This is a Validated Antibody Database (VAD) review about human IFI16, based on 13 published articles (read how Labome selects the articles), using IFI16 antibody in all methods. It is aimed to help Labome visitors find the most suited IFI16 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
IFI16 synonym: IFNGIP1; PYHIN2

Knockout validation
Santa Cruz Biotechnology
mouse monoclonal (1G7)
  • western blot knockout validation; human; loading ...; fig 5a
  • proximity ligation assay; human; loading ...; fig 4f, 8b
  • chromatin immunoprecipitation; human; loading ...; fig 4b
Santa Cruz Biotechnology IFI16 antibody (Santa Cruz, sc-8023) was used in western blot knockout validation on human samples (fig 5a), in proximity ligation assay on human samples (fig 4f, 8b) and in chromatin immunoprecipitation on human samples (fig 4b). Cell Mol Life Sci (2022) ncbi
Santa Cruz Biotechnology
mouse monoclonal (1G7)
  • western blot knockout validation; human; fig 2a
Santa Cruz Biotechnology IFI16 antibody (Santa Cruz, sc-8023) was used in western blot knockout validation on human samples (fig 2a). MBio (2019) ncbi
Santa Cruz Biotechnology
mouse monoclonal (1G7)
  • immunocytochemistry knockout validation; human; loading ...; fig 3a
  • western blot knockout validation; human; loading ...; fig 2m
  • immunoprecipitation; human; loading ...; fig 5a
Santa Cruz Biotechnology IFI16 antibody (SantaCruz, 1G7) was used in immunocytochemistry knockout validation on human samples (fig 3a), in western blot knockout validation on human samples (fig 2m) and in immunoprecipitation on human samples (fig 5a). Nat Commun (2017) ncbi
Santa Cruz Biotechnology
mouse monoclonal (1G7)
  • immunohistochemistry - frozen section; human; 1:50; loading ...; fig 3d
Santa Cruz Biotechnology IFI16 antibody (Santa Cruz, sc-8023) was used in immunohistochemistry - frozen section on human samples at 1:50 (fig 3d). Front Med (Lausanne) (2022) ncbi
mouse monoclonal (1G7)
  • western blot knockout validation; human; loading ...; fig 5a
  • proximity ligation assay; human; loading ...; fig 4f, 8b
  • chromatin immunoprecipitation; human; loading ...; fig 4b
Santa Cruz Biotechnology IFI16 antibody (Santa Cruz, sc-8023) was used in western blot knockout validation on human samples (fig 5a), in proximity ligation assay on human samples (fig 4f, 8b) and in chromatin immunoprecipitation on human samples (fig 4b). Cell Mol Life Sci (2022) ncbi
mouse monoclonal (1G7)
  • western blot; human; 1:500; loading ...; fig 1d, 1i
Santa Cruz Biotechnology IFI16 antibody (Santa Cruz, sc-8023) was used in western blot on human samples at 1:500 (fig 1d, 1i). Cell Rep (2021) ncbi
mouse monoclonal (1G7)
  • western blot knockout validation; human; fig 2a
Santa Cruz Biotechnology IFI16 antibody (Santa Cruz, sc-8023) was used in western blot knockout validation on human samples (fig 2a). MBio (2019) ncbi
mouse monoclonal (1G7)
  • western blot; human; loading ...; fig 1b
Santa Cruz Biotechnology IFI16 antibody (SantaCruz, 1G7) was used in western blot on human samples (fig 1b). J Exp Med (2017) ncbi
mouse monoclonal (1G7)
  • immunocytochemistry knockout validation; human; loading ...; fig 3a
  • western blot knockout validation; human; loading ...; fig 2m
  • immunoprecipitation; human; loading ...; fig 5a
Santa Cruz Biotechnology IFI16 antibody (SantaCruz, 1G7) was used in immunocytochemistry knockout validation on human samples (fig 3a), in western blot knockout validation on human samples (fig 2m) and in immunoprecipitation on human samples (fig 5a). Nat Commun (2017) ncbi
mouse monoclonal (1G7)
  • immunoprecipitation; human; fig 5
  • immunocytochemistry; human; tbl 4
  • western blot; human; fig 5
In order to study novel activities of human cytomegalovirus tegument protein pUL103 by study of protein-protein interactions, Santa Cruz Biotechnology IFI16 antibody (Santa Cruz, sc-8023) was used in immunoprecipitation on human samples (fig 5), in immunocytochemistry on human samples (tbl 4) and in western blot on human samples (fig 5). J Virol (2016) ncbi
mouse monoclonal (1G7)
  • immunohistochemistry; human; fig 2
  • ELISA; human; fig 1
Santa Cruz Biotechnology IFI16 antibody (Santa Cruz, sc-8023) was used in immunohistochemistry on human samples (fig 2) and in ELISA on human samples (fig 1). Arthritis Res Ther (2015) ncbi
mouse monoclonal (1G7)
  • western blot; human
Santa Cruz Biotechnology IFI16 antibody (Santa Cruz Biotechnology, 1G7) was used in western blot on human samples . J Immunol (2014) ncbi
mouse monoclonal (1G7)
  • immunocytochemistry; human
  • western blot; human
Santa Cruz Biotechnology IFI16 antibody (Santa Cruz Biotechnology, sc-8023) was used in immunocytochemistry on human samples and in western blot on human samples . J Immunol (2013) ncbi
Abcam
domestic rabbit monoclonal (EPR11767(B))
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 5c
Abcam IFI16 antibody (Abcam, ab169788) was used in immunohistochemistry - paraffin section on human samples at 1:200 (fig 5c). Nat Commun (2021) ncbi
mouse monoclonal
  • western blot; human; fig 4b
Abcam IFI16 antibody (Abcam, ab55328) was used in western blot on human samples (fig 4b). Mol Cell Proteomics (2017) ncbi
mouse monoclonal
  • immunohistochemistry - paraffin section; human; fig 3
In order to characterize psoriatic epidermis and NOD-like receptor signaling and inflammasome-related pathways involved, Abcam IFI16 antibody (Abcam, ab55328) was used in immunohistochemistry - paraffin section on human samples (fig 3). Sci Rep (2016) ncbi
Novus Biologicals
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; fig 3
In order to characterize psoriatic epidermis and NOD-like receptor signaling and inflammasome-related pathways involved, Novus Biologicals IFI16 antibody (Novus Biologicals, NBP1-83118) was used in immunohistochemistry - paraffin section on human samples (fig 3). Sci Rep (2016) ncbi
Articles Reviewed
  1. Rosa T, Mendes M, Linhares N, Rodrigues T, Dias A, Leal Calvo T, et al. The Type I Interferon Pathway Is Upregulated in the Cutaneous Lesions and Blood of Multibacillary Leprosy Patients With Erythema Nodosum Leprosum. Front Med (Lausanne). 2022;9:899998 pubmed publisher
  2. Ka N, Lim G, Kim S, Hwang S, Han J, Lee Y, et al. Type I IFN stimulates IFI16-mediated aromatase expression in adipocytes that promotes E2-dependent growth of ER-positive breast cancer. Cell Mol Life Sci. 2022;79:306 pubmed publisher
  3. Bruand M, Barras D, Mina M, Ghisoni E, Morotti M, Lanitis E, et al. Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING. Cell Rep. 2021;36:109412 pubmed publisher
  4. Matsui H, Ito J, Matsui N, Uechi T, Onodera O, Kakita A. Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson's disease. Nat Commun. 2021;12:3101 pubmed publisher
  5. Botto S, Abraham J, Mizuno N, Pryke K, Gall B, Landais I, et al. Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome. MBio. 2019;10: pubmed publisher
  6. Cerboni S, Jeremiah N, Gentili M, Gehrmann U, Conrad C, Stolzenberg M, et al. Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes. J Exp Med. 2017;214:1769-1785 pubmed publisher
  7. Almine J, O Hare C, Dunphy G, Haga I, Naik R, Atrih A, et al. IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes. Nat Commun. 2017;8:14392 pubmed publisher
  8. Crow M, Cristea I. Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation. Mol Cell Proteomics. 2017;16:S200-S214 pubmed publisher
  9. Ortiz D, Glassbrook J, Pellett P. Protein-Protein Interactions Suggest Novel Activities of Human Cytomegalovirus Tegument Protein pUL103. J Virol. 2016;90:7798-810 pubmed publisher
  10. Tervaniemi M, Katayama S, Skoog T, Siitonen H, Vuola J, Nuutila K, et al. NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis. Sci Rep. 2016;6:22745 pubmed publisher
  11. Alunno A, Caneparo V, Carubbi F, Bistoni O, Caterbi S, Bartoloni E, et al. Interferon gamma-inducible protein 16 in primary Sjögren's syndrome: a novel player in disease pathogenesis?. Arthritis Res Ther. 2015;17:208 pubmed publisher
  12. Chiliveru S, Rahbek S, Jensen S, Jørgensen S, Nissen S, Christiansen S, et al. Inflammatory cytokines break down intrinsic immunological tolerance of human primary keratinocytes to cytosolic DNA. J Immunol. 2014;192:2395-404 pubmed publisher
  13. Horan K, Hansen K, Jakobsen M, Holm C, Søby S, Unterholzner L, et al. Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors. J Immunol. 2013;190:2311-9 pubmed publisher