This is a Validated Antibody Database (VAD) review about human MCU, based on 14 published articles (read how Labome selects the articles), using MCU antibody in all methods. It is aimed to help Labome visitors find the most suited MCU antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
MCU synonym: C10orf42; CCDC109A; HsMCU

MilliporeSigma
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 1c
MilliporeSigma MCU antibody (Sigma, HPA016480) was used in western blot on mouse samples at 1:1000 (fig 1c). Nature (2019) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; mouse; loading ...; fig s1a
MilliporeSigma MCU antibody (Sigma-Aldrich, HPA016480) was used in immunohistochemistry on mouse samples (fig s1a). Front Mol Neurosci (2018) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 1b
MilliporeSigma MCU antibody (Sigma, HPA016480) was used in western blot on mouse samples at 1:1000 (fig 1b). Nature (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:2000; loading ...; fig 1d
  • immunoprecipitation; mouse; fig 3a
MilliporeSigma MCU antibody (Sigma, HPA016480) was used in western blot on human samples at 1:2000 (fig 1d) and in immunoprecipitation on mouse samples (fig 3a). Proc Natl Acad Sci U S A (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 1b
In order to show the role of Pex3 and Pex14 in generating human peroxisomes, MilliporeSigma MCU antibody (Sigma, HPA016480) was used in western blot on human samples (fig 1b). Nature (2017) ncbi
domestic rabbit polyclonal
  • western blot; rat; loading ...; fig 3b
In order to ask if SK channels in the mitochondria inner membrane play an important role in regulating mitochondrial function in chronic cardiac diseases, MilliporeSigma MCU antibody (Sigma, HPA016480) was used in western blot on rat samples (fig 3b). Cardiovasc Res (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 1e
In order to characterize a mouse model of MICU1 deficiency, MilliporeSigma MCU antibody (Sigma, HPA016480) was used in western blot on mouse samples (fig 1e). Cell Rep (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:500; fig s2
In order to elucidate the role of EMRE as a matrix Ca(2+) sensor that controls gatekeeping of the mitochondrial Ca(2+) uniporter, MilliporeSigma MCU antibody (Sigma, HPA016480) was used in western blot on human samples at 1:500 (fig s2). Cell Rep (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 1
MilliporeSigma MCU antibody (Sigma, HPA016480) was used in western blot on mouse samples (fig 1). J Biol Chem (2016) ncbi
domestic rabbit polyclonal
In order to report the crystal structure of the mitochondrial calcium uniporter N-terminal domain and assess its function, MilliporeSigma MCU antibody (Sigma, HPA016480) was used . EMBO Rep (2015) ncbi
domestic rabbit polyclonal
MilliporeSigma MCU antibody (Sigma, HPA016480) was used . Oncotarget (2015) ncbi
domestic rabbit polyclonal
In order to examine the contribution of the mitochondrial Ca(2+) uniporter to the regulation of oxidative phosphorylation and metabolism-secretion coupling in beta-cells and rat pancreatic islets, MilliporeSigma MCU antibody (Sigma, HPA016480) was used . J Biol Chem (2015) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D2Z3B)
  • western blot; human; 1:2500; loading ...; fig 4b
Cell Signaling Technology MCU antibody (Cell Signaling Technology, 14977) was used in western blot on human samples at 1:2500 (fig 4b). Oncogene (2020) ncbi
domestic rabbit monoclonal (D2Z3B)
  • western blot; human; 1:2000; loading ...; fig 1b
In order to determine the role of calcium regulation in sporadic inclusion body myositis, Cell Signaling Technology MCU antibody (Cell Signaling, 14997) was used in western blot on human samples at 1:2000 (fig 1b). Acta Neuropathol Commun (2017) ncbi
Articles Reviewed
  1. Wu P, Hong S, Starenki D, Oshima K, Shao H, Gestwicki J, et al. Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability. Oncogene. 2020;39:4257-4270 pubmed publisher
  2. Paggio A, Checchetto V, Campo A, Menabò R, Di Marco G, Di Lisa F, et al. Identification of an ATP-sensitive potassium channel in mitochondria. Nature. 2019;572:609-613 pubmed publisher
  3. Wang X, Zhu Y, Long H, Pan S, Xiong H, Fang Q, et al. Mitochondrial Calcium Transporters Mediate Sensitivity to Noise-Induced Losses of Hair Cells and Cochlear Synapses. Front Mol Neurosci. 2018;11:469 pubmed publisher
  4. Luongo T, Lambert J, Gross P, Nwokedi M, Lombardi A, Shanmughapriya S, et al. The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability. Nature. 2017;545:93-97 pubmed publisher
  5. Tsai C, Wu Y, Pao P, Phillips C, Williams C, Miller C, et al. Proteolytic control of the mitochondrial calcium uniporter complex. Proc Natl Acad Sci U S A. 2017;114:4388-4393 pubmed publisher
  6. Amici D, Pinal Fernández I, Mázala D, Lloyd T, Corse A, Christopher Stine L, et al. Calcium dysregulation, functional calpainopathy, and endoplasmic reticulum stress in sporadic inclusion body myositis. Acta Neuropathol Commun. 2017;5:24 pubmed publisher
  7. Sugiura A, Mattie S, Prudent J, McBride H. Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes. Nature. 2017;542:251-254 pubmed publisher
  8. Kim T, Terentyeva R, Roder K, Li W, Liu M, Greener I, et al. SK channel enhancers attenuate Ca2+-dependent arrhythmia in hypertrophic hearts by regulating mito-ROS-dependent oxidation and activity of RyR. Cardiovasc Res. 2017;113:343-353 pubmed publisher
  9. Liu J, Liu J, Holmström K, Menazza S, Parks R, Fergusson M, et al. MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload. Cell Rep. 2016;16:1561-1573 pubmed publisher
  10. Vais H, Mallilankaraman K, Mak D, Hoff H, Payne R, Tanis J, et al. EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter. Cell Rep. 2016;14:403-410 pubmed publisher
  11. Marland J, Hasel P, Bonnycastle K, Cousin M. Mitochondrial Calcium Uptake Modulates Synaptic Vesicle Endocytosis in Central Nerve Terminals. J Biol Chem. 2016;291:2080-6 pubmed publisher
  12. Lee Y, Min C, Kim T, Song H, Lim Y, Kim D, et al. Structure and function of the N-terminal domain of the human mitochondrial calcium uniporter. EMBO Rep. 2015;16:1318-33 pubmed publisher
  13. Patergnani S, Giorgi C, Maniero S, Missiroli S, Maniscalco P, Bononi I, et al. The endoplasmic reticulum mitochondrial calcium cross talk is downregulated in malignant pleural mesothelioma cells and plays a critical role in apoptosis inhibition. Oncotarget. 2015;6:23427-44 pubmed
  14. Quan X, Nguyen T, Choi S, Xu S, Das R, Cha S, et al. Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells. J Biol Chem. 2015;290:4086-96 pubmed publisher