This is a Validated Antibody Database (VAD) review about human GCLC, based on 13 published articles (read how Labome selects the articles), using GCLC antibody in all methods. It is aimed to help Labome visitors find the most suited GCLC antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
GCLC synonym: GCL; GCS; GLCL; GLCLC

Abcam
domestic rabbit monoclonal (EP13475)
  • western blot; mouse; 1:1000; loading ...; fig s4a
Abcam GCLC antibody (Abcam, Ab190685) was used in western blot on mouse samples at 1:1000 (fig s4a). Cancer Cell (2020) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig s5d
Abcam GCLC antibody (Abcam, ab53179) was used in immunohistochemistry - frozen section on mouse samples at 1:200 (fig s5d). Atherosclerosis (2019) ncbi
domestic rabbit monoclonal (EP13475)
  • western blot; human; 1:10,000; loading ...; fig s1c
Abcam GCLC antibody (Abcam, ab190685) was used in western blot on human samples at 1:10,000 (fig s1c). Atherosclerosis (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 3c
Abcam GCLC antibody (Abcam, ab53179) was used in western blot on mouse samples (fig 3c). Neuroscience (2018) ncbi
domestic rabbit monoclonal (EP13475)
  • immunohistochemistry; human; 1:200; fig 1a
Abcam GCLC antibody (Abcam, ab190685) was used in immunohistochemistry on human samples at 1:200 (fig 1a). Am J Physiol Gastrointest Liver Physiol (2018) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 6
Abcam GCLC antibody (Abcam, ab41463) was used in western blot on mouse samples (fig 6). Redox Biol (2016) ncbi
domestic rabbit monoclonal (EP13475)
  • western blot; mouse; 1:25,000; loading ...; fig 2d
Abcam GCLC antibody (Abcam, ab19068) was used in western blot on mouse samples at 1:25,000 (fig 2d). Toxicol Appl Pharmacol (2016) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - frozen section; mouse; 1:500; fig 3
Abcam GCLC antibody (Abcam, ab41463) was used in immunohistochemistry - frozen section on mouse samples at 1:500 (fig 3). J Transl Med (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:2000; loading ...; fig 6a
Abcam GCLC antibody (Abcam, ab53179) was used in western blot on mouse samples at 1:2000 (fig 6a). Redox Biol (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (G-12)
  • western blot; mouse; 1:1000; fig s7c
Santa Cruz Biotechnology GCLC antibody (Santa Cruz, sc-166345) was used in western blot on mouse samples at 1:1000 (fig s7c). Nat Commun (2021) ncbi
mouse monoclonal (G-12)
  • western blot; human; 1:200; fig 4
Santa Cruz Biotechnology GCLC antibody (Santa Cruz, sc166345) was used in western blot on human samples at 1:200 (fig 4). Biochem Pharmacol (2016) ncbi
Invitrogen
domestic rabbit polyclonal
  • western blot; human; 1:1000
In order to study the epigenetic regulation of oxidative genes involved in the pathogenesis of chronic obstructive pulmonary disease, Invitrogen GCLC antibody (Lab Vision, PA5-19702) was used in western blot on human samples at 1:1000. Chest (2016) ncbi
domestic rabbit polyclonal
In order to test if erythroid 2-like 2 regulates expression of ITPR3, Invitrogen GCLC antibody (Thermo Scientific, PA5-19702) was used . Gastroenterology (2015) ncbi
Aviva Systems Biology
domestic rabbit polyclonal
  • western blot; human; 1:500; loading ...; fig 3d
Aviva Systems Biology GCLC antibody (Aviva biologicals, ARP54577_P050) was used in western blot on human samples at 1:500 (fig 3d). Biomolecules (2019) ncbi
Articles Reviewed
  1. Bebber C, Thomas E, Stroh J, Chen Z, Androulidaki A, Schmitt A, et al. Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nat Commun. 2021;12:2048 pubmed publisher
  2. Cheung E, DeNicola G, Nixon C, Blyth K, Labuschagne C, Tuveson D, et al. Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer. Cancer Cell. 2020;37:168-182.e4 pubmed publisher
  3. Zhu Y, Zhang Y, Huang X, Xie Y, Qu Y, Long H, et al. Z-Ligustilide protects vascular endothelial cells from oxidative stress and rescues high fat diet-induced atherosclerosis by activating multiple NRF2 downstream genes. Atherosclerosis. 2019;284:110-120 pubmed publisher
  4. McCambridge G, Agrawal M, Keady A, Kern P, Hasturk H, Nikolajczyk B, et al. Saturated Fatty Acid Activates T Cell Inflammation Through a Nicotinamide Nucleotide Transhydrogenase (NNT)-Dependent Mechanism. Biomolecules. 2019;9: pubmed publisher
  5. Lv W, Deng B, Duan W, Li Y, Liu Y, Li Z, et al. Schwann Cell Plasticity is Regulated by a Weakened Intrinsic Antioxidant Defense System in Acute Peripheral Nerve Injury. Neuroscience. 2018;382:1-13 pubmed publisher
  6. Brown I, Gulbransen B. The antioxidant glutathione protects against enteric neuron death in situ, but its depletion is protective during colitis. Am J Physiol Gastrointest Liver Physiol. 2018;314:G39-G52 pubmed publisher
  7. Shanmugam G, Narasimhan M, Sakthivel R, Kumar R R, Davidson C, Palaniappan S, et al. A biphasic effect of TNF-? in regulation of the Keap1/Nrf2 pathway in cardiomyocytes. Redox Biol. 2016;9:77-89 pubmed publisher
  8. Wang Y, Chen M, Zhang Y, Huo T, Fang Y, Jiao X, et al. Effects of realgar on GSH synthesis in the mouse hippocampus: Involvement of system XAG(-), system XC(-), MRP-1 and Nrf2. Toxicol Appl Pharmacol. 2016;308:91-101 pubmed publisher
  9. Kumar R, Narasimhan M, Shanmugam G, Hong J, Devarajan A, Palaniappan S, et al. Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress. J Transl Med. 2016;14:86 pubmed publisher
  10. Koyani C, Kitz K, Rossmann C, Bernhart E, Huber E, Trummer C, et al. Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death. Biochem Pharmacol. 2016;104:29-41 pubmed publisher
  11. Chaiprasongsuk A, Onkoksoong T, Pluemsamran T, Limsaengurai S, Panich U. Photoprotection by dietary phenolics against melanogenesis induced by UVA through Nrf2-dependent antioxidant responses. Redox Biol. 2016;8:79-90 pubmed publisher
  12. Cheng L, Liu J, Li B, Liu S, Li X, Tu H. Cigarette Smoke-Induced Hypermethylation of the GCLC Gene Is Associated With COPD. Chest. 2016;149:474-482 pubmed publisher
  13. Weerachayaphorn J, Amaya M, Spirli C, Chansela P, Mitchell Richards K, Ananthanarayanan M, et al. Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes. Gastroenterology. 2015;149:211-222.e10 pubmed publisher