This is a Validated Antibody Database (VAD) review about human LATS2, based on 14 published articles (read how Labome selects the articles), using LATS2 antibody in all methods. It is aimed to help Labome visitors find the most suited LATS2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
LATS2 synonym: KPM

Knockout validation
Cell Signaling Technology
domestic rabbit monoclonal (D83D6)
  • western blot; human; loading ...; fig s2c
  • western blot knockout validation; mouse; loading ...; fig s3a
Cell Signaling Technology LATS2 antibody (Cell signaling technology, 5888) was used in western blot on human samples (fig s2c) and in western blot knockout validation on mouse samples (fig s3a). Nat Commun (2021) ncbi
Invitrogen
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 3a
Invitrogen LATS2 antibody (Invitrogen, PA5-38804) was used in western blot on mouse samples at 1:1000 (fig 3a). J Clin Invest (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 3a
Invitrogen LATS2 antibody (Invitrogen, PA5-64591) was used in western blot on mouse samples at 1:1000 (fig 3a). J Clin Invest (2021) ncbi
Abcam
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 5d
Abcam LATS2 antibody (Abcam, ab111344) was used in western blot on human samples (fig 5d). Cell Death Dis (2019) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 3d, 5d
Abcam LATS2 antibody (Abcam, ab111344) was used in western blot on human samples at 1:1000 (fig 3d, 5d). EBioMedicine (2019) ncbi
Abnova
mouse monoclonal (ST-3B11)
  • western blot; human; 1:500; fig 3
Abnova LATS2 antibody (Abnova, MAB0009) was used in western blot on human samples at 1:500 (fig 3). Oncol Lett (2016) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D83D6)
  • western blot; human; loading ...; fig 4g
Cell Signaling Technology LATS2 antibody (Cell Signal, 5888) was used in western blot on human samples (fig 4g). Clin Transl Med (2021) ncbi
domestic rabbit monoclonal (D83D6)
  • western blot; human; loading ...; fig s2c
  • western blot knockout validation; mouse; loading ...; fig s3a
Cell Signaling Technology LATS2 antibody (Cell signaling technology, 5888) was used in western blot on human samples (fig s2c) and in western blot knockout validation on mouse samples (fig s3a). Nat Commun (2021) ncbi
domestic rabbit monoclonal (D83D6)
  • western blot; human; loading ...; fig 6e
Cell Signaling Technology LATS2 antibody (Cell Signaling Technology, 5888) was used in western blot on human samples (fig 6e). EBioMedicine (2020) ncbi
domestic rabbit monoclonal (D83D6)
  • western blot; human; loading ...; fig 1f
Cell Signaling Technology LATS2 antibody (Cell Signaling, 5888) was used in western blot on human samples (fig 1f). Curr Biol (2019) ncbi
domestic rabbit monoclonal (D83D6)
  • western blot; mouse; loading ...; fig 2b
Cell Signaling Technology LATS2 antibody (Cell Signaling, 5888) was used in western blot on mouse samples (fig 2b). Oncogene (2019) ncbi
domestic rabbit monoclonal (D83D6)
  • western blot; human; loading ...; fig 1c
Cell Signaling Technology LATS2 antibody (Cell Signaling, 5888) was used in western blot on human samples (fig 1c). Mol Cell (2017) ncbi
domestic rabbit monoclonal (D83D6)
  • western blot; human; fig 5
Cell Signaling Technology LATS2 antibody (Cell signaling, 5888) was used in western blot on human samples (fig 5). J Biol Chem (2016) ncbi
domestic rabbit monoclonal (D83D6)
  • western blot; human; fig 3
In order to study the activation mechanisms of core Hippo pathway components, Cell Signaling Technology LATS2 antibody (Cell Signaling Technology, 5888) was used in western blot on human samples (fig 3). EMBO Rep (2016) ncbi
domestic rabbit monoclonal (D83D6)
  • western blot; human; 1:1000; fig 1
Cell Signaling Technology LATS2 antibody (Cell signaling, 5888) was used in western blot on human samples at 1:1000 (fig 1). Nat Commun (2015) ncbi
domestic rabbit monoclonal (D83D6)
  • western blot; human; fig 3
Cell Signaling Technology LATS2 antibody (Cell Signaling, 5888) was used in western blot on human samples (fig 3). Nat Commun (2014) ncbi
Articles Reviewed
  1. Zhang Y, He L, Huang L, Yao S, Lin N, Li P, et al. Oncogenic PAX6 elicits CDK4/6 inhibitor resistance by epigenetically inactivating the LATS2-Hippo signaling pathway. Clin Transl Med. 2021;11:e503 pubmed publisher
  2. Yuan T, Annamalai K, Naik S, Lupse B, Geravandi S, Pal A, et al. The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis. Nat Commun. 2021;12:4928 pubmed publisher
  3. Tamura T, Kodama T, Sato K, Murai K, Yoshioka T, Shigekawa M, et al. Dysregulation of PI3K and Hippo signaling pathways synergistically induces chronic pancreatitis via CTGF upregulation. J Clin Invest. 2021;131: pubmed publisher
  4. Yin L, Li W, Xu A, Shi H, Wang K, Yang H, et al. SH3BGRL2 inhibits growth and metastasis in clear cell renal cell carcinoma via activating hippo/TEAD1-Twist1 pathway. EBioMedicine. 2020;51:102596 pubmed publisher
  5. Yu S, Zhang Y, Li Q, Zhang Z, Zhao G, Xu J. CLDN6 promotes tumor progression through the YAP1-snail1 axis in gastric cancer. Cell Death Dis. 2019;10:949 pubmed publisher
  6. Yu M, Cui R, Huang Y, Luo Y, Qin S, Zhong M. Increased proton-sensing receptor GPR4 signalling promotes colorectal cancer progression by activating the hippo pathway. EBioMedicine. 2019;48:264-276 pubmed publisher
  7. Rausch V, Bostrom J, Park J, Bravo I, Feng Y, Hay D, et al. The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae. Curr Biol. 2019;29:242-255.e6 pubmed publisher
  8. Pan W, Moroishi T, Koo J, Guan K. Cell type-dependent function of LATS1/2 in cancer cell growth. Oncogene. 2019;38:2595-2610 pubmed publisher
  9. Peng C, Zhu Y, Zhang W, Liao Q, Chen Y, Zhao X, et al. Regulation of the Hippo-YAP Pathway by Glucose Sensor O-GlcNAcylation. Mol Cell. 2017;68:591-604.e5 pubmed publisher
  10. Zheng Y, Xiao K, Xiao G, Tong S, Ding Y, Wang Q, et al. MicroRNA-103 promotes tumor growth and metastasis in colorectal cancer by directly targeting LATS2. Oncol Lett. 2016;12:2194-2200 pubmed
  11. Chen X, Stauffer S, Chen Y, Dong J. Ajuba Phosphorylation by CDK1 Promotes Cell Proliferation and Tumorigenesis. J Biol Chem. 2016;291:14761-72 pubmed publisher
  12. Kim M, Kim M, Park S, Lee C, Lim D. Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition. EMBO Rep. 2016;17:64-78 pubmed publisher
  13. Meng Z, Moroishi T, Mottier Pavie V, Plouffe S, Hansen C, Hong A, et al. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun. 2015;6:8357 pubmed publisher
  14. Kim M, Kim M, Lee M, Kim C, Lim D. The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis. Nat Commun. 2014;5:5370 pubmed publisher