This is a Validated Antibody Database (VAD) review about human LRIG1, based on 3 published articles (read how Labome selects the articles), using LRIG1 antibody in all methods. It is aimed to help Labome visitors find the most suited LRIG1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
LRIG1 synonym: LIG-1; LIG1; leucine-rich repeats and immunoglobulin-like domains protein 1; leucine-rich repeat protein LRIG1; ortholog of mouse integral membrane glycoprotein LIG-1

R&D Systems
sheep polyclonal
  • immunohistochemistry; mouse; 1:100; fig 2e
In order to test if LRIG1 contributes to the ontogeny of interstitial cells of Cajal in the small and large intestines, R&D Systems LRIG1 antibody (R&D systems, AF7498) was used in immunohistochemistry on mouse samples at 1:100 (fig 2e). Gastroenterology (2015) ncbi
sheep polyclonal
  • western blot; mouse; 1:100
In order to study duodenal adenomas in leucine-rich repeats and immunoglobulin-like domains 1 -/- mice, R&D Systems LRIG1 antibody (R&D systems, AF7498) was used in western blot on mouse samples at 1:100. Am J Pathol (2015) ncbi
GeneTex
rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:100; fig 12b
In order to demonstrate that LRIG1 functions as a growth suppressor in breast cancer cells, GeneTex LRIG1 antibody (Genetex, GTX119485) was used in immunohistochemistry - paraffin section on human samples at 1:100 (fig 12b). Oncogene (2016) ncbi
Articles Reviewed
  1. Yokdang N, Hatakeyama J, Wald J, Simion C, Tellez J, Chang D, et al. LRIG1 opposes epithelial-to-mesenchymal transition and inhibits invasion of basal-like breast cancer cells. Oncogene. 2016;35:2932-47 pubmed publisher
  2. Kondo J, Powell A, Wang Y, Musser M, Southard Smith E, Franklin J, et al. LRIG1 Regulates Ontogeny of Smooth Muscle-Derived Subsets of Interstitial Cells of Cajal in Mice. Gastroenterology. 2015;149:407-19.e8 pubmed publisher
  3. Wang Y, Shi C, Lu Y, Poulin E, Franklin J, Coffey R. Loss of Lrig1 leads to expansion of Brunner glands followed by duodenal adenomas with gastric metaplasia. Am J Pathol. 2015;185:1123-34 pubmed publisher