This is a Validated Antibody Database (VAD) review about human KAT2A, based on 17 published articles (read how Labome selects the articles), using KAT2A antibody in all methods. It is aimed to help Labome visitors find the most suited KAT2A antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
KAT2A synonym: GCN5; GCN5L2; PCAF-b; hGCN5

Knockout validation
Abcam
domestic rabbit monoclonal (EPR21146)
  • western blot knockout validation; human; 1:2000; loading ...; fig 2a
  • ChIP-Seq; human; loading ...; fig 4d
  • immunohistochemistry - paraffin section; human; loading ...; fig 1g
Abcam KAT2A antibody (Abcam, ab217876) was used in western blot knockout validation on human samples at 1:2000 (fig 2a), in ChIP-Seq on human samples (fig 4d) and in immunohistochemistry - paraffin section on human samples (fig 1g). Front Cell Dev Biol (2021) ncbi
Santa Cruz Biotechnology
mouse monoclonal (A-11)
  • western blot; human; loading ...; fig 2a
Santa Cruz Biotechnology KAT2A antibody (Santa Cruz, sc-365321) was used in western blot on human samples (fig 2a). BMC Cancer (2020) ncbi
mouse monoclonal (A-11)
  • western blot; human; loading ...; fig 6c
Santa Cruz Biotechnology KAT2A antibody (Santa Cruz Biotechnology, sc-365321) was used in western blot on human samples (fig 6c). Oncogene (2018) ncbi
mouse monoclonal (A-11)
  • immunohistochemistry - paraffin section; human; fig 6
  • chromatin immunoprecipitation; human; fig 5
  • western blot; human; fig 1
Santa Cruz Biotechnology KAT2A antibody (Santa Cruz, sc-365321) was used in immunohistochemistry - paraffin section on human samples (fig 6), in chromatin immunoprecipitation on human samples (fig 5) and in western blot on human samples (fig 1). Sci Rep (2016) ncbi
Abcam
domestic rabbit monoclonal (EPR21146)
  • western blot knockout validation; human; 1:2000; loading ...; fig 2a
  • ChIP-Seq; human; loading ...; fig 4d
  • immunohistochemistry - paraffin section; human; loading ...; fig 1g
Abcam KAT2A antibody (Abcam, ab217876) was used in western blot knockout validation on human samples at 1:2000 (fig 2a), in ChIP-Seq on human samples (fig 4d) and in immunohistochemistry - paraffin section on human samples (fig 1g). Front Cell Dev Biol (2021) ncbi
Invitrogen
mouse monoclonal (2GC-2C11)
In order to characterize the human lysine acetyltransferases KAT2A and KAT2B, Invitrogen KAT2A antibody (Thermo Fisher Scientific, 2GC2C11) was used . Nat Commun (2016) ncbi
Active Motif
mouse monoclonal (2GC-2C11)
  • western blot; human; loading ...; fig 2a
Active Motif KAT2A antibody (Active Motif, 39975) was used in western blot on human samples (fig 2a). Nat Commun (2017) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (C26A10)
  • chromatin immunoprecipitation; human; loading ...; fig s6d, s6e
  • immunoprecipitation; human; 1:200; loading ...; fig 6d
  • western blot; human; 1:1000; loading ...; fig s6a
Cell Signaling Technology KAT2A antibody (CST, 3305) was used in chromatin immunoprecipitation on human samples (fig s6d, s6e), in immunoprecipitation on human samples at 1:200 (fig 6d) and in western blot on human samples at 1:1000 (fig s6a). Nat Commun (2022) ncbi
domestic rabbit monoclonal (C26A10)
  • western blot; human; loading ...; fig 3g
Cell Signaling Technology KAT2A antibody (CST, 3305) was used in western blot on human samples (fig 3g). Cell Death Dis (2021) ncbi
domestic rabbit monoclonal (C26A10)
  • other; human; loading ...; fig 4c
Cell Signaling Technology KAT2A antibody (Cell Signaling, 3305) was used in other on human samples (fig 4c). Cancer Cell (2018) ncbi
domestic rabbit monoclonal (C26A10)
  • chromatin immunoprecipitation; mouse; loading ...; fig 4h
  • immunoprecipitation; mouse; 1:1000; loading ...; fig 4e
  • western blot; mouse; 1:1000; loading ...; fig 4e
Cell Signaling Technology KAT2A antibody (CST, 3305) was used in chromatin immunoprecipitation on mouse samples (fig 4h), in immunoprecipitation on mouse samples at 1:1000 (fig 4e) and in western blot on mouse samples at 1:1000 (fig 4e). Cell Death Differ (2018) ncbi
domestic rabbit monoclonal (C26A10)
  • western blot; human; 1:1000; loading ...; fig 6f
Cell Signaling Technology KAT2A antibody (Cell Signaling, 3305) was used in western blot on human samples at 1:1000 (fig 6f). Nat Commun (2018) ncbi
domestic rabbit monoclonal (C26A10)
  • western blot; human; 1:1000; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology KAT2A antibody (Cell Signaling, 3305) was used in western blot on human samples at 1:1000 (fig st1). Nat Commun (2016) ncbi
domestic rabbit monoclonal (C26A10)
  • western blot; human; fig 2
Cell Signaling Technology KAT2A antibody (Cell Signaling Technologies, 3305S) was used in western blot on human samples (fig 2). Chem Biol (2015) ncbi
domestic rabbit monoclonal (C26A10)
  • western blot; human; fig 6
Cell Signaling Technology KAT2A antibody (Cell Signaling Technology, 3305) was used in western blot on human samples (fig 6). J Biol Chem (2015) ncbi
domestic rabbit monoclonal (C26A10)
  • immunohistochemistry - free floating section; mouse; 1:100
  • immunoprecipitation; mouse
  • western blot; mouse; 1:1000
Cell Signaling Technology KAT2A antibody (Cell Signaling, 3305) was used in immunohistochemistry - free floating section on mouse samples at 1:100, in immunoprecipitation on mouse samples and in western blot on mouse samples at 1:1000. EMBO J (2014) ncbi
domestic rabbit monoclonal (C26A10)
  • immunoprecipitation; human
  • western blot; human
Cell Signaling Technology KAT2A antibody (Cell Signaling, 3305) was used in immunoprecipitation on human samples and in western blot on human samples . J Biol Chem (2013) ncbi
domestic rabbit monoclonal (C26A10)
  • western blot; human
Cell Signaling Technology KAT2A antibody (Cell Signaling, 3305) was used in western blot on human samples . Epigenetics (2013) ncbi
Articles Reviewed
  1. Yu B, Su J, Shi Q, Liu Q, Ma J, Ru G, et al. KMT5A-methylated SNIP1 promotes triple-negative breast cancer metastasis by activating YAP signaling. Nat Commun. 2022;13:2192 pubmed publisher
  2. Guo Y, Liu B, Liu Y, Sun W, Gao W, Mao S, et al. Oncogenic Chromatin Modifier KAT2A Activates MCT1 to Drive the Glycolytic Process and Tumor Progression in Renal Cell Carcinoma. Front Cell Dev Biol. 2021;9:690796 pubmed publisher
  3. Feng L, Chen M, Li Y, Li M, Hu S, Zhou B, et al. Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis. Cell Death Dis. 2021;12:405 pubmed publisher
  4. Zhou Y, Pei F, Ji M, Zhang F, Sun Y, Zhao Q, et al. WDHD1 facilitates G1 checkpoint abrogation in HPV E7 expressing cells by modulating GCN5. BMC Cancer. 2020;20:840 pubmed publisher
  5. Zhao C, Li Y, Qiu W, He F, Zhang W, Zhao D, et al. C5a induces A549 cell proliferation of non-small cell lung cancer via GDF15 gene activation mediated by GCN5-dependent KLF5 acetylation. Oncogene. 2018;37:4821-4837 pubmed publisher
  6. Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  7. Fu X, Zhang C, Meng H, Zhang K, Shi L, Cao C, et al. Oncoprotein Tudor-SN is a key determinant providing survival advantage under DNA damaging stress. Cell Death Differ. 2018;25:1625-1637 pubmed publisher
  8. Li F, Liu J, Bao R, Yan G, Feng X, Xu Y, et al. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018;9:508 pubmed publisher
  9. Zhang X, Li B, Rezaeian A, Xu X, Chou P, Jin G, et al. H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis. Nat Commun. 2017;8:14799 pubmed publisher
  10. Fournier M, Orpinell M, Grauffel C, Scheer E, Garnier J, Ye T, et al. KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification. Nat Commun. 2016;7:13227 pubmed publisher
  11. Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  12. Li B, Sun J, Dong Z, Xue P, He X, Liao L, et al. GCN5 modulates osteogenic differentiation of periodontal ligament stem cells through DKK1 acetylation in inflammatory microenvironment. Sci Rep. 2016;6:26542 pubmed publisher
  13. Montgomery D, Sorum A, Guasch L, Nicklaus M, Meier J. Metabolic Regulation of Histone Acetyltransferases by Endogenous Acyl-CoA Cofactors. Chem Biol. 2015;22:1030-1039 pubmed publisher
  14. Li T, Su L, Lei Y, Liu X, Zhang Y, Liu X. DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells. J Biol Chem. 2015;290:11108-18 pubmed publisher
  15. Stilling R, Rönicke R, Benito E, Urbanke H, Capece V, Burkhardt S, et al. K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation. EMBO J. 2014;33:1912-27 pubmed publisher
  16. Liu X, Xiao W, Wang X, Li Y, Han J, Li Y. The p38-interacting protein (p38IP) regulates G2/M progression by promoting ?-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5. J Biol Chem. 2013;288:36648-61 pubmed publisher
  17. Rajendran P, Kidane A, Yu T, Dashwood W, Bisson W, LOHR C, et al. HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics. 2013;8:612-23 pubmed publisher