This is a Validated Antibody Database (VAD) review about human HNF4A, based on 33 published articles (read how Labome selects the articles), using HNF4A antibody in all methods. It is aimed to help Labome visitors find the most suited HNF4A antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
HNF4A synonym: FRTS4; HNF4; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF14

Abcam
mouse monoclonal (K9218)
  • immunohistochemistry; human; 1:1000; loading ...; fig 3
Abcam HNF4A antibody (Abcam, ab41898) was used in immunohistochemistry on human samples at 1:1000 (fig 3). Front Med (Lausanne) (2021) ncbi
domestic rabbit monoclonal (EPR16885-99)
  • immunohistochemistry - paraffin section; human; loading ...; fig 1b
Abcam HNF4A antibody (Abcam, ab201460) was used in immunohistochemistry - paraffin section on human samples (fig 1b). EBioMedicine (2021) ncbi
domestic rabbit monoclonal (EPR3648)
  • immunocytochemistry; human; loading ...; fig s4a
Abcam HNF4A antibody (Abcam, ab92378) was used in immunocytochemistry on human samples (fig s4a). Sci Rep (2020) ncbi
mouse monoclonal (K9218)
  • immunocytochemistry; rat; loading ...; fig 2a
Abcam HNF4A antibody (Abcam, 41898) was used in immunocytochemistry on rat samples (fig 2a). PLoS ONE (2019) ncbi
mouse monoclonal (K9218)
  • western blot; mouse; loading ...; fig 8b
Abcam HNF4A antibody (Abcam, ab41898) was used in western blot on mouse samples (fig 8b). J Cell Biol (2017) ncbi
mouse monoclonal (K9218)
  • flow cytometry; human; loading ...; fig 6
  • immunocytochemistry; human; fig 4a
In order to characterize the effect of the growth factor Activin A during early human embryonic stem cell fate determination in cardiac differentiation, Abcam HNF4A antibody (Abcam, K9218) was used in flow cytometry on human samples (fig 6) and in immunocytochemistry on human samples (fig 4a). Stem Cells Int (2017) ncbi
mouse monoclonal (K9218)
  • immunocytochemistry; rat; loading ...; fig 5a
  • immunocytochemistry; human; loading ...; fig 5b
Abcam HNF4A antibody (Abcam, ab41898) was used in immunocytochemistry on rat samples (fig 5a) and in immunocytochemistry on human samples (fig 5b). Toxicol In Vitro (2017) ncbi
mouse monoclonal (K9218)
  • immunocytochemistry; mouse; 1:1000; fig 7
Abcam HNF4A antibody (Abcam, ab41898) was used in immunocytochemistry on mouse samples at 1:1000 (fig 7). Sci Rep (2016) ncbi
domestic rabbit monoclonal (EPR3648)
  • flow cytometry; human; fig 1e
  • immunocytochemistry; human; fig 1c
In order to study isolation of hepatocytes derived from human pluripotent stem cells by asialoglycoprotein receptor 1 as a specific cell-surface marker, Abcam HNF4A antibody (Abcam, ab92378) was used in flow cytometry on human samples (fig 1e) and in immunocytochemistry on human samples (fig 1c). Development (2016) ncbi
domestic rabbit monoclonal (EPR3648)
  • western blot; human; fig 4
Abcam HNF4A antibody (Abcam, ab92378) was used in western blot on human samples (fig 4). PLoS ONE (2016) ncbi
mouse monoclonal (K9218)
  • chromatin immunoprecipitation; human; fig s9
Abcam HNF4A antibody (Abcam, ab41898) was used in chromatin immunoprecipitation on human samples (fig s9). Nucleic Acids Res (2016) ncbi
mouse monoclonal (K9218)
  • immunohistochemistry; mouse; fig 1
Abcam HNF4A antibody (Abcam, ab41898) was used in immunohistochemistry on mouse samples (fig 1). Nat Commun (2016) ncbi
mouse monoclonal (K9218)
  • immunocytochemistry; human; fig 1
Abcam HNF4A antibody (Abcam, ab41898) was used in immunocytochemistry on human samples (fig 1). Mol Cancer (2015) ncbi
mouse monoclonal (K9218)
  • immunohistochemistry - paraffin section; human; fig 5
  • immunohistochemistry - paraffin section; mouse; fig 5
Abcam HNF4A antibody (Abcam, ab41898) was used in immunohistochemistry - paraffin section on human samples (fig 5) and in immunohistochemistry - paraffin section on mouse samples (fig 5). Nat Genet (2015) ncbi
mouse monoclonal (K9218)
  • immunohistochemistry - paraffin section; human; 1:70
Abcam HNF4A antibody (Abcam, ab41898) was used in immunohistochemistry - paraffin section on human samples at 1:70. PLoS ONE (2014) ncbi
mouse monoclonal (K9218)
  • western blot; human; fig 2
Abcam HNF4A antibody (Abcam, ab41898) was used in western blot on human samples (fig 2). Nature (2014) ncbi
mouse monoclonal (K9218)
  • chromatin immunoprecipitation; mouse
Abcam HNF4A antibody (Abcam, ab41898) was used in chromatin immunoprecipitation on mouse samples . J Biol Chem (2013) ncbi
mouse monoclonal (K9218)
  • chromatin immunoprecipitation; mouse
  • chromatin immunoprecipitation; human
Abcam HNF4A antibody (Abcam, ab41898) was used in chromatin immunoprecipitation on mouse samples and in chromatin immunoprecipitation on human samples . PLoS ONE (2013) ncbi
R&D Systems
mouse monoclonal (K9218)
  • immunohistochemistry; mouse; loading ...; fig 4a
  • western blot; mouse; loading ...; fig 4c
R&D Systems HNF4A antibody (R&D Systems, PP-K9218-00) was used in immunohistochemistry on mouse samples (fig 4a) and in western blot on mouse samples (fig 4c). iScience (2021) ncbi
Santa Cruz Biotechnology
mouse monoclonal (H-1)
  • immunohistochemistry - paraffin section; rat; loading ...; fig 3c
Santa Cruz Biotechnology HNF4A antibody (Santa Cruz Biotechnology, sc-374229) was used in immunohistochemistry - paraffin section on rat samples (fig 3c). Sci Rep (2020) ncbi
mouse monoclonal (H-1)
  • ChIP-Seq; rat; loading ...; fig 3a
Santa Cruz Biotechnology HNF4A antibody (Santa Cruz, sc-374229) was used in ChIP-Seq on rat samples (fig 3a). Sci Rep (2017) ncbi
Abnova
mouse monoclonal (4.00E+02)
  • immunocytochemistry; human; 1:100; fig s2h
Abnova HNF4A antibody (Abnova, H00003172-M04) was used in immunocytochemistry on human samples at 1:100 (fig s2h). Nat Med (2015) ncbi
Invitrogen
mouse monoclonal (K9218)
  • immunoprecipitation; mouse; loading ...; fig 3c
  • immunocytochemistry; mouse; loading ...; fig 6a
  • western blot; mouse; loading ...; fig 1b
Invitrogen HNF4A antibody (Thermo Fisher, MA1-199) was used in immunoprecipitation on mouse samples (fig 3c), in immunocytochemistry on mouse samples (fig 6a) and in western blot on mouse samples (fig 1b). Mol Cell Biol (2018) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (C11F12)
  • immunocytochemistry; rat; 1:100; loading ...; fig 3
Cell Signaling Technology HNF4A antibody (Cell Signaling, 3113) was used in immunocytochemistry on rat samples at 1:100 (fig 3). J Pers Med (2021) ncbi
domestic rabbit monoclonal (C11F12)
  • immunohistochemistry; mouse; 1:400; loading ...; fig 1a
Cell Signaling Technology HNF4A antibody (Cell Signaling Technology, 3113) was used in immunohistochemistry on mouse samples at 1:400 (fig 1a). elife (2021) ncbi
domestic rabbit monoclonal (C11F12)
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 6b
Cell Signaling Technology HNF4A antibody (Cell Signaling, 3113) was used in immunohistochemistry - paraffin section on mouse samples at 1:500 (fig 6b). Immunity (2018) ncbi
domestic rabbit monoclonal (C11F12)
  • immunocytochemistry; human; fig s4a
Cell Signaling Technology HNF4A antibody (Cell Signaling, 3113S) was used in immunocytochemistry on human samples (fig s4a). Cell (2018) ncbi
domestic rabbit monoclonal (C11F12)
  • immunohistochemistry; mouse; 1:500; loading ...; fig 4c
Cell Signaling Technology HNF4A antibody (Cell Signaling, 3113S) was used in immunohistochemistry on mouse samples at 1:500 (fig 4c). Nature (2017) ncbi
domestic rabbit monoclonal (C11F12)
  • western blot; human; loading ...; fig 3b
Cell Signaling Technology HNF4A antibody (Cell Signaling Technology, C11F12) was used in western blot on human samples (fig 3b). PLoS ONE (2017) ncbi
domestic rabbit monoclonal (C11F12)
  • immunocytochemistry; human; 1:200; fig s7
Cell Signaling Technology HNF4A antibody (Cell Signaling Technology, 3113S) was used in immunocytochemistry on human samples at 1:200 (fig s7). Nat Commun (2016) ncbi
domestic rabbit monoclonal (C11F12)
  • immunocytochemistry; rat
In order to study the effect of bile acids on mesenchymal stem cells in liver, Cell Signaling Technology HNF4A antibody (Cell Signaling, 3113S) was used in immunocytochemistry on rat samples . Sci Rep (2015) ncbi
domestic rabbit monoclonal (C11F12)
  • immunocytochemistry; human; 1:100
In order to study two pluripotent stem cell populations in regards to a neural precurson cell population, Cell Signaling Technology HNF4A antibody (Cell Signaling Technologies, 3113S) was used in immunocytochemistry on human samples at 1:100. Stem Cell Res (2014) ncbi
domestic rabbit monoclonal (C11F12)
  • western blot; human
Cell Signaling Technology HNF4A antibody (Cell Signaling, 3113S) was used in western blot on human samples . J Virol (2014) ncbi
Articles Reviewed
  1. Wu C, Cheng D, Peng Y, Li Y, Fu C, Wang Y, et al. Hepatic BRD4 Is Upregulated in Liver Fibrosis of Various Etiologies and Positively Correlated to Fibrotic Severity. Front Med (Lausanne). 2021;8:683506 pubmed publisher
  2. Shin J, Jeong J, Choi J, Lim J, Dinesh R, Braverman J, et al. Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1. iScience. 2021;24:102411 pubmed publisher
  3. Chen Y, Chen H, Ho C, Chen H, Ho S, Hu R, et al. Preclinical Application of Reduced Manipulated Processing Strategy to Collect Transplantable Hepatocytes: A Pilot and Feasibility Study. J Pers Med. 2021;11: pubmed publisher
  4. Zewdu R, Mehrabad E, Ingram K, Fang P, Gillis K, Camolotto S, et al. An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma. elife. 2021;10: pubmed publisher
  5. Wang H, Huang J, Sue M, Ho W, Hsu Y, Chang K, et al. Interleukin-24 protects against liver injury in mouse models. EBioMedicine. 2021;64:103213 pubmed publisher
  6. Xu W, Xu Y, Zhang X, Xu Y, Jian X, Chen J, et al. Hepatic stem cell Numb gene is a potential target of Huang Qi Decoction against cholestatic liver fibrosis. Sci Rep. 2020;10:17486 pubmed publisher
  7. Famulari E, Navarro Tableros V, Herrera Sanchez M, Bortolussi G, Gai M, Conti L, et al. Human liver stem cells express UGT1A1 and improve phenotype of immunocompromised Crigler Najjar syndrome type I mice. Sci Rep. 2020;10:887 pubmed publisher
  8. Alsaeedi F, Wilson R, Candlish C, Ibrahim I, Leitch A, Abdelghany T, et al. Expression of serine/threonine protein kinase SGK1F promotes an hepatoblast state in stem cells directed to differentiate into hepatocytes. PLoS ONE. 2019;14:e0218135 pubmed publisher
  9. Mollaoglu G, Jones A, Wait S, Mukhopadhyay A, Jeong S, Arya R, et al. The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment. Immunity. 2018;49:764-779.e9 pubmed publisher
  10. Bi Y, Shi X, Zhu J, Guan X, Garbacz W, Huang Y, et al. Regulation of Cholesterol Sulfotransferase SULT2B1b by Hepatocyte Nuclear Factor 4α Constitutes a Negative Feedback Control of Hepatic Gluconeogenesis. Mol Cell Biol. 2018;38: pubmed publisher
  11. Wu X, Dao Thi V, Huang Y, Billerbeck E, Saha D, Hoffmann H, et al. Intrinsic Immunity Shapes Viral Resistance of Stem Cells. Cell. 2018;172:423-438.e25 pubmed publisher
  12. Yao J, Guihard P, Wu X, Blázquez Medela A, Spencer M, Jumabay M, et al. Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation. J Cell Biol. 2017;216:3369-3385 pubmed publisher
  13. Aschenbrenner A, Bassler K, Brondolin M, Bonaguro L, Carrera P, Klee K, et al. A cross-species approach to identify transcriptional regulators exemplified for Dnajc22 and Hnf4a. Sci Rep. 2017;7:4056 pubmed publisher
  14. Janda C, Dang L, You C, Chang J, de Lau W, Zhong Z, et al. Surrogate Wnt agonists that phenocopy canonical Wnt and ?-catenin signalling. Nature. 2017;545:234-237 pubmed publisher
  15. Lin J, Gu C, Shen Z, Liu Y, Wang W, Tao S, et al. Hepatocyte nuclear factor 1α downregulates HBV gene expression and replication by activating the NF-κB signaling pathway. PLoS ONE. 2017;12:e0174017 pubmed publisher
  16. Duelen R, Gilbert G, Patel A, de Schaetzen N, de Waele L, Roderick L, et al. Activin A Modulates CRIPTO-1/HNF4?+ Cells to Guide Cardiac Differentiation from Human Embryonic Stem Cells. Stem Cells Int. 2017;2017:4651238 pubmed publisher
  17. Chang S, Voellinger J, Van Ness K, Chapron B, Shaffer R, Neumann T, et al. Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity. Toxicol In Vitro. 2017;40:170-183 pubmed publisher
  18. Moshfegh C, Aires L, Kisielow M, Vogel V. A gonogenic stimulated transition of mouse embryonic stem cells with enhanced control of diverse differentiation pathways. Sci Rep. 2016;6:25104 pubmed publisher
  19. Peters D, Henderson C, Warren C, Friesen M, Xia F, Becker C, et al. Asialoglycoprotein receptor 1 is a specific cell-surface marker for isolating hepatocytes derived from human pluripotent stem cells. Development. 2016;143:1475-81 pubmed publisher
  20. Salloum Asfar S, Arroyo A, Teruel Montoya R, García Barberá N, Roldan V, Vicente V, et al. MiRNA-Based Regulation of Hemostatic Factors through Hepatic Nuclear Factor-4 Alpha. PLoS ONE. 2016;11:e0154751 pubmed publisher
  21. Chang H, Liu Y, Xue M, Liu H, Du S, Zhang L, et al. Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition. Nucleic Acids Res. 2016;44:2514-27 pubmed publisher
  22. Wang P, Zhang X, Luo P, Jiang X, Zhang P, Guo J, et al. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun. 2016;7:10592 pubmed publisher
  23. Guye P, Ebrahimkhani M, Kipniss N, Velazquez J, Schoenfeld E, Kiani S, et al. Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6. Nat Commun. 2016;7:10243 pubmed publisher
  24. Sawitza I, Kordes C, Götze S, Herebian D, Häussinger D. Bile acids induce hepatic differentiation of mesenchymal stem cells. Sci Rep. 2015;5:13320 pubmed publisher
  25. Conigliaro A, Costa V, Lo Dico A, Saieva L, Buccheri S, Dieli F, et al. CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA. Mol Cancer. 2015;14:155 pubmed publisher
  26. Bonner C, Kerr Conte J, Gmyr V, Queniat G, Moerman E, Thévenet J, et al. Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion. Nat Med. 2015;21:512-7 pubmed publisher
  27. Liao J, Karnik R, Gu H, Ziller M, Clement K, Tsankov A, et al. Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells. Nat Genet. 2015;47:469-78 pubmed publisher
  28. Simeone P, Trerotola M, Urbanella A, Lattanzio R, Ciavardelli D, Di Giuseppe F, et al. A unique four-hub protein cluster associates to glioblastoma progression. PLoS ONE. 2014;9:e103030 pubmed publisher
  29. Saha S, Parachoniak C, Ghanta K, Fitamant J, Ross K, Najem M, et al. Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer. Nature. 2014;513:110-4 pubmed publisher
  30. Mallon B, Hamilton R, Kozhich O, Johnson K, Fann Y, Rao M, et al. Comparison of the molecular profiles of human embryonic and induced pluripotent stem cells of isogenic origin. Stem Cell Res. 2014;12:376-86 pubmed publisher
  31. Li X, Jiang H, Qu L, Yao W, Cai H, Chen L, et al. Hepatocyte nuclear factor 4? and downstream secreted phospholipase A2 GXIIB regulate production of infectious hepatitis C virus. J Virol. 2014;88:612-27 pubmed publisher
  32. Tümer E, Bröer A, Balkrishna S, Jülich T, Broer S. Enterocyte-specific regulation of the apical nutrient transporter SLC6A19 (B(0)AT1) by transcriptional and epigenetic networks. J Biol Chem. 2013;288:33813-23 pubmed publisher
  33. Ouyang H, Qin Y, Liu Y, Xie Y, Liu J. Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription. PLoS ONE. 2013;8:e62192 pubmed publisher