This is a Validated Antibody Database (VAD) review about human MMP-3, based on 29 published articles (read how Labome selects the articles), using MMP-3 antibody in all methods. It is aimed to help Labome visitors find the most suited MMP-3 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
MMP-3 synonym: CHDS6; MMP-3; SL-1; STMY; STMY1; STR1

Knockout validation
Abcam
domestic rabbit monoclonal (EP1186Y)
  • western blot knockout validation; mouse; 1:200; loading ...; fig 2a
  • immunohistochemistry; mouse; 1:200; loading ...; fig 1e
Abcam MMP-3 antibody (Abcam, Ab52915) was used in western blot knockout validation on mouse samples at 1:200 (fig 2a) and in immunohistochemistry on mouse samples at 1:200 (fig 1e). Int J Mol Sci (2016) ncbi
Abcam
domestic rabbit monoclonal (EP1186Y)
  • immunohistochemistry; mouse; 1:200; loading ...; fig 3f
Abcam MMP-3 antibody (Abcam, 52915) was used in immunohistochemistry on mouse samples at 1:200 (fig 3f). Nat Cardiovasc Res (2022) ncbi
domestic rabbit monoclonal (EP1186Y)
  • immunohistochemistry; mouse; 1:100; loading ...; fig 7b
Abcam MMP-3 antibody (Abcam, ab52915) was used in immunohistochemistry on mouse samples at 1:100 (fig 7b). Cells (2021) ncbi
domestic rabbit monoclonal (EP1186Y)
  • western blot; mouse; 1:10,000; loading ...; fig 4b
Abcam MMP-3 antibody (Abcam, ab52915) was used in western blot on mouse samples at 1:10,000 (fig 4b). Int J Mol Sci (2021) ncbi
domestic rabbit monoclonal (EP1186Y)
  • western blot; human; 1:200; fig 1c
Abcam MMP-3 antibody (Abcam, ab52915) was used in western blot on human samples at 1:200 (fig 1c). Oxid Med Cell Longev (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 3b
Abcam MMP-3 antibody (Abcam, ab53015) was used in western blot on human samples at 1:1000 (fig 3b). Arthritis Res Ther (2020) ncbi
domestic rabbit monoclonal (EP1186Y)
  • western blot; mouse; fig 1d
Abcam MMP-3 antibody (Abcam, EP1186Y, ab52915) was used in western blot on mouse samples (fig 1d). Cancers (Basel) (2020) ncbi
domestic rabbit monoclonal (EP1186Y)
  • western blot; mouse; 1:1000; fig 4d
Abcam MMP-3 antibody (Abcam, ab52915) was used in western blot on mouse samples at 1:1000 (fig 4d). elife (2020) ncbi
domestic rabbit monoclonal (EP1186Y)
  • western blot; rat; 1:1000; loading ...; fig 6a
Abcam MMP-3 antibody (Abcam, ab52915) was used in western blot on rat samples at 1:1000 (fig 6a). Aging (Albany NY) (2020) ncbi
mouse monoclonal (SL-1 ID3)
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 1b
Abcam MMP-3 antibody (Abcam, ab3208) was used in immunohistochemistry - paraffin section on mouse samples at 1:50 (fig 1b). Bone Res (2019) ncbi
domestic rabbit monoclonal (EP1186Y)
  • western blot; human; loading ...; fig 5e
Abcam MMP-3 antibody (Abcam, ab52915) was used in western blot on human samples (fig 5e). Br J Cancer (2019) ncbi
domestic rabbit monoclonal (EP1186Y)
  • immunohistochemistry - paraffin section; mouse; fig 5c
Abcam MMP-3 antibody (Abcam, ab52915) was used in immunohistochemistry - paraffin section on mouse samples (fig 5c). Br J Pharmacol (2018) ncbi
domestic rabbit monoclonal (EP1186Y)
  • western blot; human; loading ...; fig 3a
In order to report that hypoxia alters collagen and matrix metalloproteinase expression in human patients with keratoconus, Abcam MMP-3 antibody (Abcam, ab52915) was used in western blot on human samples (fig 3a). PLoS ONE (2017) ncbi
domestic rabbit monoclonal (EP1186Y)
  • western blot; mouse; loading ...; fig 4g
In order to demonstrate that inhibition of bromodomain and extra-terminal proteins suppresses chondrocyte differentiation and restrains bone growth, Abcam MMP-3 antibody (Abcam, ab52915) was used in western blot on mouse samples (fig 4g). J Biol Chem (2016) ncbi
domestic rabbit monoclonal (EP1186Y)
  • western blot knockout validation; mouse; 1:200; loading ...; fig 2a
  • immunohistochemistry; mouse; 1:200; loading ...; fig 1e
Abcam MMP-3 antibody (Abcam, Ab52915) was used in western blot knockout validation on mouse samples at 1:200 (fig 2a) and in immunohistochemistry on mouse samples at 1:200 (fig 1e). Int J Mol Sci (2016) ncbi
domestic rabbit monoclonal (EP1186Y)
  • western blot; human; 1:1000; loading ...; fig s2
In order to elucidate the relationship between protease prolyl endopeptidase and neural cell adhesion molecule, Abcam MMP-3 antibody (Abcam, ab52915) was used in western blot on human samples at 1:1000 (fig s2). J Cell Sci (2016) ncbi
domestic rabbit monoclonal (EP1186Y)
  • western blot; human; 1:200; fig 5c
Abcam MMP-3 antibody (Abcam, ab52915) was used in western blot on human samples at 1:200 (fig 5c). Arthritis Res Ther (2016) ncbi
domestic rabbit monoclonal (EP1186Y)
  • western blot; mouse; 1:1000; loading ...; fig 6h
Abcam MMP-3 antibody (Abcam, ab52915) was used in western blot on mouse samples at 1:1000 (fig 6h). Nat Commun (2016) ncbi
domestic rabbit monoclonal (EP1186Y)
  • western blot; human; 1:1000; fig 7
Abcam MMP-3 antibody (Abcam, ab52915) was used in western blot on human samples at 1:1000 (fig 7). J Cell Mol Med (2016) ncbi
domestic rabbit monoclonal (EP1186Y)
  • ELISA; human; fig s2g
Abcam MMP-3 antibody (Abcam, ab52915) was used in ELISA on human samples (fig s2g). Arthritis Res Ther (2015) ncbi
domestic rabbit monoclonal (EP1186Y)
  • immunohistochemistry - paraffin section; mouse; 1:300
  • western blot; mouse
Abcam MMP-3 antibody (Abcam, ab52915) was used in immunohistochemistry - paraffin section on mouse samples at 1:300 and in western blot on mouse samples . PLoS ONE (2015) ncbi
Santa Cruz Biotechnology
mouse monoclonal (1B4)
  • western blot; human; 1:1000; loading ...; fig 3f
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 4f
Santa Cruz Biotechnology MMP-3 antibody (Santa Cruz Biotechnology, sc-21732) was used in western blot on human samples at 1:1000 (fig 3f) and in immunohistochemistry - paraffin section on mouse samples at 1:1000 (fig 4f). Int J Mol Med (2021) ncbi
mouse monoclonal (F-10)
  • western blot; human; 1:500
Santa Cruz Biotechnology MMP-3 antibody (Santa Cruz, sc-374029) was used in western blot on human samples at 1:500. Cancers (Basel) (2021) ncbi
mouse monoclonal (1B4)
  • western blot; mouse; loading ...; fig 5b, s5b
Santa Cruz Biotechnology MMP-3 antibody (Santa Cruz, sc-21732) was used in western blot on mouse samples (fig 5b, s5b). Cancers (Basel) (2021) ncbi
BioLegend
mouse monoclonal (M4405F10)
  • western blot; mouse; fig 2c
BioLegend MMP-3 antibody (BioLegend, 679202) was used in western blot on mouse samples (fig 2c). Brain Commun (2021) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D7F5B)
  • western blot; human; 1:1000; fig 4b
Cell Signaling Technology MMP-3 antibody (Cell Signaling, 14351) was used in western blot on human samples at 1:1000 (fig 4b). Cell Death Dis (2021) ncbi
domestic rabbit monoclonal (D7F5B)
  • western blot; human; 1:1000; loading ...; fig 3g
Cell Signaling Technology MMP-3 antibody (Cell Signaling, 14351) was used in western blot on human samples at 1:1000 (fig 3g). Mol Cancer Res (2021) ncbi
domestic rabbit monoclonal (D7F5B)
  • western blot; human; loading ...; fig 2e
Cell Signaling Technology MMP-3 antibody (Cell signaling Technology, 14351) was used in western blot on human samples (fig 2e). EBioMedicine (2020) ncbi
domestic rabbit monoclonal (D7F5B)
  • western blot; human; 1:2000; fig 3b
Cell Signaling Technology MMP-3 antibody (Cell Signaling Technology, 14351) was used in western blot on human samples at 1:2000 (fig 3b). Int J Mol Med (2019) ncbi
domestic rabbit monoclonal (D7F5B)
  • western blot; human; 1:1000; fig 8
Cell Signaling Technology MMP-3 antibody (CST, 14351) was used in western blot on human samples at 1:1000 (fig 8). Sci Rep (2016) ncbi
Articles Reviewed
  1. Cheng P, Wirka R, Kim J, Kim H, Nguyen T, Kundu R, et al. Smad3 regulates smooth muscle cell fate and mediates adverse remodeling and calcification of the atherosclerotic plaque. Nat Cardiovasc Res. 2022;1:322-333 pubmed publisher
  2. Kang C, Li W, Yu K, Li X, Huang R, Ke P, et al. Long non‑coding RNA AL355711 promotes smooth muscle cell migration through the ABCG1/MMP3 pathway. Int J Mol Med. 2021;48: pubmed publisher
  3. Kuo P, Weng W, Scofield B, Furnas D, Paraiso H, Yu I, et al. Immunoresponsive gene 1 modulates the severity of brain injury in cerebral ischaemia. Brain Commun. 2021;3:fcab187 pubmed publisher
  4. Sebastian A, McCool J, Hum N, Murugesh D, Wilson S, Christiansen B, et al. Single-Cell RNA-Seq Reveals Transcriptomic Heterogeneity and Post-Traumatic Osteoarthritis-Associated Early Molecular Changes in Mouse Articular Chondrocytes. Cells. 2021;10: pubmed publisher
  5. Zhang X, Huang Z, Wang J, Ma Z, Yang J, Corey E, et al. Targeting Feedforward Loops Formed by Nuclear Receptor RORγ and Kinase PBK in mCRPC with Hyperactive AR Signaling. Cancers (Basel). 2021;13: pubmed publisher
  6. Choi M, Jo J, Lee M, Park J, Park Y. Intra-Articular Administration of Cramp into Mouse Knee Joint Exacerbates Experimental Osteoarthritis Progression. Int J Mol Sci. 2021;22: pubmed publisher
  7. Xue Y, Chen H, Zhang S, Bao L, Chen B, Gong H, et al. Resveratrol Confers Vascular Protection by Suppressing TLR4/Syk/NLRP3 Signaling in Oxidized Low-Density Lipoprotein-Activated Platelets. Oxid Med Cell Longev. 2021;2021:8819231 pubmed publisher
  8. Feng Y, Liu S, Zha R, Sun X, Li K, ROBLING A, et al. Mechanical Loading-Driven Tumor Suppression Is Mediated by Lrp5-Dependent and Independent Mechanisms. Cancers (Basel). 2021;13: pubmed publisher
  9. Lu M, Qin X, Zhou Y, Li G, Liu Z, Geng X, et al. Long non-coding RNA LINC00665 promotes gemcitabine resistance of Cholangiocarcinoma cells via regulating EMT and stemness properties through miR-424-5p/BCL9L axis. Cell Death Dis. 2021;12:72 pubmed publisher
  10. Sanchez D, Missiaen R, Skuli N, Steger D, Simon M. Cell-Intrinsic Tumorigenic Functions of PPARγ in Bladder Urothelial Carcinoma. Mol Cancer Res. 2021;19:598-611 pubmed publisher
  11. Xu J, Jiang C, Cai Y, Guo Y, Wang X, Zhang J, et al. Intervening upregulated SLC7A5 could mitigate inflammatory mediator by mTOR-P70S6K signal in rheumatoid arthritis synoviocytes. Arthritis Res Ther. 2020;22:200 pubmed publisher
  12. Okusha Y, Eguchi T, Tran M, Sogawa C, Yoshida K, Itagaki M, et al. Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer. Cancers (Basel). 2020;12: pubmed publisher
  13. Che H, Li J, Li Y, Ma C, Liu H, Qin J, et al. p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle. elife. 2020;9: pubmed publisher
  14. Xiang Q, Kang L, Wang J, Liao Z, Song Y, Zhao K, et al. CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis. EBioMedicine. 2020;53:102679 pubmed publisher
  15. Jiang L, Xu K, Li J, Zhou X, Xu L, Wu Z, et al. Nesfatin-1 suppresses interleukin-1β-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats. Aging (Albany NY). 2020;12:1760-1777 pubmed publisher
  16. Wu X, Chen S, Lu C. Amyloid precursor protein promotes the migration and invasion of breast cancer cells by regulating the MAPK signaling pathway. Int J Mol Med. 2019;: pubmed publisher
  17. Tu M, Yang M, Yu N, Zhen G, Wan M, Liu W, et al. Inhibition of cyclooxygenase-2 activity in subchondral bone modifies a subtype of osteoarthritis. Bone Res. 2019;7:29 pubmed publisher
  18. Chen Q, Yang C, Chen L, Zhang J, Ge W, Yuan H, et al. YY1 targets tubulin polymerisation-promoting protein to inhibit migration, invasion and angiogenesis in pancreatic cancer via p38/MAPK and PI3K/AKT pathways. Br J Cancer. 2019;121:912-921 pubmed publisher
  19. Kang L, Kwon E, Lee K, Cho C, Lee J, Ryu Y, et al. 3'-Sialyllactose as an inhibitor of p65 phosphorylation ameliorates the progression of experimental rheumatoid arthritis. Br J Pharmacol. 2018;175:4295-4309 pubmed publisher
  20. McKay T, Hjortdal J, Priyadarsini S, Karamichos D. Acute hypoxia influences collagen and matrix metalloproteinase expression by human keratoconus cells in vitro. PLoS ONE. 2017;12:e0176017 pubmed publisher
  21. Niu N, Shao R, Yan G, Zou W. Bromodomain and Extra-terminal (BET) Protein Inhibitors Suppress Chondrocyte Differentiation and Restrain Bone Growth. J Biol Chem. 2016;291:26647-26657 pubmed publisher
  22. Van Hove I, Lefevere E, De Groef L, Sergeys J, Salinas Navarro M, Libert C, et al. MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment. Int J Mol Sci. 2016;17: pubmed
  23. Jaako K, Waniek A, Parik K, Klimaviciusa L, Aonurm Helm A, Noortoots A, et al. Prolyl endopeptidase is involved in the degradation of neural cell adhesion molecules in vitro. J Cell Sci. 2016;129:3792-3802 pubmed
  24. Wu X, Liu W, Duan Z, Gao Y, Li S, Wang K, et al. The Involvement of Protease Nexin-1 (PN1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration. Sci Rep. 2016;6:30563 pubmed publisher
  25. Müller S, Acevedo L, Wang X, Karim M, Matta A, Mehrkens A, et al. Notochordal cell conditioned medium (NCCM) regenerates end-stage human osteoarthritic articular chondrocytes and promotes a healthy phenotype. Arthritis Res Ther. 2016;18:125 pubmed publisher
  26. Li C, Zhen G, Chai Y, Xie L, Crane J, Farber E, et al. RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF-VEGF complex in extracellular matrix. Nat Commun. 2016;7:11455 pubmed publisher
  27. Zhao L, Li S, Gan L, Li C, Qiu Z, Feng Y, et al. Paired box 5 is a frequently methylated lung cancer tumour suppressor gene interfering β-catenin signalling and GADD45G expression. J Cell Mol Med. 2016;20:842-54 pubmed publisher
  28. Lowin T, Apitz M, Anders S, Straub R. Anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner. Arthritis Res Ther. 2015;17:321 pubmed publisher
  29. Jakobs C, Perner S, Hornung V. AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis. PLoS ONE. 2015;10:e0131702 pubmed publisher