This is a Validated Antibody Database (VAD) review about human LRP1, based on 32 published articles (read how Labome selects the articles), using LRP1 antibody in all methods. It is aimed to help Labome visitors find the most suited LRP1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
LRP1 synonym: A2MR; APOER; APR; CD91; IGFBP-3R; IGFBP3R; IGFBP3R1; KPA; LRP; LRP1A; TGFBR5

Knockout validation
Abcam
domestic rabbit monoclonal (EPR3724)
  • immunohistochemistry knockout validation; mouse; 1:500; loading ...; fig 1a
  • western blot; mouse; 1:10,000; loading ...; fig 1f
Abcam LRP1 antibody (Abcam, ab92544) was used in immunohistochemistry knockout validation on mouse samples at 1:500 (fig 1a) and in western blot on mouse samples at 1:10,000 (fig 1f). Front Cell Neurosci (2021) ncbi
Abcam
domestic rabbit monoclonal (EPR3724)
  • immunohistochemistry knockout validation; mouse; 1:100; fig 1g
Abcam LRP1 antibody (Abcam, ab92544) was used in immunohistochemistry knockout validation on mouse samples at 1:100 (fig 1g). J Exp Med (2021) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • western blot knockout validation; human; 1:1000; fig s1e
MilliporeSigma LRP1 antibody (Sigma, L2295) was used in western blot knockout validation on human samples at 1:1000 (fig s1e). Nature (2020) ncbi
Abcam
domestic rabbit monoclonal (EPR3724)
  • western blot; human; 1:1000; fig 6e
Abcam LRP1 antibody (Abcam, ab92544) was used in western blot on human samples at 1:1000 (fig 6e). Cell Mol Life Sci (2022) ncbi
domestic rabbit monoclonal (EPR3724)
  • western blot; mouse
Abcam LRP1 antibody (Abcam, EPR3724) was used in western blot on mouse samples . Adv Sci (Weinh) (2021) ncbi
domestic rabbit monoclonal (EPR3724)
  • western blot; mouse
Abcam LRP1 antibody (Abcam, EPR3724) was used in western blot on mouse samples . Alzheimers Res Ther (2021) ncbi
domestic rabbit monoclonal (EPR3724)
  • immunohistochemistry knockout validation; mouse; 1:500; loading ...; fig 1a
  • western blot; mouse; 1:10,000; loading ...; fig 1f
Abcam LRP1 antibody (Abcam, ab92544) was used in immunohistochemistry knockout validation on mouse samples at 1:500 (fig 1a) and in western blot on mouse samples at 1:10,000 (fig 1f). Front Cell Neurosci (2021) ncbi
domestic rabbit monoclonal (EPR3724)
  • immunohistochemistry knockout validation; mouse; 1:100; fig 1g
Abcam LRP1 antibody (Abcam, ab92544) was used in immunohistochemistry knockout validation on mouse samples at 1:100 (fig 1g). J Exp Med (2021) ncbi
domestic rabbit monoclonal (EPR3724)
  • immunohistochemistry; human; 1:200; loading ...; fig 6c
Abcam LRP1 antibody (Abcam, ab92544) was used in immunohistochemistry on human samples at 1:200 (fig 6c). Acta Neuropathol (2020) ncbi
domestic rabbit monoclonal (EPR3724)
  • immunocytochemistry; human; 1:200; loading ...; fig 4a
  • western blot; human; 1:2000; loading ...; fig 4b
Abcam LRP1 antibody (Abcam, ab92544) was used in immunocytochemistry on human samples at 1:200 (fig 4a) and in western blot on human samples at 1:2000 (fig 4b). Acta Neuropathol Commun (2019) ncbi
domestic rabbit monoclonal (EPR3724)
  • western blot; mouse; 1:1000; loading ...; fig 2j
Abcam LRP1 antibody (Abcam, ab92544) was used in western blot on mouse samples at 1:1000 (fig 2j). CNS Neurosci Ther (2020) ncbi
domestic rabbit monoclonal (EPR3724)
  • other; mouse; loading ...; fig 4f
  • immunocytochemistry; mouse; loading ...; fig 5a
Abcam LRP1 antibody (Abcam, ab195567) was used in other on mouse samples (fig 4f) and in immunocytochemistry on mouse samples (fig 5a). J Exp Med (2019) ncbi
domestic rabbit monoclonal (EPR3724)
  • western blot; human; loading ...; fig 4a
Abcam LRP1 antibody (Abcam, ab92544) was used in western blot on human samples (fig 4a). Cell Rep (2018) ncbi
domestic rabbit monoclonal (EPR3724)
  • immunohistochemistry; mouse; 1:500; loading ...; fig 4d
Abcam LRP1 antibody (Abcam, ab92544) was used in immunohistochemistry on mouse samples at 1:500 (fig 4d). Brain Behav Immun (2018) ncbi
domestic rabbit monoclonal (EPR3724)
  • western blot; mouse; loading ...; fig s1a
Abcam LRP1 antibody (Abcam, ab92544) was used in western blot on mouse samples (fig s1a). Arterioscler Thromb Vasc Biol (2018) ncbi
domestic rabbit monoclonal (EPR3724)
  • western blot; mouse; loading ...; fig s5d
Abcam LRP1 antibody (Abcam, ab92544) was used in western blot on mouse samples (fig s5d). PLoS Genet (2017) ncbi
domestic rabbit monoclonal (EPR3724)
  • blocking or activating experiments; rat; loading ...; fig 3g
In order to elucidate the regulation and function of enzymatically inactive heparanase, Abcam LRP1 antibody (Abcam, ab92544) was used in blocking or activating experiments on rat samples (fig 3g). Cardiovasc Res (2016) ncbi
domestic rabbit monoclonal (EPR3724)
  • western blot; mouse; fig  1
Abcam LRP1 antibody (Epitomics, 2703-1) was used in western blot on mouse samples (fig  1). J Mol Cell Cardiol (2015) ncbi
mouse monoclonal (8G1)
  • western blot; human
In order to identify the intracellular signaling pathways by which IL-1 causes aggrecan degradation by human chondrocytes and investigate how aggrecanase activity is regulated in chondrocytes, Abcam LRP1 antibody (Abcam, 8G1) was used in western blot on human samples . Arthritis Rheumatol (2015) ncbi
domestic rabbit monoclonal (EPR3724)
  • western blot; mouse
Abcam LRP1 antibody (Epitomics, 2703-1) was used in western blot on mouse samples . J Neuroinflammation (2014) ncbi
Invitrogen
domestic rabbit recombinant (SA0290)
  • immunohistochemistry; mouse; 1:300; loading ...
Invitrogen LRP1 antibody (Thermo Fisher, MA5-31959) was used in immunohistochemistry on mouse samples at 1:300. Nat Commun (2021) ncbi
mouse monoclonal (A2MR-alpha-2)
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 5i
Invitrogen LRP1 antibody (Thermo Fisher, 37-3800) was used in immunohistochemistry - frozen section on mouse samples at 1:100 (fig 5i). Nat Commun (2020) ncbi
mouse monoclonal (A2MR-a2)
  • flow cytometry; human; tbl 1
In order to compare methods of isolating skin mononuclear phagocytes, Invitrogen LRP1 antibody (eBioscience, A2MR-a2) was used in flow cytometry on human samples (tbl 1). J Leukoc Biol (2017) ncbi
mouse monoclonal (8G1)
  • flow cytometry; human; 20 ug/ml; fig 4
In order to investigate the impact of CD1c positive dendritic cells on immunogenic cell death, Invitrogen LRP1 antibody (Thermo Fisher, MA1-27198) was used in flow cytometry on human samples at 20 ug/ml (fig 4). Oncoimmunology (2016) ncbi
mouse monoclonal (A2MR-beta-1)
  • western blot; human; fig 3
In order to report that heat shock protein-90alpha allows cancer cells to survive hypoxia, Invitrogen LRP1 antibody (Life Technologies, 37?C7600) was used in western blot on human samples (fig 3). Sci Rep (2016) ncbi
mouse monoclonal (8G1)
  • blocking or activating experiments; human; 30 ug/ml
In order to study the role of low-density lipoprotein receptor-related protein 1 in abdominal aortic aneurysm, Invitrogen LRP1 antibody (Thermo, MA1-27198) was used in blocking or activating experiments on human samples at 30 ug/ml. Eur J Vasc Endovasc Surg (2015) ncbi
mouse monoclonal (A2MR-beta-1)
  • western blot; human
In order to elucidate a role for heat shock proteins in ischemia, Invitrogen LRP1 antibody (Life Technologies, 37-7600) was used in western blot on human samples . J Cell Sci (2015) ncbi
mouse monoclonal (A2MR-beta-1)
  • immunoprecipitation; human; fig 4
  • western blot; human; fig 4
In order to elucidate the mechanism by which eHsp90alpha regulates promotility action, Invitrogen LRP1 antibody (Invitrogen, 37-7600) was used in immunoprecipitation on human samples (fig 4) and in western blot on human samples (fig 4). Mol Cell Biol (2013) ncbi
mouse monoclonal (A2Mr alpha-2)
  • immunohistochemistry - paraffin section; human; 1:50
  • immunohistochemistry; human; 1:50
In order to study the expression of gp96, CD91 and TLR4 at the maternal-fetal interface and the clinical significance, Invitrogen LRP1 antibody (Thermo Scientific Pierce, A2Mr alpha-2) was used in immunohistochemistry - paraffin section on human samples at 1:50 and in immunohistochemistry on human samples at 1:50. Am J Reprod Immunol (2013) ncbi
mouse monoclonal (A2MR-alpha-2)
  • immunohistochemistry - paraffin section; human; 1:50
In order to study the expression of gp96, CD91 and TLR4 at the maternal-fetal interface and the clinical significance, Invitrogen LRP1 antibody (Thermo Scientific Pierce, A2Mr alpha-2) was used in immunohistochemistry - paraffin section on human samples at 1:50. Am J Reprod Immunol (2013) ncbi
Bio-Rad
mouse monoclonal (A2Mr alpha-2)
  • immunoprecipitation; human
Bio-Rad LRP1 antibody (Serotec, MCA1965) was used in immunoprecipitation on human samples . FASEB J (2013) ncbi
Santa Cruz Biotechnology
mouse monoclonal (5A6)
  • ELISA; mouse; 1:500; fig 4
Santa Cruz Biotechnology LRP1 antibody (Santa Cruz, sc-57351) was used in ELISA on mouse samples at 1:500 (fig 4). Front Neurosci (2016) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • western blot knockout validation; human; 1:1000; fig s1e
MilliporeSigma LRP1 antibody (Sigma, L2295) was used in western blot knockout validation on human samples at 1:1000 (fig s1e). Nature (2020) ncbi
mouse monoclonal (LRP1-11)
  • immunocytochemistry; human; 1:200; fig s7
  • western blot; human; 1:1000; fig s7
MilliporeSigma LRP1 antibody (Sigma, L2420) was used in immunocytochemistry on human samples at 1:200 (fig s7) and in western blot on human samples at 1:1000 (fig s7). Nat Commun (2015) ncbi
BD Biosciences
mouse monoclonal (A2MR-?2)
  • flow cytometry; human; loading ...; fig 1d
BD Biosciences LRP1 antibody (BD Biosciences, 550496) was used in flow cytometry on human samples (fig 1d). PLoS ONE (2016) ncbi
mouse monoclonal (A2MR-?2)
  • flow cytometry; human; fig st1
In order to find cell-surface markers specific to human neutrophils, BD Biosciences LRP1 antibody (BD, 550497) was used in flow cytometry on human samples (fig st1). Exp Cell Res (2016) ncbi
Articles Reviewed
  1. Wakao S, Oguma Y, Kushida Y, Kuroda Y, Tatsumi K, Dezawa M. Phagocytosing differentiated cell-fragments is a novel mechanism for controlling somatic stem cell differentiation within a short time frame. Cell Mol Life Sci. 2022;79:542 pubmed publisher
  2. Dai X, Jiang Y, Gu J, Jiang Z, Wu Y, Yu C, et al. The CNOT4 Subunit of the CCR4-NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis. Adv Sci (Weinh). 2021;8:2003636 pubmed publisher
  3. Tournissac M, Vu T, Vrabic N, Hozer C, Tremblay C, Mélançon K, et al. Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model. Alzheimers Res Ther. 2021;13:103 pubmed publisher
  4. He B, Chen P, Zambrano S, Dabaghie D, Hu Y, Möller Hackbarth K, et al. Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes. Nat Commun. 2021;12:2141 pubmed publisher
  5. Romeo R, Boden El Mourabit D, Scheller A, Mark M, Faissner A. Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) as a Novel Regulator of Early Astroglial Differentiation. Front Cell Neurosci. 2021;15:642521 pubmed publisher
  6. Nikolakopoulou A, Wang Y, Ma Q, Sagare A, Montagne A, Huuskonen M, et al. Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A. J Exp Med. 2021;218: pubmed publisher
  7. Rauch J, Luna G, Guzman E, Audouard M, Challis C, Sibih Y, et al. LRP1 is a master regulator of tau uptake and spread. Nature. 2020;580:381-385 pubmed publisher
  8. Shi H, Koronyo Y, Rentsendorj A, Regis G, Sheyn J, Fuchs D, et al. Identification of early pericyte loss and vascular amyloidosis in Alzheimer's disease retina. Acta Neuropathol. 2020;139:813-836 pubmed publisher
  9. Wang G, Xu J, Zhao J, Yin W, Liu D, Chen W, et al. Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice. Nat Commun. 2020;11:220 pubmed publisher
  10. Kirabali T, Rigotti S, Siccoli A, Liebsch F, Shobo A, Hock C, et al. The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer's disease. Acta Neuropathol Commun. 2019;7:194 pubmed publisher
  11. Zhang R, Liu Y, Chen Y, Li Q, Marshall C, Wu T, et al. Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption. CNS Neurosci Ther. 2020;26:228-239 pubmed publisher
  12. Weckbach L, Grabmaier U, Uhl A, Gess S, Boehm F, Zehrer A, et al. Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis. J Exp Med. 2019;216:350-368 pubmed publisher
  13. Leslie P, Franklin D, Liu Y, Zhang Y. p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. Cell Rep. 2018;24:1484-1495 pubmed publisher
  14. Storck S, Hartz A, Bernard J, Wolf A, Kachlmeier A, Mahringer A, et al. The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM. Brain Behav Immun. 2018;73:21-33 pubmed publisher
  15. Yu P, Xiong T, Tenedero C, Lebeau P, Ni R, Macdonald M, et al. Rosuvastatin Reduces Aortic Sinus and Coronary Artery Atherosclerosis in SR-B1 (Scavenger Receptor Class B Type 1)/ApoE (Apolipoprotein E) Double Knockout Mice Independently of Plasma Cholesterol Lowering. Arterioscler Thromb Vasc Biol. 2018;38:26-39 pubmed publisher
  16. Rocchi A, Yamamoto S, Ting T, Fan Y, SADLEIR K, Wang Y, et al. A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease. PLoS Genet. 2017;13:e1006962 pubmed publisher
  17. Botting R, Bertram K, Baharlou H, Sandgren K, Fletcher J, Rhodes J, et al. Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes. J Leukoc Biol. 2017;101:1393-1403 pubmed publisher
  18. Wang F, Jia J, Lal N, Zhang D, Chiu A, Wan A, et al. High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature. Cardiovasc Res. 2016;112:656-668 pubmed
  19. Di Blasio S, Wortel I, van Bladel D, de Vries L, Duiveman de Boer T, Worah K, et al. Human CD1c(+) DCs are critical cellular mediators of immune responses induced by immunogenic cell death. Oncoimmunology. 2016;5:e1192739 pubmed publisher
  20. Pinilla Vera M, Xiong Z, Zhao Y, Zhao J, Donahoe M, Barge S, et al. Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling. PLoS ONE. 2016;11:e0159329 pubmed publisher
  21. Löffler T, Flunkert S, Temmel M, Hutter Paier B. Decreased Plasma A? in Hyperlipidemic APPSL Transgenic Mice Is Associated with BBB Dysfunction. Front Neurosci. 2016;10:232 pubmed publisher
  22. Lakschevitz F, Hassanpour S, Rubin A, Fine N, Sun C, Glogauer M. Identification of neutrophil surface marker changes in health and inflammation using high-throughput screening flow cytometry. Exp Cell Res. 2016;342:200-9 pubmed publisher
  23. Dong H, Zou M, Bhatia A, Jayaprakash P, Hofman F, YING Q, et al. Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90α) to Survive a Hostile Hypoxic Environment. Sci Rep. 2016;6:20605 pubmed publisher
  24. Chaumet A, Wright G, Seet S, Tham K, Gounko N, Bard F. Nuclear envelope-associated endosomes deliver surface proteins to the nucleus. Nat Commun. 2015;6:8218 pubmed publisher
  25. Moxon J, Behl Gilhotra R, Morton S, Krishna S, Seto S, Biros E, et al. Plasma Low-density Lipoprotein Receptor-related Protein 1 Concentration is not Associated with Human Abdominal Aortic Aneurysm Presence. Eur J Vasc Endovasc Surg. 2015;50:466-73 pubmed publisher
  26. Revuelta López E, Cal R, Herraiz Martínez A, De Gonzalo Calvo D, Nasarre L, Roura S, et al. Hypoxia-driven sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) downregulation depends on low-density lipoprotein receptor-related protein 1 (LRP1)-signalling in cardiomyocytes. J Mol Cell Cardiol. 2015;85:25-36 pubmed publisher
  27. Ismail H, Yamamoto K, Vincent T, Nagase H, Troeberg L, Saklatvala J. Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes. Arthritis Rheumatol. 2015;67:1826-36 pubmed publisher
  28. Jayaprakash P, Dong H, Zou M, Bhatia A, O Brien K, Chen M, et al. Hsp90α and Hsp90β together operate a hypoxia and nutrient paucity stress-response mechanism during wound healing. J Cell Sci. 2015;128:1475-80 pubmed publisher
  29. Niesman I, Schilling J, Shapiro L, Kellerhals S, Bonds J, Kleschevnikov A, et al. Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice. J Neuroinflammation. 2014;11:39 pubmed publisher
  30. Tsen F, Bhatia A, O Brien K, Cheng C, Chen M, Hay N, et al. Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo. Mol Cell Biol. 2013;33:4947-59 pubmed publisher
  31. Gulic T, Laskarin G, Redzovic A, Eminović S, Haller H, Rukavina D. The significance of heat-shock protein gp96 and its receptors' CD91 and Toll-like receptor 4 expression at the maternal foetal interface. Am J Reprod Immunol. 2013;70:10-23 pubmed publisher
  32. Barcelona P, Jaldin Fincati J, Sanchez M, Chiabrando G. Activated ?2-macroglobulin induces Müller glial cell migration by regulating MT1-MMP activity through LRP1. FASEB J. 2013;27:3181-97 pubmed publisher