This is a Validated Antibody Database (VAD) review about human KMT2A, based on 8 published articles (read how Labome selects the articles), using KMT2A antibody in all methods. It is aimed to help Labome visitors find the most suited KMT2A antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
KMT2A synonym: ALL-1; CXXC7; HRX; HTRX1; MLL; MLL1; MLL1A; TRX1; WDSTS

Santa Cruz Biotechnology
mouse monoclonal (H-10)
  • western blot; human; fig 3
Santa Cruz Biotechnology KMT2A antibody (Santa Cruz, sc-374392) was used in western blot on human samples (fig 3). Oncotarget (2016) ncbi
Active Motif
mouse monoclonal (N4.4)
  • western blot; human; fig 2
Active Motif KMT2A antibody (Active Motif, 39829) was used in western blot on human samples (fig 2). Nat Struct Mol Biol (2015) ncbi
GeneTex
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 1b
In order to discuss the use of a Kmt2a/Men1 double knockout mouse as a model for advanced pancreatic neuroendocrine tumor, GeneTex KMT2A antibody (GeneTax, GTX17959) was used in immunohistochemistry - paraffin section on mouse samples at 1:400 (fig 1b). Cancer Biol Ther (2016) ncbi
Cell Signaling Technology
monoclonal (D2M7U)
  • immunoprecipitation; human; loading ...; fig s1f
  • immunocytochemistry; human; fig 1e
  • western blot; human; loading ...; fig 2d, s1b
Cell Signaling Technology KMT2A antibody (Cell Signaling, 14689) was used in immunoprecipitation on human samples (fig s1f), in immunocytochemistry on human samples (fig 1e) and in western blot on human samples (fig 2d, s1b). Genes Dev (2019) ncbi
monoclonal (D6G8N)
  • immunocytochemistry; human; loading ...; fig s1d
  • western blot; human; loading ...; fig 1d, 2d, s1b
Cell Signaling Technology KMT2A antibody (Cell Signaling, 14197) was used in immunocytochemistry on human samples (fig s1d) and in western blot on human samples (fig 1d, 2d, s1b). Genes Dev (2019) ncbi
EMD Millipore
mouse monoclonal (9-12)
  • chromatin immunoprecipitation; human; loading ...; fig 3c
  • western blot; human; 1:500; loading ...; fig 1c
In order to test if posterior HOXD gene activation and Ewing sarcoma tumorigenicity are both regulated by MLL1 and/or menin, EMD Millipore KMT2A antibody (Millipore, 05-765) was used in chromatin immunoprecipitation on human samples (fig 3c) and in western blot on human samples at 1:500 (fig 1c). Oncotarget (2017) ncbi
mouse monoclonal (9-12)
  • chromatin immunoprecipitation; mouse; fig 1
  • immunoprecipitation; mouse; fig 1
  • western blot; mouse; fig 1
EMD Millipore KMT2A antibody (Millipore, 05-765) was used in chromatin immunoprecipitation on mouse samples (fig 1), in immunoprecipitation on mouse samples (fig 1) and in western blot on mouse samples (fig 1). Diabetes (2016) ncbi
mouse monoclonal (9-12)
  • chromatin immunoprecipitation; human
  • chromatin immunoprecipitation; mouse
  • immunoprecipitation; mouse
EMD Millipore KMT2A antibody (Millipore, 05-765) was used in chromatin immunoprecipitation on human samples , in chromatin immunoprecipitation on mouse samples and in immunoprecipitation on mouse samples . J Clin Invest (2013) ncbi
mouse monoclonal (9-12)
  • western blot; human; 1:1000
EMD Millipore KMT2A antibody (Millipore, 05-765) was used in western blot on human samples at 1:1000. Cancer Res (2013) ncbi
Articles Reviewed
  1. Zhao Z, Wang L, Volk A, Birch N, Stoltz K, Bartom E, et al. Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia. Genes Dev. 2019;33:61-74 pubmed publisher
  2. Svoboda L, Bailey N, Van Noord R, Krook M, Harris A, Cramer C, et al. Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin. Oncotarget. 2017;8:458-471 pubmed publisher
  3. Lin W, FRANCIS J, Li H, Gao X, Pedamallu C, Ernst P, et al. Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets. Cancer Biol Ther. 2016;17:1274-1281 pubmed publisher
  4. Dhawan S, Dirice E, Kulkarni R, Bhushan A. Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication. Diabetes. 2016;65:1208-18 pubmed publisher
  5. Wu S, Yang Z, Ye R, An D, Li C, Wang Y, et al. Novel variants in MLL confer to bladder cancer recurrence identified by whole-exome sequencing. Oncotarget. 2016;7:2629-45 pubmed publisher
  6. Aguilar Arnal L, Katada S, Orozco Solis R, Sassone Corsi P. NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1. Nat Struct Mol Biol. 2015;22:312-8 pubmed publisher
  7. Zhou J, Dhawan S, Fu H, Snyder E, Bottino R, Kundu S, et al. Combined modulation of polycomb and trithorax genes rejuvenates ? cell replication. J Clin Invest. 2013;123:4849-58 pubmed
  8. Gallo M, Ho J, Coutinho F, Vanner R, Lee L, Head R, et al. A tumorigenic MLL-homeobox network in human glioblastoma stem cells. Cancer Res. 2013;73:417-27 pubmed publisher