This is a Validated Antibody Database (VAD) review about human MCPH1, based on 3 published articles (read how Labome selects the articles), using MCPH1 antibody in all methods. It is aimed to help Labome visitors find the most suited MCPH1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
MCPH1 synonym: BRIT1; MCT; microcephalin; BRCT-repeat inhibitor of TERT expression 1; truncated microcephalin

Knockout validation
Cell Signaling Technology
rabbit monoclonal (D38G5)
  • western blot knockout validation; African green monkey; 1:1000; loading ...; fig 1e
Cell Signaling Technology MCPH1 antibody (Cell Signaling, 4120) was used in western blot knockout validation on African green monkey samples at 1:1000 (fig 1e). Cell Res (2016) ncbi
Invitrogen
mouse monoclonal (AB11)
  • chromatin immunoprecipitation; human
  • EMSA; human
  • immunoprecipitation; human
In order to investigate the functional role of MCPH1 in regulation of ANGPT2 in chronic lymphocytic leukemia, Invitrogen MCPH1 antibody (Thermoscientific, MA5-18057) was used in chromatin immunoprecipitation on human samples , in EMSA on human samples and in immunoprecipitation on human samples . FEBS J (2015) ncbi
MilliporeSigma
rabbit polyclonal
  • western blot; human; loading ...; fig s9d
MilliporeSigma MCPH1 antibody (Cambridge Bioscience, HPA008238) was used in western blot on human samples (fig s9d). Science (2017) ncbi
Cell Signaling Technology
rabbit monoclonal (D38G5)
  • western blot knockout validation; African green monkey; 1:1000; loading ...; fig 1e
Cell Signaling Technology MCPH1 antibody (Cell Signaling, 4120) was used in western blot knockout validation on African green monkey samples at 1:1000 (fig 1e). Cell Res (2016) ncbi
Articles Reviewed
  1. Chavali P, Stojic L, Meredith L, Joseph N, Nahorski M, Sanford T, et al. Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication. Science. 2017;357:83-88 pubmed publisher
  2. Ke Q, Li W, Lai X, Chen H, Huang L, Kang Z, et al. TALEN-based generation of a cynomolgus monkey disease model for human microcephaly. Cell Res. 2016;26:1048-61 pubmed publisher
  3. Kopparapu P, Miranda C, Fogelstrand L, Mishra K, Andersson P, Kanduri C, et al. MCPH1 maintains long-term epigenetic silencing of ANGPT2 in chronic lymphocytic leukemia. FEBS J. 2015;282:1939-52 pubmed publisher