This is a Validated Antibody Database (VAD) review about human MEK2, based on 18 published articles (read how Labome selects the articles), using MEK2 antibody in all methods. It is aimed to help Labome visitors find the most suited MEK2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
MEK2 synonym: CFC4; MAPKK2; MEK2; MKK2; PRKMK2

Abcam
domestic rabbit monoclonal (EPR16667)
  • western blot; mouse; 1:1000; loading ...; fig 7a, 7e
Abcam MEK2 antibody (Abcam, ab178876) was used in western blot on mouse samples at 1:1000 (fig 7a, 7e). elife (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 5f
Abcam MEK2 antibody (Abcam, ab194754) was used in western blot on human samples at 1:1000 (fig 5f). Aging (Albany NY) (2021) ncbi
domestic rabbit monoclonal (EPR16667)
  • western blot; human; 1:5000; loading ...; fig 5f
Abcam MEK2 antibody (Abcam, ab178876) was used in western blot on human samples at 1:5000 (fig 5f). Aging (Albany NY) (2021) ncbi
domestic rabbit monoclonal (EPR16667)
  • other; human; 1:2500; loading ...; fig 2d, 3d, 4d, 5d, 6d, 7d
Abcam MEK2 antibody (Abcam, #ab178876) was used in other on human samples at 1:2500 (fig 2d, 3d, 4d, 5d, 6d, 7d). Sci Rep (2019) ncbi
domestic rabbit monoclonal (EPR16667)
  • western blot; human; loading ...; fig 4a
Abcam MEK2 antibody (Abcam, (ab178876) was used in western blot on human samples (fig 4a). BMC Cancer (2019) ncbi
domestic rabbit monoclonal (EPR16667)
  • western blot; human; loading ...; fig 5b
Abcam MEK2 antibody (Abcam, ab178876) was used in western blot on human samples (fig 5b). Eur Rev Med Pharmacol Sci (2019) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 5b
Abcam MEK2 antibody (Abcam, ab194754) was used in western blot on human samples (fig 5b). Eur Rev Med Pharmacol Sci (2019) ncbi
domestic rabbit monoclonal (EPR16667)
  • western blot; human; 1:1000; loading ...; fig 5c
Abcam MEK2 antibody (Abcam, ab178876) was used in western blot on human samples at 1:1000 (fig 5c). Sci Rep (2017) ncbi
domestic rabbit monoclonal (Y78)
  • western blot; human; fig 6
Abcam MEK2 antibody (Abcam, ab32517) was used in western blot on human samples (fig 6). Oncotarget (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 6
Abcam MEK2 antibody (Abcam, ab131095) was used in western blot on human samples (fig 6). Oncotarget (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (7E10)
  • western blot; human; loading ...; fig 3b
Santa Cruz Biotechnology MEK2 antibody (Santa Cruz, sc-81503) was used in western blot on human samples (fig 3b). Int J Oncol (2018) ncbi
mouse monoclonal (7E10)
  • western blot; human; loading ...; fig 6b
Santa Cruz Biotechnology MEK2 antibody (Santa Cruz Biotechnology, sc-81503) was used in western blot on human samples (fig 6b). BMC Cancer (2015) ncbi
mouse monoclonal (9G3)
  • western blot; human; loading ...; fig 6b
Santa Cruz Biotechnology MEK2 antibody (Santa Cruz Biotechnology, sc-81504) was used in western blot on human samples (fig 6b). BMC Cancer (2015) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (13E3)
  • flow cytometry; mouse; loading ...; fig s1a
Cell Signaling Technology MEK2 antibody (Cell Signaling, 13E3) was used in flow cytometry on mouse samples (fig s1a). Cell Stem Cell (2018) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 2c
In order to determine the role of p21-activated kinases in response to BRAF inhibitors, Cell Signaling Technology MEK2 antibody (Cell Signaling, 9125) was used in western blot on human samples (fig 2c). Mol Carcinog (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology MEK2 antibody (Cell Signaling, 9125) was used in western blot on human samples at 1:1000 (fig st1). Nat Commun (2016) ncbi
domestic rabbit monoclonal (13E3)
  • western blot; human; 1:1000; fig  6
Cell Signaling Technology MEK2 antibody (Cell Signalling Technology, 9147) was used in western blot on human samples at 1:1000 (fig  6). Cell Signal (2015) ncbi
BD Biosciences
mouse monoclonal (96/MEK2)
  • western blot; mouse; fig 1
BD Biosciences MEK2 antibody (BD Transduction Laboratories, 610236) was used in western blot on mouse samples (fig 1). Oncotarget (2016) ncbi
mouse monoclonal (96/MEK2)
  • western blot; mouse; fig 1
BD Biosciences MEK2 antibody (BD Transduction Laboratories, 610235) was used in western blot on mouse samples (fig 1). Nat Commun (2016) ncbi
mouse monoclonal (96/MEK2)
  • western blot; human; fig s2
BD Biosciences MEK2 antibody (BD Transduction Laboratories, 610235) was used in western blot on human samples (fig s2). Cell Commun Signal (2016) ncbi
mouse monoclonal (96/MEK2)
  • western blot; human; fig 4
BD Biosciences MEK2 antibody (BD Transduction, 610235) was used in western blot on human samples (fig 4). Cell Cycle (2015) ncbi
mouse monoclonal (96/MEK2)
  • western blot; human
BD Biosciences MEK2 antibody (BD, 610235) was used in western blot on human samples . J Biol Chem (2014) ncbi
Articles Reviewed
  1. Li D, Chen J, Guo J, Li L, Cai G, Chen S, et al. A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2α-induced corpus luteum regression. elife. 2021;10: pubmed publisher
  2. Shao G, Fan X, Zhang P, Liu X, Huang L, Ji S. Methylation-dependent MCM6 repression induced by LINC00472 inhibits triple-negative breast cancer metastasis by disturbing the MEK/ERK signaling pathway. Aging (Albany NY). 2021;13:4962-4975 pubmed publisher
  3. Smolko C, Janes K. An ultrasensitive fiveplex activity assay for cellular kinases. Sci Rep. 2019;9:19409 pubmed publisher
  4. Wang N, Fan Y, Yuan C, Song J, Yao Y, Liu W, et al. Selective ERK1/2 agonists isolated from Melia azedarach with potent anti-leukemic activity. BMC Cancer. 2019;19:764 pubmed publisher
  5. Zhao J, Sun H, Zhang J, Wang M, Du X, Zhang J. Long non-coding RNA ANRIL down-regulates microRNA-7 to protect human trabecular meshwork cells in an experimental model for glaucoma. Eur Rev Med Pharmacol Sci. 2019;23:3173-3182 pubmed publisher
  6. Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, et al. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. Cell Stem Cell. 2018;22:879-892.e6 pubmed publisher
  7. Qi Z, Xu H, Zhang S, Xu J, Li S, Gao H, et al. RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling. Int J Oncol. 2018;52:1105-1116 pubmed publisher
  8. Fu S, Xu H, Gu M, Liu C, Wang Q, Wan X, et al. Adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity. Sci Rep. 2017;7:43771 pubmed publisher
  9. Babagana M, Johnson S, Slabodkin H, Bshara W, Morrison C, Kandel E. P21-activated kinase 1 regulates resistance to BRAF inhibition in human cancer cells. Mol Carcinog. 2017;56:1515-1525 pubmed publisher
  10. Nowacka J, Baumgartner C, Pelorosso C, Roth M, Zuber J, Baccarini M. MEK1 is required for the development of NRAS-driven leukemia. Oncotarget. 2016;7:80113-80130 pubmed publisher
  11. Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  12. An X, Zhao Z, Luo Y, Zhang R, Tang X, Hao D, et al. Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer. Oncotarget. 2016;7:24719-33 pubmed publisher
  13. Ahuja A, Jodkowska K, Teloni F, Bizard A, Zellweger R, Herrador R, et al. A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells. Nat Commun. 2016;7:10660 pubmed publisher
  14. Hennig A, Markwart R, Wolff K, Schubert K, Cui Y, Prior I, et al. Feedback activation of neurofibromin terminates growth factor-induced Ras activation. Cell Commun Signal. 2016;14:5 pubmed publisher
  15. Kumarasamy V, Shin Y, White J, Sun D. Selective repression of RET proto-oncogene in medullary thyroid carcinoma by a natural alkaloid berberine. BMC Cancer. 2015;15:599 pubmed publisher
  16. Tanaka T, Iino M. Sec8 regulates cytokeratin8 phosphorylation and cell migration by controlling the ERK and p38 MAPK signalling pathways. Cell Signal. 2015;27:1110-9 pubmed publisher
  17. Lindsey Boltz L, Kemp M, Capp C, Sancar A. RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling. Cell Cycle. 2015;14:99-108 pubmed publisher
  18. Kemp M, Gaddameedhi S, Choi J, Hu J, Sancar A. DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair. J Biol Chem. 2014;289:26574-83 pubmed publisher