This is a Validated Antibody Database (VAD) review about human MEK5, based on 7 published articles (read how Labome selects the articles), using MEK5 antibody in all methods. It is aimed to help Labome visitors find the most suited MEK5 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
MEK5 synonym: HsT17454; MAPKK5; MEK5; PRKMK5; dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPKK 5; MEK 5

Santa Cruz Biotechnology
mouse monoclonal (21)
  • western blot; human; 1:500; loading ...; fig 4b
Santa Cruz Biotechnology MEK5 antibody (SantaCruz, sc-135986) was used in western blot on human samples at 1:500 (fig 4b). Oncol Lett (2017) ncbi
mouse monoclonal (21)
  • western blot; human; fig 2 a',' b
In order to assess the contribution of MEK5/ERK5 signaling in the sensitivity of colon cancer cells to 5-fluorouracil, Santa Cruz Biotechnology MEK5 antibody (Santa Cruz Biotechnology, sc-135986) was used in western blot on human samples (fig 2 a',' b). Oncotarget (2016) ncbi
mouse monoclonal (21)
  • western blot; human; fig 1
Santa Cruz Biotechnology MEK5 antibody (Santa Cruz, sc-135986) was used in western blot on human samples (fig 1). Cell Death Dis (2015) ncbi
Invitrogen
rabbit polyclonal
  • immunocytochemistry; rat; loading ...; fig 2d
  • western blot; rat; loading ...; fig 2b
In order to assess characteristics of the astrocytic acute response to methamphetamine, Invitrogen MEK5 antibody (Thermo Fisher, PA5-29236) was used in immunocytochemistry on rat samples (fig 2d) and in western blot on rat samples (fig 2b). J Neuroinflammation (2017) ncbi
BD Biosciences
mouse monoclonal (21/MEK5)
  • western blot; mouse; fig 8b
BD Biosciences MEK5 antibody (BD biosciences, 610957) was used in western blot on mouse samples (fig 8b). EMBO Mol Med (2016) ncbi
mouse monoclonal (21/MEK5)
  • western blot; human; fig 1
BD Biosciences MEK5 antibody (BD Biosciences, 610956) was used in western blot on human samples (fig 1). EMBO J (2014) ncbi
EMD Millipore
rabbit polyclonal
  • western blot; human; fig 2
EMD Millipore MEK5 antibody (Chemicon, AB3184) was used in western blot on human samples (fig 2). Cardiovasc Res (2015) ncbi
Articles Reviewed
  1. Yang W, Wang X, Yuan H, Liu Z, Gao S, Peng L. Exploring the mechanism of WWOX growth inhibitory effects on oral squamous cell carcinoma. Oncol Lett. 2017;13:3198-3204 pubmed publisher
  2. Bortell N, Basova L, Semenova S, Fox H, Ravasi T, Marcondes M. Astrocyte-specific overexpressed gene signatures in response to methamphetamine exposure in vitro. J Neuroinflammation. 2017;14:49 pubmed publisher
  3. Pereira D, Simões A, Gomes S, Castro R, Carvalho T, Rodrigues C, et al. MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism. Oncotarget. 2016;7:34322-40 pubmed publisher
  4. Cuttano R, Rudini N, Bravi L, Corada M, Giampietro C, Papa E, et al. KLF4 is a key determinant in the development and progression of cerebral cavernous malformations. EMBO Mol Med. 2016;8:6-24 pubmed publisher
  5. Simões A, Pereira D, Gomes S, Brito H, Carvalho T, French A, et al. Aberrant MEK5/ERK5 signalling contributes to human colon cancer progression via NF-κB activation. Cell Death Dis. 2015;6:e1718 pubmed publisher
  6. Komaravolu R, Adam C, Moonen J, Harmsen M, Goebeler M, Schmidt M. Erk5 inhibits endothelial migration via KLF2-dependent down-regulation of PAK1. Cardiovasc Res. 2015;105:86-95 pubmed publisher
  7. Takeda A, Oberoi Khanuja T, Glatz G, Schulenburg K, Scholz R, Carpy A, et al. Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1. EMBO J. 2014;33:1784-801 pubmed publisher