This is a Validated Antibody Database (VAD) review about human LRRC8, based on 3 published articles (read how Labome selects the articles), using LRRC8 antibody in all methods. It is aimed to help Labome visitors find the most suited LRRC8 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
LRRC8 synonym: AGM5; LRRC8; SWELL1; volume-regulated anion channel subunit LRRC8A; leucine rich repeat containing 8 family member A; leucine-rich repeat-containing protein 8A; swelling protein 1

Bethyl
rabbit polyclonal
  • western blot; human; loading ...; fig 1a
Bethyl LRRC8 antibody (Bethyl antibodies, A304-175-A) was used in western blot on human samples (fig 1a). Neurobiol Dis (2018) ncbi
rabbit polyclonal
  • immunoprecipitation; mouse; fig 7a
  • western blot; mouse; fig 3a
Bethyl LRRC8 antibody (Bethyl Laboratories, A304-175A) was used in immunoprecipitation on mouse samples (fig 7a) and in western blot on mouse samples (fig 3a). Free Radic Biol Med (2016) ncbi
Sigma-Aldrich
rabbit polyclonal
  • western blot; human; fig 8
Sigma-Aldrich LRRC8 antibody (Sigma-Aldrich, HPA01681) was used in western blot on human samples (fig 8). Proc Natl Acad Sci U S A (2015) ncbi
Articles Reviewed
  1. Elorza Vidal X, Sirisi S, Gaitán Peñas H, Pérez Rius C, Alonso Gardón M, Armand Ugon M, et al. GlialCAM/MLC1 modulates LRRC8/VRAC currents in an indirect manner: Implications for megalencephalic leukoencephalopathy. Neurobiol Dis. 2018;119:88-99 pubmed publisher
  2. Choi H, Ettinger N, Rohrbough J, Dikalova A, Nguyen H, Lamb F. LRRC8A channels support TNF?-induced superoxide production by Nox1 which is required for receptor endocytosis. Free Radic Biol Med. 2016;101:413-423 pubmed publisher
  3. Milenkovic A, Brandl C, Milenkovic V, Jendryke T, Sirianant L, Wanitchakool P, et al. Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells. Proc Natl Acad Sci U S A. 2015;112:E2630-9 pubmed publisher