This is a Validated Antibody Database (VAD) review about human IKZF1, based on 9 published articles (read how Labome selects the articles), using IKZF1 antibody in all methods. It is aimed to help Labome visitors find the most suited IKZF1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
IKZF1 synonym: CVID13; Hs.54452; IK1; IKAROS; LYF1; LyF-1; PPP1R92; PRO0758; ZNFN1A1

Abcam
domestic rabbit monoclonal (EPR13790)
  • immunohistochemistry; mouse; loading ...; fig s6c
Abcam IKZF1 antibody (Abcam, ab191394) was used in immunohistochemistry on mouse samples (fig s6c). J Clin Invest (2018) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 7b
Cell Signaling Technology IKZF1 antibody (Cell Signaling Technology, 5443) was used in western blot on human samples (fig 7b). Sci Adv (2021) ncbi
domestic rabbit monoclonal (D10E5)
  • ChIP-Seq; human; 1-2 ug / 500 ul chr; loading ...; fig 4c
  • chromatin immunoprecipitation; human; loading ...; fig 4c
Cell Signaling Technology IKZF1 antibody (Cell Signaling, 9034) was used in ChIP-Seq on human samples at 1-2 ug / 500 ul chr (fig 4c) and in chromatin immunoprecipitation on human samples (fig 4c). Cell Rep (2019) ncbi
domestic rabbit monoclonal (D10E5)
  • western blot; human; loading ...; fig 3a
Cell Signaling Technology IKZF1 antibody (Cell Signaling, 9034) was used in western blot on human samples (fig 3a). Leukemia (2019) ncbi
domestic rabbit monoclonal (D6N9Y)
  • western blot; mouse; fig 6d
  • western blot; human; fig 6a
Cell Signaling Technology IKZF1 antibody (Cell Signaling, 14859S) was used in western blot on mouse samples (fig 6d) and in western blot on human samples (fig 6a). Cell (2018) ncbi
domestic rabbit monoclonal (D6N9Y)
  • western blot; mouse; fig s4
In order to use knockout mice to determine the role of cereblon in T cells, Cell Signaling Technology IKZF1 antibody (Cell Signaling, D6N9Y) was used in western blot on mouse samples (fig s4). Proc Natl Acad Sci U S A (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; fig s4
  • western blot; human; 1:1000; fig 1
In order to study disruption of the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity due to immunomodulatory drugs, Cell Signaling Technology IKZF1 antibody (Cell Signaling Technology, 5443) was used in western blot on mouse samples at 1:1000 (fig s4) and in western blot on human samples at 1:1000 (fig 1). Nat Med (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig s2
Cell Signaling Technology IKZF1 antibody (Cell Signaling, 5443) was used in western blot on mouse samples (fig s2). Biol Open (2016) ncbi
domestic rabbit monoclonal (D10E5)
  • chromatin immunoprecipitation; mouse; fig s3
Cell Signaling Technology IKZF1 antibody (Cell Signaling, 9034) was used in chromatin immunoprecipitation on mouse samples (fig s3). Biol Open (2016) ncbi
domestic rabbit monoclonal (D10E5)
  • immunohistochemistry - frozen section; mouse; 1:500
Cell Signaling Technology IKZF1 antibody (Cell Signaling, D10E5) was used in immunohistochemistry - frozen section on mouse samples at 1:500. PLoS ONE (2014) ncbi
Articles Reviewed
  1. Liu J, Hideshima T, Xing L, Wang S, Zhou W, Samur M, et al. ERK signaling mediates resistance to immunomodulatory drugs in the bone marrow microenvironment. Sci Adv. 2021;7: pubmed publisher
  2. Senigl F, Maman Y, Dinesh R, Alinikula J, Seth R, Pecnova L, et al. Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation. Cell Rep. 2019;29:3902-3915.e8 pubmed publisher
  3. Zhou N, Gutierrez Uzquiza A, Zheng X, Chang R, Vogl D, Garfall A, et al. RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation. Leukemia. 2019;: pubmed publisher
  4. Boutboul D, Kuehn H, Van de Wyngaert Z, Niemela J, Callebaut I, Stoddard J, et al. Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency. J Clin Invest. 2018;128:3071-3087 pubmed publisher
  5. Xiao G, Chan L, Klemm L, Braas D, Chen Z, Geng H, et al. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell. 2018;173:470-484.e18 pubmed publisher
  6. Kang J, Park S, Jeong S, Han M, Lee C, Lee K, et al. Epigenetic regulation of Kcna3-encoding Kv1.3 potassium channel by cereblon contributes to regulation of CD4+ T-cell activation. Proc Natl Acad Sci U S A. 2016;113:8771-6 pubmed publisher
  7. Eichner R, Heider M, Fernández Sáiz V, van Bebber F, Garz A, Lemeer S, et al. Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity. Nat Med. 2016;22:735-43 pubmed publisher
  8. Carofino B, Ayanga B, Tracey L, Brooke Bisschop T, Justice M. PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL. Biol Open. 2016;5:645-53 pubmed publisher
  9. Sadleir K, Eimer W, Kaufman R, Osten P, Vassar R. Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. PLoS ONE. 2014;9:e101643 pubmed publisher