This is a Validated Antibody Database (VAD) review about human MPC1, based on 7 published articles (read how Labome selects the articles), using MPC1 antibody in all methods. It is aimed to help Labome visitors find the most suited MPC1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
MPC1 synonym: BRP44L; CGI-129; MPYCD; SLC54A1

Knockout validation
Cell Signaling Technology
domestic rabbit monoclonal (D2L9I)
  • western blot knockout validation; mouse; loading ...; fig 5a
Cell Signaling Technology MPC1 antibody (Cell Signaling Technologies, 14462) was used in western blot knockout validation on mouse samples (fig 5a). elife (2020) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • western blot; human; fig 2
  • western blot knockout validation; mouse; fig 3
  • immunohistochemistry - frozen section; mouse; fig 6
In order to study placental mammal-specific mitochondrial pyruvate carrier subunit called MPC1-like and its expression in post-meiotic male germ cells, MilliporeSigma MPC1 antibody (Sigma, HPA045119) was used in western blot on human samples (fig 2), in western blot knockout validation on mouse samples (fig 3) and in immunohistochemistry - frozen section on mouse samples (fig 6). J Biol Chem (2016) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig 1e
MilliporeSigma MPC1 antibody (Sigma, HPA045119) was used in western blot knockout validation on mouse samples (fig 1e). PLoS Genet (2016) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D2L9I)
  • western blot knockout validation; mouse; loading ...; fig 5a
Cell Signaling Technology MPC1 antibody (Cell Signaling Technologies, 14462) was used in western blot knockout validation on mouse samples (fig 5a). elife (2020) ncbi
domestic rabbit monoclonal (D2L9I)
  • western blot; human; loading ...; fig 4b
Cell Signaling Technology MPC1 antibody (Cell Signaling Technology, 14462) was used in western blot on human samples (fig 4b). Cell Rep (2019) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig e2d
MilliporeSigma MPC1 antibody (Sigma, HPA045119) was used in immunohistochemistry - paraffin section on mouse samples at 1:100 (fig e2d). Nat Metab (2021) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; human; 1:500; loading ...; fig 1a
  • western blot; human; 1:1000; loading ...; fig 1b
MilliporeSigma MPC1 antibody (Sigma, HPA045119) was used in immunocytochemistry on human samples at 1:500 (fig 1a) and in western blot on human samples at 1:1000 (fig 1b). Oncotarget (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 3e
In order to report that E4F1 is a master regulator of the pyruvate dehydrogenase complex, MilliporeSigma MPC1 antibody (Sigma, HPA045119) was used in western blot on mouse samples (fig 3e). Proc Natl Acad Sci U S A (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 2
  • western blot knockout validation; mouse; fig 3
  • immunohistochemistry - frozen section; mouse; fig 6
In order to study placental mammal-specific mitochondrial pyruvate carrier subunit called MPC1-like and its expression in post-meiotic male germ cells, MilliporeSigma MPC1 antibody (Sigma, HPA045119) was used in western blot on human samples (fig 2), in western blot knockout validation on mouse samples (fig 3) and in immunohistochemistry - frozen section on mouse samples (fig 6). J Biol Chem (2016) ncbi
domestic rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig 1e
MilliporeSigma MPC1 antibody (Sigma, HPA045119) was used in western blot knockout validation on mouse samples (fig 1e). PLoS Genet (2016) ncbi
Articles Reviewed
  1. Choi J, Sebastian C, Ferrer C, Lewis C, Sade Feldman M, LaSalle T, et al. A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma. Nat Metab. 2021;3:182-195 pubmed publisher
  2. Panic V, Pearson S, Banks J, Tippetts T, Velasco Silva J, Lee S, et al. Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis. elife. 2020;9: pubmed publisher
  3. Park S, Safi R, Liu X, Baldi R, Liu W, Liu J, et al. Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer. Cell Rep. 2019;27:3587-3601.e4 pubmed publisher
  4. Li Y, Li X, Kan Q, Zhang M, Li X, Xu R, et al. Mitochondrial pyruvate carrier function is negatively linked to Warburg phenotype in vitro and malignant features in esophageal squamous cell carcinomas. Oncotarget. 2017;8:1058-1073 pubmed publisher
  5. Lacroix M, Rodier G, Kirsh O, Houles T, Delpech H, Seyran B, et al. E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity. Proc Natl Acad Sci U S A. 2016;113:10998-1003 pubmed publisher
  6. Vanderperre B, Cermakova K, Escoffier J, Kaba M, Bender T, Nef S, et al. MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells. J Biol Chem. 2016;291:16448-61 pubmed publisher
  7. Vanderperre B, Herzig S, Krznar P, Hörl M, Ammar Z, Montessuit S, et al. Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet. PLoS Genet. 2016;12:e1006056 pubmed publisher