This is a Validated Antibody Database (VAD) review about human MEKK3, based on 3 published articles (read how Labome selects the articles), using MEKK3 antibody in all methods. It is aimed to help Labome visitors find the most suited MEKK3 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
MEKK3 synonym: MAPKKK3; MEKK3; mitogen-activated protein kinase kinase kinase 3; MAP/ERK kinase kinase 3; MAPK/ERK kinase kinase 3; MEK kinase 3; MEKK 3

Knockout validation
R&D Systems
mouse monoclonal (576240)
  • western blot knockout validation; mouse; 1:1000; fig 1
  • immunocytochemistry; mouse; 1:200; fig s3
R&D Systems MEKK3 antibody (R&D, MAB6095) was used in western blot knockout validation on mouse samples at 1:1000 (fig 1) and in immunocytochemistry on mouse samples at 1:200 (fig s3). Nat Commun (2015) ncbi
Proteintech Group
rabbit polyclonal
  • immunohistochemistry; mouse; loading ...; fig 3b
Proteintech Group MEKK3 antibody (Proteintech, 21072-1-AP) was used in immunohistochemistry on mouse samples (fig 3b). Oncogene (2018) ncbi
R&D Systems
mouse monoclonal (576240)
  • western blot knockout validation; mouse; 1:1000; fig 1
  • immunocytochemistry; mouse; 1:200; fig s3
R&D Systems MEKK3 antibody (R&D, MAB6095) was used in western blot knockout validation on mouse samples at 1:1000 (fig 1) and in immunocytochemistry on mouse samples at 1:200 (fig s3). Nat Commun (2015) ncbi
Cell Signaling Technology
rabbit monoclonal (D36G5)
  • western blot; mouse; fig 8a
Cell Signaling Technology MEKK3 antibody (Cell Signaling, 5727) was used in western blot on mouse samples (fig 8a). EMBO Mol Med (2016) ncbi
Articles Reviewed
  1. Lu J, Liu L, Zheng M, Li X, Wu A, Wu Q, et al. MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function. Oncogene. 2018;37:3864-3878 pubmed publisher
  2. Cuttano R, Rudini N, Bravi L, Corada M, Giampietro C, Papa E, et al. KLF4 is a key determinant in the development and progression of cerebral cavernous malformations. EMBO Mol Med. 2016;8:6-24 pubmed publisher
  3. Fisher O, Deng H, Liu D, Zhang Y, Wei R, Deng Y, et al. Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex. Nat Commun. 2015;6:7937 pubmed publisher