This is a Validated Antibody Database (VAD) review about human IRS-1, based on 70 published articles (read how Labome selects the articles), using IRS-1 antibody in all methods. It is aimed to help Labome visitors find the most suited IRS-1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
IRS-1 synonym: HIRS-1

Knockout validation
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot knockout validation; human; 1:1000; fig 1e
Cell Signaling Technology IRS-1 antibody (cell signalling technology, 2382) was used in western blot knockout validation on human samples at 1:1000 (fig 1e). Nat Commun (2021) ncbi
Abcam
domestic rabbit monoclonal (EP260Y)
  • western blot; mouse; 1:1000; loading ...; fig 6g
Abcam IRS-1 antibody (Abcam, ab46800) was used in western blot on mouse samples at 1:1000 (fig 6g). Int J Mol Sci (2021) ncbi
domestic rabbit monoclonal (EP263Y)
  • western blot; human; loading ...; fig 5a
Abcam IRS-1 antibody (Abcam, ab40777) was used in western blot on human samples (fig 5a). Cell Death Dis (2021) ncbi
domestic rabbit monoclonal (EP263Y)
  • western blot; human; 1:2000; loading ...; fig 3d
Abcam IRS-1 antibody (Abcam, ab40777) was used in western blot on human samples at 1:2000 (fig 3d). Genome Biol (2020) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 2e
Abcam IRS-1 antibody (Abcam, ab52167) was used in western blot on mouse samples at 1:1000 (fig 2e). Mol Metab (2020) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 4b, 7d
Abcam IRS-1 antibody (Abcam, ab52167) was used in western blot on mouse samples (fig 4b, 7d). Pharmacol Res (2020) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:300; loading ...; fig 4bc
Abcam IRS-1 antibody (Abcam, ab1194) was used in western blot on mouse samples at 1:300 (fig 4bc). J Proteomics (2020) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; mouse; loading ...; fig 3g
Abcam IRS-1 antibody (Abcam, ab5603) was used in immunocytochemistry on mouse samples (fig 3g). Stem Cell Reports (2019) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; human; 1:100; loading ...; fig 5a
In order to investigate the interaction between GRAF1 and RAB8, Abcam IRS-1 antibody (Abcam, ab1194) was used in immunocytochemistry on human samples at 1:100 (fig 5a). J Cell Sci (2017) ncbi
domestic rabbit monoclonal (EP260Y)
  • western blot; mouse; loading ...; fig S1b
Abcam IRS-1 antibody (Abcam, ab46800) was used in western blot on mouse samples (fig S1b). Cell Death Dis (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig S1b
Abcam IRS-1 antibody (Abcam, ab52167) was used in western blot on mouse samples (fig S1b). Cell Death Dis (2016) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 2d
In order to explore the role of insulin receptor substrate-1 in tumor development, Abcam IRS-1 antibody (Abcam, 52167) was used in immunohistochemistry - paraffin section on mouse samples (fig 2d). Proc Natl Acad Sci U S A (2016) ncbi
domestic rabbit monoclonal (EP260Y)
  • western blot; mouse; 1:1000; fig 4
Abcam IRS-1 antibody (Abcam, 46800) was used in western blot on mouse samples at 1:1000 (fig 4). Sci Rep (2016) ncbi
domestic rabbit monoclonal (EP263Y)
  • western blot; human; fig 3
In order to analyze NPM-ALK+ T-cell lymphoma and the transcription factors MZF1 and Ik-1 that downregulate IGF-IR expression, Abcam IRS-1 antibody (Abcam, ab40777) was used in western blot on human samples (fig 3). Mol Cancer (2015) ncbi
domestic rabbit monoclonal (EP263Y)
  • western blot; human
Abcam IRS-1 antibody (Abcam, ab40777) was used in western blot on human samples . J Proteomics (2015) ncbi
domestic rabbit monoclonal (EP263Y)
  • western blot; human
In order to evaluate a novel insulin/IGF signaling pathway inhibitor for its protective effect on age-onset, neurodegeneration-linked proteotoxicity, Abcam IRS-1 antibody (Abcam, ab40777) was used in western blot on human samples . Aging Cell (2014) ncbi
Invitrogen
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 1f
Invitrogen IRS-1 antibody (Invitrogen, 44-550G) was used in immunohistochemistry - paraffin section on mouse samples at 1:500 (fig 1f). Front Immunol (2022) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:300; fig 4h
Invitrogen IRS-1 antibody (Thermo Fisher Scientific, PA1-1054) was used in western blot on mouse samples at 1:300 (fig 4h). Redox Biol (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; fig 6e
Invitrogen IRS-1 antibody (Invitrogen, 44-816G) was used in western blot on mouse samples at 1:1000 (fig 6e). Sci Rep (2021) ncbi
domestic rabbit monoclonal (K.346.8)
  • immunoprecipitation; mouse; 1:100; loading ...; fig s9c
  • western blot; mouse; 1:1000; loading ...; fig s9c
Invitrogen IRS-1 antibody (Invitrogen, MA5-15068) was used in immunoprecipitation on mouse samples at 1:100 (fig s9c) and in western blot on mouse samples at 1:1000 (fig s9c). Nat Commun (2021) ncbi
domestic rabbit polyclonal
  • western blot; rat; loading ...; fig 3b
Invitrogen IRS-1 antibody (ThermoFisher, 44-813G) was used in western blot on rat samples (fig 3b). Molecules (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 4i
In order to show that DNA hypermethylation at the PPARgamma1 promoter is induced by obesity-related factors, Invitrogen IRS-1 antibody (Invitrogen, 44-816G) was used in western blot on mouse samples (fig 4i). JCI Insight (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 4
In order to study protection of mice from high fat diet-induced liver injury by receptor interacting protein 3, Invitrogen IRS-1 antibody (Thermo Fisher, 44-813G) was used in western blot on mouse samples (fig 4). Hepatology (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 3
In order to utilize a novel targe for type 2 diabetes and regulate the effects of GPR21, Invitrogen IRS-1 antibody (Life Technologiesy, 44-816G) was used in western blot on human samples (fig 3). Sci Rep (2016) ncbi
domestic rabbit polyclonal
In order to study the insulin/IGF1 signaling pathway in human astrocytes, Invitrogen IRS-1 antibody (Life Technologies, 44-550G) was used . Mol Brain (2015) ncbi
domestic rabbit polyclonal
In order to study the insulin/IGF1 signaling pathway in human astrocytes, Invitrogen IRS-1 antibody (Life Technologies, 44-816G) was used . Mol Brain (2015) ncbi
domestic rabbit polyclonal
In order to assess the activity of a novel dual PI3K/mTOR inhibitor on mesothelioma, Invitrogen IRS-1 antibody (Thermo Scientific, PA5-29667) was used . PLoS ONE (2015) ncbi
domestic rabbit polyclonal
In order to investigate how loss of RE-1 Silencing Transcription Factor affects breast cancer, Invitrogen IRS-1 antibody (Invitrogen, 44816G) was used . Mol Cell Biol (2015) ncbi
domestic rabbit polyclonal
In order to elucidate the role of farnesylation in burn-induced metabolic aberration, Invitrogen IRS-1 antibody (Life Technologies, 44-816G) was used . PLoS ONE (2015) ncbi
Santa Cruz Biotechnology
mouse monoclonal (E-12)
  • western blot; mouse; 1:1000; loading ...; fig 3e
Santa Cruz Biotechnology IRS-1 antibody (Santa Cruz Biotechnology, E-12) was used in western blot on mouse samples at 1:1000 (fig 3e). Theranostics (2021) ncbi
mouse monoclonal
  • western blot; mouse; loading ...; fig 8b
In order to show that PTI-125 therapeutically alters filamin A and reverses proteopathy, Santa Cruz Biotechnology IRS-1 antibody (SantaCruz, SC-515017) was used in western blot on mouse samples (fig 8b). Neurobiol Aging (2017) ncbi
mouse monoclonal (E-12)
  • western blot; mouse; fig 4
In order to study protection of mice from high fat diet-induced liver injury by receptor interacting protein 3, Santa Cruz Biotechnology IRS-1 antibody (Santa Cruz, sc-8038) was used in western blot on mouse samples (fig 4). Hepatology (2016) ncbi
mouse monoclonal (E-12)
  • western blot; rat; 1:200
Santa Cruz Biotechnology IRS-1 antibody (Santa Cruz Biotechnology, sc-8038) was used in western blot on rat samples at 1:200. Life Sci (2015) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D23G12)
  • western blot; mouse; 1:1000; loading ...; fig s6-1b
Cell Signaling Technology IRS-1 antibody (Cell Signaling Technology, 3407) was used in western blot on mouse samples at 1:1000 (fig s6-1b). elife (2022) ncbi
domestic rabbit monoclonal (C15H5)
  • western blot; mouse; 1:1000; loading ...; fig s10e
Cell Signaling Technology IRS-1 antibody (Cell Signaling, 3203) was used in western blot on mouse samples at 1:1000 (fig s10e). Nat Commun (2022) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; mouse; 1:100; fig 7b
Cell Signaling Technology IRS-1 antibody (Cell Signalling Technology, CST2382) was used in immunocytochemistry on mouse samples at 1:100 (fig 7b). BMC Biol (2021) ncbi
domestic rabbit monoclonal (D23G12)
  • western blot; mouse; 1:1000; loading ...; fig 5e
Cell Signaling Technology IRS-1 antibody (Cell Signalling Technology, 3407) was used in western blot on mouse samples at 1:1000 (fig 5e). elife (2021) ncbi
domestic rabbit monoclonal (D23G12)
  • western blot; mouse; 1:1000; loading ...; fig 5e
Cell Signaling Technology IRS-1 antibody (Cell Signalling Technology, 3407) was used in western blot on mouse samples at 1:1000 (fig 5e). BMC Neurol (2021) ncbi
domestic rabbit monoclonal (D23G12)
  • western blot; mouse; 1:1000; loading ...; fig 5e
Cell Signaling Technology IRS-1 antibody (Cell Signalling Technology, 3407) was used in western blot on mouse samples at 1:1000 (fig 5e). Nature (2021) ncbi
domestic rabbit monoclonal (D23G12)
  • western blot; mouse; 1:1000; loading ...; fig 5e
Cell Signaling Technology IRS-1 antibody (Cell Signalling Technology, 3407) was used in western blot on mouse samples at 1:1000 (fig 5e). elife (2021) ncbi
domestic rabbit monoclonal (C15H5)
  • western blot; mouse; 1:1000; loading ...; fig 6g
Cell Signaling Technology IRS-1 antibody (Cell Signaling, 3203P) was used in western blot on mouse samples at 1:1000 (fig 6g). Int J Mol Sci (2021) ncbi
domestic rabbit monoclonal (D23G12)
  • western blot; mouse; 1:1000; loading ...; fig 6g
Cell Signaling Technology IRS-1 antibody (Cell Signaling, 3407P) was used in western blot on mouse samples at 1:1000 (fig 6g). Int J Mol Sci (2021) ncbi
domestic rabbit monoclonal (C15H5)
  • western blot; mouse; 1:2000; loading ...; fig 5a
Cell Signaling Technology IRS-1 antibody (Cell Signaling, 3203) was used in western blot on mouse samples at 1:2000 (fig 5a). J Inflamm Res (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:2000; loading ...; fig 5a
Cell Signaling Technology IRS-1 antibody (Cell Signaling, 2382) was used in western blot on mouse samples at 1:2000 (fig 5a). J Inflamm Res (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:2000; loading ...; fig 5c
Cell Signaling Technology IRS-1 antibody (Cell Signaling, 2381) was used in western blot on mouse samples at 1:2000 (fig 5c). J Inflamm Res (2021) ncbi
domestic rabbit polyclonal
  • western blot; rat; loading ...; fig 5b
Cell Signaling Technology IRS-1 antibody (Cell Signaling Technology, 2382) was used in western blot on rat samples (fig 5b). Aging (Albany NY) (2021) ncbi
domestic rabbit polyclonal
  • western blot knockout validation; human; 1:1000; fig 1e
Cell Signaling Technology IRS-1 antibody (cell signalling technology, 2382) was used in western blot knockout validation on human samples at 1:1000 (fig 1e). Nat Commun (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig s6b
Cell Signaling Technology IRS-1 antibody (CST, 3070S) was used in western blot on human samples (fig s6b). J Biol Chem (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 3f
Cell Signaling Technology IRS-1 antibody (Cell Signaling Technology, 2381) was used in western blot on mouse samples at 1:1000 (fig 3f). Theranostics (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 5c
Cell Signaling Technology IRS-1 antibody (Cell Signaling, 2382) was used in western blot on mouse samples at 1:1000 (fig 5c). Aging Cell (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:500; loading ...; fig 4a
Cell Signaling Technology IRS-1 antibody (Cell Signaling Technology, 2382) was used in western blot on mouse samples at 1:500 (fig 4a). Int J Mol Sci (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 1g
Cell Signaling Technology IRS-1 antibody (Cell Signaling, 2382) was used in western blot on mouse samples (fig 1g). elife (2020) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 5d
Cell Signaling Technology IRS-1 antibody (CST, 2381T) was used in western blot on mouse samples (fig 5d). J Neuroinflammation (2020) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 5d
Cell Signaling Technology IRS-1 antibody (CST, 2382S) was used in western blot on mouse samples (fig 5d). J Neuroinflammation (2020) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4a
Cell Signaling Technology IRS-1 antibody (Cell signalling technology, 2384) was used in immunohistochemistry - paraffin section on mouse samples (fig 4a). Pharmacol Res (2020) ncbi
domestic rabbit monoclonal (D23G12)
  • western blot; mouse; loading ...; fig 4f
  • immunocytochemistry; human; loading ...; fig 3c, 3e
  • western blot; human; loading ...; fig 1a, 1e
Cell Signaling Technology IRS-1 antibody (Cell Signaling, 3407) was used in western blot on mouse samples (fig 4f), in immunocytochemistry on human samples (fig 3c, 3e) and in western blot on human samples (fig 1a, 1e). J Biol Chem (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 3b
Cell Signaling Technology IRS-1 antibody (Cell signaling, 2388s) was used in western blot on mouse samples (fig 3b). Cardiovasc Diabetol (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 3b
Cell Signaling Technology IRS-1 antibody (Cell signaling, 2382s) was used in western blot on mouse samples (fig 3b). Cardiovasc Diabetol (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 1a
Cell Signaling Technology IRS-1 antibody (Cell Signaling Technology, 2382) was used in western blot on mouse samples at 1:1000 (fig 1a). Nat Commun (2019) ncbi
domestic rabbit monoclonal (59G8)
  • western blot; human; loading ...; fig 4a
Cell Signaling Technology IRS-1 antibody (Cell Signaling Technology, 2390s) was used in western blot on human samples (fig 4a). Eur J Obstet Gynecol Reprod Biol (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 3h
Cell Signaling Technology IRS-1 antibody (Cell Signaling Technology, 2382) was used in western blot on mouse samples (fig 3h). Hepatology (2019) ncbi
domestic rabbit polyclonal
  • western blot; rat; 1:1000; loading ...; fig 4f, 5f
Cell Signaling Technology IRS-1 antibody (Cell Signaling, 2382) was used in western blot on rat samples at 1:1000 (fig 4f, 5f). Br J Pharmacol (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 4a
Cell Signaling Technology IRS-1 antibody (Cell Signalling, 2382) was used in western blot on mouse samples at 1:1000 (fig 4a). J Endocrinol (2018) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 7
Cell Signaling Technology IRS-1 antibody (Cell Signaling, 3070) was used in western blot on human samples (fig 7). Mol Oncol (2017) ncbi
domestic rabbit monoclonal (C15H5)
  • western blot; human; loading ...; fig 2
Cell Signaling Technology IRS-1 antibody (Cell Signaling, 3203) was used in western blot on human samples (fig 2). Mol Oncol (2017) ncbi
mouse monoclonal (L3D12)
  • western blot; mouse; 1:1000; loading ...; fig 7a
Cell Signaling Technology IRS-1 antibody (Cell Signaling, 3194) was used in western blot on mouse samples at 1:1000 (fig 7a). PLoS ONE (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 2a
Cell Signaling Technology IRS-1 antibody (Cell Signaling, 2381) was used in western blot on mouse samples (fig 2a). Exp Clin Endocrinol Diabetes (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 2a
Cell Signaling Technology IRS-1 antibody (Cell Signaling, 2382) was used in western blot on mouse samples (fig 2a). Exp Clin Endocrinol Diabetes (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig s20a
In order to delineate the mechanism for lung tumorigenesis by a tobacco-specific carcinogen, Cell Signaling Technology IRS-1 antibody (Cell Signaling, 2382) was used in western blot on human samples at 1:1000 (fig s20a). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; fig 3
Cell Signaling Technology IRS-1 antibody (Cell signaling, 2580) was used in western blot on mouse samples at 1:1000 (fig 3). PLoS ONE (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig s8i
Cell Signaling Technology IRS-1 antibody (Cell signalling, 2388) was used in western blot on mouse samples (fig s8i). Cell Rep (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:250; loading ...; fig 5f
In order to explore the role of insulin receptor substrate-1 in tumor development, Cell Signaling Technology IRS-1 antibody (Cell Signaling, 2382) was used in western blot on human samples at 1:250 (fig 5f). Proc Natl Acad Sci U S A (2016) ncbi
domestic rabbit monoclonal (D23G12)
  • western blot; human; fig 2
In order to utilize a novel targe for type 2 diabetes and regulate the effects of GPR21, Cell Signaling Technology IRS-1 antibody (Cell Signaling Technology, 3407) was used in western blot on human samples (fig 2). Sci Rep (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; fig st2
Cell Signaling Technology IRS-1 antibody (Cell signaling, 2382) was used in western blot on mouse samples at 1:1000 (fig st2). PLoS ONE (2016) ncbi
domestic rabbit monoclonal (D23G12)
  • western blot; mouse; 1:1000; fig 6
Cell Signaling Technology IRS-1 antibody (Cell Signaling, 3407) was used in western blot on mouse samples at 1:1000 (fig 6). Sci Rep (2016) ncbi
domestic rabbit monoclonal (D51C3)
  • western blot; mouse; 1:1000; fig 7
Cell Signaling Technology IRS-1 antibody (Cell Signaling Technology, 5610) was used in western blot on mouse samples at 1:1000 (fig 7). Nat Immunol (2016) ncbi
domestic rabbit monoclonal (D23G12)
  • western blot; mouse; 1:1000; fig 6
Cell Signaling Technology IRS-1 antibody (Cell signaling, 3407) was used in western blot on mouse samples at 1:1000 (fig 6). Sci Rep (2016) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; mouse; 1:100; fig 6
Cell Signaling Technology IRS-1 antibody (Cell Signaling, 2381) was used in immunocytochemistry on mouse samples at 1:100 (fig 6). Physiol Rep (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 6
Cell Signaling Technology IRS-1 antibody (Cell Signaling, 3070) was used in western blot on mouse samples (fig 6). J Clin Invest (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 4b
Cell Signaling Technology IRS-1 antibody (Cell Signaling, 2388) was used in western blot on human samples (fig 4b). Oncotarget (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 3
In order to assess the inhibition of mammalian target of rapamycin complex 1 in mice due to fibroblast growth factor 21 improving hepatic insulin sensitivity, Cell Signaling Technology IRS-1 antibody (Cell Signaling, 2385) was used in western blot on mouse samples (fig 3). Hepatology (2016) ncbi
mouse monoclonal (L3D12)
  • western blot; human; loading ...; fig 2a
Cell Signaling Technology IRS-1 antibody (Cell Signaling Technology, 3194) was used in western blot on human samples (fig 2a). Mol Endocrinol (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000
Cell Signaling Technology IRS-1 antibody (Cell Signaling, 2388) was used in western blot on mouse samples at 1:1000. Nat Commun (2016) ncbi
domestic rabbit monoclonal (D23G12)
  • western blot; mouse; 1:1000; fig 3
Cell Signaling Technology IRS-1 antibody (Cell signaling, 3407) was used in western blot on mouse samples at 1:1000 (fig 3). Free Radic Biol Med (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:500; fig 3
Cell Signaling Technology IRS-1 antibody (Cell signaling, 2381) was used in western blot on mouse samples at 1:500 (fig 3). Free Radic Biol Med (2016) ncbi
domestic rabbit monoclonal (D23G12)
  • western blot; human; fig 5
In order to investigate how loss of RE-1 Silencing Transcription Factor affects breast cancer, Cell Signaling Technology IRS-1 antibody (cell signaling, 3407) was used in western blot on human samples (fig 5). Mol Cell Biol (2015) ncbi
domestic rabbit monoclonal (D23G12)
  • western blot; mouse; loading ...; fig 2e
In order to demonstrate that Hedgehog engages insulin-like growth signaling to activate the osteogenic program, Cell Signaling Technology IRS-1 antibody (Cell Signaling, 3407) was used in western blot on mouse samples (fig 2e). Proc Natl Acad Sci U S A (2015) ncbi
domestic rabbit monoclonal (D23G12)
  • western blot; rat; 1:1000
Cell Signaling Technology IRS-1 antibody (Cell signaling, 3407) was used in western blot on rat samples at 1:1000. J Exerc Nutrition Biochem (2014) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • western blot; rat; 1:1000; loading ...; fig 4f, 5f
MilliporeSigma IRS-1 antibody (Sigma, I2658) was used in western blot on rat samples at 1:1000 (fig 4f, 5f). Br J Pharmacol (2019) ncbi
BD Biosciences
mouse monoclonal (K9-211)
  • other; human; loading ...; fig st1
In order to use size exclusion chromatography-microsphere-based affinity proteomics to study clinical samples obtained from pediatric acute leukemia patients, BD Biosciences IRS-1 antibody (BD, K9-211) was used in other on human samples (fig st1). Mol Cell Proteomics (2016) ncbi
Articles Reviewed
  1. Zhao M, Banhos Danneskiold Sams xf8 e N, Uličná L, Nguyen Q, Voilquin L, Lee D, et al. Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1. elife. 2022;11: pubmed publisher
  2. Park J, Li J, Mayer J, Ball K, Wu J, Hall C, et al. Activation of the insulin receptor by an insulin mimetic peptide. Nat Commun. 2022;13:5594 pubmed publisher
  3. Erlandsson M, Erdogan S, Was xe9 n C, Andersson K, Silfversw xe4 rd S, Pullerits R, et al. IGF1R signalling is a guardian of self-tolerance restricting autoantibody production. Front Immunol. 2022;13:958206 pubmed publisher
  4. Mahata T, Sengar A, Basak M, Das K, Pramanick A, Verma S, et al. Hepatic Regulator of G Protein Signaling 6 (RGS6) drives non-alcoholic fatty liver disease by promoting oxidative stress and ATM-dependent cell death. Redox Biol. 2021;46:102105 pubmed publisher
  5. Coudert L, Osseni A, Gangloff Y, Schaeffer L, Leblanc P. The ESCRT-0 subcomplex component Hrs/Hgs is a master regulator of myogenesis via modulation of signaling and degradation pathways. BMC Biol. 2021;19:153 pubmed publisher
  6. Lertpatipanpong P, Lee J, Kim I, Eling T, Oh S, Seong J, et al. The anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice. Sci Rep. 2021;11:15027 pubmed publisher
  7. Bruce J, Sánchez Alvarez R, Sans M, Sugden S, Qi N, James A, et al. Insulin protects acinar cells during pancreatitis by preserving glycolytic ATP supply to calcium pumps. Nat Commun. 2021;12:4386 pubmed publisher
  8. Kearney A, Norris D, Ghomlaghi M, Kin Lok Wong M, Humphrey S, Carroll L, et al. Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis. elife. 2021;10: pubmed publisher
  9. Alanazy M, Bakry S, Alqahtani A, AlAkeel N, Alazwary N, Osman A, et al. Clinical features and outcome of Guillain-Barre syndrome in Saudi Arabia: a multicenter, retrospective study. BMC Neurol. 2021;21:275 pubmed publisher
  10. Arunachalam P, Scott M, Hagan T, Li C, Feng Y, Wimmers F, et al. Systems vaccinology of the BNT162b2 mRNA vaccine in humans. Nature. 2021;596:410-416 pubmed publisher
  11. Zilova L, Weinhardt V, Tavhelidse T, Schlagheck C, Thumberger T, Wittbrodt J. Fish primary embryonic pluripotent cells assemble into retinal tissue mirroring in vivo early eye development. elife. 2021;10: pubmed publisher
  12. López Gambero A, Rosell Valle C, Medina Vera D, Navarro J, Vargas A, Rivera P, et al. A Negative Energy Balance Is Associated with Metabolic Dysfunctions in the Hypothalamus of a Humanized Preclinical Model of Alzheimer's Disease, the 5XFAD Mouse. Int J Mol Sci. 2021;22: pubmed publisher
  13. Li L, Yang L, Yang F, Zhao X, Xue S, Gong F. Ginkgo biloba Extract 50 (GBE50) Ameliorates Insulin Resistance, Hepatic Steatosis and Liver Injury in High Fat Diet-Fed Mice. J Inflamm Res. 2021;14:1959-1971 pubmed publisher
  14. Zou Z, Chai M, Guo F, Fu X, Lan Y, Cao S, et al. MicroRNA-126 engineered muscle-derived stem cells attenuates cavernosa injury-induced erectile dysfunction in rats. Aging (Albany NY). 2021;13:14399-14415 pubmed publisher
  15. Luo L, Zhang Z, Qiu N, Ling L, Jia X, Song Y, et al. Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer. Nat Commun. 2021;12:2699 pubmed publisher
  16. Chen Y, Hu W, Li Q, Zhao S, Zhao D, Zhang S, et al. NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021;296:100624 pubmed publisher
  17. Li D, Sun S, Fu J, Ouyang S, Zhao Q, Su L, et al. NAD+-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin. Theranostics. 2021;11:4381-4402 pubmed publisher
  18. Wallace M, Aguirre N, Marcotte G, Marshall A, Baehr L, Hughes D, et al. The ketogenic diet preserves skeletal muscle with aging in mice. Aging Cell. 2021;20:e13322 pubmed publisher
  19. Ogura Y, Tajiri K, Murakoshi N, Xu D, Yonebayashi S, Li S, et al. Neutrophil Elastase Deficiency Ameliorates Myocardial Injury Post Myocardial Infarction in Mice. Int J Mol Sci. 2021;22: pubmed publisher
  20. Pan S, Zhao X, Shao C, Fu B, Huang Y, Zhang N, et al. STIM1 promotes angiogenesis by reducing exosomal miR-145 in breast cancer MDA-MB-231 cells. Cell Death Dis. 2021;12:38 pubmed publisher
  21. Eyler C, Matsunaga H, Hovestadt V, Vantine S, van Galen P, Bernstein B. Single-cell lineage analysis reveals genetic and epigenetic interplay in glioblastoma drug resistance. Genome Biol. 2020;21:174 pubmed publisher
  22. Ruiz Velasco A, Zi M, Hille S, Azam T, Kaur N, Jiang J, et al. Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure. elife. 2020;9: pubmed publisher
  23. Xu M, Ge C, Qin Y, Lou D, Li Q, Feng J, et al. Functional loss of inactive rhomboid-like protein 2 mitigates obesity by suppressing pro-inflammatory macrophage activation-triggered adipose inflammation. Mol Metab. 2020;34:112-123 pubmed publisher
  24. Shi H, Wang Q, Zheng M, Hao S, Lum J, Chen X, et al. Supplement of microbiota-accessible carbohydrates prevents neuroinflammation and cognitive decline by improving the gut microbiota-brain axis in diet-induced obese mice. J Neuroinflammation. 2020;17:77 pubmed publisher
  25. Yang S, Ma C, Wu H, Zhang H, Yuan F, Yang G, et al. Tectorigenin attenuates diabetic nephropathy by improving vascular endothelium dysfunction through activating AdipoR1/2 pathway. Pharmacol Res. 2020;153:104678 pubmed publisher
  26. Tian S, Jia W, Lu M, Zhao J, Sun X. Dual-specificity tyrosine phosphorylation-regulated kinase 1A ameliorates insulin resistance in neurons by up-regulating IRS-1 expression. J Biol Chem. 2019;: pubmed publisher
  27. Yang N, Yu L, Deng Y, Han Q, Wang J, Yu L, et al. Identification and characterization of proteins that are differentially expressed in adipose tissue of olanzapine-induced insulin resistance rat by iTRAQ quantitative proteomics. J Proteomics. 2020;212:103570 pubmed publisher
  28. Uddin G, Zhang L, Shah S, Fukushima A, Wagg C, Gopal K, et al. Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure. Cardiovasc Diabetol. 2019;18:86 pubmed publisher
  29. Ogawa S, Yamada M, Nakamura A, Sugawara T, Nakamura A, Miyajima S, et al. Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis. Stem Cell Reports. 2019;12:1366-1379 pubmed publisher
  30. Bazzari F, Abdallah D, El Abhar H. Chenodeoxycholic Acid Ameliorates AlCl3-Induced Alzheimer's Disease Neurotoxicity and Cognitive Deterioration via Enhanced Insulin Signaling in Rats. Molecules. 2019;24: pubmed publisher
  31. Hwang J, Kim A, Kim K, Il Park J, Oh H, Moon S, et al. TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression. Nat Commun. 2019;10:421 pubmed publisher
  32. He T, Liu Y, Zhao S, Liu H, Wang Z, Shi Y. Comprehensive assessment the expression of core elements related to IGFIR/PI3K pathway in granulosa cells of women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2019;233:134-140 pubmed publisher
  33. Ye P, Liu J, Xu W, Liu D, Ding X, Le S, et al. Dual-Specificity Phosphatase 26 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through Transforming Growth Factor Beta-Activated Kinase 1 Suppression. Hepatology. 2019;69:1946-1964 pubmed publisher
  34. Zhou X, Zhang R, Zou Z, Shen X, Xie T, Xu C, et al. Hypoglycaemic effects of glimepiride in sulfonylurea receptor 1 deficient rat. Br J Pharmacol. 2019;176:478-490 pubmed publisher
  35. Ameen G, Mora S. Cbl downregulation increases RBP4 expression in adipocytes of female mice. J Endocrinol. 2018;236:29-41 pubmed publisher
  36. Baumann C, Ullrich A, Torka R. GAS6-expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance. Mol Oncol. 2017;11:1430-1447 pubmed publisher
  37. Wang H, Lee K, Pei Z, Khan A, Bakshi K, Burns L. PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis. Neurobiol Aging. 2017;55:99-114 pubmed publisher
  38. Vidal Quadras M, Holst M, Francis M, Larsson E, Hachimi M, Yau W, et al. Endocytic turnover of Rab8 controls cell polarization. J Cell Sci. 2017;130:1147-1157 pubmed publisher
  39. Yu N, Fang X, Zhao D, Mu Q, Zuo J, Ma Y, et al. Anti-Diabetic Effects of Jiang Tang Xiao Ke Granule via PI3K/Akt Signalling Pathway in Type 2 Diabetes KKAy Mice. PLoS ONE. 2017;12:e0168980 pubmed publisher
  40. Tian X, Ye M, Cao Y, Wang C. Losartan Improves Palmitate-Induced Insulin Resistance in 3T3-L1 Adipocytes Through Upregulation of Src Phosphorylation. Exp Clin Endocrinol Diabetes. 2017;125:136-140 pubmed publisher
  41. Liu Z, Gan L, Wu T, Feng F, Luo D, Gu H, et al. Adiponectin reduces ER stress-induced apoptosis through PPARα transcriptional regulation of ATF2 in mouse adipose. Cell Death Dis. 2016;7:e2487 pubmed publisher
  42. Wang X, Cao Q, Yu L, Shi H, Xue B, Shi H. Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity. JCI Insight. 2016;1:e87748 pubmed publisher
  43. Boo H, Min H, Jang H, Yun H, Smith J, Jin Q, et al. The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells. Nat Commun. 2016;7:12961 pubmed publisher
  44. Na H, Hegde V, Dubuisson O, Dhurandhar N. E4orf1 Enhances Glucose Uptake Independent of Proximal Insulin Signaling. PLoS ONE. 2016;11:e0161275 pubmed publisher
  45. Tsai S, Rodriguez A, Dastidar S, Del Greco E, Carr K, Sitzmann J, et al. Increased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice. Cell Rep. 2016;16:1903-14 pubmed publisher
  46. Metz H, Kargl J, Busch S, Kim K, Kurland B, Abberbock S, et al. Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma. Proc Natl Acad Sci U S A. 2016;113:8795-800 pubmed publisher
  47. Roychowdhury S, McCullough R, Sanz Garcia C, Saikia P, Alkhouri N, Matloob A, et al. Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury. Hepatology. 2016;64:1518-1533 pubmed publisher
  48. Leonard S, Kinsella G, Benetti E, Findlay J. Regulating the effects of GPR21, a novel target for type 2 diabetes. Sci Rep. 2016;6:27002 pubmed publisher
  49. Gharib M, Tao H, Fungwe T, Hajri T. Cluster Differentiating 36 (CD36) Deficiency Attenuates Obesity-Associated Oxidative Stress in the Heart. PLoS ONE. 2016;11:e0155611 pubmed publisher
  50. Wang K, Cao P, Wang H, Tang Z, Wang N, Wang J, et al. Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice. Sci Rep. 2016;6:26229 pubmed publisher
  51. Swamy M, Pathak S, Grzes K, Damerow S, Sinclair L, van Aalten D, et al. Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy. Nat Immunol. 2016;17:712-20 pubmed publisher
  52. Dinger K, Kasper P, Hucklenbruch Rother E, Vohlen C, Jobst E, Janoschek R, et al. Early-onset obesity dysregulates pulmonary adipocytokine/insulin signaling and induces asthma-like disease in mice. Sci Rep. 2016;6:24168 pubmed publisher
  53. Talukder M, Preda M, Ryzhova L, Prudovsky I, PINZ I. Heterozygous caveolin-3 mice show increased susceptibility to palmitate-induced insulin resistance. Physiol Rep. 2016;4: pubmed publisher
  54. Winnay J, Solheim M, Dirice E, Sakaguchi M, Noh H, Kang H, et al. PI3-kinase mutation linked to insulin and growth factor resistance in vivo. J Clin Invest. 2016;126:1401-12 pubmed publisher
  55. Atiq R, Hertz R, Eldad S, Smeir E, Bar Tana J. Suppression of B-Raf(V600E) cancers by MAPK hyper-activation. Oncotarget. 2016;7:18694-704 pubmed publisher
  56. Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, et al. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice. Hepatology. 2016;64:425-38 pubmed publisher
  57. Liao B, McManus S, Hughes W, Schmitz Peiffer C. Flavin-Containing Monooxygenase 3 Reduces Endoplasmic Reticulum Stress in Lipid-Treated Hepatocytes. Mol Endocrinol. 2016;30:417-28 pubmed publisher
  58. Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  59. Kim K, Qiang L, Hayden M, Sparling D, Purcell N, Pajvani U. mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2. Nat Commun. 2016;7:10255 pubmed publisher
  60. Barone E, Di Domenico F, Cassano T, Arena A, Tramutola A, Lavecchia M, et al. Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm. Free Radic Biol Med. 2016;91:127-42 pubmed publisher
  61. Garwood C, Ratcliffe L, Morgan S, Simpson J, Owens H, Vazquez Villaseñor I, et al. Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors. Mol Brain. 2015;8:51 pubmed publisher
  62. Barbone D, Follo C, Echeverry N, Gerbaudo V, Klabatsa A, Bueno R, et al. Autophagy Correlates with the Therapeutic Responsiveness of Malignant Pleural Mesothelioma in 3D Models. PLoS ONE. 2015;10:e0134825 pubmed publisher
  63. Meyer K, Albaugh B, Schoenike B, Roopra A. Type 1 Insulin-Like Growth Factor Receptor/Insulin Receptor Substrate 1 Signaling Confers Pathogenic Activity on Breast Tumor Cells Lacking REST. Mol Cell Biol. 2015;35:2991-3004 pubmed publisher
  64. Vishwamitra D, Curry C, Alkan S, Song Y, Gallick G, Kaseb A, et al. The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK⁺ T-cell lymphoma. Mol Cancer. 2015;14:53 pubmed publisher
  65. Shi Y, Chen J, Karner C, Long F. Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation. Proc Natl Acad Sci U S A. 2015;112:4678-83 pubmed publisher
  66. Nakazawa H, Yamada M, Tanaka T, Kramer J, Yu Y, Fischman A, et al. Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. PLoS ONE. 2015;10:e0116633 pubmed publisher
  67. Kang E, Cho J. Effects of treadmill exercise on brain insulin signaling and β-amyloid in intracerebroventricular streptozotocin induced-memory impairment in rats. J Exerc Nutrition Biochem. 2014;18:89-96 pubmed publisher
  68. Passos E, Pereira C, Gonçalves I, Rocha Rodrigues S, Silva N, Guimarães J, et al. Role of physical exercise on hepatic insulin, glucocorticoid and inflammatory signaling pathways in an animal model of non-alcoholic steatohepatitis. Life Sci. 2015;123:51-60 pubmed publisher
  69. Xu W, Yang X, Li D, Zheng K, Qiu P, Zhang W, et al. Up-regulation of fatty acid oxidation in the ligament as a contributing factor of ankylosing spondylitis: A comparative proteomic study. J Proteomics. 2015;113:57-72 pubmed publisher
  70. El Ami T, Moll L, Carvalhal Marques F, Volovik Y, Reuveni H, Cohen E. A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity. Aging Cell. 2014;13:165-74 pubmed publisher