This is a Validated Antibody Database (VAD) review about human LRRK2, based on 43 published articles (read how Labome selects the articles), using LRRK2 antibody in all methods. It is aimed to help Labome visitors find the most suited LRRK2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
LRRK2 synonym: AURA17; DARDARIN; PARK8; RIPK7; ROCO2

Knockout validation
Abcam
domestic rabbit monoclonal (MJFF2 (c41-2))
  • western blot knockout validation; mouse; 1:1000; loading ...; fig s7b
Abcam LRRK2 antibody (Abcam, ab133474) was used in western blot knockout validation on mouse samples at 1:1000 (fig s7b). Acta Neuropathol (2019) ncbi
Abcam
domestic rabbit monoclonal (MJFF2 (c41-2))
  • western blot knockout validation; mouse; 1:2000; loading ...; fig s1a
Abcam LRRK2 antibody (Abcam, ab133474) was used in western blot knockout validation on mouse samples at 1:2000 (fig s1a). NPJ Parkinsons Dis (2018) ncbi
Abcam
domestic rabbit monoclonal (UDD2 10(12))
  • western blot knockout validation; mouse; 1:2000; loading ...; fig s1a
Abcam LRRK2 antibody (Abcam, ab133450) was used in western blot knockout validation on mouse samples at 1:2000 (fig s1a). NPJ Parkinsons Dis (2018) ncbi
Abcam
domestic rabbit monoclonal (MJFF2 (c41-2))
  • western blot knockout validation; human; loading ...; fig 5b
  • immunoprecipitation; human; loading ...; fig 6e
In order to find that LRRK2 regulates Rip2 and promotes inflammatory cytokine induction through the Nod1/2-Rip2 pathway, Abcam LRRK2 antibody (Epitomics, MJFF2 c41-2) was used in western blot knockout validation on human samples (fig 5b) and in immunoprecipitation on human samples (fig 6e). Protein Cell (2017) ncbi
Abcam
domestic rabbit monoclonal (MJFF2 (c41-2))
  • western blot knockout validation; mouse; 1:2000; fig 7
Abcam LRRK2 antibody (Epitomics, MJFF2) was used in western blot knockout validation on mouse samples at 1:2000 (fig 7). J Biol Chem (2014) ncbi
Abcam
domestic rabbit monoclonal (UDD3 30(12))
  • western blot knockout validation; mouse; fig 1
  • immunoprecipitation; mouse; fig 2
  • immunoprecipitation; human; fig 2
  • western blot; human; fig 1
Abcam LRRK2 antibody (Abcam, ab133518) was used in western blot knockout validation on mouse samples (fig 1), in immunoprecipitation on mouse samples (fig 2), in immunoprecipitation on human samples (fig 2) and in western blot on human samples (fig 1). Biochem J (2013) ncbi
Abcam
domestic rabbit monoclonal (MJFF4)
  • immunohistochemistry knockout validation; mouse; fig 4
  • western blot knockout validation; mouse; fig 1
  • immunoprecipitation; mouse; fig 2
  • immunoprecipitation; human; fig 2
  • western blot; human; fig 1
Abcam LRRK2 antibody (Abcam, ab181386) was used in immunohistochemistry knockout validation on mouse samples (fig 4), in western blot knockout validation on mouse samples (fig 1), in immunoprecipitation on mouse samples (fig 2), in immunoprecipitation on human samples (fig 2) and in western blot on human samples (fig 1). Biochem J (2013) ncbi
Abcam
domestic rabbit monoclonal (MJFF2 (c41-2))
  • immunohistochemistry knockout validation; rat; fig 6
  • immunohistochemistry - free floating section; rat; fig 6
  • western blot; human; fig 1
  • immunohistochemistry knockout validation; mouse; fig 4
  • western blot knockout validation; mouse; fig 1, s2
  • immunohistochemistry - free floating section; mouse; fig 4
Abcam LRRK2 antibody (Abcam, ab133474) was used in immunohistochemistry knockout validation on rat samples (fig 6), in immunohistochemistry - free floating section on rat samples (fig 6), in western blot on human samples (fig 1), in immunohistochemistry knockout validation on mouse samples (fig 4), in western blot knockout validation on mouse samples (fig 1, s2) and in immunohistochemistry - free floating section on mouse samples (fig 4). Biochem J (2013) ncbi
Abcam
domestic rabbit monoclonal (MJFF2 (c41-2))
  • immunohistochemistry knockout validation; mouse; 1:4000; fig 1
Abcam LRRK2 antibody (Epitomics, MJFF2 (c41-2)) was used in immunohistochemistry knockout validation on mouse samples at 1:4000 (fig 1). Mol Neurodegener (2012) ncbi
Neuromab
mouse monoclonal (N241A/34)
  • immunohistochemistry knockout validation; mouse; 1:100-1:400; loading ...; fig 3a
  • western blot; mouse; 1:1000; loading ...; fig 2a
Neuromab LRRK2 antibody (NeuroMab, N241A/34) was used in immunohistochemistry knockout validation on mouse samples at 1:100-1:400 (fig 3a) and in western blot on mouse samples at 1:1000 (fig 2a). Mov Disord (2017) ncbi
Neuromab
mouse monoclonal (N241A/34)
  • western blot knockout validation; rat; 1:1000; fig 1
Neuromab LRRK2 antibody (Neuromab, N241) was used in western blot knockout validation on rat samples at 1:1000 (fig 1). Hum Mol Genet (2015) ncbi
Neuromab
mouse monoclonal (N241A/34)
  • immunohistochemistry knockout validation; mouse; fig 1
  • western blot knockout validation; mouse; fig 6
  • immunohistochemistry knockout validation; rat; fig 1
  • western blot knockout validation; human; fig 7
Neuromab LRRK2 antibody (NeuroMab, 73-253) was used in immunohistochemistry knockout validation on mouse samples (fig 1), in western blot knockout validation on mouse samples (fig 6), in immunohistochemistry knockout validation on rat samples (fig 1) and in western blot knockout validation on human samples (fig 7). J Comp Neurol (2014) ncbi
Neuromab
mouse monoclonal (N138/6)
  • western blot knockout validation; mouse; fig s2
  • western blot; human; fig 1
  • western blot knockout validation; rat; fig 5
Neuromab LRRK2 antibody (Neuromab, N138/6) was used in western blot knockout validation on mouse samples (fig s2), in western blot on human samples (fig 1) and in western blot knockout validation on rat samples (fig 5). Biochem J (2013) ncbi
Neuromab
mouse monoclonal (N241A/34)
  • western blot knockout validation; rat; fig 5
  • immunohistochemistry; rat; fig 6
  • immunoprecipitation; human; fig 2
  • western blot; human; fig 1
  • immunocytochemistry knockout validation; mouse; fig s3
  • western blot knockout validation; mouse; fig 1, s2
  • immunoprecipitation; mouse; fig 2
Neuromab LRRK2 antibody (Neuromab, N241A/34) was used in western blot knockout validation on rat samples (fig 5), in immunohistochemistry on rat samples (fig 6), in immunoprecipitation on human samples (fig 2), in western blot on human samples (fig 1), in immunocytochemistry knockout validation on mouse samples (fig s3), in western blot knockout validation on mouse samples (fig 1, s2) and in immunoprecipitation on mouse samples (fig 2). Biochem J (2013) ncbi
Abcam
domestic rabbit monoclonal (UDD2 10(12))
  • western blot; mouse; 1:1000; loading ...; fig s1a, s1b
Abcam LRRK2 antibody (Abcam, ab133450) was used in western blot on mouse samples at 1:1000 (fig s1a, s1b). NPJ Parkinsons Dis (2022) ncbi
domestic rabbit monoclonal (MJFF2 (c41-2))
  • western blot; mouse; 1:1000; loading ...; fig s1a, s1b, s4
Abcam LRRK2 antibody (Abcam, ab133474) was used in western blot on mouse samples at 1:1000 (fig s1a, s1b, s4). NPJ Parkinsons Dis (2022) ncbi
domestic rabbit monoclonal (MJFR-19-7-8)
  • western blot; mouse; 1:300; loading ...; fig s5a
Abcam LRRK2 antibody (Abcam, ab203181) was used in western blot on mouse samples at 1:300 (fig s5a). Neurobiol Dis (2021) ncbi
domestic rabbit monoclonal (MJFF2 (c41-2))
  • western blot; mouse; 1:300; loading ...; fig s5b
Abcam LRRK2 antibody (Abcam, ab133474) was used in western blot on mouse samples at 1:300 (fig s5b). Neurobiol Dis (2021) ncbi
domestic rabbit monoclonal
  • western blot; human; loading ...; fig s1
Abcam LRRK2 antibody (Abcam, ab133449) was used in western blot on human samples (fig s1). Clin Transl Med (2021) ncbi
domestic rabbit monoclonal (UDD2 10(12))
  • western blot; human; loading ...; fig s1
Abcam LRRK2 antibody (Abcam, ab133450) was used in western blot on human samples (fig s1). Clin Transl Med (2021) ncbi
domestic rabbit monoclonal (UDD2 10(12))
  • western blot; rat; 1:2000; loading ...; fig 6a, 6e, 6i
Abcam LRRK2 antibody (Abcam, ab133450) was used in western blot on rat samples at 1:2000 (fig 6a, 6e, 6i). Neurobiol Dis (2021) ncbi
domestic rabbit monoclonal (MJFR-19-7-8)
  • western blot; rat; 1:2000; loading ...; fig 6a, 6e, 6i
Abcam LRRK2 antibody (Abcam, ab203181) was used in western blot on rat samples at 1:2000 (fig 6a, 6e, 6i). Neurobiol Dis (2021) ncbi
domestic rabbit monoclonal (MJFF2 (c41-2))
  • western blot; rat; 1:2000; loading ...; fig 6a, 6e, 6i
Abcam LRRK2 antibody (Abcam, ab133474) was used in western blot on rat samples at 1:2000 (fig 6a, 6e, 6i). Neurobiol Dis (2021) ncbi
domestic rabbit monoclonal (MJFR-19-7-8)
  • western blot; rat; loading ...; fig 1a
Abcam LRRK2 antibody (Abcam, MJFR-19-7-8) was used in western blot on rat samples (fig 1a). Proc Natl Acad Sci U S A (2020) ncbi
domestic rabbit monoclonal (UDD3 30(12))
  • western blot; human; loading ...; fig 2a
Abcam LRRK2 antibody (Abcam, ab133518) was used in western blot on human samples (fig 2a). J Cell Biol (2019) ncbi
domestic rabbit monoclonal (MJFF2 (c41-2))
  • western blot knockout validation; mouse; 1:1000; loading ...; fig s7b
Abcam LRRK2 antibody (Abcam, ab133474) was used in western blot knockout validation on mouse samples at 1:1000 (fig s7b). Acta Neuropathol (2019) ncbi
domestic rabbit monoclonal (MJFF2 (c41-2))
  • western blot knockout validation; mouse; 1:2000; loading ...; fig s1a
Abcam LRRK2 antibody (Abcam, ab133474) was used in western blot knockout validation on mouse samples at 1:2000 (fig s1a). NPJ Parkinsons Dis (2018) ncbi
domestic rabbit monoclonal (MJFR-19-7-8)
  • western blot; mouse; 1:2000; loading ...; fig s1a
Abcam LRRK2 antibody (Abcam, MJF-19-7-8) was used in western blot on mouse samples at 1:2000 (fig s1a). NPJ Parkinsons Dis (2018) ncbi
domestic rabbit monoclonal (UDD2 10(12))
  • western blot knockout validation; mouse; 1:2000; loading ...; fig s1a
Abcam LRRK2 antibody (Abcam, ab133450) was used in western blot knockout validation on mouse samples at 1:2000 (fig s1a). NPJ Parkinsons Dis (2018) ncbi
domestic rabbit monoclonal (MJFR-19-7-8)
  • western blot; mouse; loading ...; fig 2h
Abcam LRRK2 antibody (Abcam, ab203181) was used in western blot on mouse samples (fig 2h). Proc Natl Acad Sci U S A (2018) ncbi
domestic rabbit monoclonal (MJFF2 (c41-2))
  • immunohistochemistry - frozen section; mouse; loading ...; fig s3e
Abcam LRRK2 antibody (Abcam, ab133474) was used in immunohistochemistry - frozen section on mouse samples (fig s3e). Proc Natl Acad Sci U S A (2018) ncbi
domestic rabbit monoclonal (MJFR-19-7-8)
  • western blot; human; loading ...; fig 1a, 5a
Abcam LRRK2 antibody (Abcam, ab203181) was used in western blot on human samples (fig 1a, 5a). EMBO J (2018) ncbi
domestic rabbit monoclonal
  • western blot; human; loading ...; fig 8a
Abcam LRRK2 antibody (Abcam, ab133449) was used in western blot on human samples (fig 8a). EMBO J (2018) ncbi
domestic rabbit monoclonal
  • western blot; human; loading ...; fig 8a
Abcam LRRK2 antibody (Abcam, ab181364) was used in western blot on human samples (fig 8a). EMBO J (2018) ncbi
domestic rabbit monoclonal
  • western blot; human; loading ...; fig 8a
Abcam LRRK2 antibody (Abcam, ab169521) was used in western blot on human samples (fig 8a). EMBO J (2018) ncbi
domestic rabbit monoclonal (MJFR-19-7-8)
  • western blot; mouse; 1:300; loading ...; fig 1
In order to elucidate the effects of mutations in leucine-rich repeat kinase 2 on nigro0striatal dopamine neurons, Abcam LRRK2 antibody (Abcam, ab203181) was used in western blot on mouse samples at 1:300 (fig 1). Acta Neuropathol Commun (2017) ncbi
domestic rabbit monoclonal (MJFF2 (c41-2))
  • western blot; mouse; 1:300; loading ...; fig 1
In order to elucidate the effects of mutations in leucine-rich repeat kinase 2 on nigro0striatal dopamine neurons, Abcam LRRK2 antibody (Abcam, ab133474) was used in western blot on mouse samples at 1:300 (fig 1). Acta Neuropathol Commun (2017) ncbi
domestic rabbit monoclonal (MJFF2 (c41-2))
  • western blot knockout validation; human; loading ...; fig 5b
  • immunoprecipitation; human; loading ...; fig 6e
In order to find that LRRK2 regulates Rip2 and promotes inflammatory cytokine induction through the Nod1/2-Rip2 pathway, Abcam LRRK2 antibody (Epitomics, MJFF2 c41-2) was used in western blot knockout validation on human samples (fig 5b) and in immunoprecipitation on human samples (fig 6e). Protein Cell (2017) ncbi
domestic rabbit monoclonal (MJFF2 (c41-2))
  • western blot; human; fig 2b
Abcam LRRK2 antibody (Abcam, ab133474) was used in western blot on human samples (fig 2b). PLoS ONE (2016) ncbi
domestic rabbit monoclonal (MJFR-19-7-8)
  • western blot; human; fig s4
Abcam LRRK2 antibody (Abcam, ab203181) was used in western blot on human samples (fig s4). PLoS ONE (2016) ncbi
domestic rabbit monoclonal (UDD2 10(12))
  • western blot; human; fig s4
Abcam LRRK2 antibody (Abcam, ab133450) was used in western blot on human samples (fig s4). PLoS ONE (2016) ncbi
domestic rabbit monoclonal (MJFR-19-7-8)
  • western blot; mouse; 1 ug/ml; loading ...; fig 2a
In order to develop a Rab Phos-tag assay and use it to study LRRK2 signaling, Abcam LRRK2 antibody (Abcam, ab203181) was used in western blot on mouse samples at 1 ug/ml (fig 2a). Biochem J (2016) ncbi
domestic rabbit monoclonal (MJFF3 (c69-6))
  • immunohistochemistry; zebrafish ; 1:200; loading ...; fig 6a
  • western blot; zebrafish ; 1:500; loading ...; fig 1a
In order to describe multifaceted roles of LRRK2 in zebrafish, Abcam LRRK2 antibody (Abcam, ab133475) was used in immunohistochemistry on zebrafish samples at 1:200 (fig 6a) and in western blot on zebrafish samples at 1:500 (fig 1a). J Neurosci Res (2016) ncbi
domestic rabbit monoclonal (UDD2 10(12))
  • immunocytochemistry; human
  • western blot; human; fig s3
In order to study the effect of G2019S on neuronal subtypes, Abcam LRRK2 antibody (Abcam, ab133450) was used in immunocytochemistry on human samples and in western blot on human samples (fig s3). Stem Cell Reports (2015) ncbi
domestic rabbit monoclonal (MJFF2 (c41-2))
  • western blot; human; 1:2000; loading ...; fig 1c
Abcam LRRK2 antibody (Abcam, ab133474) was used in western blot on human samples at 1:2000 (fig 1c). Mol Neurobiol (2016) ncbi
domestic rabbit monoclonal (UDD2 10(12))
  • western blot; mouse; 1:500; fig 6d
Abcam LRRK2 antibody (Abcam, ab133450) was used in western blot on mouse samples at 1:500 (fig 6d). Mol Brain (2015) ncbi
domestic rabbit monoclonal (MJFF2 (c41-2))
  • immunoprecipitation; human; fig 2a
  • western blot; human; fig 2b
Abcam LRRK2 antibody (Abcam, ab133474) was used in immunoprecipitation on human samples (fig 2a) and in western blot on human samples (fig 2b). Mol Brain (2015) ncbi
domestic rabbit monoclonal (MJF-R8 (21-2e))
  • western blot; human; 1:2000; loading ...; fig 5b
Abcam LRRK2 antibody (Abcam, 156577) was used in western blot on human samples at 1:2000 (fig 5b). J Neurochem (2015) ncbi
domestic rabbit monoclonal (MJFR5-88-3)
  • western blot; human; 1:2000; loading ...; fig 5b
Abcam LRRK2 antibody (Abcam, 140106) was used in western blot on human samples at 1:2000 (fig 5b). J Neurochem (2015) ncbi
domestic rabbit monoclonal (MJFF2 (c41-2))
  • western blot; mouse; 1:1000; fig 4
  • western blot; rat; 1:1000; fig 3
  • western blot; human; 1:1000; fig 3
Abcam LRRK2 antibody (Abcam, ab133474) was used in western blot on mouse samples at 1:1000 (fig 4), in western blot on rat samples at 1:1000 (fig 3) and in western blot on human samples at 1:1000 (fig 3). Nat Commun (2015) ncbi
domestic rabbit monoclonal (UDD2 10(12))
  • immunoprecipitation; human; 1:1000; fig 8
Abcam LRRK2 antibody (Abcam, ab133450) was used in immunoprecipitation on human samples at 1:1000 (fig 8). Nat Commun (2015) ncbi
domestic rabbit monoclonal (MJFF4)
  • immunoprecipitation; mouse; fig s3
  • immunoprecipitation; rat; fig 3
  • immunoprecipitation; human; fig 3
Abcam LRRK2 antibody (Abcam, ab181386) was used in immunoprecipitation on mouse samples (fig s3), in immunoprecipitation on rat samples (fig 3) and in immunoprecipitation on human samples (fig 3). Nat Commun (2015) ncbi
domestic rabbit monoclonal (MJFF2 (c41-2))
  • western blot; human; 1:3000; fig 1c
  • western blot; mouse; 1:3000; fig 1d
In order to analyze protein kinase LRRK2, parkinson's disease associated, which modulates notch signaling via the endosomal pathway, Abcam LRRK2 antibody (Abcam, MJFF2) was used in western blot on human samples at 1:3000 (fig 1c) and in western blot on mouse samples at 1:3000 (fig 1d). PLoS Genet (2015) ncbi
domestic rabbit monoclonal (MJFF4)
  • western blot; mouse; 1:1000; fig 2d
In order to compare cognitive and motor behaviors in various LRRK2 transgenic mice, Abcam LRRK2 antibody (Abcam, ab133476) was used in western blot on mouse samples at 1:1000 (fig 2d). Parkinsonism Relat Disord (2015) ncbi
domestic rabbit monoclonal (MJFF2 (c41-2))
  • western blot; human
In order to elucidate the relationship between LRRK2 and Rab5b, Abcam LRRK2 antibody (Abcam, ab133474) was used in western blot on human samples . J Biochem (2015) ncbi
domestic rabbit monoclonal (MJFF2 (c41-2))
  • western blot; human; 1:1000; fig 3
Abcam LRRK2 antibody (Abcam, ab133474) was used in western blot on human samples at 1:1000 (fig 3). Biomed Res Int (2014) ncbi
domestic rabbit monoclonal (MJFF4)
  • western blot; rat
In order to examine the p.G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) and it's role in Parkinson's disease, Abcam LRRK2 antibody (Abcam, ab133476) was used in western blot on rat samples . J Parkinsons Dis (2014) ncbi
domestic rabbit monoclonal (MJFF2 (c41-2))
  • western blot knockout validation; mouse; 1:2000; fig 7
Abcam LRRK2 antibody (Epitomics, MJFF2) was used in western blot knockout validation on mouse samples at 1:2000 (fig 7). J Biol Chem (2014) ncbi
domestic rabbit monoclonal (MJFF2 (c41-2))
  • immunohistochemistry knockout validation; rat; fig 6
  • immunohistochemistry - free floating section; rat; fig 6
  • western blot; human; fig 1
  • immunohistochemistry knockout validation; mouse; fig 4
  • western blot knockout validation; mouse; fig 1, s2
  • immunohistochemistry - free floating section; mouse; fig 4
Abcam LRRK2 antibody (Abcam, ab133474) was used in immunohistochemistry knockout validation on rat samples (fig 6), in immunohistochemistry - free floating section on rat samples (fig 6), in western blot on human samples (fig 1), in immunohistochemistry knockout validation on mouse samples (fig 4), in western blot knockout validation on mouse samples (fig 1, s2) and in immunohistochemistry - free floating section on mouse samples (fig 4). Biochem J (2013) ncbi
domestic rabbit monoclonal (MJFF4)
  • immunohistochemistry knockout validation; mouse; fig 4
  • western blot knockout validation; mouse; fig 1
  • immunoprecipitation; mouse; fig 2
  • immunoprecipitation; human; fig 2
  • western blot; human; fig 1
Abcam LRRK2 antibody (Abcam, ab181386) was used in immunohistochemistry knockout validation on mouse samples (fig 4), in western blot knockout validation on mouse samples (fig 1), in immunoprecipitation on mouse samples (fig 2), in immunoprecipitation on human samples (fig 2) and in western blot on human samples (fig 1). Biochem J (2013) ncbi
domestic rabbit monoclonal (UDD3 30(12))
  • western blot knockout validation; mouse; fig 1
  • immunoprecipitation; mouse; fig 2
  • immunoprecipitation; human; fig 2
  • western blot; human; fig 1
Abcam LRRK2 antibody (Abcam, ab133518) was used in western blot knockout validation on mouse samples (fig 1), in immunoprecipitation on mouse samples (fig 2), in immunoprecipitation on human samples (fig 2) and in western blot on human samples (fig 1). Biochem J (2013) ncbi
domestic rabbit monoclonal (MJFF2 (c41-2))
  • immunohistochemistry knockout validation; mouse; 1:4000; fig 1
Abcam LRRK2 antibody (Epitomics, MJFF2 (c41-2)) was used in immunohistochemistry knockout validation on mouse samples at 1:4000 (fig 1). Mol Neurodegener (2012) ncbi
Novus Biologicals
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig 3c
In order to discuss the contribution of leucine-rich repeat kinase 2 mutations to Parkinson's disease, Novus Biologicals LRRK2 antibody (Novus Biologicals, NB110-58771) was used in western blot on human samples at 1:1000 (fig 3c). J Neuroinflammation (2016) ncbi
Invitrogen
domestic rabbit polyclonal
  • western blot; fruit fly ; 1:5000; loading ...; fig 1
In order to find that knocking down the leucine-rich repeat kinase gene by RNAi in DAergic neurons untreated or treated with paraquat neither affects the number of DAergic clusters, tyrosine hydroxylase protein levels, lifespan nor locomotor activity, Invitrogen LRRK2 antibody (Thermo, PA1-16770) was used in western blot on fruit fly samples at 1:5000 (fig 1). Brain Res (2017) ncbi
BioLegend
mouse monoclonal (MC.028.83.76.242)
  • western blot; human; fig 1
  • immunoprecipitation; mouse; fig 2
BioLegend LRRK2 antibody (biolegend, 808201) was used in western blot on human samples (fig 1) and in immunoprecipitation on mouse samples (fig 2). Biochem J (2013) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; rat; loading ...; fig 4f
Cell Signaling Technology LRRK2 antibody (Cell Signaling Technology, 5559) was used in western blot on rat samples (fig 4f). Am J Physiol Endocrinol Metab (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 4d
In order to discuss the contribution of LINK-A to cancer, Cell Signaling Technology LRRK2 antibody (Cell Signaling, 5559) was used in western blot on human samples at 1:1000 (fig 4d). Nat Cell Biol (2016) ncbi
Neuromab
mouse monoclonal (N241A/34)
  • western blot; human; 1 ug/ml; fig 1a
Neuromab LRRK2 antibody (Neuromab, 75-253) was used in western blot on human samples at 1 ug/ml (fig 1a). Acta Neuropathol (2021) ncbi
mouse monoclonal (N241A/34)
  • proximity ligation assay; rat; 1:500; loading ...; fig 4a
Neuromab LRRK2 antibody (NeuroMab UC Davis, N241A/34) was used in proximity ligation assay on rat samples at 1:500 (fig 4a). Neurobiol Dis (2021) ncbi
mouse monoclonal (N241A/34)
  • western blot; human; 1:1000; loading ...; fig 2d
Neuromab LRRK2 antibody (Neuromab, 75-253) was used in western blot on human samples at 1:1000 (fig 2d). elife (2019) ncbi
mouse monoclonal (N241A/34)
  • western blot; mouse; 1:1000; loading ...; fig 4a
Neuromab LRRK2 antibody (Antibodies Incorporated, 75-253) was used in western blot on mouse samples at 1:1000 (fig 4a). Biochem J (2018) ncbi
mouse monoclonal (N241A/34)
  • western blot; human; loading ...; fig 5a, 6a
Neuromab LRRK2 antibody (NeuroMab, N241A/34) was used in western blot on human samples (fig 5a, 6a). EMBO J (2018) ncbi
mouse monoclonal (N241A/34)
  • western blot; human; 1:1000; loading ...; fig 2b
Neuromab LRRK2 antibody (Antibodies Incorporated, 75-253) was used in western blot on human samples at 1:1000 (fig 2b). Biochem J (2018) ncbi
mouse monoclonal (N241A/34)
  • western blot; human; fig 5a
Neuromab LRRK2 antibody (NeuroMab, 75-253) was used in western blot on human samples (fig 5a). Hum Mol Genet (2017) ncbi
mouse monoclonal (N241A/34)
  • immunohistochemistry knockout validation; mouse; 1:100-1:400; loading ...; fig 3a
  • western blot; mouse; 1:1000; loading ...; fig 2a
Neuromab LRRK2 antibody (NeuroMab, N241A/34) was used in immunohistochemistry knockout validation on mouse samples at 1:100-1:400 (fig 3a) and in western blot on mouse samples at 1:1000 (fig 2a). Mov Disord (2017) ncbi
mouse monoclonal (N138/6)
  • immunoprecipitation; mouse; 1:1000; fig 1
  • western blot; mouse; 1:1000; fig 1
  • immunoprecipitation; human; 1:1000; fig 1
  • western blot; human; 1:1000; fig 1
Neuromab LRRK2 antibody (NeuroMab, N138/6) was used in immunoprecipitation on mouse samples at 1:1000 (fig 1), in western blot on mouse samples at 1:1000 (fig 1), in immunoprecipitation on human samples at 1:1000 (fig 1) and in western blot on human samples at 1:1000 (fig 1). Nat Commun (2016) ncbi
mouse monoclonal (N241A/34)
  • immunocytochemistry; human; fig 3
In order to study the effect of G2019S on neuronal subtypes, Neuromab LRRK2 antibody (NeuroMab, 73-253) was used in immunocytochemistry on human samples (fig 3). Stem Cell Reports (2015) ncbi
mouse monoclonal (N241A/34)
  • proximity ligation assay; mouse; 1:50; fig 6
  • immunocytochemistry; mouse; 1:50; fig s5
Neuromab LRRK2 antibody (NeuroMab, N241A/34) was used in proximity ligation assay on mouse samples at 1:50 (fig 6) and in immunocytochemistry on mouse samples at 1:50 (fig s5). Nat Commun (2015) ncbi
mouse monoclonal (N231B/34)
  • proximity ligation assay; human; 1:50; fig s6
  • immunocytochemistry; human; 1:50; fig s6
  • proximity ligation assay; mouse; 1:50; fig 6
  • immunocytochemistry; mouse; 1:50; fig 6
Neuromab LRRK2 antibody (NeuroMab, N231B/34) was used in proximity ligation assay on human samples at 1:50 (fig s6), in immunocytochemistry on human samples at 1:50 (fig s6), in proximity ligation assay on mouse samples at 1:50 (fig 6) and in immunocytochemistry on mouse samples at 1:50 (fig 6). Nat Commun (2015) ncbi
mouse monoclonal (N241A/34)
  • western blot; human; loading ...; fig 1a,1e,1f,2a,2d,3a
Neuromab LRRK2 antibody (Neuromab, N241) was used in western blot on human samples (fig 1a,1e,1f,2a,2d,3a). Biochem J (2015) ncbi
mouse monoclonal (N241A/34)
  • western blot knockout validation; rat; 1:1000; fig 1
Neuromab LRRK2 antibody (Neuromab, N241) was used in western blot knockout validation on rat samples at 1:1000 (fig 1). Hum Mol Genet (2015) ncbi
mouse monoclonal (N241A/34)
Neuromab LRRK2 antibody (NeuroMab, 75-253) was used . Sci Transl Med (2015) ncbi
mouse monoclonal (N241A/34)
  • immunohistochemistry knockout validation; mouse; fig 1
  • western blot knockout validation; mouse; fig 6
  • immunohistochemistry knockout validation; rat; fig 1
  • western blot knockout validation; human; fig 7
Neuromab LRRK2 antibody (NeuroMab, 73-253) was used in immunohistochemistry knockout validation on mouse samples (fig 1), in western blot knockout validation on mouse samples (fig 6), in immunohistochemistry knockout validation on rat samples (fig 1) and in western blot knockout validation on human samples (fig 7). J Comp Neurol (2014) ncbi
mouse monoclonal (N138/6)
  • western blot knockout validation; mouse; fig s2
  • western blot; human; fig 1
  • western blot knockout validation; rat; fig 5
Neuromab LRRK2 antibody (Neuromab, N138/6) was used in western blot knockout validation on mouse samples (fig s2), in western blot on human samples (fig 1) and in western blot knockout validation on rat samples (fig 5). Biochem J (2013) ncbi
mouse monoclonal (N241A/34)
  • western blot knockout validation; rat; fig 5
  • immunohistochemistry; rat; fig 6
  • immunoprecipitation; human; fig 2
  • western blot; human; fig 1
  • immunocytochemistry knockout validation; mouse; fig s3
  • western blot knockout validation; mouse; fig 1, s2
  • immunoprecipitation; mouse; fig 2
Neuromab LRRK2 antibody (Neuromab, N241A/34) was used in western blot knockout validation on rat samples (fig 5), in immunohistochemistry on rat samples (fig 6), in immunoprecipitation on human samples (fig 2), in western blot on human samples (fig 1), in immunocytochemistry knockout validation on mouse samples (fig s3), in western blot knockout validation on mouse samples (fig 1, s2) and in immunoprecipitation on mouse samples (fig 2). Biochem J (2013) ncbi
mouse monoclonal (N231B/34)
  • immunoprecipitation; mouse; fig 2
  • immunocytochemistry; mouse; fig s3
  • western blot; mouse; fig 1
  • western blot; rat; fig 5
  • immunoprecipitation; human; fig 2
  • western blot; human; fig 1
Neuromab LRRK2 antibody (Neuromab, n231b/34) was used in immunoprecipitation on mouse samples (fig 2), in immunocytochemistry on mouse samples (fig s3), in western blot on mouse samples (fig 1), in western blot on rat samples (fig 5), in immunoprecipitation on human samples (fig 2) and in western blot on human samples (fig 1). Biochem J (2013) ncbi
Articles Reviewed
  1. Ho P, Chang E, Leung C, Liu H, Malki Y, Pang S, et al. Long-term inhibition of mutant LRRK2 hyper-kinase activity reduced mouse brain α-synuclein oligomers without adverse effects. NPJ Parkinsons Dis. 2022;8:115 pubmed publisher
  2. Albanese F, Mercatelli D, Finetti L, Lamonaca G, Pizzi S, Shimshek D, et al. Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo. Neurobiol Dis. 2021;159:105487 pubmed publisher
  3. Fan Y, Nirujogi R, Garrido A, Ruiz Martinez J, Bergareche Yarza A, Mondragón Rezola E, et al. R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils. Acta Neuropathol. 2021;142:475-494 pubmed publisher
  4. Chen L, Hou J, Zeng X, Guo Q, Deng M, Kloeber J, et al. LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination-mediated DNA double strand break repair. Clin Transl Med. 2021;11:e341 pubmed publisher
  5. De Miranda B, Castro S, Rocha E, Bodle C, Johnson K, Greenamyre J. The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson's disease. Neurobiol Dis. 2021;153:105312 pubmed publisher
  6. Nguyen A, Tsika E, Kelly K, Levine N, Chen X, West A, et al. Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity. Proc Natl Acad Sci U S A. 2020;117:17296-17307 pubmed publisher
  7. Berndsen K, Lis P, Yeshaw W, Wawro P, Nirujogi R, Wightman M, et al. PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins. elife. 2019;8: pubmed publisher
  8. Gomez R, Wawro P, Lis P, Alessi D, Pfeffer S. Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases. J Cell Biol. 2019;218:4157-4170 pubmed publisher
  9. Bieri G, Brahic M, Bousset L, Couthouis J, Kramer N, Ma R, et al. LRRK2 modifies α-syn pathology and spread in mouse models and human neurons. Acta Neuropathol. 2019;137:961-980 pubmed publisher
  10. Mir R, Tonelli F, Lis P, MacArtney T, Polinski N, Martinez T, et al. The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human. Biochem J. 2018;475:1861-1883 pubmed publisher
  11. Kluss J, Conti M, Kaganovich A, Beilina A, Melrose H, Cookson M, et al. Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity. NPJ Parkinsons Dis. 2018;4:13 pubmed publisher
  12. Xiong Y, Neifert S, Karuppagounder S, Liu Q, Stankowski J, Lee B, et al. Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice. Proc Natl Acad Sci U S A. 2018;115:1635-1640 pubmed publisher
  13. Purlyte E, Dhekne H, Sarhan A, Gomez R, Lis P, Wightman M, et al. Rab29 activation of the Parkinson's disease-associated LRRK2 kinase. EMBO J. 2018;37:1-18 pubmed publisher
  14. Fan Y, Howden A, Sarhan A, Lis P, Ito G, Martinez T, et al. Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils. Biochem J. 2018;475:23-44 pubmed publisher
  15. Pinto S, Lamon S, Stephenson E, Kalanon M, Mikovic J, Koch L, et al. Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity. Am J Physiol Endocrinol Metab. 2017;313:E335-E343 pubmed publisher
  16. Longo F, Mercatelli D, Novello S, Arcuri L, Brugnoli A, Vincenzi F, et al. Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice. Acta Neuropathol Commun. 2017;5:22 pubmed publisher
  17. Kim M, Deng H, Wong Y, Siddique T, Krainc D. The Parkinson's disease-linked protein TMEM230 is required for Rab8a-mediated secretory vesicle trafficking and retromer trafficking. Hum Mol Genet. 2017;26:729-741 pubmed publisher
  18. Quintero Espinosa D, Jimenez Del Rio M, Velez Pardo C. Knockdown transgenic Lrrk Drosophila resists paraquat-induced locomotor impairment and neurodegeneration: A therapeutic strategy for Parkinson's disease. Brain Res. 2017;1657:253-261 pubmed publisher
  19. Dzamko N, Gysbers A, Bandopadhyay R, Bolliger M, Uchino A, Zhao Y, et al. LRRK2 levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies. Mov Disord. 2017;32:423-432 pubmed publisher
  20. López de Maturana R, Lang V, Zubiarrain A, Sousa A, Vázquez N, Gorostidi A, et al. Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons. J Neuroinflammation. 2016;13:295 pubmed
  21. Yan R, Liu Z. LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation. Protein Cell. 2017;8:55-66 pubmed publisher
  22. Speidel A, Felk S, Reinhardt P, Sterneckert J, Gillardon F. Leucine-Rich Repeat Kinase 2 Influences Fate Decision of Human Monocytes Differentiated from Induced Pluripotent Stem Cells. PLoS ONE. 2016;11:e0165949 pubmed publisher
  23. Ito G, Katsemonova K, Tonelli F, Lis P, Baptista M, Shpiro N, et al. Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors. Biochem J. 2016;473:2671-85 pubmed publisher
  24. Nucifora F, Nucifora L, Ng C, Arbez N, Guo Y, Roby E, et al. Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1. Nat Commun. 2016;7:11792 pubmed publisher
  25. Prabhudesai S, Bensabeur F, Abdullah R, Basak I, Baez S, Alves G, et al. LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation. J Neurosci Res. 2016;94:717-35 pubmed publisher
  26. Lin A, Li C, Xing Z, Hu Q, Liang K, Han L, et al. The LINK-A lncRNA activates normoxic HIF1? signalling in triple-negative breast cancer. Nat Cell Biol. 2016;18:213-24 pubmed publisher
  27. Schwab A, Ebert A. Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation. Stem Cell Reports. 2015;5:1039-1052 pubmed publisher
  28. Smith G, Jansson J, Rocha E, Osborn T, Hallett P, Isacson O. Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition. Mol Neurobiol. 2016;53:5161-77 pubmed publisher
  29. Ho D, Kim H, Kim J, Sim H, Ahn H, Kim J, et al. Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression. Mol Brain. 2015;8:54 pubmed publisher
  30. Civiero L, Cirnaru M, Beilina A, Rodella U, Russo I, Belluzzi E, et al. Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain. J Neurochem. 2015;135:1242-56 pubmed publisher
  31. Choi I, Kim B, Byun J, Baik S, Huh Y, Kim J, et al. LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase. Nat Commun. 2015;6:8255 pubmed publisher
  32. Imai Y, Kobayashi Y, Inoshita T, Meng H, Arano T, Uemura K, et al. The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. PLoS Genet. 2015;11:e1005503 pubmed publisher
  33. Volta M, Cataldi S, Beccano Kelly D, Munsie L, Tatarnikov I, Chou P, et al. Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release. Parkinsonism Relat Disord. 2015;21:1156-63 pubmed publisher
  34. Zhao J, Molitor T, Langston J, Nichols R. LRRK2 dephosphorylation increases its ubiquitination. Biochem J. 2015;469:107-20 pubmed publisher
  35. Boddu R, Hull T, Bolisetty S, Hu X, Moehle M, Daher J, et al. Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury. Hum Mol Genet. 2015;24:4078-93 pubmed publisher
  36. Fuji R, Flagella M, Baca M, Baptista M, Brodbeck J, Chan B, et al. Effect of selective LRRK2 kinase inhibition on nonhuman primate lung. Sci Transl Med. 2015;7:273ra15 pubmed publisher
  37. Yun H, Kim H, Ga I, Oh H, Ho D, Kim J, et al. An early endosome regulator, Rab5b, is an LRRK2 kinase substrate. J Biochem. 2015;157:485-95 pubmed publisher
  38. Ho D, Yi S, Seo H, Son I, Seol W. Increased DJ-1 in urine exosome of Korean males with Parkinson's disease. Biomed Res Int. 2014;2014:704678 pubmed publisher
  39. Walker M, Volta M, Cataldi S, Dinelle K, Beccano Kelly D, Munsie L, et al. Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging. J Parkinsons Dis. 2014;4:483-98 pubmed publisher
  40. West A, Cowell R, Daher J, Moehle M, Hinkle K, Melrose H, et al. Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents. J Comp Neurol. 2014;522:2465-80 pubmed publisher
  41. Law B, Spain V, Leinster V, Chia R, Beilina A, Cho H, et al. A direct interaction between leucine-rich repeat kinase 2 and specific ?-tubulin isoforms regulates tubulin acetylation. J Biol Chem. 2014;289:895-908 pubmed publisher
  42. Davies P, Hinkle K, Sukar N, Sepulveda B, Mesias R, Serrano G, et al. Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies. Biochem J. 2013;453:101-13 pubmed publisher
  43. Hinkle K, Yue M, Behrouz B, Dachsel J, Lincoln S, Bowles E, et al. LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors. Mol Neurodegener. 2012;7:25 pubmed publisher