking combination therapy via activating cGAS/STING signaling in gastric cancer cells. J Exp Clin Cancer Res. 2021;40:315 pubmed publisher
  2. Baxley R, Leung W, Schmit M, Matson J, Yin L, Oram M, et al. Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening. Nat Commun. 2021;12:1626 pubmed publisher
  3. Xu M, Qin J, Wang L, Lee H, Kao C, Liu D, et al. Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway. Sci Adv. 2019;5:eaax6366 pubmed publisher
  4. Meisenberg C, Ashour M, El Shafie L, Liao C, Hodgson A, Pilborough A, et al. Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic Acids Res. 2017;45:1159-1176 pubmed publisher
  5. Jo U, Cai W, Wang J, Kwon Y, D Andrea A, Kim H. PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress. PLoS Genet. 2016;12:e1006465 pubmed publisher
  6. Xing M, Wang X, Palmai Pallag T, Shen H, Helleday T, Hickson I, et al. Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response. Oncotarget. 2015;6:37638-46 pubmed publisher
  7. Fu H, Martin M, Regairaz M, Huang L, You Y, Lin C, et al. The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage. Nat Commun. 2015;6:6746 pubmed publisher
  8. Thangavel S, Berti M, Levikova M, Pinto C, Gomathinayagam S, Vujanovic M, et al. DNA2 drives processing and restart of reversed replication forks in human cells. J Cell Biol. 2015;208:545-62 pubmed publisher
  9. Saint Léger A, Koelblen M, Civitelli L, Bah A, Djerbi N, Giraud Panis M, et al. The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres. Cell Cycle. 2014;13:2469-74 pubmed publisher
  10. Chan Y, West S. Spatial control of the GEN1 Holliday junction resolvase ensures genome stability. Nat Commun. 2014;5:4844 pubmed publisher
  11. Sarbajna S, Davies D, West S. Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe. Genes Dev. 2014;28:1124-36 pubmed publisher
  12. Laguette N, Brégnard C, Hue P, Basbous J, Yatim A, Larroque M, et al. Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing. Cell. 2014;156:134-45 pubmed publisher
  13. Stoepker C, Hain K, Schuster B, Hilhorst Hofstee Y, Rooimans M, Steltenpool J, et al. SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype. Nat Genet. 2011;43:138-41 pubmed publisher