This is a Validated Antibody Database (VAD) review about human LONP1, based on 5 published articles (read how Labome selects the articles), using LONP1 antibody in all methods. It is aimed to help Labome visitors find the most suited LONP1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
LONP1 synonym: CODASS; LON; LONP; LonHS; PIM1; PRSS15; hLON; lon protease homolog, mitochondrial; hLON ATP-dependent protease; lon protease-like protein; mitochondrial ATP-dependent protease Lon; mitochondrial lon protease-like protein; serine protease 15

Abcam
rabbit polyclonal
  • western blot; mouse; 1:1000; fig 2
In order to study the alleviation of mitochondrial cardiomyopathy without affecting the mammalian UPRmt due to loss of CLPP, Abcam LONP1 antibody (Abcam, ab103809) was used in western blot on mouse samples at 1:1000 (fig 2). EMBO Rep (2016) ncbi
rabbit polyclonal
  • western blot; mouse; 1:250; fig s12
In order to investigate PINK1-Mfn2-Parkin-mediated mitophagy in mouse hearts, Abcam LONP1 antibody (Abcam, ab103809) was used in western blot on mouse samples at 1:250 (fig s12). Science (2015) ncbi
rabbit polyclonal
  • western blot; mouse; 1:500; fig 3
Abcam LONP1 antibody (Abcam, ab103809) was used in western blot on mouse samples at 1:500 (fig 3). Cell Metab (2015) ncbi
Proteintech Group
rabbit polyclonal
  • immunohistochemistry - paraffin section; human; loading ...; fig 1c
  • immunocytochemistry; human; fig 3a
  • western blot; human; fig 2e
Proteintech Group LONP1 antibody (ProteinTech Group, 15440-1-AP) was used in immunohistochemistry - paraffin section on human samples (fig 1c), in immunocytochemistry on human samples (fig 3a) and in western blot on human samples (fig 2e). Oncotarget (2016) ncbi
Novus Biologicals
rabbit polyclonal
  • western blot; fruit fly; 1:500
In order to investigate how PINK1 is degraded, Novus Biologicals LONP1 antibody (Novus Biologicals, NBP1-81734) was used in western blot on fruit fly samples at 1:500. PLoS Genet (2014) ncbi
Articles Reviewed
  1. Di K, Lomeli N, Wood S, Vanderwal C, Bota D. Mitochondrial Lon is over-expressed in high-grade gliomas, and mediates hypoxic adaptation: potential role of Lon as a therapeutic target in glioma. Oncotarget. 2016;7:77457-77467 pubmed publisher
  2. Seiferling D, Szczepanowska K, Becker C, Senft K, Hermans S, Maiti P, et al. Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt. EMBO Rep. 2016;17:953-64 pubmed publisher
  3. Gong G, Song M, Csordás G, Kelly D, Matkovich S, Dorn G. Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science. 2015;350:aad2459 pubmed publisher
  4. Song M, Mihara K, Chen Y, Scorrano L, Dorn G. Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metab. 2015;21:273-85 pubmed publisher
  5. Thomas R, Andrews L, Burman J, Lin W, Pallanck L. PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix. PLoS Genet. 2014;10:e1004279 pubmed publisher