This is a Validated Antibody Database (VAD) review about human HMGA2, based on 13 published articles (read how Labome selects the articles), using HMGA2 antibody in all methods. It is aimed to help Labome visitors find the most suited HMGA2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
HMGA2 synonym: BABL; HMGI-C; HMGIC; LIPO; STQTL9

Knockout validation
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot knockout validation; human; 1:1000; loading ...; fig 1d, 1i
Cell Signaling Technology HMGA2 antibody (CST, 5269S) was used in western blot knockout validation on human samples at 1:1000 (fig 1d, 1i). Front Mol Biosci (2021) ncbi
Abcam
domestic rabbit monoclonal (EPR18114)
  • western blot; human; 1:1000; loading ...; fig 4k
Abcam HMGA2 antibody (Abcam, ab207301) was used in western blot on human samples at 1:1000 (fig 4k). Aging (Albany NY) (2020) ncbi
Santa Cruz Biotechnology
mouse monoclonal (2421C6a)
  • western blot; human; 1:500; loading ...; fig 2b
Santa Cruz Biotechnology HMGA2 antibody (Santa Cruz, sc-130024) was used in western blot on human samples at 1:500 (fig 2b). Sci Rep (2016) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D1A7)
  • western blot; human; loading ...; fig 4k, 4l, 6d
  • western blot; mouse; fig s6a
Cell Signaling Technology HMGA2 antibody (Cell Signaling, 8179S) was used in western blot on human samples (fig 4k, 4l, 6d) and in western blot on mouse samples (fig s6a). Cancer Commun (Lond) (2022) ncbi
domestic rabbit polyclonal
  • western blot knockout validation; human; 1:1000; loading ...; fig 1d, 1i
Cell Signaling Technology HMGA2 antibody (CST, 5269S) was used in western blot knockout validation on human samples at 1:1000 (fig 1d, 1i). Front Mol Biosci (2021) ncbi
domestic rabbit monoclonal (D1A7)
  • immunohistochemistry; rat; 1:100; loading ...; fig 4c
Cell Signaling Technology HMGA2 antibody (Cell Signaling, 8179S) was used in immunohistochemistry on rat samples at 1:100 (fig 4c). Invest Ophthalmol Vis Sci (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 3c
Cell Signaling Technology HMGA2 antibody (Cell Signaling, 5269S) was used in western blot on human samples (fig 3c). Cancer Cell (2018) ncbi
domestic rabbit monoclonal (D1A7)
  • western blot; human; loading ...; fig 4a
In order to investigate the effect off miR-509-5p and miR-1243 on gemcitabine efficacy in pancreatic cancer and its mechanism, Cell Signaling Technology HMGA2 antibody (Cell Signaling, 8179) was used in western blot on human samples (fig 4a). Sci Rep (2017) ncbi
domestic rabbit monoclonal (D1A7)
  • immunohistochemistry - paraffin section; human; 1:400; loading ...; fig 1
  • immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 3
Cell Signaling Technology HMGA2 antibody (Cell Signaling, 8179) was used in immunohistochemistry - paraffin section on human samples at 1:400 (fig 1) and in immunohistochemistry - paraffin section on mouse samples at 1:400 (fig 3). Br J Cancer (2017) ncbi
domestic rabbit monoclonal (D1A7)
  • western blot; human; 1:1000; loading ...; fig 3b
Cell Signaling Technology HMGA2 antibody (Cell Signaling, 8179) was used in western blot on human samples at 1:1000 (fig 3b). J Drug Target (2017) ncbi
domestic rabbit polyclonal
  • chromatin immunoprecipitation; mouse; 1:100; fig 6a
  • western blot; mouse; 1:500; fig 1d
Cell Signaling Technology HMGA2 antibody (Cell Signaling, 5269) was used in chromatin immunoprecipitation on mouse samples at 1:100 (fig 6a) and in western blot on mouse samples at 1:500 (fig 1d). BMC Biol (2016) ncbi
domestic rabbit monoclonal (D1A7)
  • western blot; human; loading ...; fig 4c
In order to present the role of nuclear Src and p300 signaling axis in pancreatic cancer, Cell Signaling Technology HMGA2 antibody (Cell Signaling, D1A7) was used in western blot on human samples (fig 4c). Oncotarget (2016) ncbi
domestic rabbit monoclonal (D1A7)
  • western blot; mouse; 1:1000; fig s1
Cell Signaling Technology HMGA2 antibody (Cell Signalling, 8179) was used in western blot on mouse samples at 1:1000 (fig s1). Nat Commun (2015) ncbi
domestic rabbit monoclonal (D1A7)
  • immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 3d
Cell Signaling Technology HMGA2 antibody (Cell Signaling, 8179) was used in immunohistochemistry - paraffin section on mouse samples at 1:400 (fig 3d). PLoS Genet (2015) ncbi
Articles Reviewed
  1. Liu C, Zheng S, Wang Z, Wang S, Wang X, Yang L, et al. KRAS-G12D mutation drives immune suppression and the primary resistance of anti-PD-1/PD-L1 immunotherapy in non-small cell lung cancer. Cancer Commun (Lond). 2022;42:828-847 pubmed publisher
  2. Wu Z, Wang M, Li F, Wang F, Jia J, Feng Z, et al. CDK13-Mediated Cell Cycle Disorder Promotes Tumorigenesis of High HMGA2 Expression Gastric Cancer. Front Mol Biosci. 2021;8:707295 pubmed publisher
  3. Frasson L, Dalmaso B, Akamine P, Kimura E, Hamassaki D, Del Debbio C. Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium and Retinal Progenitor Cells. Invest Ophthalmol Vis Sci. 2021;62:31 pubmed publisher
  4. Han X, Huang T, Han J. Long noncoding RNA VPS9D1-AS1 augments the malignant phenotype of non-small cell lung cancer by sponging microRNA-532-3p and thereby enhancing HMGA2 expression. Aging (Albany NY). 2020;12:370-386 pubmed publisher
  5. Stewart E, McEvoy J, Wang H, Chen X, Honnell V, Ocarz M, et al. Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses. Cancer Cell. 2018;34:411-426.e19 pubmed publisher
  6. Hiramoto H, Muramatsu T, Ichikawa D, Tanimoto K, Yasukawa S, Otsuji E, et al. miR-509-5p and miR-1243 increase the sensitivity to gemcitabine by inhibiting epithelial-mesenchymal transition in pancreatic cancer. Sci Rep. 2017;7:4002 pubmed publisher
  7. Strell C, Norberg K, Mezheyeuski A, Schnittert J, Kuninty P, Moro C, et al. Stroma-regulated HMGA2 is an independent prognostic marker in PDAC and AAC. Br J Cancer. 2017;117:65-77 pubmed publisher
  8. Yang X, Zhao Q, Yin H, Lei X, Gan R. MiR-33b-5p sensitizes gastric cancer cells to chemotherapy drugs via inhibiting HMGA2 expression. J Drug Target. 2017;25:653-660 pubmed publisher
  9. Roberts C, Tran M, Pitruzzello M, Wen W, Loeza J, Dellinger T, et al. TWIST1 drives cisplatin resistance and cell survival in an ovarian cancer model, via upregulation of GAS6, L1CAM, and Akt signalling. Sci Rep. 2016;6:37652 pubmed publisher
  10. Navarra A, Musto A, Gargiulo A, Petrosino G, Pierantoni G, Fusco A, et al. Hmga2 is necessary for Otx2-dependent exit of embryonic stem cells from the pluripotent ground state. BMC Biol. 2016;14:24 pubmed publisher
  11. Paladino D, Yue P, Furuya H, Acoba J, Rosser C, Turkson J. A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer. Oncotarget. 2016;7:7253-67 pubmed publisher
  12. Gökbuget D, Pereira J, Bachofner S, Marchais A, Ciaudo C, Stoffel M, et al. The Lin28/let-7 axis is critical for myelination in the peripheral nervous system. Nat Commun. 2015;6:8584 pubmed publisher
  13. Madison B, Jeganathan A, Mizuno R, Winslow M, Castells A, Cuatrecasas M, et al. Let-7 Represses Carcinogenesis and a Stem Cell Phenotype in the Intestine via Regulation of Hmga2. PLoS Genet. 2015;11:e1005408 pubmed publisher