This is a Validated Antibody Database (VAD) review about human MKK4, based on 22 published articles (read how Labome selects the articles), using MKK4 antibody in all methods. It is aimed to help Labome visitors find the most suited MKK4 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
MKK4 synonym: JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK-1; SAPKK1; SEK1; SERK1; SKK1

Knockout validation
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig 5a
Cell Signaling Technology MKK4 antibody (Cell Signaling, 9152) was used in western blot knockout validation on human samples (fig 5a). Cell Res (2018) ncbi
Abcam
domestic rabbit polyclonal
  • immunohistochemistry - frozen section; mouse; 1:75; loading ...; fig 5g
  • western blot; mouse; 1:2000; loading ...; fig 5k
Abcam MKK4 antibody (Abcam, ab131494) was used in immunohistochemistry - frozen section on mouse samples at 1:75 (fig 5g) and in western blot on mouse samples at 1:2000 (fig 5k). Front Aging Neurosci (2020) ncbi
domestic rabbit monoclonal (EP615Y)
  • western blot; human; 1:2000; fig 4a
Abcam MKK4 antibody (Abcam, ab33912) was used in western blot on human samples at 1:2000 (fig 4a). Int J Mol Med (2019) ncbi
domestic rabbit monoclonal (EP615Y)
  • western blot; rat; loading ...; fig 4g
Abcam MKK4 antibody (Abcam, ab33912) was used in western blot on rat samples (fig 4g). Am J Physiol Endocrinol Metab (2017) ncbi
Santa Cruz Biotechnology
mouse monoclonal (G-7)
  • western blot; mouse; 1:1000; loading ...; fig s2
Santa Cruz Biotechnology MKK4 antibody (Santa Cruz Biotechnology, 376838) was used in western blot on mouse samples at 1:1000 (fig s2). Nat Commun (2018) ncbi
mouse monoclonal (G-6)
  • western blot; human
Santa Cruz Biotechnology MKK4 antibody (Santa Cruz, sc-166168) was used in western blot on human samples . Clin Immunol (2015) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (5c10)
  • western blot; mouse; 1:1000; loading ...; fig 7c
Cell Signaling Technology MKK4 antibody (Cell Signaling Technology, 3346) was used in western blot on mouse samples at 1:1000 (fig 7c). Cells (2021) ncbi
domestic rabbit monoclonal (C36C11)
  • western blot; mouse; 1:1000; loading ...; fig 7c
Cell Signaling Technology MKK4 antibody (Cell Signaling Technology, 4514) was used in western blot on mouse samples at 1:1000 (fig 7c). Cells (2021) ncbi
domestic rabbit monoclonal (C36C11)
  • flow cytometry; mouse
Cell Signaling Technology MKK4 antibody (Cell Signaling Technology, 4514) was used in flow cytometry on mouse samples . Cancer Cell (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:250; loading ...; fig 1a
  • western blot; mouse; 1:250; loading ...; fig 2b, 3b
Cell Signaling Technology MKK4 antibody (CST, 9156) was used in western blot on human samples at 1:250 (fig 1a) and in western blot on mouse samples at 1:250 (fig 2b, 3b). Pain (2021) ncbi
domestic rabbit monoclonal (C36C11)
  • western blot; mouse; loading ...; fig 1
Cell Signaling Technology MKK4 antibody (Cell Signaling Technologies, 4514S) was used in western blot on mouse samples (fig 1). Cell Rep (2021) ncbi
domestic rabbit monoclonal (5c10)
  • western blot; mouse; loading ...; fig 1
Cell Signaling Technology MKK4 antibody (Cell Signaling Technologies, 3346S) was used in western blot on mouse samples (fig 1). Cell Rep (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 4g
Cell Signaling Technology MKK4 antibody (Cell Signaling, 9152) was used in western blot on mouse samples (fig 4g). Sci Adv (2020) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 4g
Cell Signaling Technology MKK4 antibody (Cell Signaling, 9156) was used in western blot on mouse samples (fig 4g). Sci Adv (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 4d
Cell Signaling Technology MKK4 antibody (Cell Signaling, 9156) was used in western blot on human samples (fig 4d). BMC Cancer (2019) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 4d
Cell Signaling Technology MKK4 antibody (Cell Signaling, 9152) was used in western blot on human samples (fig 4d). BMC Cancer (2019) ncbi
domestic rabbit monoclonal (C36C11)
  • western blot; mouse; loading ...; fig 6c
Cell Signaling Technology MKK4 antibody (Cell Signaling Technology, 4514) was used in western blot on mouse samples (fig 6c). Hepatology (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 6c
Cell Signaling Technology MKK4 antibody (Cell Signaling Technology, 9152) was used in western blot on mouse samples (fig 6c). Hepatology (2019) ncbi
domestic rabbit monoclonal (C36C11)
  • western blot; human; fig 4f
Cell Signaling Technology MKK4 antibody (Cell Signaling Technology, 4514) was used in western blot on human samples (fig 4f). FASEB J (2019) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 4f
Cell Signaling Technology MKK4 antibody (Cell Signaling Technology, 9152) was used in western blot on human samples (fig 4f). FASEB J (2019) ncbi
domestic rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig 5a
Cell Signaling Technology MKK4 antibody (Cell Signaling, 9152) was used in western blot knockout validation on human samples (fig 5a). Cell Res (2018) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig s5e
Cell Signaling Technology MKK4 antibody (Cell Signaling, 9152) was used in western blot on mouse samples (fig s5e). Nature (2017) ncbi
domestic rabbit monoclonal (C36C11)
  • western blot; mouse; loading ...; fig s5e
Cell Signaling Technology MKK4 antibody (Cell Signaling, 4514) was used in western blot on mouse samples (fig s5e). Nature (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 5a
Cell Signaling Technology MKK4 antibody (CST, 9156) was used in western blot on mouse samples (fig 5a). PLoS ONE (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 2-s1
Cell Signaling Technology MKK4 antibody (Cell Signaling, 9156S) was used in western blot on mouse samples at 1:1000 (fig 2-s1). elife (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 6-s1c
Cell Signaling Technology MKK4 antibody (Cell Signaling, 9152) was used in western blot on mouse samples at 1:1000 (fig 6-s1c). elife (2017) ncbi
domestic rabbit monoclonal (C36C11)
  • western blot; human; 1:1000; loading ...; fig 6b
Cell Signaling Technology MKK4 antibody (Cell signaling, 4514) was used in western blot on human samples at 1:1000 (fig 6b). Oncotarget (2016) ncbi
domestic rabbit monoclonal (5c10)
  • western blot; human; 1:1000; loading ...; fig 6b
Cell Signaling Technology MKK4 antibody (Cell signaling, 3346) was used in western blot on human samples at 1:1000 (fig 6b). Oncotarget (2016) ncbi
domestic rabbit monoclonal (C36C11)
  • western blot; human; loading ...; fig 3e
Cell Signaling Technology MKK4 antibody (Cell Signalling, 4514) was used in western blot on human samples (fig 3e). Oncogene (2017) ncbi
domestic rabbit polyclonal
  • western blot; pigs ; loading ...; fig 1b
In order to demonstrate that injury results in TAK1 activation by phosphorylation and K63-linked polyubiquitination, Cell Signaling Technology MKK4 antibody (Cell Signaling, 9151S) was used in western blot on pigs samples (fig 1b). Arthritis Rheumatol (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:200; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology MKK4 antibody (Cell Signaling, 9156) was used in western blot on human samples at 1:200 (fig st1). Nat Commun (2016) ncbi
domestic rabbit monoclonal (C36C11)
  • western blot; mouse
Cell Signaling Technology MKK4 antibody (Cell Signaling Technology, 4514) was used in western blot on mouse samples . J Biol Chem (2014) ncbi
Articles Reviewed
  1. Zhu W, Hibbert J, Lin K, Steinert N, Lemens J, Jorgenson K, et al. Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise. Cells. 2021;10: pubmed publisher
  2. Hutton C, Heider F, Blanco Gómez A, Banyard A, Kononov A, Zhang X, et al. Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity. Cancer Cell. 2021;: pubmed publisher
  3. Ma J, Goodwani S, Acton P, Buggia Prevot V, Kesler S, Jamal I, et al. Inhibition of dual leucine zipper kinase prevents chemotherapy-induced peripheral neuropathy and cognitive impairments. Pain. 2021;162:2599-2612 pubmed publisher
  4. Steinert N, Potts G, Wilson G, Klamen A, Lin K, Hermanson J, et al. Mapping of the contraction-induced phosphoproteome identifies TRIM28 as a significant regulator of skeletal muscle size and function. Cell Rep. 2021;34:108796 pubmed publisher
  5. Fu Y, Ding Y, Wang Q, Zhu F, Tan Y, Lu X, et al. Blood-stage malaria parasites manipulate host innate immune responses through the induction of sFGL2. Sci Adv. 2020;6:eaay9269 pubmed publisher
  6. Tang Y, Xu A, Shao S, Zhou Y, Xiong B, Li Z. Electroacupuncture Ameliorates Cognitive Impairment by Inhibiting the JNK Signaling Pathway in a Mouse Model of Alzheimer's Disease. Front Aging Neurosci. 2020;12:23 pubmed publisher
  7. Wu X, Chen S, Lu C. Amyloid precursor protein promotes the migration and invasion of breast cancer cells by regulating the MAPK signaling pathway. Int J Mol Med. 2019;: pubmed publisher
  8. Li Z, Mbah N, Overmeyer J, Sarver J, George S, Trabbic C, et al. The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma. BMC Cancer. 2019;19:77 pubmed publisher
  9. Ye P, Liu J, Xu W, Liu D, Ding X, Le S, et al. Dual-Specificity Phosphatase 26 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through Transforming Growth Factor Beta-Activated Kinase 1 Suppression. Hepatology. 2019;69:1946-1964 pubmed publisher
  10. Xiao N, Li H, Yu W, Gu C, Fang H, Peng Y, et al. SUMO-specific protease 2 (SENP2) suppresses keratinocyte migration by targeting NDR1 for de-SUMOylation. FASEB J. 2019;33:163-174 pubmed publisher
  11. Lam J, van den Bosch M, Wegrzyn J, Parker J, Ibrahim R, Slowski K, et al. miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling. Nat Commun. 2018;9:2418 pubmed publisher
  12. Xue Z, Vis D, Bruna A, Sustic T, van Wageningen S, Batra A, et al. MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models. Cell Res. 2018;28:719-729 pubmed publisher
  13. Pinto S, Lamon S, Stephenson E, Kalanon M, Mikovic J, Koch L, et al. Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity. Am J Physiol Endocrinol Metab. 2017;313:E335-E343 pubmed publisher
  14. Genovese G, Carugo A, TEPPER J, Robinson F, Li L, Svelto M, et al. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature. 2017;542:362-366 pubmed publisher
  15. Tormos A, Rius Pérez S, Jorques M, Rada P, Ramírez L, Valverde A, et al. p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging. PLoS ONE. 2017;12:e0171738 pubmed publisher
  16. Walker L, Summers D, Sasaki Y, Brace E, Milbrandt J, DiAntonio A. MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2. elife. 2017;6: pubmed publisher
  17. Farsam V, Basu A, Gatzka M, Treiber N, Schneider L, Mulaw M, et al. Senescent fibroblast-derived Chemerin promotes squamous cell carcinoma migration. Oncotarget. 2016;7:83554-83569 pubmed publisher
  18. Dunnill C, Ibraheem K, Mohamed A, Southgate J, Georgopoulos N. A redox state-dictated signalling pathway deciphers the malignant cell specificity of CD40-mediated apoptosis. Oncogene. 2017;36:2515-2528 pubmed publisher
  19. Ismail H, Didangelos A, Vincent T, Saklatvala J. Rapid Activation of Transforming Growth Factor ?-Activated Kinase 1 in Chondrocytes by Phosphorylation and K63 -Linked Polyubiquitination Upon Injury to Animal Articular Cartilage. Arthritis Rheumatol. 2017;69:565-575 pubmed publisher
  20. Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  21. Shchetynsky K, Protsyuk D, Ronninger M, Diaz Gallo L, Klareskog L, Padyukov L. Gene-gene interaction and RNA splicing profiles of MAP2K4 gene in rheumatoid arthritis. Clin Immunol. 2015;158:19-28 pubmed publisher
  22. Resch U, Cuapio A, Sturtzel C, Hofer E, de Martin R, Holper Schichl Y. Polyubiquitinated tristetraprolin protects from TNF-induced, caspase-mediated apoptosis. J Biol Chem. 2014;289:25088-100 pubmed publisher