This is a Validated Antibody Database (VAD) review about human GITR, based on 15 published articles (read how Labome selects the articles), using GITR antibody in all methods. It is aimed to help Labome visitors find the most suited GITR antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
GITR synonym: AITR; CD357; ENERGEN; GITR; GITR-D

BioLegend
mouse monoclonal (108-17)
  • flow cytometry; human; loading ...; fig 1c, s1a
BioLegend GITR antibody (Biolegend, 108-17) was used in flow cytometry on human samples (fig 1c, s1a). Oncoimmunology (2022) ncbi
mouse monoclonal (108-17)
  • flow cytometry; human; fig 2a
BioLegend GITR antibody (BioLegend, 108-17) was used in flow cytometry on human samples (fig 2a). Front Immunol (2021) ncbi
mouse monoclonal (621)
  • flow cytometry; human; fig 3a
  • immunocytochemistry; human; fig 2c
BioLegend GITR antibody (Biolegend, 621) was used in flow cytometry on human samples (fig 3a) and in immunocytochemistry on human samples (fig 2c). Commun Biol (2021) ncbi
mouse monoclonal (108-17)
  • flow cytometry; human; fig 7g
BioLegend GITR antibody (BioLegend, 371202) was used in flow cytometry on human samples (fig 7g). Cell (2018) ncbi
mouse monoclonal (621)
  • mass cytometry; human; loading ...; fig 2a
In order to investigate the immune composition of tumor microenvironment in hepatocellular carcinoma, BioLegend GITR antibody (Biolegend, 621) was used in mass cytometry on human samples (fig 2a). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (621)
  • mass cytometry; human; fig s8
BioLegend GITR antibody (BioLegend, 311602) was used in mass cytometry on human samples (fig s8). Nature (2017) ncbi
mouse monoclonal (621)
  • flow cytometry; human; fig st1
In order to find cell-surface markers specific to human neutrophils, BioLegend GITR antibody (BioLegen, 311610) was used in flow cytometry on human samples (fig st1). Exp Cell Res (2016) ncbi
Invitrogen
mouse monoclonal (eBioAITR)
  • flow cytometry; human; loading ...; fig 4b
Invitrogen GITR antibody (eBioscience, eBioAITR) was used in flow cytometry on human samples (fig 4b). BMC Immunol (2020) ncbi
mouse monoclonal (eBioAITR)
  • flow cytometry; human; loading ...; fig s3a
Invitrogen GITR antibody (eBioscience, eBioAITR) was used in flow cytometry on human samples (fig s3a). Cancer (2019) ncbi
mouse monoclonal (eBioAITR)
  • flow cytometry; rhesus macaque; fig 6g
  • flow cytometry; human; fig 1g
In order to identify and characterize CXCR5hiCD44hiCD8 T cells in HIV-infected individuals, Invitrogen GITR antibody (eBioscience, 12-5875) was used in flow cytometry on rhesus macaque samples (fig 6g) and in flow cytometry on human samples (fig 1g). PLoS Pathog (2016) ncbi
mouse monoclonal (eBioAITR)
  • flow cytometry; human; loading ...; fig 6a
In order to define the contribution of CD103+ tumor-infiltrating lymphocytes to high-grade serous epithelial ovarian cancer, Invitrogen GITR antibody (eBioscience, eBioAITR) was used in flow cytometry on human samples (fig 6a). Oncotarget (2016) ncbi
mouse monoclonal (eBioAITR)
  • flow cytometry; human; loading ...; fig 3b
In order to demonstrate that TGF-beta induces the differentiation of human CXCL13-producing CD4 positive T cells from naive CD4 positive T cells, Invitrogen GITR antibody (eBioscience, eBioAITR) was used in flow cytometry on human samples (fig 3b). Eur J Immunol (2016) ncbi
mouse monoclonal (eBioAITR)
  • flow cytometry; human; fig s2
Invitrogen GITR antibody (eBioscience, 12-5875) was used in flow cytometry on human samples (fig s2). Nat Commun (2015) ncbi
mouse monoclonal (eBioAITR)
  • flow cytometry; human
Invitrogen GITR antibody (eBioscience, eBioAITR) was used in flow cytometry on human samples . Clin Cancer Res (2014) ncbi
R&D Systems
mouse monoclonal (110416)
  • mass cytometry; human; loading ...; fig s4a
R&D Systems GITR antibody (R&D, MAB689) was used in mass cytometry on human samples (fig s4a). Biomark Res (2022) ncbi
mouse monoclonal (110416)
  • blocking or activating experiments; human; fig 4c
R&D Systems GITR antibody (R&D Systems, 110416) was used in blocking or activating experiments on human samples (fig 4c). Commun Biol (2021) ncbi
MilliporeSigma
mouse monoclonal (2H4)
  • western blot; human; 2.5 ug/ml; fig 1c
MilliporeSigma GITR antibody (SIGMA-ALDRICH, 2H4) was used in western blot on human samples at 2.5 ug/ml (fig 1c). Commun Biol (2021) ncbi
Articles Reviewed
  1. Pan C, Wu Q, Wang S, Mei Z, Zhang L, Gao X, et al. Combination with Toll-like receptor 4 (TLR4) agonist reverses GITR agonism mediated M2 polarization of macrophage in Hepatocellular carcinoma. Oncoimmunology. 2022;11:2073010 pubmed publisher
  2. Jiang Z, Qin L, Tang Y, Liao R, Shi J, He B, et al. Human induced-T-to-natural killer cells have potent anti-tumour activities. Biomark Res. 2022;10:13 pubmed publisher
  3. Ming S, Yin H, Li X, Gong S, Zhang G, Wu Y. GITR Promotes the Polarization of TFH-Like Cells in Helicobacter pylori-Positive Gastritis. Front Immunol. 2021;12:736269 pubmed publisher
  4. Chan M, Wu L, Yun Z, McKee T, Cabanero M, Zhao Y, et al. Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma. Commun Biol. 2021;4:914 pubmed publisher
  5. Liu G, Yu Y, Feng F, Zhu P, Zhang H, Zhang D, et al. Human CD8+CD28- T suppressor cells expanded by common gamma chain (γc) cytokines retain steady allospecific suppressive capacity in vivo. BMC Immunol. 2020;21:23 pubmed publisher
  6. Williams P, Basu S, Garcia Manero G, Hourigan C, Oetjen K, Cortes J, et al. The distribution of T-cell subsets and the expression of immune checkpoint receptors and ligands in patients with newly diagnosed and relapsed acute myeloid leukemia. Cancer. 2019;125:1470-1481 pubmed publisher
  7. Tavazoie M, Pollack I, Tanqueco R, Ostendorf B, Reis B, Gonsalves F, et al. LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer. Cell. 2018;172:825-840.e18 pubmed publisher
  8. Chew V, Lai L, Pan L, Lim C, Li J, Ong R, et al. Delineation of an immunosuppressive gradient in hepatocellular carcinoma using high-dimensional proteomic and transcriptomic analyses. Proc Natl Acad Sci U S A. 2017;114:E5900-E5909 pubmed publisher
  9. Lu X, Horner J, Paul E, Shang X, Troncoso P, Deng P, et al. Effective combinatorial immunotherapy for castration-resistant prostate cancer. Nature. 2017;543:728-732 pubmed publisher
  10. Miles B, Miller S, Folkvord J, Levy D, Rakasz E, Skinner P, et al. Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection. PLoS Pathog. 2016;12:e1005924 pubmed publisher
  11. Komdeur F, Wouters M, Workel H, Tijans A, Terwindt A, Brunekreeft K, et al. CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy. Oncotarget. 2016;7:75130-75144 pubmed publisher
  12. Lakschevitz F, Hassanpour S, Rubin A, Fine N, Sun C, Glogauer M. Identification of neutrophil surface marker changes in health and inflammation using high-throughput screening flow cytometry. Exp Cell Res. 2016;342:200-9 pubmed publisher
  13. Kobayashi S, Watanabe T, Suzuki R, Furu M, Ito H, Ito J, et al. TGF-β induces the differentiation of human CXCL13-producing CD4(+) T cells. Eur J Immunol. 2016;46:360-71 pubmed publisher
  14. Miles B, Miller S, Folkvord J, Kimball A, Chamanian M, Meditz A, et al. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. 2015;6:8608 pubmed publisher
  15. Ohue Y, Kurose K, Mizote Y, Matsumoto H, Nishio Y, Isobe M, et al. Prolongation of overall survival in advanced lung adenocarcinoma patients with the XAGE1 (GAGED2a) antibody. Clin Cancer Res. 2014;20:5052-63 pubmed publisher