This is a Validated Antibody Database (VAD) review about human Kv1.2, based on 17 published articles (read how Labome selects the articles), using Kv1.2 antibody in all methods. It is aimed to help Labome visitors find the most suited Kv1.2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Kv1.2 synonym: EIEE32; HBK5; HK4; HUKIV; KV1.2; MK2; NGK1; RBK2

Abcam
mouse monoclonal (K14/16)
  • immunohistochemistry; mouse; 1:200; loading ...; fig 5f
Abcam Kv1.2 antibody (Abcam, Ab192758) was used in immunohistochemistry on mouse samples at 1:200 (fig 5f). J Cell Biol (2018) ncbi
Neuromab
mouse monoclonal (K14/16)
  • immunohistochemistry - free floating section; mouse; 1:300; loading ...; fig 6
Neuromab Kv1.2 antibody (NeuroMab, N75-008) was used in immunohistochemistry - free floating section on mouse samples at 1:300 (fig 6). elife (2022) ncbi
mouse monoclonal (K14/16)
  • immunohistochemistry - frozen section; mouse; loading ...; fig s7
Neuromab Kv1.2 antibody (NeuroMab, 75-008) was used in immunohistochemistry - frozen section on mouse samples (fig s7). Proc Natl Acad Sci U S A (2021) ncbi
mouse monoclonal (K14/16)
  • immunohistochemistry; rat; 1:100; loading ...; fig 7e
  • western blot; rat; 1:500; loading ...; fig 5a
Neuromab Kv1.2 antibody (NeuroMab, 75-C008) was used in immunohistochemistry on rat samples at 1:100 (fig 7e) and in western blot on rat samples at 1:500 (fig 5a). elife (2020) ncbi
mouse monoclonal (K14/16)
  • western blot; mouse; loading ...; fig 3g
Neuromab Kv1.2 antibody (UC Davis/NIH NeuroMab Facility, 75-008) was used in western blot on mouse samples (fig 3g). Neuron (2021) ncbi
mouse monoclonal (K14/16)
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 5d
Neuromab Kv1.2 antibody (Neuromab, K14_16) was used in immunohistochemistry - frozen section on mouse samples at 1:500 (fig 5d). elife (2020) ncbi
mouse monoclonal (K14/16)
  • immunohistochemistry; mouse; 1:200; loading ...; fig 2
  • western blot; mouse; 1:1000; loading ...; fig 3g
Neuromab Kv1.2 antibody (UC Davis/NIH NeuroMab, 75?\008) was used in immunohistochemistry on mouse samples at 1:200 (fig 2) and in western blot on mouse samples at 1:1000 (fig 3g). J Neurosci Res (2019) ncbi
mouse monoclonal (K14/16)
  • immunocytochemistry; mouse; fig 2a
  • western blot; mouse; loading ...; fig 2f
Neuromab Kv1.2 antibody (NeuroMab, K14/16) was used in immunocytochemistry on mouse samples (fig 2a) and in western blot on mouse samples (fig 2f). Mol Psychiatry (2018) ncbi
mouse monoclonal (K14/16)
  • immunohistochemistry; mouse; loading ...; fig 4c
Neuromab Kv1.2 antibody (UC Davis/NIH NeuroMab Facility, K14/16) was used in immunohistochemistry on mouse samples (fig 4c). Eneuro (2017) ncbi
mouse monoclonal (K14/16)
  • immunocytochemistry; mouse; 1:200; fig 3e
Neuromab Kv1.2 antibody (NeuroMab, 75-008) was used in immunocytochemistry on mouse samples at 1:200 (fig 3e). Front Cell Neurosci (2017) ncbi
mouse monoclonal (K14/16)
  • immunohistochemistry; mouse; 1:500
In order to investigate mechanisms that regulate myelin growth and nerve conduction, Neuromab Kv1.2 antibody (Antibodies incorporated, 75-008) was used in immunohistochemistry on mouse samples at 1:500. Nat Commun (2016) ncbi
mouse monoclonal (K14/16)
  • western blot; mouse; fig 7
In order to analyze selective partitioning into complexes and supercomplexes during synapse maturation by NMDA receptors, Neuromab Kv1.2 antibody (NeuroMab, 75-008) was used in western blot on mouse samples (fig 7). Nat Commun (2016) ncbi
mouse monoclonal (K14/16)
  • immunohistochemistry - frozen section; mouse; 1:200; fig 2
Neuromab Kv1.2 antibody (Neuromab, 75-008) was used in immunohistochemistry - frozen section on mouse samples at 1:200 (fig 2). Stem Cell Reports (2016) ncbi
mouse monoclonal (K14/16)
  • western blot; mouse; 1:2
In order to assess if impaired voltage-gated K(+) channel function contributes to arterial tone during diabetes, Neuromab Kv1.2 antibody (NeuroMab, 14/16) was used in western blot on mouse samples at 1:2. J Biol Chem (2015) ncbi
mouse monoclonal (K14/16)
  • western blot; mouse; 1:1000; fig 3b
In order to use mouse models to discover mechanisms that lead to LGI1-related epilepsy, Neuromab Kv1.2 antibody (NeuroMab, K14/16) was used in western blot on mouse samples at 1:1000 (fig 3b). Nat Med (2015) ncbi
mouse monoclonal (K14/16)
  • western blot; mouse; fig 4
In order to elucidate the molecular mechanisms underlying paranodal junction assembly, Neuromab Kv1.2 antibody (NeuroMab, K14/16) was used in western blot on mouse samples (fig 4). Nat Neurosci (2014) ncbi
mouse monoclonal (K14/16)
  • immunohistochemistry - free floating section; rat; 10 ug/ml
In order to study Kv2.1 function and membrane excitability in the axon initial segment, Neuromab Kv1.2 antibody (NeuroMab, 75-008) was used in immunohistochemistry - free floating section on rat samples at 10 ug/ml. J Comp Neurol (2014) ncbi
Articles Reviewed
  1. Merseburg A, Kasemir J, Buss E, Leroy F, Bock T, Porro A, et al. Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy. elife. 2022;11: pubmed publisher
  2. Fukata Y, Chen X, Chiken S, Hirano Y, Yamagata A, Inahashi H, et al. LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  3. Sanders S, Hernandez L, Soh H, Karnam S, Walikonis R, Tzingounis A, et al. The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment. elife. 2020;9: pubmed publisher
  4. Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht M, et al. Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum. Neuron. 2021;109:299-313.e9 pubmed publisher
  5. Liu C, Stevens S, Teliska L, Stankewich M, Mohler P, Hund T, et al. Nodal β spectrins are required to maintain Na+ channel clustering and axon integrity. elife. 2020;9: pubmed publisher
  6. Saifetiarova J, Bhat M. Ablation of cytoskeletal scaffolding proteins, Band 4.1B and Whirlin, leads to cerebellar purkinje axon pathology and motor dysfunction. J Neurosci Res. 2019;97:313-331 pubmed publisher
  7. Yang Y, Arsenault J, Bah A, Krzeminski M, Fekete A, Chao O, et al. Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain. Mol Psychiatry. 2018;: pubmed publisher
  8. Montani L, Pereira J, Norrmen C, Pohl H, Tinelli E, Trötzmüller M, et al. De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination. J Cell Biol. 2018;217:1353-1368 pubmed publisher
  9. Browne L, Smith K, Jagger D. Identification of Persistent and Resurgent Sodium Currents in Spiral Ganglion Neurons Cultured from the Mouse Cochlea. Eneuro. 2017;4: pubmed publisher
  10. Taylor A, Saifetiarova J, Bhat M. Postnatal Loss of Neuronal and Glial Neurofascins Differentially Affects Node of Ranvier Maintenance and Myelinated Axon Function. Front Cell Neurosci. 2017;11:11 pubmed publisher
  11. Fernando R, Cotter L, Perrin Tricaud C, Berthelot J, Bartolami S, Pereira J, et al. Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway. Nat Commun. 2016;7:12186 pubmed publisher
  12. Frank R, Komiyama N, Ryan T, Zhu F, O Dell T, Grant S. NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation. Nat Commun. 2016;7:11264 pubmed publisher
  13. Kawabata S, Takano M, Numasawa Kuroiwa Y, Itakura G, Kobayashi Y, Nishiyama Y, et al. Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury. Stem Cell Reports. 2016;6:1-8 pubmed publisher
  14. Nieves Cintrón M, Nystoriak M, Prada M, Johnson K, Fayer W, Dell Acqua M, et al. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes. J Biol Chem. 2015;290:7918-29 pubmed publisher
  15. Yokoi N, Fukata Y, Kase D, Miyazaki T, Jaegle M, Ohkawa T, et al. Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy. Nat Med. 2015;21:19-26 pubmed publisher
  16. Chang K, Zollinger D, Susuki K, Sherman D, Makara M, Brophy P, et al. Glial ankyrins facilitate paranodal axoglial junction assembly. Nat Neurosci. 2014;17:1673-81 pubmed publisher
  17. King A, Manning C, Trimmer J. A unique ion channel clustering domain on the axon initial segment of mammalian neurons. J Comp Neurol. 2014;522:2594-608 pubmed publisher