This is a Validated Antibody Database (VAD) review about human MERTK, based on 14 published articles (read how Labome selects the articles), using MERTK antibody in all methods. It is aimed to help Labome visitors find the most suited MERTK antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
MERTK synonym: MER; RP38; Tyro12; c-Eyk; c-mer; tyrosine-protein kinase Mer; MER receptor tyrosine kinase; STK kinase; c-mer proto-oncogene tyrosine kinase; proto-oncogene c-Mer; receptor tyrosine kinase MerTK

Abcam
rabbit polyclonal
  • western blot; mouse; loading ...; fig 4d
In order to engineer and characterize a second-generation, high-affinity AXL decoy receptor, Abcam MERTK antibody (Abcam, ab14921) was used in western blot on mouse samples (fig 4d). J Clin Invest (2017) ncbi
rabbit monoclonal (Y323)
  • western blot; mouse; loading ...; fig 4d
In order to engineer and characterize a second-generation, high-affinity AXL decoy receptor, Abcam MERTK antibody (Abcam, ab52968) was used in western blot on mouse samples (fig 4d). J Clin Invest (2017) ncbi
rabbit monoclonal (Y323)
  • immunocytochemistry; human; 1:50; loading ...; fig s1a
In order to optimize retinal pigment epithelium yield after differentiation, Abcam MERTK antibody (Abcam, ab52968) was used in immunocytochemistry on human samples at 1:50 (fig s1a). Stem Cells Transl Med (2016) ncbi
rabbit monoclonal (Y323)
  • immunohistochemistry - paraffin section; human; 1:300; fig 4
In order to elucidate a screening that identifies kinases involved in prostate cancer visceral and bone metastasis, Abcam MERTK antibody (Abcam, ab52968) was used in immunohistochemistry - paraffin section on human samples at 1:300 (fig 4). Proc Natl Acad Sci U S A (2016) ncbi
rabbit monoclonal (Y323)
  • western blot; human; fig s1
Abcam MERTK antibody (Abcam, ab52968) was used in western blot on human samples (fig s1). PLoS ONE (2015) ncbi
rabbit monoclonal (Y323)
  • western blot; human
Abcam MERTK antibody (Abcam, ab52968) was used in western blot on human samples . Oncotarget (2014) ncbi
R&D Systems
goat polyclonal
  • blocking or activating experiments; human; loading ...; fig 2d
R&D Systems MERTK antibody (R&D, AF891) was used in blocking or activating experiments on human samples (fig 2d). Eur J Immunol (2018) ncbi
mouse monoclonal (125518)
  • flow cytometry; human; loading ...; fig 1e
R&D Systems MERTK antibody (R&D Systems, 125518) was used in flow cytometry on human samples (fig 1e). J Exp Med (2018) ncbi
mouse monoclonal (125518)
  • flow cytometry; human; fig 2a
R&D Systems MERTK antibody (R&D Systems, 125518) was used in flow cytometry on human samples (fig 2a). Front Immunol (2017) ncbi
Santa Cruz Biotechnology
mouse monoclonal (B-1)
  • western blot; human; 1:2000; loading ...; fig 7d
Santa Cruz Biotechnology MERTK antibody (Santa Cruz Biotechnology, sc-365499) was used in western blot on human samples at 1:2000 (fig 7d). elife (2019) ncbi
mouse monoclonal (B-1)
  • western blot; human; 1:1000; loading ...; fig 6b
In order to identify conditions in which low-passage ARPE-19 cells express genes specific to native human RPE cells, Santa Cruz Biotechnology MERTK antibody (Santa Cruz, SC-365499) was used in western blot on human samples at 1:1000 (fig 6b). Mol Vis (2017) ncbi
Cell Signaling Technology
rabbit monoclonal (D21F11)
  • western blot; human; loading ...; fig 1b
Cell Signaling Technology MERTK antibody (Cell Signaling, D21F11) was used in western blot on human samples (fig 1b). Eur J Immunol (2018) ncbi
rabbit monoclonal (D21F11)
  • western blot; human; loading ...; fig 1a
Cell Signaling Technology MERTK antibody (Cell Signaling, 4319) was used in western blot on human samples (fig 1a). Mol Oncol (2017) ncbi
rabbit monoclonal (D21F11)
  • western blot; human; loading ...; fig 2a
Cell Signaling Technology MERTK antibody (Cell Signaling, 4319) was used in western blot on human samples (fig 2a). Oncotarget (2016) ncbi
rabbit monoclonal (D21F11)
  • western blot; human; 1:1000; fig 4
Cell Signaling Technology MERTK antibody (Cell Signalng, 4319) was used in western blot on human samples at 1:1000 (fig 4). Oncotarget (2016) ncbi
Sigma-Aldrich
rabbit polyclonal
  • immunohistochemistry; human; loading ...; fig 1a
Sigma-Aldrich MERTK antibody (Sigma-Aldrich, HPA036196) was used in immunohistochemistry on human samples (fig 1a). Oncotarget (2016) ncbi
mouse monoclonal (2D2)
  • other; human; loading ...; fig st1
In order to use size exclusion chromatography-microsphere-based affinity proteomics to study clinical samples obtained from pediatric acute leukemia patients, Sigma-Aldrich MERTK antibody (SIGMA, 2D2) was used in other on human samples (fig st1). Mol Cell Proteomics (2016) ncbi
Articles Reviewed
  1. Xu H, Xu S, Xie S, Zhang Y, Yang J, Zhang W, et al. MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway. elife. 2019;8: pubmed publisher
  2. Grabiec A, Goenka A, Fife M, Fujimori T, Hussell T. Axl and MerTK receptor tyrosine kinases maintain human macrophage efferocytic capacity in the presence of viral triggers. Eur J Immunol. 2018;48:855-860 pubmed publisher
  3. Bujko A, Atlasy N, Landsverk O, Richter L, Yaqub S, Horneland R, et al. Transcriptional and functional profiling defines human small intestinal macrophage subsets. J Exp Med. 2018;215:441-458 pubmed publisher
  4. Jeong J, Hong S, Kwon O, Ghang B, Hwang I, Kim Y, et al. CD14+ Cells with the Phenotype of Infiltrated Monocytes Consist of Distinct Populations Characterized by Anti-inflammatory as well as Pro-inflammatory Activity in Gouty Arthritis. Front Immunol. 2017;8:1260 pubmed publisher
  5. Baumann C, Ullrich A, Torka R. GAS6-expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance. Mol Oncol. 2017;11:1430-1447 pubmed publisher
  6. Samuel W, Jaworski C, Postnikova O, Kutty R, Duncan T, Tan L, et al. Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells. Mol Vis. 2017;23:60-89 pubmed
  7. Kariolis M, Miao Y, Diep A, Nash S, Olcina M, Jiang D, et al. Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. J Clin Invest. 2017;127:183-198 pubmed publisher
  8. Choudhary P, Gutteridge A, Impey E, Storer R, Owen R, Whiting P, et al. Targeting the cAMP and Transforming Growth Factor-? Pathway Increases Proliferation to Promote Re-Epithelialization of Human Stem Cell-Derived Retinal Pigment Epithelium. Stem Cells Transl Med. 2016;5:925-37 pubmed publisher
  9. von Mässenhausen A, SANDERS C, Thewes B, Deng M, Queisser A, Vogel W, et al. MERTK as a novel therapeutic target in head and neck cancer. Oncotarget. 2016;7:32678-94 pubmed publisher
  10. Jung Y, Decker A, Wang J, Lee E, Kana L, Yumoto K, et al. Endogenous GAS6 and Mer receptor signaling regulate prostate cancer stem cells in bone marrow. Oncotarget. 2016;7:25698-711 pubmed publisher
  11. Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  12. Faltermeier C, Drake J, Clark P, Smith B, Zong Y, Volpe C, et al. Functional screen identifies kinases driving prostate cancer visceral and bone metastasis. Proc Natl Acad Sci U S A. 2016;113:E172-81 pubmed publisher
  13. Roggia M, Ueta T. αvβ5 Integrin/FAK/PGC-1α Pathway Confers Protective Effects on Retinal Pigment Epithelium. PLoS ONE. 2015;10:e0134870 pubmed publisher
  14. Knubel K, Pernu B, Sufit A, Nelson S, Pierce A, Keating A. MerTK inhibition is a novel therapeutic approach for glioblastoma multiforme. Oncotarget. 2014;5:1338-51 pubmed