This is a Validated Antibody Database (VAD) review about human KLRB1, based on 40 published articles (read how Labome selects the articles), using KLRB1 antibody in all methods. It is aimed to help Labome visitors find the most suited KLRB1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
KLRB1 synonym: CD161; CLEC5B; NKR; NKR-P1; NKR-P1A; NKRP1A; hNKR-P1A

BioLegend
mouse monoclonal (HP-3G10)
  • flow cytometry; human; 1:25; loading ...; fig 1d
BioLegend KLRB1 antibody (Biolegend, 339942) was used in flow cytometry on human samples at 1:25 (fig 1d). elife (2020) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; human; 1:250; loading ...
BioLegend KLRB1 antibody (BioLegend, 339917) was used in flow cytometry on human samples at 1:250. Nature (2020) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; human; loading ...; fig s20
BioLegend KLRB1 antibody (Biolegend, 339913) was used in flow cytometry on human samples (fig s20). Science (2019) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; human; loading ...; fig 1f
BioLegend KLRB1 antibody (BioLegend, 339918) was used in flow cytometry on human samples (fig 1f). Science (2019) ncbi
mouse monoclonal (HP-3G10)
  • other; human; loading ...; fig 4b
BioLegend KLRB1 antibody (BioLegend, 339945) was used in other on human samples (fig 4b). Cell (2019) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; human; loading ...; fig ex1
BioLegend KLRB1 antibody (BioLegend, HP-3G10) was used in flow cytometry on human samples (fig ex1). Nature (2019) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; human; loading ...; fig 1a
BioLegend KLRB1 antibody (Biolegend, 339902) was used in flow cytometry on human samples (fig 1a). Cell (2018) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; human; fig e1b
BioLegend KLRB1 antibody (BioLegend, HP-3G10) was used in flow cytometry on human samples (fig e1b). J Allergy Clin Immunol (2018) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; human; fig 10
In order to study the involvement of Notch signaling in NK cell lineage determination, BioLegend KLRB1 antibody (biolegend, HP-3G10) was used in flow cytometry on human samples (fig 10). J Immunol (2017) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; human; loading ...; fig 1a
BioLegend KLRB1 antibody (BioLegend, HP-3G10) was used in flow cytometry on human samples (fig 1a). J Immunol (2017) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; human; loading ...; fig s1a
In order to detail MAIT cell responses to various microorganisms and cytokines, BioLegend KLRB1 antibody (BioLegend, HP-3G10) was used in flow cytometry on human samples (fig s1a). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; human; loading ...; fig s5a
In order to use CD49a expression to define subsets of tissue-resident memory T cells in the skin, BioLegend KLRB1 antibody (Biolegend, HP-3G10) was used in flow cytometry on human samples (fig s5a). Immunity (2017) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; human; loading ...; fig 1
In order to report the effect of antiretroviral treatment initiation and different antiretroviral treatment regimens on the reconstitution of mucosal T cells within the gut associated lymphoid tissue, BioLegend KLRB1 antibody (Biolegend, HP-3G10) was used in flow cytometry on human samples (fig 1). PLoS ONE (2016) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; human; loading ...; tbl 1
In order to demonstrate that freezing already-stained samples suspended in 10% DMSO in FBS is practical and efficient way to preserve already-stained samples for mass cytometry assessment, BioLegend KLRB1 antibody (Biolegend, HP-3G10) was used in flow cytometry on human samples (tbl 1). Cytometry A (2017) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; rhesus macaque; loading ...; fig 2
In order to assess the efficacy of targeting alpha4 beta7 integrin to treat SIV, BioLegend KLRB1 antibody (BioLegend, 339904) was used in flow cytometry on rhesus macaque samples (fig 2). Science (2016) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; human; loading ...; fig 3a
BioLegend KLRB1 antibody (BioLegend, HP-3G10) was used in flow cytometry on human samples (fig 3a). Sci Rep (2016) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; human; loading ...; fig 1a
BioLegend KLRB1 antibody (BioLegend, HP-3G10) was used in flow cytometry on human samples (fig 1a). Nat Immunol (2016) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; human; fig 2
In order to assess arming of MAIT cell cytolytic antimicrobial activity and induction by IL-7 and faulty in HIV-1 infection, BioLegend KLRB1 antibody (Biolegend, HP-3G10) was used in flow cytometry on human samples (fig 2). PLoS Pathog (2015) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; human; fig s2
BioLegend KLRB1 antibody (BioLegend, HP-3G10) was used in flow cytometry on human samples (fig s2). J Immunol (2015) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; human; fig 1
BioLegend KLRB1 antibody (BioLegend, HP-3G10) was used in flow cytometry on human samples (fig 1). Immunol Cell Biol (2015) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; human
BioLegend KLRB1 antibody (BioLegend, HP-3G10) was used in flow cytometry on human samples . Rheumatology (Oxford) (2015) ncbi
Miltenyi Biotec
mouse monoclonal (191B8)
  • immunohistochemistry - frozen section; human; loading ...; fig 1c4
  • flow cytometry; human; loading ...; fig 2b
Miltenyi Biotec KLRB1 antibody (Miltenyi, 191B8) was used in immunohistochemistry - frozen section on human samples (fig 1c4) and in flow cytometry on human samples (fig 2b). Arthritis Res Ther (2019) ncbi
mouse monoclonal (191B8)
  • flow cytometry; human; loading ...; fig s2d
Miltenyi Biotec KLRB1 antibody (Miltenyi, 191B8) was used in flow cytometry on human samples (fig s2d). J Infect Dis (2019) ncbi
mouse monoclonal (191B8)
  • flow cytometry; human; loading ...; fig 1b
Miltenyi Biotec KLRB1 antibody (Miltenyi Biotec, 191B8) was used in flow cytometry on human samples (fig 1b). Front Immunol (2018) ncbi
mouse monoclonal (191B8)
  • flow cytometry; human; loading ...; fig 3a
Miltenyi Biotec KLRB1 antibody (Miltenyi Biotec, 191B8) was used in flow cytometry on human samples (fig 3a). PLoS ONE (2017) ncbi
mouse monoclonal (191B8)
  • flow cytometry; human; loading ...; fig s6a
Miltenyi Biotec KLRB1 antibody (Miltenyi, 191B8) was used in flow cytometry on human samples (fig s6a). Front Immunol (2017) ncbi
mouse monoclonal (191B8)
  • flow cytometry; human; loading ...; fig st12
In order to identify new types of human blood dendritic cells, monocytes, and progenitors through single-cell RNA-seq, Miltenyi Biotec KLRB1 antibody (Miltenyi Biotec, 191B8) was used in flow cytometry on human samples (fig st12). Science (2017) ncbi
Invitrogen
mouse monoclonal (HP-3G10)
  • flow cytometry; human; loading ...; fig 1d
In order to report that autosomal recessive, partial Go-Ichi-Ni-San 1 deficiency impairs DNA replication and underlies intra-uterine and postnatal growth retardation, chronic neutropenia, and natural killer cell deficiency, Invitrogen KLRB1 antibody (eBiosciences, HP-3G10) was used in flow cytometry on human samples (fig 1d). J Clin Invest (2017) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; human; loading ...; fig 3b
Invitrogen KLRB1 antibody (eBiosciences, HP-3G10) was used in flow cytometry on human samples (fig 3b). J Immunol (2017) ncbi
mouse monoclonal (HP-3G10)
  • flow cytometry; human; tbl 1
In order to study the effect of innate lymphoid cells on B cells, Invitrogen KLRB1 antibody (eBioscience, HP-3G10) was used in flow cytometry on human samples (tbl 1). Nat Immunol (2014) ncbi
BD Biosciences
mouse monoclonal (DX12)
  • flow cytometry; human; loading ...; fig s1a
BD Biosciences KLRB1 antibody (BD Biosciences, DX12) was used in flow cytometry on human samples (fig s1a). Proc Natl Acad Sci U S A (2018) ncbi
mouse monoclonal (DX12)
  • flow cytometry; human; loading ...; fig 1a
BD Biosciences KLRB1 antibody (BD Biosciences, 550968) was used in flow cytometry on human samples (fig 1a). elife (2018) ncbi
mouse monoclonal (DX12)
  • flow cytometry; human; loading ...; fig 4h
In order to detail MAIT cell responses to various microorganisms and cytokines, BD Biosciences KLRB1 antibody (BD Biosciences, DX12) was used in flow cytometry on human samples (fig 4h). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (DX12)
  • flow cytometry; human; loading ...; tbl s9
In order to optimize and assess potential malaria vaccine regimens, BD Biosciences KLRB1 antibody (BD, 551138) was used in flow cytometry on human samples (tbl s9). Nature (2017) ncbi
mouse monoclonal (DX12)
  • flow cytometry; human; loading ...; fig s1c
In order to describe complete autosomal recessive IL-17RA deficiency in patients with chronic mucocutaneous candidiasis, BD Biosciences KLRB1 antibody (BD Biosciences, DX12) was used in flow cytometry on human samples (fig s1c). Proc Natl Acad Sci U S A (2016) ncbi
mouse monoclonal (DX12)
  • flow cytometry; human; loading ...
In order to identify RLTPR in patients and determine the effects of these mutations on CD4 positive T cells, BD Biosciences KLRB1 antibody (BD, DX12) was used in flow cytometry on human samples . J Exp Med (2016) ncbi
mouse monoclonal (DX12)
  • flow cytometry; human; loading ...; fig 6b
BD Biosciences KLRB1 antibody (BD, DX12) was used in flow cytometry on human samples (fig 6b). J Immunol (2016) ncbi
mouse monoclonal (DX12)
  • flow cytometry; human; fig st1
In order to find cell-surface markers specific to human neutrophils, BD Biosciences KLRB1 antibody (BD, 556081) was used in flow cytometry on human samples (fig st1). Exp Cell Res (2016) ncbi
mouse monoclonal (DX12)
  • flow cytometry; human; fig 1
In order to assess arming of MAIT cell cytolytic antimicrobial activity and induction by IL-7 and faulty in HIV-1 infection, BD Biosciences KLRB1 antibody (BD Biosciences, DX12) was used in flow cytometry on human samples (fig 1). PLoS Pathog (2015) ncbi
mouse monoclonal (DX12)
  • flow cytometry; human; loading ...; fig 3c
In order to elucidate Th17 cell polarization, depletion, and restoration in response to HIV infection and antiretroviral therapy, BD Biosciences KLRB1 antibody (BD Pharmingen, DX12) was used in flow cytometry on human samples (fig 3c). Retrovirology (2015) ncbi
mouse monoclonal (DX12)
  • flow cytometry; human; fig 5
In order to investigate when Vgamma9Vdelta2 T cells develop, BD Biosciences KLRB1 antibody (BD Bioscience, DX12) was used in flow cytometry on human samples (fig 5). Proc Natl Acad Sci U S A (2015) ncbi
mouse monoclonal (DX12)
  • flow cytometry; human; fig 1
In order to study mucosal associated invariant T cells and B cell interactions, BD Biosciences KLRB1 antibody (BD Pharmingen, clone DX12) was used in flow cytometry on human samples (fig 1). Front Immunol (2014) ncbi
Articles Reviewed
  1. Bennstein S, Weinhold S, Manser A, Scherenschlich N, Noll A, Raba K, et al. Umbilical cord blood-derived ILC1-like cells constitute a novel precursor for mature KIR+NKG2A- NK cells. elife. 2020;9: pubmed publisher
  2. Gate D, Saligrama N, Leventhal O, Yang A, Unger M, Middeldorp J, et al. Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease. Nature. 2020;577:399-404 pubmed publisher
  3. Uhlen M, Karlsson M, Zhong W, Tebani A, Pou C, Mikes J, et al. A genome-wide transcriptomic analysis of protein-coding genes in human blood cells. Science. 2019;366: pubmed publisher
  4. Constantinides M, Link V, Tamoutounour S, Wong A, Pérez Chaparro P, Han S, et al. MAIT cells are imprinted by the microbiota in early life and promote tissue repair. Science. 2019;366: pubmed publisher
  5. Stuart T, Butler A, Hoffman P, Hafemeister C, Papalexi E, Mauck W, et al. Comprehensive Integration of Single-Cell Data. Cell. 2019;: pubmed publisher
  6. Ardain A, Domingo Gonzalez R, Das S, Kazer S, Howard N, Singh A, et al. Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis. Nature. 2019;: pubmed publisher
  7. Koppejan H, Jansen D, Hameetman M, Thomas R, Toes R, van Gaalen F. Altered composition and phenotype of mucosal-associated invariant T cells in early untreated rheumatoid arthritis. Arthritis Res Ther. 2019;21:3 pubmed publisher
  8. Dias J, Boulouis C, Gorin J, van den Biggelaar R, Lal K, Gibbs A, et al. The CD4-CD8- MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8+ MAIT cell pool. Proc Natl Acad Sci U S A. 2018;115:E11513-E11522 pubmed publisher
  9. van Erp E, Feyaerts D, Duijst M, Mulder H, Wicht O, Luytjes W, et al. Respiratory Syncytial Virus Infects Primary Neonatal and Adult Natural Killer Cells and Affects Their Antiviral Effector Function. J Infect Dis. 2019;219:723-733 pubmed publisher
  10. Olin A, Henckel E, Chen Y, Lakshmikanth T, Pou C, Mikes J, et al. Stereotypic Immune System Development in Newborn Children. Cell. 2018;174:1277-1292.e14 pubmed publisher
  11. Provine N, Binder B, FitzPatrick M, Schuch A, Garner L, Williamson K, et al. Unique and Common Features of Innate-Like Human Vδ2+ γδT Cells and Mucosal-Associated Invariant T Cells. Front Immunol. 2018;9:756 pubmed publisher
  12. Lee C, Zhang H, Singh S, Koo L, Kabat J, Tsang H, et al. C/EBPδ drives interactions between human MAIT cells and endothelial cells that are important for extravasation. elife. 2018;7: pubmed publisher
  13. Jeffery H, McDowell P, Lutz P, Wawman R, Roberts S, Bagnall C, et al. Human intrahepatic ILC2 are IL-13positive amphiregulinpositive and their frequency correlates with model of end stage liver disease score. PLoS ONE. 2017;12:e0188649 pubmed publisher
  14. Maric J, Ravindran A, Mazzurana L, Björklund Ã, Van Acker A, Rao A, et al. Prostaglandin E2 suppresses human group 2 innate lymphoid cell function. J Allergy Clin Immunol. 2018;141:1761-1773.e6 pubmed publisher
  15. Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, et al. Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors. J Immunol. 2017;199:2777-2793 pubmed publisher
  16. Salio M, Gasser O, González López C, Martens A, Veerapen N, Gileadi U, et al. Activation of Human Mucosal-Associated Invariant T Cells Induces CD40L-Dependent Maturation of Monocyte-Derived and Primary Dendritic Cells. J Immunol. 2017;199:2631-2638 pubmed publisher
  17. Delso Vallejo M, Kollet J, Koehl U, Huppert V. Influence of Irradiated Peripheral Blood Mononuclear Cells on Both Ex Vivo Proliferation of Human Natural Killer Cells and Change in Cellular Property. Front Immunol. 2017;8:854 pubmed publisher
  18. Dias J, Leeansyah E, Sandberg J. Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines. Proc Natl Acad Sci U S A. 2017;114:E5434-E5443 pubmed publisher
  19. Villani A, Satija R, Reynolds G, Sarkizova S, Shekhar K, Fletcher J, et al. Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors. Science. 2017;356: pubmed publisher
  20. Cottineau J, Kottemann M, Lach F, Kang Y, Vély F, Deenick E, et al. Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency. J Clin Invest. 2017;127:1991-2006 pubmed publisher
  21. Szabo P, Goswami A, Mazzuca D, Kim K, O Gorman D, Hess D, et al. Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology. J Immunol. 2017;198:2805-2818 pubmed publisher
  22. Cheuk S, Schlums H, Gallais Sérézal I, Martini E, Chiang S, Marquardt N, et al. CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin. Immunity. 2017;46:287-300 pubmed publisher
  23. Mordmuller B, Surat G, Lagler H, Chakravarty S, Ishizuka A, Lalremruata A, et al. Sterile protection against human malaria by chemoattenuated PfSPZ vaccine. Nature. 2017;542:445-449 pubmed publisher
  24. Lévy R, Okada S, Béziat V, Moriya K, Liu C, Chai L, et al. Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency. Proc Natl Acad Sci U S A. 2016;113:E8277-E8285 pubmed publisher
  25. Briceno O, Pinto Cardoso S, Rodríguez Bernabe N, Murakami Ogasawara A, Reyes Teran G. Gut Homing CD4+ and CD8+ T-Cell Frequencies in HIV Infected Individuals on Antiretroviral Treatment. PLoS ONE. 2016;11:e0166496 pubmed publisher
  26. Sumatoh H, Teng K, Cheng Y, Newell E. Optimization of mass cytometry sample cryopreservation after staining. Cytometry A. 2017;91:48-61 pubmed publisher
  27. Byrareddy S, Arthos J, Cicala C, Villinger F, Ortiz K, Little D, et al. Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy. Science. 2016;354:197-202 pubmed
  28. Wang Y, Ma C, Ling Y, Bousfiha A, Camcioglu Y, Jacquot S, et al. Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations. J Exp Med. 2016;213:2413-2435 pubmed
  29. Jiang J, Chen X, An H, Yang B, Zhang F, Cheng X. Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling. Sci Rep. 2016;6:32320 pubmed publisher
  30. Suliman S, Geldenhuys H, Johnson J, Hughes J, Smit E, Murphy M, et al. Bacillus Calmette-Guérin (BCG) Revaccination of Adults with Latent Mycobacterium tuberculosis Infection Induces Long-Lived BCG-Reactive NK Cell Responses. J Immunol. 2016;197:1100-1110 pubmed publisher
  31. Bal S, Bernink J, Nagasawa M, Groot J, Shikhagaie M, Golebski K, et al. IL-1?, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs. Nat Immunol. 2016;17:636-45 pubmed publisher
  32. Lakschevitz F, Hassanpour S, Rubin A, Fine N, Sun C, Glogauer M. Identification of neutrophil surface marker changes in health and inflammation using high-throughput screening flow cytometry. Exp Cell Res. 2016;342:200-9 pubmed publisher
  33. Leeansyah E, Svärd J, Dias J, Buggert M, Nyström J, Quigley M, et al. Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection. PLoS Pathog. 2015;11:e1005072 pubmed publisher
  34. DaFonseca S, Niessl J, Pouvreau S, Wacleche V, Gosselin A, Cleret Buhot A, et al. Impaired Th17 polarization of phenotypically naive CD4(+) T-cells during chronic HIV-1 infection and potential restoration with early ART. Retrovirology. 2015;12:38 pubmed publisher
  35. Marquardt N, Béziat V, Nyström S, Hengst J, Ivarsson M, Kekäläinen E, et al. Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells. J Immunol. 2015;194:2467-71 pubmed publisher
  36. Dimova T, Brouwer M, Gosselin F, Tassignon J, Leo O, Donner C, et al. Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire. Proc Natl Acad Sci U S A. 2015;112:E556-65 pubmed publisher
  37. Fernandez C, Amarasena T, Kelleher A, Rossjohn J, McCluskey J, Godfrey D, et al. MAIT cells are depleted early but retain functional cytokine expression in HIV infection. Immunol Cell Biol. 2015;93:177-88 pubmed publisher
  38. Jansen D, Hameetman M, van Bergen J, Huizinga T, van der Heijde D, Toes R, et al. IL-17-producing CD4+ T cells are increased in early, active axial spondyloarthritis including patients without imaging abnormalities. Rheumatology (Oxford). 2015;54:728-35 pubmed publisher
  39. Magri G, Miyajima M, Bascones S, Mortha A, Puga I, Cassis L, et al. Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells. Nat Immunol. 2014;15:354-364 pubmed publisher
  40. Salerno Goncalves R, Rezwan T, Sztein M. B cells modulate mucosal associated invariant T cell immune responses. Front Immunol. 2014;4:511 pubmed publisher