This is a Validated Antibody Database (VAD) review about human IREB2, based on 15 published articles (read how Labome selects the articles), using IREB2 antibody in all methods. It is aimed to help Labome visitors find the most suited IREB2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
IREB2 synonym: ACO3; IRE-BP 2; IRE-BP2; IRP2; IRP2AD; NDCAMA

Santa Cruz Biotechnology
mouse monoclonal (7H6)
  • western blot; human; loading ...; fig 5b
Santa Cruz Biotechnology IREB2 antibody (Santa, sc-33682) was used in western blot on human samples (fig 5b). Cell (2019) ncbi
mouse monoclonal (7H6)
  • western blot; human; 1:1000; loading ...; fig 5a
Santa Cruz Biotechnology IREB2 antibody (Santa Cruz, sc-33682) was used in western blot on human samples at 1:1000 (fig 5a). Science (2017) ncbi
mouse monoclonal (7H6)
  • western blot; human; 1:1000; loading ...; fig 4h
Santa Cruz Biotechnology IREB2 antibody (SantaCruz, sc-33682) was used in western blot on human samples at 1:1000 (fig 4h). Mol Cell Biol (2017) ncbi
mouse monoclonal (7H6)
  • western blot; mouse; 1:1000; fig 8
Santa Cruz Biotechnology IREB2 antibody (Santa Cruz, sc-33682) was used in western blot on mouse samples at 1:1000 (fig 8). Nat Med (2016) ncbi
mouse monoclonal (7H6)
  • western blot; human; 1:500; fig 2
Santa Cruz Biotechnology IREB2 antibody (Santa Cruz, Sc-33682) was used in western blot on human samples at 1:500 (fig 2). elife (2015) ncbi
mouse monoclonal (7H6)
  • western blot; human; 1:500; fig 2
Santa Cruz Biotechnology IREB2 antibody (Santa Cruz Biotechnology, sc-33682) was used in western blot on human samples at 1:500 (fig 2). Biochem J (2015) ncbi
mouse monoclonal (7H6)
  • western blot; human
Santa Cruz Biotechnology IREB2 antibody (Santa Cruz Biotechnology, SC-33682) was used in western blot on human samples . J Biol Chem (2014) ncbi
mouse monoclonal (7H6)
  • western blot; human
In order to study the role of HERC2 in FBXL5 degradation and iron metabolism, Santa Cruz Biotechnology IREB2 antibody (Santa Cruz Biotechnology, sc-33682) was used in western blot on human samples . J Biol Chem (2014) ncbi
mouse monoclonal (7H6)
  • western blot; human; 1:500
Santa Cruz Biotechnology IREB2 antibody (Santa, Sc-33682) was used in western blot on human samples at 1:500. Nature (2014) ncbi
Abcam
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 2e, s2e
Abcam IREB2 antibody (Abcam, ab232994) was used in western blot on human samples at 1:1000 (fig 2e, s2e). Oncol Lett (2021) ncbi
domestic rabbit monoclonal (EPR13854)
  • western blot; rat; loading ...; fig 4c
Abcam IREB2 antibody (Abcam, ab181153) was used in western blot on rat samples (fig 4c). Front Mol Biosci (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...
Abcam IREB2 antibody (Abcam, ab232994) was used in western blot on human samples . Theranostics (2021) ncbi
domestic rabbit monoclonal (EPR13854)
  • western blot; turquoise killifish; 1:1000; loading ...; fig 4d
In order to analyze the role of the microRNA miR-29 in limiting neuronal iron accumulation, Abcam IREB2 antibody (Abcam, ab181153) was used in western blot on turquoise killifish samples at 1:1000 (fig 4d). BMC Biol (2017) ncbi
domestic rabbit monoclonal (EPR13854)
  • immunohistochemistry; mouse; 1:50; fig s1
Abcam IREB2 antibody (Abcam, ab181153) was used in immunohistochemistry on mouse samples at 1:50 (fig s1). Nat Med (2016) ncbi
domestic goat polyclonal
  • immunohistochemistry; mouse; 1:50; fig s1
Abcam IREB2 antibody (Abcam, ab106926) was used in immunohistochemistry on mouse samples at 1:50 (fig s1). Nat Med (2016) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D6E6W)
  • western blot; human; 1:1000; loading ...; fig 8A
In order to identify cellular processes that regulate HIF1alpha, Cell Signaling Technology IREB2 antibody (Cell signaling, 37135) was used in western blot on human samples at 1:1000 (fig 8A). elife (2017) ncbi
domestic rabbit monoclonal (D6E6W)
  • western blot; human; 1:200; loading ...; fig 5
In order to report polyphenols with iron-chelating potential, Cell Signaling Technology IREB2 antibody (cell signalling, 37135) was used in western blot on human samples at 1:200 (fig 5). Mol Nutr Food Res (2017) ncbi
Articles Reviewed
  1. Yao F, Cui X, Zhang Y, Bei Z, Wang H, Zhao D, et al. Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma. Oncol Lett. 2021;22:657 pubmed publisher
  2. Chang B, Guan H, Wang X, Chen Z, Zhu W, Wei X, et al. Cox4i2 Triggers an Increase in Reactive Oxygen Species, Leading to Ferroptosis and Apoptosis in HHV7 Infected Schwann Cells. Front Mol Biosci. 2021;8:660072 pubmed publisher
  3. Zhang X, Yu K, Ma L, Qian Z, Tian X, Miao Y, et al. Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma. Theranostics. 2021;11:5650-5674 pubmed publisher
  4. Ast T, Meisel J, Patra S, Wang H, Grange R, Kim S, et al. Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis. Cell. 2019;: pubmed publisher
  5. Grillo A, SantaMaria A, Kafina M, Cioffi A, Huston N, Han M, et al. Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals. Science. 2017;356:608-616 pubmed publisher
  6. Miles A, Burr S, Grice G, Nathan J. The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1? prolyl hydroxylation by regulating cellular iron levels. elife. 2017;6: pubmed publisher
  7. Kerins M, Vashisht A, Liang B, Duckworth S, Praslicka B, WOHLSCHLEGEL J, et al. Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes. Mol Cell Biol. 2017;37: pubmed publisher
  8. Ripa R, Dolfi L, Terrigno M, Pandolfini L, Savino A, Arcucci V, et al. MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging. BMC Biol. 2017;15:9 pubmed publisher
  9. Horniblow R, Henesy D, Iqbal T, Tselepis C. Modulation of iron transport, metabolism and reactive oxygen status by quercetin-iron complexes in vitro. Mol Nutr Food Res. 2017;61: pubmed publisher
  10. Cloonan S, Glass K, Laucho Contreras M, Bhashyam A, Cervo M, Pabón M, et al. Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice. Nat Med. 2016;22:163-74 pubmed publisher
  11. Mancias J, Pontano Vaites L, Nissim S, Biancur D, Kim A, Wang X, et al. Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis. elife. 2015;4: pubmed publisher
  12. Bauckman K, Haller E, Taran N, Rockfield S, Ruiz Rivera A, Nanjundan M. Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells. Biochem J. 2015;466:401-13 pubmed publisher
  13. Yang N, Tan S, Ng S, Shi Y, Zhou J, Tan K, et al. Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin. J Biol Chem. 2014;289:33425-41 pubmed publisher
  14. Moroishi T, Yamauchi T, Nishiyama M, Nakayama K. HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism. J Biol Chem. 2014;289:16430-41 pubmed publisher
  15. Mancias J, Wang X, Gygi S, Harper J, Kimmelman A. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature. 2014;509:105-9 pubmed publisher