This is a Validated Antibody Database (VAD) review about human HEXIM1, based on 8 published articles (read how Labome selects the articles), using HEXIM1 antibody in all methods. It is aimed to help Labome visitors find the most suited HEXIM1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
HEXIM1 synonym: CLP1; EDG1; HIS1; MAQ1; protein HEXIM1; HMBA-inducible; cardiac lineage protein 1; estrogen down-regulated gene 1 protein; hexamethylene bis-acetamide inducible 1; hexamethylene bis-acetamide-inducible protein 1; hexamethylene bisacetamide-inducible protein; hexamethylene-bis-acetamide-inducible transcript 1; hexamthylene bis-acetamide inducible 1; menage a quatre 1; menage a quatre protein 1

Abcam
rabbit polyclonal
  • RNA immunoprecipitation; mouse; fig s5
  • western blot; mouse; fig s6
Abcam HEXIM1 antibody (Abcam, ab25388) was used in RNA immunoprecipitation on mouse samples (fig s5) and in western blot on mouse samples (fig s6). Nat Struct Mol Biol (2016) ncbi
rabbit polyclonal
  • western blot; human
In order to study the inhibitory effect of hypoxia on gene transcription and its mechanism, Abcam HEXIM1 antibody (Abcam, ab25388) was used in western blot on human samples . Nucleic Acids Res (2014) ncbi
sheep polyclonal
  • western blot; human
In order to study the inhibitory effect of hypoxia on gene transcription and its mechanism, Abcam HEXIM1 antibody (Abcam, ab28016) was used in western blot on human samples . Nucleic Acids Res (2014) ncbi
rabbit polyclonal
  • chromatin immunoprecipitation; human
Abcam HEXIM1 antibody (Abcam, ab25388) was used in chromatin immunoprecipitation on human samples . J Biol Chem (2014) ncbi
rabbit polyclonal
  • immunoprecipitation; human; 1 ug
Abcam HEXIM1 antibody (Abcam, ab25388) was used in immunoprecipitation on human samples at 1 ug. J Biol Chem (2013) ncbi
Bethyl
rabbit polyclonal
  • western blot; human; loading ...; fig 3b
Bethyl HEXIM1 antibody (Bethyl, A303-113A) was used in western blot on human samples (fig 3b). Nucleic Acids Res (2017) ncbi
rabbit polyclonal
  • western blot; human; fig 4
Bethyl HEXIM1 antibody (Bethyl, A303-113A) was used in western blot on human samples (fig 4). Nature (2015) ncbi
Santa Cruz Biotechnology
mouse monoclonal
  • western blot; human; loading ...; fig 1a
Santa Cruz Biotechnology HEXIM1 antibody (Santa Cruz, sc-398479) was used in western blot on human samples (fig 1a). Oncotarget (2016) ncbi
mouse monoclonal (E-7)
  • western blot; human; fig 3
In order to assess reduction of c-MYC in acute leukemia cells due to a BET inhibitor OTX015 that targets BRD2 and BRD4, Santa Cruz Biotechnology HEXIM1 antibody (Santa Cruz, sc-365413) was used in western blot on human samples (fig 3). Oncotarget (2015) ncbi
Articles Reviewed
  1. Blank M, Chen S, Poetz F, Schnolzer M, Voit R, Grummt I. SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription. Nucleic Acids Res. 2017;45:2675-2686 pubmed publisher
  2. Huang M, Garcia J, Thomas D, Zhu L, Nguyen L, Chan S, et al. Autophagy mediates proteolysis of NPM1 and HEXIM1 and sensitivity to BET inhibition in AML cells. Oncotarget. 2016;7:74917-74930 pubmed publisher
  3. Flynn R, Do B, Rubin A, Calo E, Lee B, Kuchelmeister H, et al. 7SK-BAF axis controls pervasive transcription at enhancers. Nat Struct Mol Biol. 2016;23:231-8 pubmed publisher
  4. Coudé M, Braun T, Berrou J, Dupont M, Bertrand S, Massé A, et al. BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells. Oncotarget. 2015;6:17698-712 pubmed
  5. Calo E, Flynn R, Martin L, Spitale R, Chang H, Wysocka J. RNA helicase DDX21 coordinates transcription and ribosomal RNA processing. Nature. 2015;518:249-53 pubmed publisher
  6. Safronova O, Nakahama K, Morita I. Acute hypoxia affects P-TEFb through HDAC3 and HEXIM1-dependent mechanism to promote gene-specific transcriptional repression. Nucleic Acids Res. 2014;42:8954-69 pubmed publisher
  7. Liu P, Xiang Y, Fujinaga K, Bartholomeeusen K, Nilson K, Price D, et al. Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription. J Biol Chem. 2014;289:9918-25 pubmed publisher
  8. Bartholomeeusen K, Fujinaga K, Xiang Y, Peterlin B. Histone deacetylase inhibitors (HDACis) that release the positive transcription elongation factor b (P-TEFb) from its inhibitory complex also activate HIV transcription. J Biol Chem. 2013;288:14400-7 pubmed publisher