This is a Validated Antibody Database (VAD) review about human LRP8, based on 9 published articles (read how Labome selects the articles), using LRP8 antibody in all methods. It is aimed to help Labome visitors find the most suited LRP8 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
LRP8 synonym: APOER2; HSZ75190; LRP-8; MCI1; low-density lipoprotein receptor-related protein 8; ApoE receptor 2; low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

Knockout validation
Abcam
rabbit monoclonal (EPR3326)
  • western blot knockout validation; mouse; fig 3a
  • immunoprecipitation; mouse; fig 3i
Abcam LRP8 antibody (Abcam, ab108208) was used in western blot knockout validation on mouse samples (fig 3a) and in immunoprecipitation on mouse samples (fig 3i). Neuron (2015) ncbi
Abcam
rabbit monoclonal (EPR3326)
  • western blot; mouse; 1:2000; loading ...; fig 4c
Abcam LRP8 antibody (Abcam, ab108208) was used in western blot on mouse samples at 1:2000 (fig 4c). EMBO Mol Med (2016) ncbi
rabbit monoclonal (EPR3326)
  • immunohistochemistry - frozen section; mouse; 1:500; fig 2
  • immunocytochemistry; mouse; 1:500; fig 1
  • western blot; mouse; 1:500; fig 3
Abcam LRP8 antibody (Abcam, ab108208) was used in immunohistochemistry - frozen section on mouse samples at 1:500 (fig 2), in immunocytochemistry on mouse samples at 1:500 (fig 1) and in western blot on mouse samples at 1:500 (fig 3). Front Cell Neurosci (2015) ncbi
rabbit monoclonal (EPR3326)
  • western blot knockout validation; mouse; fig 3a
  • immunoprecipitation; mouse; fig 3i
Abcam LRP8 antibody (Abcam, ab108208) was used in western blot knockout validation on mouse samples (fig 3a) and in immunoprecipitation on mouse samples (fig 3i). Neuron (2015) ncbi
rabbit monoclonal (EPR3326)
Abcam LRP8 antibody (Abcam, ab108208) was used . PLoS ONE (2014) ncbi
rabbit monoclonal (EPR3326)
  • immunohistochemistry - frozen section; mouse
  • western blot; mouse
Abcam LRP8 antibody (Abcam, ab108208) was used in immunohistochemistry - frozen section on mouse samples and in western blot on mouse samples . J Comp Neurol (2015) ncbi
rabbit monoclonal (EPR3326)
  • western blot; mouse
Abcam LRP8 antibody (Abcam, ab108208) was used in western blot on mouse samples . J Neurosci (2013) ncbi
Abnova
mouse monoclonal (3H2)
  • western blot; mouse; 0.2 ug/ml
In order to test if proprotein convertase subtilisin/kexin type 9 modulates the levels of low-density lipoprotein receptor and other membrane-bound proteins in the adult mouse brain, Abnova LRP8 antibody (Abnova, H00007804-M01) was used in western blot on mouse samples at 0.2 ug/ml. J Lipid Res (2010) ncbi
MilliporeSigma
rabbit polyclonal
  • western blot; human; 1:1000; fig 2a
MilliporeSigma LRP8 antibody (Sigma, A3481) was used in western blot on human samples at 1:1000 (fig 2a). Science (2018) ncbi
rabbit polyclonal
In order to test if impairment of reelin signaling in adult neurons reactivates the dendritic architecture, MilliporeSigma LRP8 antibody (Sigma, A-3481) was used . J Cell Physiol (2017) ncbi
Articles Reviewed
  1. Segarra M, Aburto M, Cop F, Llaó Cid C, Härtl R, Damm M, et al. Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system. Science. 2018;361: pubmed publisher
  2. Ampuero E, Jury N, Hartel S, Marzolo M, van Zundert B. Interfering of the Reelin/ApoER2/PSD95 Signaling Axis Reactivates Dendritogenesis of Mature Hippocampal Neurons. J Cell Physiol. 2017;232:1187-1199 pubmed publisher
  3. Hinrich A, Jodelka F, Chang J, Brutman D, Bruno A, Briggs C, et al. Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides. EMBO Mol Med. 2016;8:328-45 pubmed publisher
  4. Brai E, Marathe S, Astori S, Fredj N, Perry E, Lamy C, et al. Notch1 Regulates Hippocampal Plasticity Through Interaction with the Reelin Pathway, Glutamatergic Transmission and CREB Signaling. Front Cell Neurosci. 2015;9:447 pubmed publisher
  5. Telese F, Ma Q, Perez P, Notani D, Oh S, Li W, et al. LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation. Neuron. 2015;86:696-710 pubmed publisher
  6. Burrell T, Divekar S, Weeber E, Rebeck G. Fyn tyrosine kinase increases Apolipoprotein E Receptor 2 levels and phosphorylation. PLoS ONE. 2014;9:e110845 pubmed publisher
  7. Hirota Y, Kubo K, Katayama K, Honda T, Fujino T, Yamamoto T, et al. Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex. J Comp Neurol. 2015;523:463-78 pubmed publisher
  8. Trotter J, Lee G, Kazdoba T, Crowell B, Domogauer J, Mahoney H, et al. Dab1 is required for synaptic plasticity and associative learning. J Neurosci. 2013;33:15652-68 pubmed publisher
  9. Liu M, Wu G, Baysarowich J, Kavana M, Addona G, Bierilo K, et al. PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain. J Lipid Res. 2010;51:2611-8 pubmed publisher