This is a Validated Antibody Database (VAD) review about human MT1-MMP, based on 29 published articles (read how Labome selects the articles), using MT1-MMP antibody in all methods. It is aimed to help Labome visitors find the most suited MT1-MMP antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
MT1-MMP synonym: MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP; MT1MMP; MTMMP1; WNCHRS

Knockout validation
Abcam
domestic rabbit monoclonal (EP1264Y)
  • western blot knockout validation; mouse; 1:2000; fig 3
Abcam MT1-MMP antibody (Abcam, ab51074) was used in western blot knockout validation on mouse samples at 1:2000 (fig 3). Nat Commun (2016) ncbi
Abcam
domestic rabbit monoclonal (EP1264Y)
  • immunohistochemistry; mouse; 1:150; loading ...; fig 3e
Abcam MT1-MMP antibody (Abcam, ab51074) was used in immunohistochemistry on mouse samples at 1:150 (fig 3e). Nature (2020) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 7j
Abcam MT1-MMP antibody (Abcam, ab38971) was used in immunohistochemistry - paraffin section on mouse samples at 1:100 (fig 7j). J Bone Miner Res (2020) ncbi
mouse monoclonal (LEM-2/63.1)
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig ex5b
Abcam MT1-MMP antibody (Abcam, ab78738) was used in immunohistochemistry - frozen section on mouse samples at 1:100 (fig ex5b). Nature (2019) ncbi
domestic rabbit polyclonal
Abcam MT1-MMP antibody (Abcam, ab3644) was used . J Biol Chem (2017) ncbi
domestic rabbit monoclonal (EP1264Y)
  • immunocytochemistry; human; loading ...; fig 2e
Abcam MT1-MMP antibody (Abcam, ab51074) was used in immunocytochemistry on human samples (fig 2e). Oncogene (2017) ncbi
mouse monoclonal (LEM-2/63.1)
  • blocking or activating experiments; mouse; loading ...; fig 5h
Abcam MT1-MMP antibody (Abcam, ab78738) was used in blocking or activating experiments on mouse samples (fig 5h). Oncogene (2017) ncbi
domestic rabbit monoclonal (EP1264Y)
  • western blot; human; 1:1000; loading ...; fig 4d
In order to explore the contribution of CD105 to leukemogenesis, Abcam MT1-MMP antibody (Abcam, EP1264Y) was used in western blot on human samples at 1:1000 (fig 4d). Blood (2017) ncbi
domestic rabbit monoclonal (EP1264Y)
  • western blot; human; loading ...; fig 7a
Abcam MT1-MMP antibody (Abcam, ab51074) was used in western blot on human samples (fig 7a). FASEB J (2017) ncbi
domestic rabbit monoclonal (EP1264Y)
  • western blot; human; fig 1a
Abcam MT1-MMP antibody (Abcam, ab51074) was used in western blot on human samples (fig 1a). Stem Cell Reports (2016) ncbi
domestic rabbit monoclonal (EP1264Y)
  • immunocytochemistry; human; fig 1c
  • western blot; human; fig 3c
Abcam MT1-MMP antibody (Abcam, Ab51074) was used in immunocytochemistry on human samples (fig 1c) and in western blot on human samples (fig 3c). J Cell Sci (2016) ncbi
domestic rabbit monoclonal (EP1264Y)
  • western blot knockout validation; mouse; 1:2000; fig 3
Abcam MT1-MMP antibody (Abcam, ab51074) was used in western blot knockout validation on mouse samples at 1:2000 (fig 3). Nat Commun (2016) ncbi
domestic rabbit monoclonal (EP1264Y)
  • immunohistochemistry; mouse; 1:50; fig 4
Abcam MT1-MMP antibody (Abcam, ab51074) was used in immunohistochemistry on mouse samples at 1:50 (fig 4). PLoS ONE (2016) ncbi
domestic rabbit monoclonal (EP1264Y)
  • immunohistochemistry - paraffin section; rat; 1:200; fig s2
  • western blot; rat
Abcam MT1-MMP antibody (abcam, ab51074) was used in immunohistochemistry - paraffin section on rat samples at 1:200 (fig s2) and in western blot on rat samples . Sci Rep (2016) ncbi
domestic rabbit polyclonal
  • flow cytometry; human; fig 5
  • western blot; human; fig 5
In order to report that PKD2 controls secretion of matrix metalloproteinase cargo, Abcam MT1-MMP antibody (Abcam, ab3644) was used in flow cytometry on human samples (fig 5) and in western blot on human samples (fig 5). J Biol Chem (2016) ncbi
domestic rabbit monoclonal (EP1264Y)
  • western blot; human; 1:1000; fig 3d
In order to investigate factors involved in the crosstalk between basal cells and endothelial cells, Abcam MT1-MMP antibody (Abcam, ab51074) was used in western blot on human samples at 1:1000 (fig 3d). J Cell Sci (2015) ncbi
domestic rabbit monoclonal (EP1264Y)
  • immunocytochemistry; human; 1:200
Abcam MT1-MMP antibody (Abcam, ab51074) was used in immunocytochemistry on human samples at 1:200. Biomaterials (2015) ncbi
domestic rabbit monoclonal (EP1264Y)
  • western blot; human; fig 7
In order to test if hepatocytes produce MMPs, regulated by CD147, that remodel fibrotic extracellular matrix independent of HSC, Abcam MT1-MMP antibody (Abcam, EP1264Y) was used in western blot on human samples (fig 7). PLoS ONE (2014) ncbi
domestic rabbit monoclonal (EP1264Y)
  • flow cytometry; human; fig 1
Abcam MT1-MMP antibody (Abcam, ab51074) was used in flow cytometry on human samples (fig 1). BMC Cancer (2013) ncbi
domestic rabbit monoclonal (EP1264Y)
  • western blot; human
Abcam MT1-MMP antibody (Abcam, ab51074) was used in western blot on human samples . Mol Syst Biol (2013) ncbi
domestic rabbit monoclonal (EP1264Y)
  • immunocytochemistry; mouse
Abcam MT1-MMP antibody (Abcam, ab51074) was used in immunocytochemistry on mouse samples . J Am Heart Assoc (2012) ncbi
domestic rabbit monoclonal (EP1264Y)
  • immunohistochemistry - frozen section; human; 1:200
Abcam MT1-MMP antibody (Abcam, Ab 51074) was used in immunohistochemistry - frozen section on human samples at 1:200. J Comp Neurol (2012) ncbi
R&D Systems
mouse monoclonal (128527)
  • flow cytometry; human; loading ...; fig 2f
R&D Systems MT1-MMP antibody (R&D, FAB9181P) was used in flow cytometry on human samples (fig 2f). J Exp Med (2018) ncbi
domestic goat polyclonal
  • western blot; human; fig 3e
R&D Systems MT1-MMP antibody (R&D Systems, AF918) was used in western blot on human samples (fig 3e). J Immunol (2017) ncbi
mouse monoclonal (128527)
  • flow cytometry; human
R&D Systems MT1-MMP antibody (R&D Systems, FAB9181P) was used in flow cytometry on human samples . J Immunol (2015) ncbi
MilliporeSigma
mouse monoclonal (114-6G6)
  • immunocytochemistry; human; loading ...; fig 3d
MilliporeSigma MT1-MMP antibody (MilliporeSigma, MAB3319) was used in immunocytochemistry on human samples (fig 3d). Invest Ophthalmol Vis Sci (2019) ncbi
GeneTex
domestic rabbit monoclonal (EP1264Y)
  • immunohistochemistry - paraffin section; human; 1:200; tbl 2
In order to study the clinical significance and expression of metalloproteases and their inhibitors in invasive breast carcinoma endothelial cells, GeneTex MT1-MMP antibody (GeneTex, GTX61603) was used in immunohistochemistry - paraffin section on human samples at 1:200 (tbl 2). Clin Breast Cancer (2016) ncbi
Invitrogen
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 3b
In order to evaluate the effect of TNF-alpha on the migration of breast cancer cells and investigate its association with membrane-associated proteases in lipid rafts, Invitrogen MT1-MMP antibody (Thermo Scientific, PA5-13183) was used in western blot on human samples (fig 3b). Cell Oncol (Dordr) (2016) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D1E4)
  • western blot; human; loading ...; fig 3b
Cell Signaling Technology MT1-MMP antibody (Cell Signaling Technology, 13130) was used in western blot on human samples (fig 3b). Breast Cancer Res (2019) ncbi
domestic rabbit monoclonal (D1E4)
  • western blot; human; loading ...; fig 6b
In order to study how CUB domain-containing protein1 contributes to metastasis and drug resistance, Cell Signaling Technology MT1-MMP antibody (Cell Signaling, 13130) was used in western blot on human samples (fig 6b). Breast Cancer Res (2016) ncbi
domestic rabbit monoclonal (D1E4)
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 6g
  • western blot; human; 1:1000; loading ...; fig 6a
Cell Signaling Technology MT1-MMP antibody (Cell Signaling Technology, 13130) was used in immunohistochemistry - paraffin section on human samples at 1:100 (fig 6g) and in western blot on human samples at 1:1000 (fig 6a). J Clin Invest (2016) ncbi
Articles Reviewed
  1. Kyprianou C, Christodoulou N, Hamilton R, Nahaboo W, Boomgaard D, Amadei G, et al. Basement membrane remodelling regulates mouse embryogenesis. Nature. 2020;582:253-258 pubmed publisher
  2. Kegelman C, Coulombe J, Jordan K, Horan D, Qin L, Robling A, et al. YAP and TAZ Mediate Osteocyte Perilacunar/Canalicular Remodeling. J Bone Miner Res. 2020;35:196-210 pubmed publisher
  3. Hori A, Shimoda M, Naoi Y, Kagara N, Tanei T, Miyake T, et al. Vasculogenic mimicry is associated with trastuzumab resistance of HER2-positive breast cancer. Breast Cancer Res. 2019;21:88 pubmed publisher
  4. Tikhonova A, Dolgalev I, Hu H, Sivaraj K, Hoxha E, Cuesta Dominguez A, et al. The bone marrow microenvironment at single-cell resolution. Nature. 2019;569:222-228 pubmed publisher
  5. Sun Y, Yang Y, Keller K. Myosin-X Silencing in the Trabecular Meshwork Suggests a Role for Tunneling Nanotubes in Outflow Regulation. Invest Ophthalmol Vis Sci. 2019;60:843-851 pubmed publisher
  6. Kelly A, Günaltay S, McEntee C, Shuttleworth E, Smedley C, Houston S, et al. Human monocytes and macrophages regulate immune tolerance via integrin αvβ8-mediated TGFβ activation. J Exp Med. 2018;215:2725-2736 pubmed publisher
  7. Emori T, Hirose J, Ise K, Yomoda J, Kasahara M, Shinkuma T, et al. Constitutive Activation of Integrin ?9 Augments Self-Directed Hyperplastic and Proinflammatory Properties of Fibroblast-like Synoviocytes of Rheumatoid Arthritis. J Immunol. 2017;199:3427-3436 pubmed publisher
  8. Brasher M, Martynowicz D, Grafinger O, Hucik A, Shanks Skinner E, Uniacke J, et al. Interaction of Munc18c and syntaxin4 facilitates invadopodium formation and extracellular matrix invasion of tumor cells. J Biol Chem. 2017;292:16199-16210 pubmed publisher
  9. Swayampakula M, McDonald P, Vallejo M, Coyaud E, Chafe S, Westerback A, et al. The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion. Oncogene. 2017;36:6244-6261 pubmed publisher
  10. Dourado K, Baik J, Oliveira V, Beltrame M, Yamamoto A, Theuer C, et al. Endoglin: a novel target for therapeutic intervention in acute leukemias revealed in xenograft mouse models. Blood. 2017;129:2526-2536 pubmed publisher
  11. Bertier L, Boucherie C, Zwaenepoel O, Vanloo B, Van Troys M, Van Audenhove I, et al. Inhibitory cortactin nanobodies delineate the role of NTA- and SH3-domain-specific functions during invadopodium formation and cancer cell invasion. FASEB J. 2017;31:2460-2476 pubmed publisher
  12. Bogachek M, Park J, De Andrade J, Lorenzen A, Kulak M, White J, et al. Inhibiting the SUMO Pathway Represses the Cancer Stem Cell Population in Breast and Colorectal Carcinomas. Stem Cell Reports. 2016;7:1140-1151 pubmed publisher
  13. LAW M, Ferreira R, Davis B, Higgins P, Kim J, Castellano R, et al. CUB domain-containing protein 1 and the epidermal growth factor receptor cooperate to induce cell detachment. Breast Cancer Res. 2016;18:80 pubmed publisher
  14. Cid S, Eiró N, Gonzalez L, Béridze N, Vazquez J, Vizoso F. Expression and Clinical Significance of Metalloproteases and Their Inhibitors by Endothelial Cells From Invasive Breast Carcinomas. Clin Breast Cancer. 2016;16:e83-91 pubmed publisher
  15. Daubon T, Spuul P, Alonso F, Fremaux I, Genot E. VEGF-A stimulates podosome-mediated collagen-IV proteolysis in microvascular endothelial cells. J Cell Sci. 2016;129:2586-98 pubmed publisher
  16. Huang M, Liu T, Ma P, Mitteer R, Zhang Z, Kim H, et al. c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. J Clin Invest. 2016;126:1801-14 pubmed publisher
  17. Wolczyk D, Zaremba Czogalla M, Hryniewicz Jankowska A, Tabola R, Grabowski K, Sikorski A, et al. TNF-? promotes breast cancer cell migration and enhances the concentration of membrane-associated proteases in lipid rafts. Cell Oncol (Dordr). 2016;39:353-63 pubmed publisher
  18. Wong H, Jin G, Cao R, Zhang S, Cao Y, Zhou Z. MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis. Nat Commun. 2016;7:10824 pubmed publisher
  19. Tsaousi A, Hayes E, Di Gregoli K, Bond A, Bevan L, Thomas A, et al. Plaque Size Is Decreased but M1 Macrophage Polarization and Rupture Related Metalloproteinase Expression Are Maintained after Deleting T-Bet in ApoE Null Mice. PLoS ONE. 2016;11:e0148873 pubmed publisher
  20. Zhao W, Wang C, Liu R, Wei C, Duan J, Liu K, et al. Effect of TGF-β1 on the Migration and Recruitment of Mesenchymal Stem Cells after Vascular Balloon Injury: Involvement of Matrix Metalloproteinase-14. Sci Rep. 2016;6:21176 pubmed publisher
  21. Eiseler T, Wille C, Koehler C, Illing A, Seufferlein T. Protein Kinase D2 Assembles a Multiprotein Complex at the Trans-Golgi Network to Regulate Matrix Metalloproteinase Secretion. J Biol Chem. 2016;291:462-77 pubmed publisher
  22. Ding B, Gomi K, Rafii S, Crystal R, Walters M. Endothelial MMP14 is required for endothelial-dependent growth support of human airway basal cells. J Cell Sci. 2015;128:2983-8 pubmed publisher
  23. Sathyamoorthy T, Tezera L, Walker N, Brilha S, Saraiva L, Mauri F, et al. Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis. J Immunol. 2015;195:882-91 pubmed publisher
  24. Ho F, Zhang W, Li Y, Chan B. Mechanoresponsive, omni-directional and local matrix-degrading actin protrusions in human mesenchymal stem cells microencapsulated in a 3D collagen matrix. Biomaterials. 2015;53:392-405 pubmed publisher
  25. Calabro S, Maczurek A, Morgan A, Tu T, Wen V, Yee C, et al. Hepatocyte produced matrix metalloproteinases are regulated by CD147 in liver fibrogenesis. PLoS ONE. 2014;9:e90571 pubmed publisher
  26. Havre P, Dang L, Ohnuma K, Iwata S, Morimoto C, Dang N. CD26 expression on T-anaplastic large cell lymphoma (ALCL) line Karpas 299 is associated with increased expression of versican and MT1-MMP and enhanced adhesion. BMC Cancer. 2013;13:517 pubmed publisher
  27. Kuttner V, Mack C, Rigbolt K, Kern J, Schilling O, Busch H, et al. Global remodelling of cellular microenvironment due to loss of collagen VII. Mol Syst Biol. 2013;9:657 pubmed publisher
  28. Ming X, Rajapakse A, Yepuri G, Xiong Y, Carvas J, Ruffieux J, et al. Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis. J Am Heart Assoc. 2012;1:e000992 pubmed publisher
  29. Farahani R, Sarrafpour B, Simonian M, Li Q, Hunter N. Directed glia-assisted angiogenesis in a mature neurosensory structure: pericytes mediate an adaptive response in human dental pulp that maintains blood-barrier function. J Comp Neurol. 2012;520:3803-26 pubmed publisher