This is a Validated Antibody Database (VAD) review about human HDAC6, based on 22 published articles (read how Labome selects the articles), using HDAC6 antibody in all methods. It is aimed to help Labome visitors find the most suited HDAC6 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
HDAC6 synonym: CPBHM; HD6; JM21; PPP1R90

Santa Cruz Biotechnology
mouse monoclonal (D-11)
  • western blot; human; fig 2a
Santa Cruz Biotechnology HDAC6 antibody (Santa Cruz Biotechnology, sc-28386) was used in western blot on human samples (fig 2a). Cancers (Basel) (2021) ncbi
mouse monoclonal (D-11)
  • immunohistochemistry - paraffin section; human; 1:200; fig 1
Santa Cruz Biotechnology HDAC6 antibody (santa Cruz, sc-28386) was used in immunohistochemistry - paraffin section on human samples at 1:200 (fig 1). BMC Gastroenterol (2015) ncbi
mouse monoclonal (D-11)
  • western blot; human; loading ...; fig 5b; 3g
Santa Cruz Biotechnology HDAC6 antibody (Santa Cruz, sc-28386) was used in western blot on human samples (fig 5b; 3g). J Biol Chem (2015) ncbi
Abcam
mouse monoclonal (159)
  • western blot; pigs ; loading ...; fig 4b
Abcam HDAC6 antibody (Abcam, ab253032) was used in western blot on pigs samples (fig 4b). PLoS Pathog (2021) ncbi
domestic rabbit polyclonal
  • western blot; rat; 1:1000; loading ...
Abcam HDAC6 antibody (Abcam, ab1440) was used in western blot on rat samples at 1:1000. Signal Transduct Target Ther (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig 3
Abcam HDAC6 antibody (Abcam, ab1440) was used in western blot on human samples at 1:1000 (fig 3). J Neurosci (2016) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D2E5)
  • western blot; human; loading ...; fig 5a
Cell Signaling Technology HDAC6 antibody (Cell Signaling Technology, 7558) was used in western blot on human samples (fig 5a). Cell Death Dis (2021) ncbi
domestic rabbit monoclonal (D21B10)
  • western blot; human; 1:1000; loading ...; fig 10a, 10b, 10c
Cell Signaling Technology HDAC6 antibody (Cell Signaling, 7612) was used in western blot on human samples at 1:1000 (fig 10a, 10b, 10c). Biology (Basel) (2021) ncbi
domestic rabbit monoclonal (D2E5)
  • immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 1a, 1b
  • western blot; human; 1:1000; loading ...; fig 3a
Cell Signaling Technology HDAC6 antibody (CST, 7558) was used in immunohistochemistry - paraffin section on human samples at 1:1000 (fig 1a, 1b) and in western blot on human samples at 1:1000 (fig 3a). Oncol Lett (2021) ncbi
domestic rabbit monoclonal (D21B10)
  • western blot; mouse; 1:1000; loading ...; fig 3a
Cell Signaling Technology HDAC6 antibody (Cell Signaling Technology, 7612S) was used in western blot on mouse samples at 1:1000 (fig 3a). Science (2020) ncbi
domestic rabbit monoclonal (D21B10)
  • western blot; human; loading ...; fig s1a
  • western blot; mouse; loading ...; fig 2b
Cell Signaling Technology HDAC6 antibody (Cell Signaling Technology, 7612) was used in western blot on human samples (fig s1a) and in western blot on mouse samples (fig 2b). Cell Rep (2019) ncbi
domestic rabbit monoclonal (D2E5)
  • western blot; human; 1:1000; loading ...; fig s4a
Cell Signaling Technology HDAC6 antibody (Cell Signaling, 7558) was used in western blot on human samples at 1:1000 (fig s4a). Nature (2018) ncbi
domestic rabbit monoclonal (D21B10)
  • immunoprecipitation; mouse; fig 1b
  • western blot; mouse; 1:1000; fig 2a
Cell Signaling Technology HDAC6 antibody (Cell Signaling, 7612) was used in immunoprecipitation on mouse samples (fig 1b) and in western blot on mouse samples at 1:1000 (fig 2a). Nat Commun (2018) ncbi
domestic rabbit monoclonal (D21B10)
  • western blot; human; 1:1000; loading ...; fig 2a
Cell Signaling Technology HDAC6 antibody (Cell Signaling Technologies, 7612) was used in western blot on human samples at 1:1000 (fig 2a). Nat Cell Biol (2017) ncbi
domestic rabbit monoclonal (D21B10)
  • western blot; human; 1:1000; loading ...; fig 1a
Cell Signaling Technology HDAC6 antibody (Cell Signaling, 7612) was used in western blot on human samples at 1:1000 (fig 1a). Oncotarget (2017) ncbi
domestic rabbit monoclonal (D2E5)
  • immunocytochemistry; human; loading ...; fig 3c
In order to identify compounds that inhibit the proteasome 19S subunit Rpn11, Cell Signaling Technology HDAC6 antibody (Cell Signaling, 7558S) was used in immunocytochemistry on human samples (fig 3c). Nat Chem Biol (2017) ncbi
domestic rabbit monoclonal (D21B10)
  • western blot; mouse; 1:1000; loading ...; fig 7a
In order to examine the effect of piceatannol on renal fibrosis and histone deacetylase expression in a mouse model of unilateral ureteral obstruction, Cell Signaling Technology HDAC6 antibody (Cell signaling, 7612) was used in western blot on mouse samples at 1:1000 (fig 7a). PLoS ONE (2016) ncbi
domestic rabbit monoclonal (D21B10)
  • western blot; mouse; 1:500; fig 2
Cell Signaling Technology HDAC6 antibody (Cell signaling, 7612) was used in western blot on mouse samples at 1:500 (fig 2). Mol Biol Rep (2016) ncbi
domestic rabbit monoclonal (D2E5)
  • western blot; human; fig 7
Cell Signaling Technology HDAC6 antibody (Cell signaling, 7558) was used in western blot on human samples (fig 7). Oncogenesis (2016) ncbi
domestic rabbit monoclonal (D2E5)
  • immunocytochemistry; human; loading ...; fig s2
In order to show that Axin point mutants derail Wnt signaling and promote tumor growth in vivo, Cell Signaling Technology HDAC6 antibody (cell signalling, 7558) was used in immunocytochemistry on human samples (fig s2). Nat Struct Mol Biol (2016) ncbi
domestic rabbit monoclonal (D2E5)
  • western blot; human; 1:1000; fig 2
In order to use a pharmaceutical screen to discover new mechanisms of autophagy activation, Cell Signaling Technology HDAC6 antibody (Cell Signaling, 7558) was used in western blot on human samples at 1:1000 (fig 2). Nat Commun (2015) ncbi
domestic rabbit monoclonal (D2E5)
  • western blot; human; 1:1000; loading ...; fig 10e
Cell Signaling Technology HDAC6 antibody (Cell Signaling, 7558S) was used in western blot on human samples at 1:1000 (fig 10e). J Biol Chem (2015) ncbi
Articles Reviewed
  1. Yang W, Wu A, Hsu T, Liou J, Lo W, Chang K, et al. Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells. Cell Death Dis. 2021;12:884 pubmed publisher
  2. Wang Z, Chen J, Wu X, Ma D, Zhang X, Li R, et al. PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection. PLoS Pathog. 2021;17:e1009940 pubmed publisher
  3. Fan Q, Li L, Wang T, Emerson R, Xu Y. A Novel ZIP4-HDAC4-VEGFA Axis in High-Grade Serous Ovarian Cancer. Cancers (Basel). 2021;13: pubmed publisher
  4. Urdiciain A, Erausquin E, Zelaya M, Zazpe I, Lanciego J, Melendez B, et al. Silencing of Histone Deacetylase 6 Decreases Cellular Malignancy and Contributes to Primary Cilium Restoration, Epithelial-to-Mesenchymal Transition Reversion, and Autophagy Inhibition in Glioblastoma Cell Lines. Biology (Basel). 2021;10: pubmed publisher
  5. Xu S, Tao H, Cao W, Cao L, Lin Y, Zhao S, et al. Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. Signal Transduct Target Ther. 2021;6:54 pubmed publisher
  6. Kuroki H, Anraku T, Kazama A, Shirono Y, Bilim V, Tomita Y. Histone deacetylase 6 inhibition in urothelial cancer as a potential new strategy for cancer treatment. Oncol Lett. 2021;21:64 pubmed publisher
  7. Magupalli V, Negro R, Tian Y, Hauenstein A, Di Caprio G, Skillern W, et al. HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science. 2020;369: pubmed publisher
  8. Raghu D, Mobley R, Shendy N, Perry C, Abell A. GALNT3 Maintains the Epithelial State in Trophoblast Stem Cells. Cell Rep. 2019;26:3684-3697.e7 pubmed publisher
  9. Zhu Y, Wang G, Cingoz O, Goff S. NP220 mediates silencing of unintegrated retroviral DNA. Nature. 2018;564:278-282 pubmed publisher
  10. Mo Z, Zhao X, Liu H, Hu Q, Chen X, Pham J, et al. Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy. Nat Commun. 2018;9:1007 pubmed publisher
  11. Bitler B, Wu S, Park P, Hai Y, Aird K, Wang Y, et al. ARID1A-mutated ovarian cancers depend on HDAC6 activity. Nat Cell Biol. 2017;19:962-973 pubmed publisher
  12. Tan Y, Ci Y, Dai X, Wu F, Guo J, Liu D, et al. Cullin 3SPOP ubiquitin E3 ligase promotes the poly-ubiquitination and degradation of HDAC6. Oncotarget. 2017;8:47890-47901 pubmed publisher
  13. Li J, Yakushi T, Parlati F, MacKinnon A, Pérez C, Ma Y, et al. Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol. 2017;13:486-493 pubmed publisher
  14. Choi S, Piao Z, Jin L, Kim J, Kim G, Ryu Y, et al. Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling. PLoS ONE. 2016;11:e0167340 pubmed publisher
  15. Pujol Lopez Y, Kenis G, Stettinger W, Neumeier K, De Jonge S, Steinbusch H, et al. Effects of prenatal Poly I:C exposure on global histone deacetylase (HDAC) and DNA methyltransferase (DNMT) activity in the mouse brain. Mol Biol Rep. 2016;43:711-7 pubmed publisher
  16. Chaudhary S, Madhukrishna B, Adhya A, Keshari S, Mishra S. Overexpression of caspase 7 is ER? dependent to affect proliferation and cell growth in breast cancer cells by targeting p21(Cip). Oncogenesis. 2016;5:e219 pubmed publisher
  17. Anvarian Z, Nojima H, Van Kappel E, Madl T, Spit M, Viertler M, et al. Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network. Nat Struct Mol Biol. 2016;23:324-32 pubmed publisher
  18. Wei J, Xiong Z, Lee J, Cheng J, Duffney L, Matas E, et al. Histone Modification of Nedd4 Ubiquitin Ligase Controls the Loss of AMPA Receptors and Cognitive Impairment Induced by Repeated Stress. J Neurosci. 2016;36:2119-30 pubmed publisher
  19. Chauhan S, Ahmed Z, Bradfute S, Arko Mensah J, Mandell M, Won Choi S, et al. Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential. Nat Commun. 2015;6:8620 pubmed publisher
  20. Giaginis C, Damaskos C, Koutsounas I, Zizi Serbetzoglou A, Tsoukalas N, Patsouris E, et al. Histone deacetylase (HDAC)-1, -2, -4 and -6 expression in human pancreatic adenocarcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients' survival. BMC Gastroenterol. 2015;15:148 pubmed publisher
  21. Badal S, Her Y, Maher L. Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells. J Biol Chem. 2015;290:22287-97 pubmed publisher
  22. Nakashima H, Nguyen T, Goins W, Chiocca E. Interferon-stimulated gene 15 (ISG15) and ISG15-linked proteins can associate with members of the selective autophagic process, histone deacetylase 6 (HDAC6) and SQSTM1/p62. J Biol Chem. 2015;290:1485-95 pubmed publisher