This is a Validated Antibody Database (VAD) review about human LAMTOR1, based on 10 published articles (read how Labome selects the articles), using LAMTOR1 antibody in all methods. It is aimed to help Labome visitors find the most suited LAMTOR1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
LAMTOR1 synonym: C11orf59; PDRO; Ragulator1; p18; p27RF-Rho

Knockout validation
Cell Signaling Technology
domestic rabbit monoclonal (D11H6)
  • western blot knockout validation; mouse; loading ...; fig 2i, s3c, 9c
  • western blot knockout validation; human; loading ...; fig 6c
Cell Signaling Technology LAMTOR1 antibody (Cell Signaling, 8975) was used in western blot knockout validation on mouse samples (fig 2i, s3c, 9c) and in western blot knockout validation on human samples (fig 6c). Nat Commun (2021) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D11H6)
  • western blot knockout validation; mouse; loading ...; fig 1a
Cell Signaling Technology LAMTOR1 antibody (Cell Signaling, 8975S) was used in western blot knockout validation on mouse samples (fig 1a). Front Cell Dev Biol (2021) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D11H6)
  • immunocytochemistry knockout validation; mouse; loading ...; fig 1g
  • western blot knockout validation; mouse; 1:2000; loading ...; fig 3d
In order to describe how amino acids and Lamtor1 regulate macrophage polarization, Cell Signaling Technology LAMTOR1 antibody (Cell Signaling, 8975) was used in immunocytochemistry knockout validation on mouse samples (fig 1g) and in western blot knockout validation on mouse samples at 1:2000 (fig 3d). Nat Commun (2016) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D11H6)
  • western blot knockout validation; mouse; loading ...; fig 2i, s3c, 9c
  • western blot knockout validation; human; loading ...; fig 6c
Cell Signaling Technology LAMTOR1 antibody (Cell Signaling, 8975) was used in western blot knockout validation on mouse samples (fig 2i, s3c, 9c) and in western blot knockout validation on human samples (fig 6c). Nat Commun (2021) ncbi
domestic rabbit monoclonal (D11H6)
  • western blot knockout validation; mouse; loading ...; fig 1a
Cell Signaling Technology LAMTOR1 antibody (Cell Signaling, 8975S) was used in western blot knockout validation on mouse samples (fig 1a). Front Cell Dev Biol (2021) ncbi
domestic rabbit monoclonal (D11H6)
  • western blot; human; loading ...; fig 7f
Cell Signaling Technology LAMTOR1 antibody (Cell Signaling, 8975T) was used in western blot on human samples (fig 7f). Science (2019) ncbi
domestic rabbit monoclonal (D11H6)
  • western blot; human; loading ...; fig s3a
Cell Signaling Technology LAMTOR1 antibody (Cell Signaling Technology, 8975) was used in western blot on human samples (fig s3a). Cell Metab (2019) ncbi
domestic rabbit monoclonal (D11H6)
  • western blot; human; 1:1000; loading ...; fig 4a
Cell Signaling Technology LAMTOR1 antibody (Cell Signaling, 8975) was used in western blot on human samples at 1:1000 (fig 4a). Nat Commun (2018) ncbi
domestic rabbit monoclonal (D11H6)
  • immunocytochemistry knockout validation; mouse; loading ...; fig 1g
  • western blot knockout validation; mouse; 1:2000; loading ...; fig 3d
In order to describe how amino acids and Lamtor1 regulate macrophage polarization, Cell Signaling Technology LAMTOR1 antibody (Cell Signaling, 8975) was used in immunocytochemistry knockout validation on mouse samples (fig 1g) and in western blot knockout validation on mouse samples at 1:2000 (fig 3d). Nat Commun (2016) ncbi
domestic rabbit monoclonal (D11H6)
  • western blot; human; 1:1000; fig s2
In order to elucidate the mechanisms by which mutant IDH1/2 contributes to oncogenesis, Cell Signaling Technology LAMTOR1 antibody (Cell signaling, D11H6) was used in western blot on human samples at 1:1000 (fig s2). Nat Commun (2016) ncbi
domestic rabbit monoclonal (D11H6)
  • western blot; rat; 1:1000
In order to investigate the role of p18, Rab4, Rab7, and Rab9 in vessel formation within the pulmonary vasculature, Cell Signaling Technology LAMTOR1 antibody (Cell Signaling, 8975S) was used in western blot on rat samples at 1:1000. Am J Physiol Lung Cell Mol Physiol (2015) ncbi
domestic rabbit monoclonal (D11H6)
  • western blot; human; fig 1
Cell Signaling Technology LAMTOR1 antibody (Cell signaling, 8975) was used in western blot on human samples (fig 1). Nature (2015) ncbi
domestic rabbit monoclonal (D11H6)
  • western blot; human; 1:500
Cell Signaling Technology LAMTOR1 antibody (Cell Signaling Technology, 8975) was used in western blot on human samples at 1:500. J Virol (2013) ncbi
Articles Reviewed
  1. Nakatani T, Tsujimoto K, Park J, Jo T, Kimura T, Hayama Y, et al. The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II. Nat Commun. 2021;12:3333 pubmed publisher
  2. Ying L, Zhang M, Ma X, Si Y, Li X, Su J, et al. Macrophage LAMTOR1 Deficiency Prevents Dietary Obesity and Insulin Resistance Through Inflammation-Induced Energy Expenditure. Front Cell Dev Biol. 2021;9:672032 pubmed publisher
  3. Timms R, Zhang Z, Rhee D, Harper J, Koren I, Elledge S. A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation. Science. 2019;365: pubmed publisher
  4. Son S, Park S, Lee H, Siddiqi F, Lee J, Menzies F, et al. Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A. Cell Metab. 2019;29:192-201.e7 pubmed publisher
  5. Hsu C, Lee E, Gordon K, Paz E, Shen W, Ohnishi K, et al. MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB. Nat Commun. 2018;9:942 pubmed publisher
  6. Kimura T, Nada S, Takegahara N, Okuno T, Nojima S, Kang S, et al. Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals. Nat Commun. 2016;7:13130 pubmed publisher
  7. Carbonneau M, M Gagné L, Lalonde M, Germain M, Motorina A, Guiot M, et al. The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat Commun. 2016;7:12700 pubmed publisher
  8. Chichger H, Braza J, Duong H, Stark M, Harrington E. Neovascularization in the pulmonary endothelium is regulated by the endosome: Rab4-mediated trafficking and p18-dependent signaling. Am J Physiol Lung Cell Mol Physiol. 2015;309:L700-9 pubmed publisher
  9. Rebsamen M, Pochini L, Stasyk T, de Araújo M, Galluccio M, Kandasamy R, et al. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. Nature. 2015;519:477-81 pubmed publisher
  10. McNulty S, Flint M, Nichol S, Spiropoulou C. Host mTORC1 signaling regulates andes virus replication. J Virol. 2013;87:912-22 pubmed publisher