This is a Validated Antibody Database (VAD) review about human IL 22, based on 33 published articles (read how Labome selects the articles), using IL 22 antibody in all methods. It is aimed to help Labome visitors find the most suited IL 22 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
IL 22 synonym: IL-21; IL-22; IL-D110; IL-TIF; ILTIF; TIFIL-23; TIFa; zcyto18; interleukin-22; IL-10-related T-cell-derived inducible factor; cytokine Zcyto18

Invitrogen
rat monoclonal (IL22JOP)
  • flow cytometry; mouse; 1:200; loading ...; fig 8c
Invitrogen IL 22 antibody (BioLegend, 17-7222) was used in flow cytometry on mouse samples at 1:200 (fig 8c). Front Immunol (2018) ncbi
mouse monoclonal (22URTI)
  • flow cytometry; human; loading ...; tbl 1
Invitrogen IL 22 antibody (Thermo Fisher Scientific, 12-7229-41) was used in flow cytometry on human samples (tbl 1). J Clin Invest (2018) ncbi
mouse monoclonal (22URTI)
  • flow cytometry; human; fig s3
Invitrogen IL 22 antibody (eBiosciences, 12-7229-41) was used in flow cytometry on human samples (fig s3). Cell (2018) ncbi
mouse monoclonal (22URTI)
  • flow cytometry; human; fig 1b
In order to study the involvement of Notch signaling in NK cell lineage determination, Invitrogen IL 22 antibody (ebioscience, 22URTI) was used in flow cytometry on human samples (fig 1b). J Immunol (2017) ncbi
mouse monoclonal (22URTI)
  • flow cytometry; human; fig 4b
In order to investigate the role of Vgamma9/Vdelta2 T cells in intestinal IL-22 production, Invitrogen IL 22 antibody (eBioscience, 22URTI) was used in flow cytometry on human samples (fig 4b). J Immunol (2017) ncbi
mouse monoclonal (22URTI)
  • flow cytometry; human; fig s3b
In order to study the differentiation of innate lymphoid cells, Invitrogen IL 22 antibody (eBioscience, 25-7229) was used in flow cytometry on human samples (fig s3b). Cell (2017) ncbi
mouse monoclonal (22URTI)
  • flow cytometry; human; loading ...; fig s2a
In order to investigate lactam-specific T-cell response in the skin and blood of humans, Invitrogen IL 22 antibody (eBiosciences, 22URTI) was used in flow cytometry on human samples (fig s2a). J Allergy Clin Immunol (2018) ncbi
rat monoclonal (IL22JOP)
  • flow cytometry; human; loading ...; fig 5a
In order to describe complete autosomal recessive IL-17RA deficiency in patients with chronic mucocutaneous candidiasis, Invitrogen IL 22 antibody (Ebiosciences, IL22JOP) was used in flow cytometry on human samples (fig 5a). Proc Natl Acad Sci U S A (2016) ncbi
rat monoclonal (IL22JOP)
  • flow cytometry; mouse; fig s3g
Invitrogen IL 22 antibody (eBioscience, IL22JOP) was used in flow cytometry on mouse samples (fig s3g). Immunity (2016) ncbi
mouse monoclonal (22URTI)
  • flow cytometry; human; fig 6
In order to study activation of myeloid dendritic cells, regulatory T cells and effector cells in lichen planus, Invitrogen IL 22 antibody (eBioscience, 22URTI) was used in flow cytometry on human samples (fig 6). J Transl Med (2016) ncbi
rat monoclonal (IL22JOP)
  • flow cytometry; human; fig s12b
In order to find predictive markers for patients that will develop gastrointestinal graft-versus-host-disease, Invitrogen IL 22 antibody (eBiosciences, IL22JOP) was used in flow cytometry on human samples (fig s12b). JCI Insight (2016) ncbi
mouse monoclonal (22URTI)
  • flow cytometry; human; 1:100; fig 3
In order to elucidate the marked reduction of Nkp44/Nkp46-double positive natural killer cells by celiac disease-related inflammation, Invitrogen IL 22 antibody (eBioscience, 22URTI) was used in flow cytometry on human samples at 1:100 (fig 3). PLoS ONE (2016) ncbi
mouse monoclonal (22URTI)
  • flow cytometry; human; 1:100; loading ...; fig 2b
In order to define the underlying mechanism of Runt-related transcription factor 3's involvement in the differentiation of T-helper 17 and T-helper 22 cells in psoriasis, Invitrogen IL 22 antibody (eBiosciences, 12-7229-41) was used in flow cytometry on human samples at 1:100 (fig 2b). Mol Med Rep (2016) ncbi
rat monoclonal (IL22JOP)
  • flow cytometry; mouse; fig s4
Invitrogen IL 22 antibody (eBioscience, 17-7222-82) was used in flow cytometry on mouse samples (fig s4). Cell (2016) ncbi
rat monoclonal (IL22JOP)
  • flow cytometry; Rhesus monkey; fig 1c
Invitrogen IL 22 antibody (eBiosciences, IL22JOP) was used in flow cytometry on Rhesus monkey samples (fig 1c). J Immunol (2016) ncbi
mouse monoclonal (22URTI)
  • flow cytometry; human; fig 2d
In order to Targeting CD8(+) T cells prevents psoriasis development, Invitrogen IL 22 antibody (eBiosciences, 22URTI) was used in flow cytometry on human samples (fig 2d). J Allergy Clin Immunol (2016) ncbi
mouse monoclonal (22URTI)
  • flow cytometry; human; loading ...; fig s2a
In order to study age-related changes in human immunity during a primary virus infection experimentally induced by immunization with live-attenuated yellow fever vaccine, Invitrogen IL 22 antibody (eBioscience, 22URT) was used in flow cytometry on human samples (fig s2a). J Immunol (2015) ncbi
rat monoclonal (IL22JOP)
  • flow cytometry; mouse; 1:100; fig s4
Invitrogen IL 22 antibody (eBioscience, 17-7222-82) was used in flow cytometry on mouse samples at 1:100 (fig s4). Nat Commun (2015) ncbi
mouse monoclonal (22URTI)
  • flow cytometry; human; fig 2
Invitrogen IL 22 antibody (eBioscience, 12-7229) was used in flow cytometry on human samples (fig 2). Allergy (2016) ncbi
mouse monoclonal (22URTI)
  • flow cytometry; human; fig 1
Invitrogen IL 22 antibody (eBioscience, 12-7229) was used in flow cytometry on human samples (fig 1). Stem Cell Reports (2015) ncbi
mouse monoclonal (22URTI)
  • flow cytometry; human; fig 1
In order to investigate the dynamics and characteristics of natural killer cell types in the human ocular mucosal surface in situ during infection with group D human adenoviruses, Invitrogen IL 22 antibody (eBioscience, 22URTI) was used in flow cytometry on human samples (fig 1). Mucosal Immunol (2016) ncbi
rat monoclonal (IL22JOP)
  • flow cytometry; human; fig 3
Invitrogen IL 22 antibody (eBioscience, 17-7222-82) was used in flow cytometry on human samples (fig 3). Scand J Immunol (2015) ncbi
rat monoclonal (IL22JOP)
  • dot blot; human; tbl s1
In order to use polydimethylsiloxane microchambers to co-detect 42 immune effector proteins secreted from a single LPS-stimulation macrophage, Invitrogen IL 22 antibody (Ebioscience, 16- 7222-85) was used in dot blot on human samples (tbl s1). Proc Natl Acad Sci U S A (2015) ncbi
mouse monoclonal (22URTI)
  • flow cytometry; human
Invitrogen IL 22 antibody (eBioscience, 22URTI) was used in flow cytometry on human samples . J Immunol (2014) ncbi
rat monoclonal (IL22JOP)
  • flow cytometry; mouse
Invitrogen IL 22 antibody (eBioscience, IL22JOP) was used in flow cytometry on mouse samples . J Exp Med (2014) ncbi
mouse monoclonal (22URTI)
  • flow cytometry; human; fig 2
Invitrogen IL 22 antibody (eBioscience, 22URTI) was used in flow cytometry on human samples (fig 2). Ann Rheum Dis (2014) ncbi
rat monoclonal (IL22JOP)
  • flow cytometry; African green monkey; loading ...; fig s1b
In order to investigate mucosal dysfunction in relation to HIV/SIV pathogenesis, Invitrogen IL 22 antibody (eBioscience, IL22JOP) was used in flow cytometry on African green monkey samples (fig s1b). J Immunol (2013) ncbi
rat monoclonal (IL22JOP)
  • flow cytometry; Rhesus monkey
In order to study alterations in mucosal immunity during SIV infection, Invitrogen IL 22 antibody (eBioscience, IL22JOP) was used in flow cytometry on Rhesus monkey samples . Mucosal Immunol (2012) ncbi
R&D Systems
mouse monoclonal (142928)
  • flow cytometry; human; loading ...; fig s1b
R&D Systems IL 22 antibody (R&D Systems, IC7821P) was used in flow cytometry on human samples (fig s1b). J Immunol (2016) ncbi
mouse monoclonal (142928)
  • flow cytometry; human; loading ...; fig 3f
R&D Systems IL 22 antibody (R&D Systems, 142928) was used in flow cytometry on human samples (fig 3f). PLoS ONE (2016) ncbi
goat polyclonal
  • immunohistochemistry; human; fig 2
R&D Systems IL 22 antibody (R&D Systems, AF782) was used in immunohistochemistry on human samples (fig 2). J Neuroinflammation (2015) ncbi
BioLegend
goat polyclonal (Poly5161)
  • flow cytometry; human; loading ...; tbl 1
In order to demonstrate that freezing already-stained samples suspended in 10% DMSO in FBS is practical and efficient way to preserve already-stained samples for mass cytometry assessment, BioLegend IL 22 antibody (Biolegend, Poly5161) was used in flow cytometry on human samples (tbl 1). Cytometry A (2017) ncbi
Abcam
rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse
Abcam IL 22 antibody (Abcam, ab18564) was used in immunohistochemistry - paraffin section on mouse samples . Mol Med Rep (2014) ncbi
Articles Reviewed
  1. Glal D, Sudhakar J, Lu H, Liu M, Chiang H, Liu Y, et al. ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases. Front Immunol. 2018;9:2522 pubmed publisher
  2. D Addio F, Vergani A, Potena L, Maestroni A, Usuelli V, Ben Nasr M, et al. P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes. J Clin Invest. 2018;128:3490-3503 pubmed publisher
  3. Barrow A, Edeling M, Trifonov V, Luo J, Goyal P, Bohl B, et al. Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor. Cell. 2018;172:534-548.e19 pubmed publisher
  4. Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, et al. Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors. J Immunol. 2017;199:2777-2793 pubmed publisher
  5. Tyler C, McCarthy N, Lindsay J, Stagg A, Moser B, Eberl M. Antigen-Presenting Human ?? T Cells Promote Intestinal CD4+ T Cell Expression of IL-22 and Mucosal Release of Calprotectin. J Immunol. 2017;198:3417-3425 pubmed publisher
  6. Lim A, Li Y, Lopez Lastra S, Stadhouders R, Paul F, Casrouge A, et al. Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation. Cell. 2017;168:1086-1100.e10 pubmed publisher
  7. Sullivan A, Wang E, Farrell J, Whitaker P, Faulkner L, Peckham D, et al. ?-Lactam hypersensitivity involves expansion of circulating and skin-resident TH22 cells. J Allergy Clin Immunol. 2018;141:235-249.e8 pubmed publisher
  8. Lévy R, Okada S, Béziat V, Moriya K, Liu C, Chai L, et al. Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency. Proc Natl Acad Sci U S A. 2016;113:E8277-E8285 pubmed publisher
  9. Sumatoh H, Teng K, Cheng Y, Newell E. Optimization of mass cytometry sample cryopreservation after staining. Cytometry A. 2017;91:48-61 pubmed publisher
  10. Wang S, Xia P, Chen Y, Huang G, Xiong Z, Liu J, et al. Natural Killer-like B Cells Prime Innate Lymphocytes against Microbial Infection. Immunity. 2016;45:131-44 pubmed publisher
  11. Suliman S, Geldenhuys H, Johnson J, Hughes J, Smit E, Murphy M, et al. Bacillus Calmette-Guérin (BCG) Revaccination of Adults with Latent Mycobacterium tuberculosis Infection Induces Long-Lived BCG-Reactive NK Cell Responses. J Immunol. 2016;197:1100-1110 pubmed publisher
  12. Domingues R, de Carvalho G, Aoki V, da Silva Duarte A, Sato M. Activation of myeloid dendritic cells, effector cells and regulatory T cells in lichen planus. J Transl Med. 2016;14:171 pubmed publisher
  13. Li W, Liu L, Gomez A, Zhang J, Ramadan A, Zhang Q, et al. Proteomics analysis reveals a Th17-prone cell population in presymptomatic graft-versus-host disease. JCI Insight. 2016;1: pubmed
  14. Marafini I, Monteleone I, Di Fusco D, Sedda S, Cupi M, Fina D, et al. Celiac Disease-Related Inflammation Is Marked by Reduction of Nkp44/Nkp46-Double Positive Natural Killer Cells. PLoS ONE. 2016;11:e0155103 pubmed publisher
  15. Fu D, Song X, Hu H, Sun M, Li Z, Tian Z. Downregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis. Mol Med Rep. 2016;13:4606-12 pubmed publisher
  16. Xiong H, Keith J, Samilo D, Carter R, Leiner I, Pamer E. Innate Lymphocyte/Ly6C(hi) Monocyte Crosstalk Promotes Klebsiella Pneumoniae Clearance. Cell. 2016;165:679-89 pubmed publisher
  17. Rueda C, Presicce P, Jackson C, Miller L, Kallapur S, Jobe A, et al. Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1-Dependent Inflammatory FOXP3+ CD4+ T Cells in the Fetal Rhesus Macaque. J Immunol. 2016;196:3706-15 pubmed publisher
  18. Li L, Jiang Y, Lao S, Yang B, Yu S, Zhang Y, et al. Mycobacterium tuberculosis-Specific IL-21+IFN-γ+CD4+ T Cells Are Regulated by IL-12. PLoS ONE. 2016;11:e0147356 pubmed publisher
  19. Di Meglio P, Villanova F, Navarini A, Mylonas A, Tosi I, Nestle F, et al. Targeting CD8(+) T cells prevents psoriasis development. J Allergy Clin Immunol. 2016;138:274-276.e6 pubmed publisher
  20. Schulz A, Mälzer J, Domingo C, Jürchott K, Grützkau A, Babel N, et al. Low Thymic Activity and Dendritic Cell Numbers Are Associated with the Immune Response to Primary Viral Infection in Elderly Humans. J Immunol. 2015;195:4699-711 pubmed publisher
  21. Zanvit P, Konkel J, Jiao X, Kasagi S, Zhang D, Wu R, et al. Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis. Nat Commun. 2015;6:8424 pubmed publisher
  22. Wawrzyniak M, Ochsner U, Wirz O, Wawrzyniak P, Van De Veen W, Akdis C, et al. A novel, dual cytokine-secretion assay for the purification of human Th22 cells that do not co-produce IL-17A. Allergy. 2016;71:47-57 pubmed publisher
  23. Wang W, Yen M, Liu K, Hsu P, Lin M, Chen P, et al. Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses. Stem Cell Reports. 2015;5:392-404 pubmed publisher
  24. Yawata N, Selva K, Liu Y, Tan K, Lee A, Siak J, et al. Dynamic change in natural killer cell type in the human ocular mucosa in situ as means of immune evasion by adenovirus infection. Mucosal Immunol. 2016;9:159-70 pubmed publisher
  25. Perriard G, Mathias A, Enz L, Canales M, Schluep M, Gentner M, et al. Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes. J Neuroinflammation. 2015;12:119 pubmed publisher
  26. Dyring Andersen B, Bonefeld C, Bzorek M, Løvendorf M, Lauritsen J, Skov L, et al. The Vitamin D Analogue Calcipotriol Reduces the Frequency of CD8+ IL-17+ T Cells in Psoriasis Lesions. Scand J Immunol. 2015;82:84-91 pubmed publisher
  27. Lu Y, Xue Q, Eisele M, Sulistijo E, Brower K, Han L, et al. Highly multiplexed profiling of single-cell effector functions reveals deep functional heterogeneity in response to pathogenic ligands. Proc Natl Acad Sci U S A. 2015;112:E607-15 pubmed publisher
  28. Bacher P, Kniemeyer O, Teutschbein J, Thön M, Vödisch M, Wartenberg D, et al. Identification of immunogenic antigens from Aspergillus fumigatus by direct multiparameter characterization of specific conventional and regulatory CD4+ T cells. J Immunol. 2014;193:3332-43 pubmed publisher
  29. Longman R, Diehl G, Victorio D, Huh J, Galan C, Miraldi E, et al. CX?CR1? mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. J Exp Med. 2014;211:1571-83 pubmed publisher
  30. Qin S, Wen J, Bai X, Chen T, Zheng R, Zhou G, et al. Endogenous n-3 polyunsaturated fatty acids protect against imiquimod-induced psoriasis-like inflammation via the IL-17/IL-23 axis. Mol Med Rep. 2014;9:2097-104 pubmed publisher
  31. Melis L, Van Praet L, Pircher H, Venken K, Elewaut D. Senescence marker killer cell lectin-like receptor G1 (KLRG1) contributes to TNF-? production by interaction with its soluble E-cadherin ligand in chronically inflamed joints. Ann Rheum Dis. 2014;73:1223-31 pubmed publisher
  32. Canary L, Vinton C, Morcock D, Pierce J, Estes J, Brenchley J, et al. Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques. J Immunol. 2013;190:2959-65 pubmed publisher
  33. Klatt N, Estes J, Sun X, Ortiz A, Barber J, Harris L, et al. Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection. Mucosal Immunol. 2012;5:646-57 pubmed publisher