This is a Validated Antibody Database (VAD) review about human MFN1, based on 30 published articles (read how Labome selects the articles), using MFN1 antibody in all methods. It is aimed to help Labome visitors find the most suited MFN1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
MFN1 synonym: hfzo1; hfzo2

Abcam
mouse monoclonal
  • western blot; mouse; loading ...; fig 5a
Abcam MFN1 antibody (Abcam, ab57602) was used in western blot on mouse samples (fig 5a). EMBO J (2021) ncbi
mouse monoclonal
  • western blot; mouse; 1:20,000; loading ...; fig 5a
Abcam MFN1 antibody (Abcam, ab57602) was used in western blot on mouse samples at 1:20,000 (fig 5a). Cell Death Dis (2020) ncbi
mouse monoclonal
  • western blot; mouse; loading ...; fig 3g
Abcam MFN1 antibody (Abcam, Ab57602) was used in western blot on mouse samples (fig 3g). Sci Adv (2019) ncbi
mouse monoclonal
  • western blot; mouse; 1:1000; loading ...; fig s12a
Abcam MFN1 antibody (Abcam, ab57602) was used in western blot on mouse samples at 1:1000 (fig s12a). Nat Neurosci (2019) ncbi
mouse monoclonal
  • western blot; mouse; 1:1000; loading ...; fig 5e
Abcam MFN1 antibody (Abcam, ab57602) was used in western blot on mouse samples at 1:1000 (fig 5e). Redox Biol (2019) ncbi
mouse monoclonal
  • western blot; human; 1:1000; loading ...; fig 8f
Abcam MFN1 antibody (Abcam, ab57602) was used in western blot on human samples at 1:1000 (fig 8f). J Biol Chem (2018) ncbi
mouse monoclonal
  • western blot; rat; 1:1000; loading ...; fig 5a
Abcam MFN1 antibody (Abcam, ab57602) was used in western blot on rat samples at 1:1000 (fig 5a). PLoS ONE (2017) ncbi
mouse monoclonal
  • western blot; human; loading ...; fig 3h
In order to find that a subset of SLC25A46 interacts with mitochondrial dynamics components and the MICOS complex, Abcam MFN1 antibody (Abcam, ab57602) was used in western blot on human samples (fig 3h). Mol Biol Cell (2017) ncbi
mouse monoclonal
  • western blot; human; loading ...; fig 2b
In order to demonstrate that miR-181a inhibits mitophagy, Abcam MFN1 antibody (Abcam, ab57602) was used in western blot on human samples (fig 2b). Oncotarget (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (D-10)
  • western blot; mouse; loading ...; fig 1e
Santa Cruz Biotechnology MFN1 antibody (Santa Cruz Biotechnology, sc-166644) was used in western blot on mouse samples (fig 1e). Cells (2021) ncbi
mouse monoclonal (D-10)
  • western blot; human; loading ...; fig 3d
Santa Cruz Biotechnology MFN1 antibody (Santa Cruz, D-10) was used in western blot on human samples (fig 3d). J Clin Med (2019) ncbi
mouse monoclonal
  • western blot; human; loading ...; fig 3d
Santa Cruz Biotechnology MFN1 antibody (Santa Cruz, D-10) was used in western blot on human samples (fig 3d). J Clin Med (2019) ncbi
mouse monoclonal (D-10)
  • western blot; human; loading ...; fig 4a, 8a
Santa Cruz Biotechnology MFN1 antibody (Santa Cruz, sc-166644) was used in western blot on human samples (fig 4a, 8a). Nucleic Acids Res (2019) ncbi
mouse monoclonal (D-10)
  • western blot; mouse; 1:200; loading ...; fig s2a
In order to test if heme oxygenase-1 mediates cardiac protection by altering mitochondrial quality control, Santa Cruz Biotechnology MFN1 antibody (SantaCruz, sc-166644) was used in western blot on mouse samples at 1:200 (fig s2a). JCI Insight (2016) ncbi
mouse monoclonal (D-10)
  • western blot; human; fig 4
Santa Cruz Biotechnology MFN1 antibody (santa Cruz, sc-166644) was used in western blot on human samples (fig 4). Oncotarget (2015) ncbi
mouse monoclonal (D-10)
  • western blot; human
Santa Cruz Biotechnology MFN1 antibody (Santa Cruz Biotechnology, SC-166644) was used in western blot on human samples . PLoS ONE (2014) ncbi
Abnova
mouse monoclonal (3C9)
  • western blot; human; 1:2000
Abnova MFN1 antibody (Abnova, H00055669-M04) was used in western blot on human samples at 1:2000. Nat Commun (2021) ncbi
mouse monoclonal (3C9)
  • western blot; mouse; 1:2000; loading ...; fig s2g
Abnova MFN1 antibody (Abnova, H00055669-M04) was used in western blot on mouse samples at 1:2000 (fig s2g). Sci Adv (2020) ncbi
mouse monoclonal (3C9)
  • western blot; human; fig 4
Abnova MFN1 antibody (Abnova, 3C9) was used in western blot on human samples (fig 4). Hum Mol Genet (2017) ncbi
mouse monoclonal (3C9)
  • western blot; mouse; 1:1000; fig 1a
Abnova MFN1 antibody (Abnova, H00055669-M04) was used in western blot on mouse samples at 1:1000 (fig 1a). Biochim Biophys Acta Mol Basis Dis (2017) ncbi
mouse monoclonal (3C9)
  • western blot; mouse; fig 3
Abnova MFN1 antibody (Abnova, H00055669-M04) was used in western blot on mouse samples (fig 3). Autophagy (2014) ncbi
Novus Biologicals
domestic rabbit polyclonal
  • western blot; human; 1:500; loading ...; fig 6f
  • western blot; mouse; 1:500; loading ...; fig 5c
Novus Biologicals MFN1 antibody (Novus, NBP1-51841) was used in western blot on human samples at 1:500 (fig 6f) and in western blot on mouse samples at 1:500 (fig 5c). JCI Insight (2021) ncbi
mouse monoclonal (11E9-1H12)
  • western blot; mouse; 1:500; loading ...; fig 7b
Novus Biologicals MFN1 antibody (Novus, NBP1-71775) was used in western blot on mouse samples at 1:500 (fig 7b). Cell Death Dis (2020) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 3b
Novus Biologicals MFN1 antibody (Novus Biologicals, NBP1-51841) was used in western blot on mouse samples (fig 3b). Physiol Rep (2017) ncbi
BioLegend
mouse monoclonal (1G3.B6)
  • western blot; rat; fig 3d
BioLegend MFN1 antibody (Biolegend, MMS-5021) was used in western blot on rat samples (fig 3d). J Cachexia Sarcopenia Muscle (2020) ncbi
Invitrogen
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 3b
Invitrogen MFN1 antibody (Thermo FisherScientific, PA5-67905) was used in western blot on mouse samples at 1:1000 (fig 3b). FASEB J (2019) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D6E2S)
  • western blot; human; fig 2c
Cell Signaling Technology MFN1 antibody (Cell Signaling, 14739S) was used in western blot on human samples (fig 2c). Hum Mol Genet (2018) ncbi
domestic rabbit monoclonal (D6E2S)
  • western blot; human; 1:1000; loading ...; fig s7e
In order to investigate how LACTB suppresses breast cancer cell growth, Cell Signaling Technology MFN1 antibody (Cell Signaling, 14739) was used in western blot on human samples at 1:1000 (fig s7e). Nature (2017) ncbi
domestic rabbit monoclonal (D6E2S)
  • western blot; human; 1:1000; loading ...; fig 3d
Cell Signaling Technology MFN1 antibody (Cell Signaling, D6E2S) was used in western blot on human samples at 1:1000 (fig 3d). Nat Commun (2016) ncbi
domestic rabbit monoclonal (D6E2S)
  • western blot; human; loading ...; fig 4a
Cell Signaling Technology MFN1 antibody (CST, D6E2S) was used in western blot on human samples (fig 4a). Virology (2017) ncbi
domestic rabbit monoclonal (D6E2S)
  • western blot; human; loading ...; fig 2c
Cell Signaling Technology MFN1 antibody (Cell Signaling, 14739) was used in western blot on human samples (fig 2c). DNA Cell Biol (2016) ncbi
Articles Reviewed
  1. Hu D, Sun X, Magpusao A, Fedorov Y, Thompson M, Wang B, et al. Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease. Nat Commun. 2021;12:5305 pubmed publisher
  2. Yoon Y, Go G, Yoon S, Lim J, Lee G, Lee J, et al. Melatonin Treatment Improves Renal Fibrosis via miR-4516/SIAH3/PINK1 Axis. Cells. 2021;10: pubmed publisher
  3. López Doménech G, Howden J, Covill Cooke C, Morfill C, Patel J, Bürli R, et al. Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response. EMBO J. 2021;40:e100715 pubmed publisher
  4. Xu L, Humphries F, Delagic N, Wang B, Holland A, Edgar K, et al. ECSIT is a critical limiting factor for cardiac function. JCI Insight. 2021;6: pubmed publisher
  5. Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, et al. Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease. Sci Adv. 2020;6: pubmed publisher
  6. Edwards G, Perkins G, Kim K, Kong Y, Lee Y, Choi S, et al. Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells. Cell Death Dis. 2020;11:254 pubmed publisher
  7. Shah D, Nisr R, Stretton C, Krasteva Christ G, Hundal H. Caveolin-3 deficiency associated with the dystrophy P104L mutation impairs skeletal muscle mitochondrial form and function. J Cachexia Sarcopenia Muscle. 2020;11:838-858 pubmed publisher
  8. Li T, Li K, Zhang S, Wang Y, Xu Y, Cronin S, et al. Overexpression of apoptosis inducing factor aggravates hypoxic-ischemic brain injury in neonatal mice. Cell Death Dis. 2020;11:77 pubmed publisher
  9. Ghosh A, Bhattacharjee S, Chowdhuri S, Mallick A, Rehman I, Basu S, et al. SCAN1-TDP1 trapping on mitochondrial DNA promotes mitochondrial dysfunction and mitophagy. Sci Adv. 2019;5:eaax9778 pubmed publisher
  10. Shin H, Park H, Shin N, Kwon H, Yin Y, Hwang J, et al. Pink1-Mediated Chondrocytic Mitophagy Contributes to Cartilage Degeneration in Osteoarthritis. J Clin Med. 2019;8: pubmed publisher
  11. Zheng J, Croteau D, Bohr V, Akbari M. Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells. Nucleic Acids Res. 2019;: pubmed publisher
  12. Shen M, Wang F, Li M, Sah N, Stockton M, Tidei J, et al. Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice. Nat Neurosci. 2019;22:386-400 pubmed publisher
  13. Ruegsegger G, Manjunatha S, Summer P, Gopala S, Zabeilski P, Dasari S, et al. Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes. FASEB J. 2019;33:4458-4472 pubmed publisher
  14. Li H, Feng J, Zhang Y, Feng J, Wang Q, Zhao S, et al. Mst1 deletion attenuates renal ischaemia-reperfusion injury: The role of microtubule cytoskeleton dynamics, mitochondrial fission and the GSK3β-p53 signalling pathway. Redox Biol. 2019;20:261-274 pubmed publisher
  15. De R, Sarkar S, Mazumder S, Debsharma S, Siddiqui A, Saha S, et al. Macrophage migration inhibitory factor regulates mitochondrial dynamics and cell growth of human cancer cell lines through CD74-NF-κB signaling. J Biol Chem. 2018;293:19740-19760 pubmed publisher
  16. Straub I, Janer A, Weraarpachai W, Zinman L, Robertson J, Rogaeva E, et al. Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS. Hum Mol Genet. 2018;27:178-189 pubmed publisher
  17. Parajuli N, Shrum S, Tobacyk J, Harb A, Arthur J, Macmillan Crow L. Renal cold storage followed by transplantation impairs expression of key mitochondrial fission and fusion proteins. PLoS ONE. 2017;12:e0185542 pubmed publisher
  18. Shiba Fukushima K, Ishikawa K, Inoshita T, Izawa N, Takanashi M, Sato S, et al. Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's disease. Hum Mol Genet. 2017;26:3172-3185 pubmed publisher
  19. Keckesova Z, Donaher J, De Cock J, Freinkman E, Lingrell S, Bachovchin D, et al. LACTB is a tumour suppressor that modulates lipid metabolism and cell state. Nature. 2017;543:681-686 pubmed publisher
  20. Chung E, Joiner H, Skelton T, Looten K, Manczak M, Reddy P. Maternal exercise upregulates mitochondrial gene expression and increases enzyme activity of fetal mouse hearts. Physiol Rep. 2017;5: pubmed publisher
  21. Steffen J, Vashisht A, Wan J, Jen J, Claypool S, Wohlschlegel J, et al. Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria. Mol Biol Cell. 2017;28:600-612 pubmed publisher
  22. Caino M, Seo J, Aguinaldo A, Wait E, Bryant K, Kossenkov A, et al. A neuronal network of mitochondrial dynamics regulates metastasis. Nat Commun. 2016;7:13730 pubmed publisher
  23. Guo X, Qi X. VCP cooperates with UBXD1 to degrade mitochondrial outer membrane protein MCL1 in model of Huntington's disease. Biochim Biophys Acta Mol Basis Dis. 2017;1863:552-559 pubmed publisher
  24. Barbier V, Lang D, Valois S, Rothman A, Medin C. Dengue virus induces mitochondrial elongation through impairment of Drp1-triggered mitochondrial fission. Virology. 2017;500:149-160 pubmed publisher
  25. Li H, Wang R, Jiang H, Zhang E, Tan J, Xu H, et al. Mitochondrial Ribosomal Protein L10 Associates with Cyclin B1/Cdk1 Activity and Mitochondrial Function. DNA Cell Biol. 2016;35:680-690 pubmed
  26. Cheng M, Liu L, Lao Y, Liao W, Liao M, Luo X, et al. MicroRNA-181a suppresses parkin-mediated mitophagy and sensitizes neuroblastoma cells to mitochondrial uncoupler-induced apoptosis. Oncotarget. 2016;7:42274-42287 pubmed publisher
  27. Hull T, Boddu R, Guo L, Tisher C, Traylor A, Patel B, et al. Heme oxygenase-1 regulates mitochondrial quality control in the heart. JCI Insight. 2016;1:e85817 pubmed
  28. Suzuki Karasaki Y, Fujiwara K, Saito K, Suzuki Karasaki M, Ochiai T, Soma M. Distinct effects of TRAIL on the mitochondrial network in human cancer cells and normal cells: role of plasma membrane depolarization. Oncotarget. 2015;6:21572-88 pubmed
  29. Zou J, Yue F, Li W, Song K, Jiang X, Yi J, et al. Autophagy inhibitor LRPPRC suppresses mitophagy through interaction with mitophagy initiator Parkin. PLoS ONE. 2014;9:e94903 pubmed publisher
  30. Furuya N, Ikeda S, Sato S, Soma S, Ezaki J, Oliva Trejo J, et al. PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation. Autophagy. 2014;10:631-41 pubmed publisher