This is a Validated Antibody Database (VAD) review about human GBA, based on 17 published articles (read how Labome selects the articles), using GBA antibody in all methods. It is aimed to help Labome visitors find the most suited GBA antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
GBA synonym: GBA1; GCB; GLUC

Knockout validation
Abcam
monoclonal (ab55080)
  • western blot knockout validation; human; loading ...; fig 2b
Abcam GBA antibody (Abcam, ab55080) was used in western blot knockout validation on human samples (fig 2b). J Virol (2019) ncbi
Santa Cruz Biotechnology
mouse monoclonal (A-16)
  • western blot knockout validation; mouse; loading ...; fig s7
Santa Cruz Biotechnology GBA antibody (SantaCruz, sc-100544) was used in western blot knockout validation on mouse samples (fig s7). EBioMedicine (2016) ncbi
Abcam
monoclonal (ab55080)
  • immunohistochemistry; mouse; 1:100; loading ...; fig 1c
  • western blot; mouse; loading ...; fig 3a
Abcam GBA antibody (Abcam, ab55080) was used in immunohistochemistry on mouse samples at 1:100 (fig 1c) and in western blot on mouse samples (fig 3a). Proc Natl Acad Sci U S A (2021) ncbi
domestic rabbit monoclonal (EPR5142)
  • immunohistochemistry - frozen section; human; 1:150; loading ...; fig 3
Abcam GBA antibody (Abcam, ab125065) was used in immunohistochemistry - frozen section on human samples at 1:150 (fig 3). Biochim Biophys Acta Mol Cell Biol Lipids (2020) ncbi
monoclonal (ab55080)
  • western blot knockout validation; human; loading ...; fig 2b
Abcam GBA antibody (Abcam, ab55080) was used in western blot knockout validation on human samples (fig 2b). J Virol (2019) ncbi
domestic rabbit monoclonal (EPR5143(3))
  • western blot; human; 1:1000; loading ...; fig 3e
Abcam GBA antibody (Abcam, ab128879) was used in western blot on human samples at 1:1000 (fig 3e). Biochem J (2019) ncbi
monoclonal (ab55080)
  • western blot; human; loading ...; fig 5
Abcam GBA antibody (Ab-CAM, ab55080) was used in western blot on human samples (fig 5). J Neurol (2019) ncbi
Santa Cruz Biotechnology
mouse monoclonal (C-2)
  • western blot; human; 1:500; loading ...; fig 3a
Santa Cruz Biotechnology GBA antibody (Santa Cruz, sc-365745) was used in western blot on human samples at 1:500 (fig 3a). Biochem J (2019) ncbi
mouse monoclonal (C-2)
  • western blot; human; loading ...; fig 3g
In order to study the promotion of lysosomal biogenesis and autophagy by nucleus-translocated ACSS2, Santa Cruz Biotechnology GBA antibody (Santa cruz, Sc365745) was used in western blot on human samples (fig 3g). Mol Cell (2017) ncbi
mouse monoclonal (C-2)
  • western blot; human; loading ...; fig 1c
Santa Cruz Biotechnology GBA antibody (Santa Cruz, sc- 365745) was used in western blot on human samples (fig 1c). J Cell Physiol (2017) ncbi
mouse monoclonal (A-16)
  • western blot knockout validation; mouse; loading ...; fig s7
Santa Cruz Biotechnology GBA antibody (SantaCruz, sc-100544) was used in western blot knockout validation on mouse samples (fig s7). EBioMedicine (2016) ncbi
mouse monoclonal (A-16)
  • western blot; mouse; 1:500
Santa Cruz Biotechnology GBA antibody (Santa Cruz, sc-100544) was used in western blot on mouse samples at 1:500. Blood (2015) ncbi
Abnova
mouse monoclonal (2.00E+02)
  • western blot; human; loading ...; fig 2a
Abnova GBA antibody (Abnova, H00002629-M01) was used in western blot on human samples (fig 2a). Sci Rep (2018) ncbi
mouse monoclonal (2.00E+02)
  • western blot; human; loading ...; fig 2a
Abnova GBA antibody (Abnova, H00002629-M01) was used in western blot on human samples (fig 2a). Brain (2014) ncbi
OriGene
mouse monoclonal (OTI1D12)
  • immunohistochemistry - free floating section; mouse; 1:150; loading ...; fig 2e
OriGene GBA antibody (Origene, TA803361) was used in immunohistochemistry - free floating section on mouse samples at 1:150 (fig 2e). Nat Med (2018) ncbi
New England Biolabs
domestic rabbit
  • ELISA; human; loading ...; fig 8d
In order to characterize the features of piggyBac vectors, New England Biolabs GBA antibody (New England BioLabs, E8023S) was used in ELISA on human samples (fig 8d). Mol Ther Nucleic Acids (2016) ncbi
domestic rabbit
  • western blot; human; fig 3
In order to report the crystal structure of the E6/E6AP/p53 complex, New England Biolabs GBA antibody (NEB, E8023S) was used in western blot on human samples (fig 3). Nature (2016) ncbi
domestic rabbit
New England Biolabs GBA antibody (New England Biolabs, E8023S) was used . Nat Commun (2015) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 5k
MilliporeSigma GBA antibody (Sigma, G4171) was used in western blot on mouse samples at 1:1000 (fig 5k). Neurotherapeutics (2022) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 2c
MilliporeSigma GBA antibody (Sigma, G4171) was used in western blot on mouse samples at 1:1000 (fig 2c). PLoS ONE (2021) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - free floating section; mouse; 1:1000; loading ...; fig 2e
MilliporeSigma GBA antibody (Sigma-Aldrich, G4171) was used in immunohistochemistry - free floating section on mouse samples at 1:1000 (fig 2e). Nat Med (2018) ncbi
Articles Reviewed
  1. Nuber S, Chung C, Tardiff D, Bechade P, McCaffery T, Shimanaka K, et al. A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity. Neurotherapeutics. 2022;19:1018-1036 pubmed publisher
  2. Glajch K, Moors T, Chen Y, Bechade P, Nam A, Rajsombath M, et al. Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  3. Polinski N, Martinez T, Gorodinsky A, Gareus R, Sasner M, Herberth M, et al. Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model. PLoS ONE. 2021;16:e0252325 pubmed publisher
  4. Boer D, Van Smeden J, Al Khakany H, Melnik E, van Dijk R, Absalah S, et al. Skin of atopic dermatitis patients shows disturbed β-glucocerebrosidase and acid sphingomyelinase activity that relates to changes in stratum corneum lipid composition. Biochim Biophys Acta Mol Cell Biol Lipids. 2020;1865:158673 pubmed publisher
  5. Drews K, Calgi M, Harrison W, Drews C, Costa Pinheiro P, Shaw J, et al. Glucosylceramidase Maintains Influenza Virus Infection by Regulating Endocytosis. J Virol. 2019;93: pubmed publisher
  6. Qi W, Davidson B, Nguyen M, Lindstrom T, Grey R, Burnett R, et al. Validation of anti-glucocerebrosidase antibodies for western blot analysis on protein lysates of murine and human cells. Biochem J. 2019;476:261-274 pubmed publisher
  7. Tonin R, Catarzi S, Caciotti A, Procopio E, Marini C, Guerrini R, et al. Progressive myoclonus epilepsy in Gaucher Disease due to a new Gly-Gly mutation causing loss of an Exonic Splicing Enhancer. J Neurol. 2019;266:92-101 pubmed publisher
  8. Atashrazm F, Hammond D, Perera G, Dobson Stone C, Mueller N, Pickford R, et al. Reduced glucocerebrosidase activity in monocytes from patients with Parkinson's disease. Sci Rep. 2018;8:15446 pubmed publisher
  9. Massaro G, Mattar C, Wong A, Sirka E, Buckley S, Herbert B, et al. Fetal gene therapy for neurodegenerative disease of infants. Nat Med. 2018;24:1317-1323 pubmed publisher
  10. Li X, Yu W, Qian X, Xia Y, Zheng Y, Lee J, et al. Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. Mol Cell. 2017;66:684-697.e9 pubmed publisher
  11. Squillaro T, Antonucci I, Alessio N, Esposito A, Cipollaro M, Melone M, et al. Impact of lysosomal storage disorders on biology of mesenchymal stem cells: Evidences from in vitro silencing of glucocerebrosidase (GBA) and alpha-galactosidase A (GLA) enzymes. J Cell Physiol. 2017;232:3454-3467 pubmed publisher
  12. Jian J, Tian Q, Hettinghouse A, Zhao S, Liu H, Wei J, et al. Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease. EBioMedicine. 2016;13:212-224 pubmed publisher
  13. Troyanovsky B, Bitko V, Pastukh V, Fouty B, Solodushko V. The Functionality of Minimal PiggyBac Transposons in Mammalian Cells. Mol Ther Nucleic Acids. 2016;5:e369 pubmed publisher
  14. Martinez Zapien D, Ruiz F, Poirson J, Mitschler A, Ramirez J, Forster A, et al. Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53. Nature. 2016;529:541-5 pubmed publisher
  15. Sharma R, Anguela X, Doyon Y, Wechsler T, DeKelver R, Sproul S, et al. In vivo genome editing of the albumin locus as a platform for protein replacement therapy. Blood. 2015;126:1777-84 pubmed publisher
  16. Reddy V, Sun S, Azimi E, Elmariah S, Dong X, Lerner E. Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs. Nat Commun. 2015;6:7864 pubmed publisher
  17. Murphy K, Gysbers A, Abbott S, Tayebi N, Kim W, Sidransky E, et al. Reduced glucocerebrosidase is associated with increased ?-synuclein in sporadic Parkinson's disease. Brain. 2014;137:834-48 pubmed publisher