This is a Validated Antibody Database (VAD) review about human GRN, based on 12 published articles (read how Labome selects the articles), using GRN antibody in all methods. It is aimed to help Labome visitors find the most suited GRN antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
GRN synonym: CLN11; GEP; GP88; PCDGF; PEPI; PGRN; granulins; PC cell-derived growth factor; acrogranin; granulin-epithelin; proepithelin; progranulin

Abcam
rabbit monoclonal (EPR3781)
  • immunocytochemistry; human; loading ...; fig 5a
  • western blot; human; loading ...; fig 5b
Abcam GRN antibody (Abcam, ab108608) was used in immunocytochemistry on human samples (fig 5a) and in western blot on human samples (fig 5b). Hum Mol Genet (2017) ncbi
rabbit monoclonal (EPR3781)
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 4c
  • western blot; human; 1:1000; loading ...; fig 5a
Abcam GRN antibody (Abcam, ab108608) was used in immunohistochemistry - paraffin section on human samples at 1:200 (fig 4c) and in western blot on human samples at 1:1000 (fig 5a). Mol Med Rep (2016) ncbi
rabbit monoclonal (EPR3781)
  • immunocytochemistry; mouse; 1:400; loading ...; fig 7B
Abcam GRN antibody (Abcam, ab108608) was used in immunocytochemistry on mouse samples at 1:400 (fig 7B). Oncotarget (2016) ncbi
rabbit monoclonal (EPR3781)
  • immunoprecipitation; human; loading ...; fig 4a
  • western blot; human; loading ...; fig 1a
Abcam GRN antibody (Abcam, EPR3781) was used in immunoprecipitation on human samples (fig 4a) and in western blot on human samples (fig 1a). J Psychiatry Neurosci (2016) ncbi
rabbit monoclonal (EPR3781)
  • western blot; human; 1:1000; fig 6
Abcam GRN antibody (Abcam, ab108608) was used in western blot on human samples at 1:1000 (fig 6). Biomed Res Int (2015) ncbi
Invitrogen
rabbit polyclonal
  • western blot; human; loading ...; fig 9f
In order to elucidate the mechanisms of TMEM106B-induced death, Invitrogen GRN antibody (Thermo Fisher, 40-3400) was used in western blot on human samples (fig 9f). J Biol Chem (2016) ncbi
rabbit polyclonal
  • western blot; human
In order to identify novel STAT3-interacting proteins in breast cancer cells, Invitrogen GRN antibody (Thermo Fisher Scientific, PA5-27275) was used in western blot on human samples . Genes Cancer (2015) ncbi
rabbit polyclonal
  • immunoprecipitation; human; 1 ug/time
  • immunocytochemistry; human; 1:100
  • western blot; human
In order to identify novel STAT3-interacting proteins in breast cancer cells, Invitrogen GRN antibody (Invitrogen, 40-3400) was used in immunoprecipitation on human samples at 1 ug/time, in immunocytochemistry on human samples at 1:100 and in western blot on human samples . Genes Cancer (2015) ncbi
rabbit polyclonal
  • western blot; human; 1:100
In order to examine the role of progranulin during HIV infection of the central nervous system, Invitrogen GRN antibody (Invitrogen, 40-3400) was used in western blot on human samples at 1:100. PLoS ONE (2014) ncbi
rabbit polyclonal
  • western blot; human; fig 4
In order to test if aberrant PGRN-TNFR interactions underlie the molecular basis for neuroinflammation, Invitrogen GRN antibody (Invitrogen, 40-3400) was used in western blot on human samples (fig 4). J Neurosci (2013) ncbi
R&D Systems
goat polyclonal
  • immunoprecipitation; human; fig 4
R&D Systems GRN antibody (R&D Systems, AF2420) was used in immunoprecipitation on human samples (fig 4). Sci Rep (2016) ncbi
goat polyclonal
  • western blot; human; fig 1,2,3,4,5,6
In order to determine how N-glycosylation of cysteine-proximal acceptor sites in glycoproteins requires oxidoreductase activity, R&D Systems GRN antibody (R+D systems, AF2420) was used in western blot on human samples (fig 1,2,3,4,5,6). J Cell Biol (2014) ncbi
goat polyclonal
  • western blot; human; 1:1000
In order to examine the role of progranulin during HIV infection of the central nervous system, R&D Systems GRN antibody (R&D Systems, AF2420) was used in western blot on human samples at 1:1000. PLoS ONE (2014) ncbi
Santa Cruz Biotechnology
mouse monoclonal (C-11)
  • western blot; human
In order to investigate the role of NUPR1 during liver carcinogenesis, Santa Cruz Biotechnology GRN antibody (Santa Cruz, sc-377036) was used in western blot on human samples . Hepatology (2015) ncbi
Articles Reviewed
  1. Tanaka Y, Suzuki G, Matsuwaki T, Hosokawa M, Serrano G, Beach T, et al. Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes. Hum Mol Genet. 2017;26:969-988 pubmed publisher
  2. Qian L, Lin L, Du Y, Hao X, Zhao Y, Liu X. MicroRNA-588 suppresses tumor cell migration and invasion by targeting GRN in lung squamous cell carcinoma. Mol Med Rep. 2016;14:3021-8 pubmed publisher
  3. Suzuki H, Matsuoka M. The Lysosomal Trafficking Transmembrane Protein 106B Is Linked to Cell Death. J Biol Chem. 2016;291:21448-21460 pubmed
  4. Buraschi S, Xu S, Stefanello M, Moskalev I, Morcavallo A, Genua M, et al. Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin. Oncotarget. 2016;7:39980-39995 pubmed publisher
  5. Cherepanova N, Gilmore R. Mammalian cells lacking either the cotranslational or posttranslocational oligosaccharyltransferase complex display substrate-dependent defects in asparagine linked glycosylation. Sci Rep. 2016;6:20946 pubmed publisher
  6. Alquézar C, de la Encarnación A, Moreno F, López de Munain A, Martín Requero Ã. Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers. J Psychiatry Neurosci. 2016;41:225-39 pubmed
  7. Marthandan S, Priebe S, Baumgart M, Groth M, Cellerino A, Guthke R, et al. Similarities in Gene Expression Profiles during In Vitro Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts. Biomed Res Int. 2015;2015:731938 pubmed publisher
  8. Lee Y, Jee B, Kwon S, Yoon Y, Xu W, Wang H, et al. Identification of a mitochondrial defect gene signature reveals NUPR1 as a key regulator of liver cancer progression. Hepatology. 2015;62:1174-89 pubmed publisher
  9. Yeh J, Kreimer S, Walker S, Emori M, Krystal H, Richardson A, et al. Granulin, a novel STAT3-interacting protein, enhances STAT3 transcriptional function and correlates with poorer prognosis in breast cancer. Genes Cancer. 2015;6:153-68 pubmed
  10. Cherepanova N, Shrimal S, Gilmore R. Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins. J Cell Biol. 2014;206:525-39 pubmed publisher
  11. Suh H, Lo Y, Choi N, Letendre S, Lee S. Evidence of the innate antiviral and neuroprotective properties of progranulin. PLoS ONE. 2014;9:e98184 pubmed publisher
  12. Chen X, Chang J, Deng Q, Xu J, Nguyen T, Martens L, et al. Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. J Neurosci. 2013;33:9202-13 pubmed publisher